| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ewa Obuchowicz, Jadwiga Turchan, Ryszard Przewłocki, Zbigniew S Herma. Amphetamine-induced effects on neuropeptide Y in the rat brain. Pharmacological reports : PR. vol 57. issue 3. 2006-09-07. PMID:15985714. |
moreover, amph injected 8 days after the last dose of repeated amph administration did not change npy-li up to 72 h. the minimal dose of haloperidol, the strong mixed dopaminergic d2/d1 receptor antagonist, (0.75 mg/kg injected ip 30 min before each of the multiple amph administrations) that was sufficient to completely block stereotypy and hyperlocomotion elicited by multiple amph administrations enhanced the amph-induced decrease in the striatal and accumbens npy-li. |
2006-09-07 |
2023-08-12 |
rat |
| Igor Khaliulin, Aviva Schneider, Esther Houminer, Joseph B Borman, Herzl Schwal. Apomorphine-induced myocardial protection is due to antioxidant and not adrenergic/dopaminergic effects. Free radical biology & medicine. vol 40. issue 10. 2006-08-03. PMID:16678010. |
haloperidol, a dopaminergic antagonist, did not affect the recovery with apo. |
2006-08-03 |
2023-08-12 |
rat |
| Adriana R Campos, Roberto C P Lima, Daniel E A Uchoa, Edilberto R Silveira, Flavia A Santos, Vietla S N Ra. Pro-erectile effects of an alkaloidal rich fraction from Aspidosperma ulei root bark in mice. Journal of ethnopharmacology. vol 104. issue 1-2. 2006-07-28. PMID:16229981. |
seventy-five percent of mice treated with yohimbine or f(3-5) showed penile erections, which were completely blocked by clonidine, an alpha-2-adrenoceptor agonist and haloperidol, a dopaminergic antagonist and as well as by l-name, a nitric oxide synthase inhibitor. |
2006-07-28 |
2023-08-12 |
mouse |
| Shelly T Yoshida, Shelley A Baella, Nancy M Stuebner, Cynthia A Crawford, Sanders A McDougal. Effects of a partial D2-like receptor agonist on striatal dopamine autoreceptor functioning in preweanling rats. Brain research. vol 1073-1074. 2006-07-19. PMID:16427034. |
during a state of high dopaminergic tone (i.e., after vehicle pretreatment), terguride had similar effects as haloperidol and increased dopa accumulation. |
2006-07-19 |
2023-08-12 |
rat |
| Andrzej Dekundy, Malgorzata Pietraszek, Daniela Schaefer, M Angela Cenci, Wojciech Danys. Effects of group I metabotropic glutamate receptors blockade in experimental models of Parkinson's disease. Brain research bulletin. vol 69. issue 3. 2006-07-06. PMID:16564428. |
the present study was devoted to investigate the effects of the metabotropic glutamate receptor(mglur)5 antagonist [(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine (mtep) and the mglur1 antagonist, (3-ethyl-2-methyl-quinolin-6-yl)-(4-methoxy-cyclohexyl)-methanone methanesulfonate (emqmcm), in animal studies indicative of antiparkinsonian-like activity such as haloperidol-induced catalepsy, hypoactivity in open field following haloperidol, and rotation in rats with unilateral 6-hydroxydopamine(ohda)-induced lesions of the midbrain dopaminergic system (alone and in combination with l-dopa). |
2006-07-06 |
2023-08-12 |
rat |
| Christopher J MacDonald, Warren H Mec. Differential effects of clozapine and haloperidol on interval timing in the supraseconds range. Psychopharmacology. vol 182. issue 2. 2006-01-18. PMID:16001114. |
these results support the proposal that typical antipsychotic drugs such as haloperidol and atypical antipsychotic drugs such as clozapine exert differential effects on dopaminergic, serotonergic, and glutamatergic systems within the cortex and striatum, two brain regions shown to be crucial for interval timing. |
2006-01-18 |
2023-08-12 |
rat |
| C L Parish, J Nunan, D I Finkelstein, F N McNamara, J Y Wong, J L Waddington, R M Brown, A J Lawrence, M K Horne, J Drag. Mice lacking the alpha4 nicotinic receptor subunit fail to modulate dopaminergic neuronal arbors and possess impaired dopamine transporter function. Molecular pharmacology. vol 68. issue 5. 2005-11-28. PMID:16077034. |
