| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| C S Myers, M A Contreras, M C Chang, S I Rapoport, N M Appe. Haloperidol downregulates phospholipase A(2) signaling in rat basal ganglia circuits. Brain research. vol 896. issue 1-2. 2001-06-28. PMID:11277978. |
chronic haloperidol significantly decreased [3h]aa incorporation in two primary dopaminergic basal ganglia-frontal cortex circuits, the mesocorticolimbic and nigrostriatal systems, while insignificant changes in aa incorporation were noted in other brain regions. |
2001-06-28 |
2023-08-12 |
rat |
| M Roceri, R Molteni, F Fumagalli, G Racagni, M Gennarelli, G Corsini, R Maggio, M Riv. Stimulatory role of dopamine on fibroblast growth factor-2 expression in rat striatum. Journal of neurochemistry. vol 76. issue 4. 2001-03-22. PMID:11181818. |
we found that coinjection of dopaminergic d1 (sch23390) or d2 (haloperidol) receptor antagonists prevents nicotine-induced elevation of fgf-2 expression. |
2001-03-22 |
2023-08-12 |
rat |
| L Besret, M A Caldwell, E M Torres, S B Dunnet. Antioxidant strategy to counteract the side effects of antipsychotic therapy: an in vivo study in rats. European journal of pharmacology. vol 408. issue 1. 2001-01-26. PMID:11070181. |
in order to determine whether the level of tyrosine hydroxylase could be affected by subchronic administration of haloperidol, we examined tyrosine hydroxylase-positive immunoreactive cells in the substantia nigra after blockade of dopaminergic receptors with this antipsychotic. |
2001-01-26 |
2023-08-12 |
rat |
| N M Dawson, E H Hamid, M F Egan, G E Meredit. Changes in the pattern of brain-derived neurotrophic factor immunoreactivity in the rat brain after acute and subchronic haloperidol treatment. Synapse (New York, N.Y.). vol 39. issue 1. 2001-01-25. PMID:11071712. |
these results show that blockade of dopaminergic receptors with haloperidol rapidly downregulates bdnf in reward and emotional centers of the brain. |
2001-01-25 |
2023-08-12 |
rat |
| A Fink-Jense. Novel pharmacological approaches to the treatment of schizophrenia. Danish medical bulletin. vol 47. issue 3. 2000-11-30. PMID:10913983. |
also these results are in concordance with the clinical effects of clozapine, risperidone, sertindole and haloperidol and support the hypothesis that reduced dopaminergic tone in the prefrontal cortex relates to the negative symptoms of schizophrenia. |
2000-11-30 |
2023-08-12 |
human |
| N M de Bruin, E L van Luijtelaar, S J Jansen, A R Cools, B A Ellenbroe. Dopamine characteristics in different rat genotypes: the relation to absence epilepsy. Neuroscience research. vol 38. issue 2. 2000-11-01. PMID:11000443. |
assuming that haloperidol decreases dopaminergic transmission in the nigrostriatal system via inhibition of the dopamine receptors and enhances dopaminergic transmission in the mesolimbic system via inhibition of the noradrenergic receptors, it was postulated that haloperidol would enhance the difference in dopaminergic reactivity between both systems in favor of the accumbens. |
2000-11-01 |
2023-08-12 |
rat |
| N M de Bruin, E L van Luijtelaar, S J Jansen, A R Cools, B A Ellenbroe. Dopamine characteristics in different rat genotypes: the relation to absence epilepsy. Neuroscience research. vol 38. issue 2. 2000-11-01. PMID:11000443. |
therefore, the second purpose in the present study was to investigate whether haloperidol (2 mg/kg, ip) could further potentiate swd incidence when injected in the apo-sus rats, already characterized by a relatively low dopaminergic reactivity of the nigrostriatal system and relatively high dopaminergic reactivity of the mesolimbic system, in comparison to the apo-unsus rat genotype. |
2000-11-01 |
2023-08-12 |
rat |
| N M de Bruin, E L van Luijtelaar, S J Jansen, A R Cools, B A Ellenbroe. Dopamine characteristics in different rat genotypes: the relation to absence epilepsy. Neuroscience research. vol 38. issue 2. 2000-11-01. PMID:11000443. |
it is suggested that haloperidol increases the swd incidence in apo-sus rats by enhancing the difference between the dopaminergic reactivity in the nigrostriatal and mesolimbic system. |
2000-11-01 |
2023-08-12 |
rat |
| G Kameda, M Dadmarz, W H Voge. Influence of various drugs on the voluntary intake of nicotine by rats. Neuropsychobiology. vol 41. issue 4. 2000-09-06. PMID:10828730. |
the effects of the dopaminergic agonists (l-dopa, pergolide) and antagonists (haloperidol, clozapin) and a cholinergic agonist (tacrine) and antagonist (mecamylamine) on the voluntary intake of nicotine were investigated with the 2-bottle paradigm with the test drugs being dissolved directly in the drinking fluid of the animals. |
2000-09-06 |
2023-08-12 |
rat |
| E F Field, I Q Whishaw, S M Pelli. Sex differences in catalepsy: evidence for hormone-dependent postural mechanisms in haloperidol-treated rats. Behavioural brain research. vol 109. issue 2. 2000-06-21. PMID:10762690. |
catalepsy, a symptom of parkinson's disease and related disorders can be produced in rats and other laboratory animals by the blockade of nigrostriatal dopamine using dopaminergic antagonists such as haloperidol. |
2000-06-21 |
2023-08-12 |
human |
