| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J C Merritt, D D Perry, D N Russell, B F Jone. Topical delta 9-tetrahydrocannabinol and aqueous dynamics in glaucoma. Journal of clinical pharmacology. vol 21. issue S1. 1982-01-09. PMID:6271841. |
further glaucoma research should therefore proceed with marihuanas containing insignificant levels of thc (less than 0.4%) and with various local delivery systems of the ocular-active cannabinoid found in cannabis sativa. |
1982-01-09 |
2023-08-12 |
human |
| S A Turkanis, R Karle. Electrophysiologic properties of the cannabinoids. Journal of clinical pharmacology. vol 21. issue S1. 1982-01-09. PMID:6271840. |
the effects of the psychoactive cannabinoid delta 9-tetrahydrocannabinol (thc) and the nonpsychoactive cannabinoid cannabidiol (cbd) were investigated comparatively on electrically caused transcallosal cortical evoked responses, electrically induced limbic after discharges, photically evoked cortical afterdischarges, spontaneous cortical focal epileptic potentials, and spinal monosynaptic reflexes. |
1982-01-09 |
2023-08-12 |
Not clear |
| S A Turkanis, R Karle. Electrophysiologic properties of the cannabinoids. Journal of clinical pharmacology. vol 21. issue S1. 1982-01-09. PMID:6271840. |
the results clearly demonstrate the complexity of the cns properties of thc and the selectivity of the depressant properties of cannabidiol; moreover, the data illustrate the wide range of neuropharmacologic responses that potentially any cannabinoid can effect. |
1982-01-09 |
2023-08-12 |
Not clear |
| R Karler, S A Turkani. The cannabinoids as potential antiepileptics. Journal of clinical pharmacology. vol 21. issue S1. 1982-01-09. PMID:6975285. |
comparative studies of the anticonvulsant properties of the cannabinoids and prototype antiepileptic drugs in numerous animal seizure models demonstrate that (1) as an anticonvulsant, cannabidiol (cbd), in contrast to delta 9-tetrahydrocannabinol (thc), is relatively selective in terms of both central nervous system (cns), depressant and excitatory properties; (2) the potency of cannabidiol, unlike that of phenytoin and phenobarbital, varies greatly with the species; (3) the large potency difference between the cannabinoids and the antiepileptics in the mouse appears to be due to dispositional differences, because brain concentrations of all the drugs are very similar; (4) tolerance to the anticonvulsant properties of cannabidiol is not a prominent feature; in three seizure models, tolerance developed in one, but "reverse tolerance" developed in the other two; and (5) the results of a study of the electrophysiologic mechanisms of action indicate that cannabidiol produces some unique effects and that its spectrum of antiepileptic activity may be different from that of the prototype drugs. |
1982-01-09 |
2023-08-12 |
mouse |
| C E Turner, M A Elsohl. Biological activity of cannabichromene, its homologs and isomers. Journal of clinical pharmacology. vol 21. issue S1. 1982-01-09. PMID:7298870. |
cannabichromene (cbc) is one of four major cannabinoids in cannabis sativa l. and is the second most abundant cannabinoid in drug-type cannabis. |
1982-01-09 |
2023-08-12 |
rat |
| E Bertol, F Mar. Observations on cannabinoid content in Cannabis sativa L. grown in Tuscany, Italy. Bulletin on narcotics. vol 32. issue 4. 1981-11-22. PMID:6912080. |
observations on cannabinoid content in cannabis sativa l. grown in tuscany, italy. |
1981-11-22 |
2023-08-12 |
Not clear |
| J E O'Connor, T A Rejen. EMIT cannabinoid assay: confirmation by RIA and GC/MS. Journal of analytical toxicology. vol 5. issue 4. 1981-11-22. PMID:7024638. |
analysis of 496 urine samples using the emit cannabinoid assay suggested at least a casual use of marijuana by approximately 25% of the university student population studied. |
1981-11-22 |
2023-08-12 |
Not clear |
| J Schaeffer, T Andrysiak, J T Ungerleide. Cognition and long-term use of ganja (Cannabis). Science (New York, N.Y.). vol 213. issue 4506. 1981-08-27. PMID:6972600. |
neuropsychological variables and urine cannabinoid metabolites were evaluated in ten subjects born, raised, and educated in the united states and having histories of heavy or prolonged use of cannabis. |
1981-08-27 |
2023-08-12 |
human |
| H K Borys, R Karle. Post-column derivatization procedure for the colorimetric analysis of tissue cannabinoids separated by high-performance liquid chromatography. Journal of chromatography. vol 205. issue 2. 1981-06-23. PMID:6260827. |
a new method for quantitating cannabidiol (cbd) and delta 9-tetrahydrocannabinol (thc) in mouse plasma and brain involves (1) the separation of cbd and thc from their major metabolites by the use of isocratic, reversed-phase high-performance liquid chromatography (hplc), and (2) the on-line reaction of the cannabinoids with fast blue salt b (fbb) as a the former elute from the column; the colored cannabinoid-fbb derivatives are then detected at 490 nm in a spectrophotometer with a sensitivity of less than 50 ng. |