given the known effects of nachrs on dopaminergic neurotransmission, we assessed the ability of the alpha4 nachr subunit to regulate arbor size of dopaminergic neurons by comparing responses of wild-type and alpha4 nachr subunit knockout [alpha4(-/-)] mice to long-term exposure to cocaine, amphetamine, nicotine, and haloperidol, and after substantia nigra neurotoxic lesioning. |
2005-11-28 |
2023-08-12 |
mouse |
| E A Del Bel, F S Guimarães, M Bermúdez-Echeverry, M Z Gomes, A Schiaveto-de-souza, F E Padovan-Neto, V Tumas, A P Barion-Cavalcanti, M Lazzarini, L P Nucci-da-Silva, D de Paula-Souz. Role of nitric oxide on motor behavior. Cellular and molecular neurobiology. vol 25. issue 2. 2005-09-01. PMID:16047547. |
considering these results we suggest that (i) no may modulate motor behavior, probably by interfering with dopaminergic, serotonergic, and cholinergic neurotransmission in the striatum; (ii) subchronic no synthesis inhibition induces plastic changes in no-producing neurons in brain areas related to motor control and causes cross-tolerance to the cataleptic effect of haloperidol, raising the possibility that such treatments could decrease motor side effects associated with antipsychotic medications. |
2005-09-01 |
2023-08-12 |
mouse |
| Johan P Rung, Arvid Carlsson, Katarina Rydén Markinhuhta, Maria L Carlsso. The dopaminergic stabilizers (-)-OSU6162 and ACR16 reverse (+)-MK-801-induced social withdrawal in rats. Progress in neuro-psychopharmacology & biological psychiatry. vol 29. issue 5. 2005-08-26. PMID:15913873. |
in this study we aimed to evaluate the dopaminergic stabilizers (-)-osu6162 and acr16, compared to haloperidol and clozapine, in a rat model for schizophrenia, focusing on (+)-mk-801 induced social withdrawal. |
2005-08-26 |
2023-08-12 |
rat |
| Tomohisa Mori, Shinobu Ito, Minoru Narita, Tsutomu Suzuki, Toshiko Sawaguch. Combined effects of psychostimulants and morphine on locomotor activity in mice. Journal of pharmacological sciences. vol 96. issue 4. 2005-04-28. PMID:15599100. |
it is well known that psychostimulants- and opioids-induced hyperlocomotion is mediated by the activation of the dopaminergic system, however, haloperidol (a dopamine receptor antagonist) and u50,488h (which attenuates dopamine release from nerve terminals) significantly increased the effects of methamphetamine and morphine on the locomotor activity. |
2005-04-28 |
2023-08-12 |
mouse |
| Hidekazu Kawashima, Yasuhiko Iida, Youji Kitamura, Hideo Saj. Binding of 4-(4-chlorophenyl)-1-[4-(4-fluorophenyl)-4-oxobutyl]pyridinium ion (HPP+), a metabolite of haloperidol, to synthetic melanin: implications for the dopaminergic neurotoxicity of HPP+. Neurotoxicity research. vol 6. issue 7-8. 2005-04-08. PMID:15639785. |
binding of 4-(4-chlorophenyl)-1-[4-(4-fluorophenyl)-4-oxobutyl]pyridinium ion (hpp+), a metabolite of haloperidol, to synthetic melanin: implications for the dopaminergic neurotoxicity of hpp+. |
2005-04-08 |
2023-08-12 |
rat |
| Hidekazu Kawashima, Yasuhiko Iida, Youji Kitamura, Hideo Saj. Binding of 4-(4-chlorophenyl)-1-[4-(4-fluorophenyl)-4-oxobutyl]pyridinium ion (HPP+), a metabolite of haloperidol, to synthetic melanin: implications for the dopaminergic neurotoxicity of HPP+. Neurotoxicity research. vol 6. issue 7-8. 2005-04-08. PMID:15639785. |
the toxicity of 4-(4-chlorophenyl)-1-[4-(4-fluorophenyl)-4-oxobutyl]pyridinium ion (hpp+), a metabolite of haloperidol, toward dopaminergic neurons was investigated. |
2005-04-08 |
2023-08-12 |
rat |
| B Ribeiro Do Couto, M A Aguilar, C Manzanedo, M Rodríguez-Arias, J Miñarr. NMDA glutamate but not dopamine antagonists blocks drug-induced reinstatement of morphine place preference. Brain research bulletin. vol 64. issue 6. 2005-04-01. PMID:15639545. |