| C Sebban, X Q Zhang, B Tesolin-Decros, M J Millan, M Speddin. Changes in EEG spectral power in the prefrontal cortex of conscious rats elicited by drugs interacting with dopaminergic and noradrenergic transmission. British journal of pharmacology. vol 128. issue 5. 2000-01-24. PMID:10556942. |
and dopaminergic antagonists (haloperidol 1 mg kg-1 i.p., raclopride 2.5 mg kg-1 s.c. ), which decrease dopaminergic transmission, induced an increase of eeg power. |
2000-01-24 |
2023-08-12 |
rat |
| V C Abílio, F M Freitas, M S Dolnikoff, A M Castrucci, R Frussa-Filh. Effects of continuous exposure to light on behavioral dopaminergic supersensitivity. Biological psychiatry. vol 45. issue 12. 1999-12-20. PMID:10376124. |
this study examines the effects of long-term continuous exposure to light on dopaminergic supersensitivity induced by repeated treatment with haloperidol in rats. |
1999-12-20 |
2023-08-12 |
rat |
| B Caronti, F Passarelli, C Calderaro, G Palladini, F E Pontier. Effects of haloperidol on the expression of lymphocyte dopamine receptor mRNAs in the rat. Progress in neuro-psychopharmacology & biological psychiatry. vol 23. issue 5. 1999-12-02. PMID:10509379. |
these results indicate short-lasting dynamic changes of expression of lymphocyte d1b dopamine receptor mrna by haloperidol and suggest that the effects of dopamine and dopaminergic drugs on the immune system might be mediated, at least in part, by direct interaction of these substances with dopamine receptors on lymphocyte membrane. |
1999-12-02 |
2023-08-12 |
rat |
| G Cai, H Gurdal, C Smith, H Y Wang, E Friedma. Inverse agonist properties of dopaminergic antagonists at the D(1A) dopamine receptor: uncoupling of the D(1A) dopamine receptor from G(s) protein. Molecular pharmacology. vol 56. issue 5. 1999-11-24. PMID:10531405. |
the dopaminergic antagonists clozapine, cis-flupenthixol, (+)-butaclamol, haloperidol, chlorpromazine, and fluphenazine inhibited constitutive adenylyl cyclase activity in membranes of cells expressing the d(1a) receptor. |
1999-11-24 |
2023-08-12 |
rat |
| A Ceci, A Brambilla, P Duranti, M Grauert, N Grippa, F Borsin. Effect of antipsychotic drugs and selective dopaminergic antagonists on dopamine-induced facilitatory activity in prelimbic cortical pyramidal neurons. An in vitro study. Neuroscience. vol 93. issue 1. 1999-10-08. PMID:10430475. |
the facilitatory effect of dopamine in prelimbic cortex was concentration dependently antagonized by haloperidol, risperidone, quetiapine, clozapine and by the selective d4 dopaminergic receptor antagonist l-745,870, but not by the selective d2/d3 dopaminergic receptor antagonist (-)-sulpiride. |
1999-10-08 |
2023-08-12 |
Not clear |
| B Johnston, J Ros. Role of prolactin in regulating the onset of winter fur growth in mink (Mustela vison): A reconsideration. The Journal of experimental zoology. vol 284. issue 4. 1999-09-23. PMID:10451421. |
during early july, while in the resting (telogen) stage of the hair growth cycle, mink were treated with slow release implants containing haloperidol (hal, a dopaminergic antagonist), melatonin (mel), deoxycorticosterone (doc), dhea and delta(5)-diol. |
1999-09-23 |
2023-08-12 |
Not clear |
| A R Mohn, R R Gainetdinov, M G Caron, B H Kolle. Mice with reduced NMDA receptor expression display behaviors related to schizophrenia. Cell. vol 98. issue 4. 1999-09-23. PMID:10481908. |
these behavioral alterations are similar to those observed in pharmacologically induced animal models of schizophrenia and can be ameliorated by treatment with haloperidol or clozapine, antipsychotic drugs that antagonize dopaminergic and serotonergic receptors. |
1999-09-23 |
2023-08-12 |
mouse |
| J Evenden, B Meyerso. The behavior of spontaneously hypertensive and Wistar Kyoto rats under a paced fixed consecutive number schedule of reinforcement. Pharmacology, biochemistry, and behavior. vol 63. issue 1. 1999-07-28. PMID:10340526. |
the data with d-amphetamine and haloperidol support biochemical findings that these rats have a deficit in dopaminergic function, and the strain differences in response to chlordiazepoxide and doi suggest that that there may be differences in gabaergic and 5-ht2-mediated neurotransmission relevant to regulating impulse control in the rat. |
1999-07-28 |
2023-08-12 |
rat |
| M Markianos, J Hatzimanolis, L Lykoura. Gonadal axis hormones in male schizophrenic patients during treatment with haloperidol and after switch to risperidone. Psychopharmacology. vol 143. issue 3. 1999-07-13. PMID:10353429. |
since both dopaminergic and serotonergic neuronal activities participate in regulation of the pituitary gonadal axis (pga), it is expected that a switch from treatment with haloperidol to treatment with risperidone should influence plasma levels of pga hormones. |
1999-07-13 |
2023-08-12 |
Not clear |
| M E Kelley, J K Yao, D P van Kamme. Plasma catecholamine metabolites as markers for psychosis and antipsychotic response in schizophrenia. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 20. issue 6. 1999-06-24. PMID:10327429. |
the objective of this study was to determine the association between the patterns of change in the dopaminergic metabolite plasma homovanillic acid (hva), the noradrenergic metabolite 3-methoxy-4-hydroxyphenylglycol (mhpg), and psychosis following haloperidol withdrawal in schizophrenic patients. |
1999-06-24 |
2023-08-12 |
human |