1981-06-23 |
2023-08-12 |
mouse |
| H Lazaratou, A Moschovakis, A Armaganidis, V Kapsambelis, J Kiburis, T A Kephala. The pharmacological effect of fractions obtained by smoking cannabis through a water-pipe. II. A second fractionation step. Experientia. vol 36. issue 12. 1981-05-21. PMID:7202656. |
all but one of the cannabis fractions prolonged the pentobarbital sleeping-time and disrupted the nest-building activity of mice in a way not related to their content in the main cannabinoids. |
1981-05-21 |
2023-08-12 |
mouse |
| W G Drew, C R Weet, S E De Rossett, J R Bat. Effects of hippocampal brain damage on auditory and visual recent memory: comparison with marijuana-intoxicated subjects. Biological psychiatry. vol 15. issue 6. 1981-04-24. PMID:6257312. |
results are discussed in terms of cannabinoid actions on hippocampal functioning and, in general, support the hypothesis that the action of marijuana in the brain may focus in the hippocampal region and produce behavioral changes similar to that resulting from traumatic injury or removal of the region. |
1981-04-24 |
2023-08-12 |
human |
| D Maor, T Treves, A D Korczy. Lack of effect of cannabinoids on carbonic anhydrase. Journal of neural transmission. vol 49. issue 3. 1981-03-17. PMID:6256470. |
in order to investigate whether these actions of cannabinoids are mediated through inhibition of carbonic anhydrase (ca), commercial solutions of the enzyme were exposed to delta 9-tetrahydrocannabinol and cannabidiol. |
1981-03-17 |
2023-08-12 |
Not clear |
| C E Turner, O J Bouwsma, S Billets, M A Elsohl. Constituents of Cannabis sativa L. XVIII--Electron voltage selected ion monitoring study of cannabinoids. Biomedical mass spectrometry. vol 7. issue 6. 1981-01-29. PMID:7426688. |
constituents of cannabis sativa l. xviii--electron voltage selected ion monitoring study of cannabinoids. |
1981-01-29 |
2023-08-12 |
Not clear |
| H R Frischknecht, B Sieber, P G Wase. Behavioral effects of hashish in mice. II. Nursing behavior and development of the sucklings. Psychopharmacology. vol 70. issue 2. 1981-01-26. PMID:6776575. |
adult mice were treated from parturition to weaning of their first litter with a hashish extract containing 40% delta 9-tetrahydrocannabinol (delta 9-thc), 45% cannabidiol, 9% cannabinol, and 6% other cannabinoids. |
1981-01-26 |
2023-08-12 |
mouse |
| A T Charlebois, P A Frie. Interactive effects of nutrition and cannabis upon rat perinatal development. Developmental psychobiology. vol 13. issue 6. 1981-01-26. PMID:7429020. |
in order to examine the effects of cannabinoids, malnutrition, and their possible interaction upon the developing rat fetus, female wistar rats were exposed to cannabis smoke, placebo smoke, or no smoke while concurrently consuming 1 of 3 diets differing in protein concentration (8%, 24%, 64%). |
1981-01-26 |
2023-08-12 |
rat |
| P B Baker, R Fowler, K R Bagon, T A Goug. Determination of the distribution of cannabinoids in cannabis resin using high performance liquid chromatography. Journal of analytical toxicology. vol 4. issue 3. 1980-12-18. PMID:7421149. |
determination of the distribution of cannabinoids in cannabis resin using high performance liquid chromatography. |
1980-12-18 |
2023-08-12 |
Not clear |
| P B Baker, R Fowler, K R Bagon, T A Goug. Determination of the distribution of cannabinoids in cannabis resin using high performance liquid chromatography. Journal of analytical toxicology. vol 4. issue 3. 1980-12-18. PMID:7421149. |
cannabis resin from pakistan and lebanon was examined for the presence of these cannabinoids. |
1980-12-18 |
2023-08-12 |
Not clear |
| H Rosenkrantz, H J Esbe. Cannabinoid-induced hormone changes in monkeys and rats. Journal of toxicology and environmental health. vol 6. issue 2. 1980-09-28. PMID:6248648. |
previous findings at various laboratories indicated that cannabinoids distribute to sexual behavior centers in the brain, and endocrine aberrations have consistently been observed in animals treated with cannabis constituents. |
1980-09-28 |
2023-08-12 |
rat |
| B J Gudzinowicz, M J Gudzinowicz, J Hologgitas, J L Driscol. The analysis of marijuana cannabinoids and their metabolites in biological media by GC and/or GC-MS techniques. Advances in chromatography. vol 18. 1980-09-26. PMID:6249094. |
the analysis of marijuana cannabinoids and their metabolites in biological media by gc and/or gc-ms techniques. |
1980-09-26 |
2023-08-12 |
Not clear |
| A J Ganz, P G Wase. [Testing the pharmacological activity of some synthetic cannabinoids in mice (author's transl)]. Arzneimittel-Forschung. vol 30. issue 3. 1980-08-15. PMID:7387758. |
a series of synthetic cannabinoids were tested in mice for analgesic, anticonvulsant, sedative and reserpine antagonistic properties as well as for influence on body temperature and on motor coordination and compared with the natural delta 9-tetrahydrocannabinol (delta 9-thc), delta 8-tetrahydrocannabinol (delta 8-thc) and cannabidiol (cbd). |
1980-08-15 |
2023-08-12 |
mouse |