following extinction of a place preference induced by morphine (40 mg/kg), a non-contingent injection of the dopaminergic antagonists sch 23390 (0.125, 0.5 mg/kg), raclopride (0.3, 1.2 mg/kg), haloperidol (0.1, 0.2 mg/kg) and the dopamine (da) release inhibitor cgs 10746b (1, 10 mg/kg) or glutamatergic nmda antagonists memantine (10, 20, 40 mg/kg) and mk-801 (0.1, 0.2, 0.3 mg/kg) alone or with 10 mg/kg morphine was given. |
2005-04-01 |
2023-08-12 |
mouse |
| A Gepdiremen, N Aydin, Z Halici, O S Ahin, B Unal, M D Aydin, K Bakuridz. Chronic treatment of haloperidol causes vasoconstriction on basilar arteries of rats, dose dependently. Pharmacological research. vol 50. issue 6. 2005-03-23. PMID:15501694. |
haloperidol is a widely used antipsychotic drug, which exerts its effects via antagonizing the dopaminergic d2 receptors. |
2005-03-23 |
2023-08-12 |
rat |
| Iluminada Corripio, Ana M Catafau, Víctor Perez, Dolors Puigdemont, Esther Mena, Yolanda Aguilar, Ignasi Carrió, Enric Alvare. Striatal dopaminergic D2 receptor occupancy and clinical efficacy in psychosis exacerbation: a 123I-IBZM study with ziprasidone and haloperidol. Progress in neuro-psychopharmacology & biological psychiatry. vol 29. issue 1. 2005-02-15. PMID:15610950. |
striatal dopaminergic d2 receptor occupancy and clinical efficacy in psychosis exacerbation: a 123i-ibzm study with ziprasidone and haloperidol. |
2005-02-15 |
2023-08-12 |
Not clear |
| Iluminada Corripio, Ana M Catafau, Víctor Perez, Dolors Puigdemont, Esther Mena, Yolanda Aguilar, Ignasi Carrió, Enric Alvare. Striatal dopaminergic D2 receptor occupancy and clinical efficacy in psychosis exacerbation: a 123I-IBZM study with ziprasidone and haloperidol. Progress in neuro-psychopharmacology & biological psychiatry. vol 29. issue 1. 2005-02-15. PMID:15610950. |
the aim of this study was to compare striatal dopaminergic d2 receptor occupancy (d2 ro) induced by ziprasidone and haloperidol and its relationship with clinical response and extrapyramidal side effects (eps) in patients with acute psychosis exacerbation. |
2005-02-15 |
2023-08-12 |
Not clear |
| Matteo Marti, Flora Mela, Remo Guerrini, Girolamo Calò, Clementina Bianchi, Michele Morar. Blockade of nociceptin/orphanin FQ transmission in rat substantia nigra reverses haloperidol-induced akinesia and normalizes nigral glutamate release. Journal of neurochemistry. vol 91. issue 6. 2005-01-21. PMID:15584926. |
to investigate whether such motor-stimulating action was dependent on functional dopaminergic transmission, the selective nop receptor peptide antagonist [nphe1,arg14,lys15]n/ofq-nh2 (ufp-101) was microinjected into the substantia nigra reticulata of rats made cataleptic by systemic haloperidol administration. |
2005-01-21 |
2023-08-12 |
rat |
| Ingmar H A Franken, Vincent M Hendriks, Cornelis J Stam, Wim Van den Brin. A role for dopamine in the processing of drug cues in heroin dependent patients. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 14. issue 6. 2005-01-13. PMID:15589390. |
the present study tests the hypothesis that enhanced attention for heroin cues is mediated by the dopaminergic system using haloperidol as dopamine antagonist. |
2005-01-13 |
2023-08-12 |
Not clear |
| Bob Oranje, René S Kahn, Chantal Kemner, Marinus N Verbate. Modulating sensorimotor gating in healthy volunteers: the effects of desipramine and haloperidol. Psychiatry research. vol 127. issue 3. 2004-12-14. PMID:15296819. |
both desipramine and haloperidol reduced ppi, which suggests that an enhanced noradrenergic activity and a reduced dopaminergic activity lead to a reduction in sensorimotor gating. |
2004-12-14 |
2023-08-12 |
human |
| Petra Dirks, Silke Tieding, Ilka Schneider, Jörg Mey, Reto Weile. Characterization of retinoic acid neuromodulation in the carp retina. Journal of neuroscience research. vol 78. issue 2. 2004-11-15. PMID:15378613. |
the action of at-ra, however, seems independent of the dopaminergic system, known for its light-signaling role in the retina, because at-ra effects on spinule formation persisted in retina depleted of dopaminergic neurons or in the presence of haloperidol. |
2004-11-15 |
2023-08-12 |
Not clear |