| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| P H Reggio, R D Bramblett, H Yuknavich, H H Seltzman, D N Fleming, S R Fernando, L A Stevenson, R G Pertwe. The design, synthesis and testing of desoxy-CBD: further evidence for a region of steric interference at the cannabinoid receptor. Life sciences. vol 56. issue 23-24. 1995-07-11. PMID:7776828. |
cannabidiol cbd, a non-psychoactive constituent of marihuana, has been reported to possess essentially no affinity for cannabinoid cb1 receptor binding sites in the brain. |
1995-07-11 |
2023-08-12 |
mouse |
| A Abrahamov, A Abrahamov, R Mechoula. An efficient new cannabinoid antiemetic in pediatric oncology. Life sciences. vol 56. issue 23-24. 1995-07-11. PMID:7776837. |
delta-8-tetrahydrocannabinol (delta-8-thc), a cannabinoid with lower psychotropic potency than the main cannabis constituent, delta-9-tetrahydrocannabinol (delta-9-thc), was administered (18 mg/m2 in edible oil, p.o.) |
1995-07-11 |
2023-08-12 |
Not clear |
| S K Das, B C Paria, I Chakraborty, S K De. Cannabinoid ligand-receptor signaling in the mouse uterus. Proceedings of the National Academy of Sciences of the United States of America. vol 92. issue 10. 1995-06-16. PMID:7753807. |
the psychoactive cannabinoid component of marijuana--delta 9-tetrahydrocannabinol (thc)--or anandamide, but not the inactive and nonpsychoactive cannabidiol (cbd), inhibited forskolin-stimulated cyclic amp formation in the mouse uterus, which was prevented by pertussis toxin pretreatment. |
1995-06-16 |
2023-08-12 |
mouse |
| V Cirimele, P Kintz, P Mangi. Testing human hair for cannabis. Forensic science international. vol 70. issue 1-3. 1995-03-17. PMID:7860029. |
to validate information on cannabis use, we investigated human hair and pubic hair for cannabinoids (thc and thc-cooh) by gas chromatography/mass spectrometry. |
1995-03-17 |
2023-08-12 |
human |
| V Cirimele, P Kintz, P Mangi. Testing human hair for cannabis. Forensic science international. vol 70. issue 1-3. 1995-03-17. PMID:7860029. |
in most cases, the highest cannabinoid concentration was found in pubic hair, suggesting that this sample may be the more suitable for cannabis testing. |
1995-03-17 |
2023-08-12 |
human |
| C A Newton, T W Klein, H Friedma. Secondary immunity to Legionella pneumophila and Th1 activity are suppressed by delta-9-tetrahydrocannabinol injection. Infection and immunity. vol 62. issue 9. 1994-09-21. PMID:8063421. |
in this report, delta 9-tetrahydrocannabinol (thc), the major psychoactive cannabinoid of marijuana and an immunomodulator, suppressed development of secondary immunity to l. pneumophila, which correlated with a reduction in th1 activity. |
1994-09-21 |
2023-08-12 |
mouse |
| R D Mattes, L M Shaw, K Engelma. Effects of cannabinoids (marijuana) on taste intensity and hedonic ratings and salivary flow of adults. Chemical senses. vol 19. issue 2. 1994-09-14. PMID:8055263. |
effects of cannabinoids (marijuana) on taste intensity and hedonic ratings and salivary flow of adults. |
1994-09-14 |
2023-08-12 |
Not clear |
| F Rodríguez de Fonseca, M A Gorriti, J J Fernández-Ruiz, T Palomo, J A Ramo. Downregulation of rat brain cannabinoid binding sites after chronic delta 9-tetrahydrocannabinol treatment. Pharmacology, biochemistry, and behavior. vol 47. issue 1. 1994-03-25. PMID:8115426. |
specific cannabinoid receptors have been recently described in extrapyramidal and limbic areas and presumably might mediate the effects of marijuana exposure on behavioral processes related to those areas. |
1994-03-25 |
2023-08-12 |
rat |
| F Rodríguez de Fonseca, M A Gorriti, J J Fernández-Ruiz, T Palomo, J A Ramo. Downregulation of rat brain cannabinoid binding sites after chronic delta 9-tetrahydrocannabinol treatment. Pharmacology, biochemistry, and behavior. vol 47. issue 1. 1994-03-25. PMID:8115426. |
in this work, we examined whether cannabinoid receptors exhibit downregulation as a consequence of the chronic exposure to delta 9-tetrahydrocannabinol (thc), which might explain certain tolerance phenomena observed in relation to motor and limbic effects of marijuana. |
1994-03-25 |
2023-08-12 |
rat |
| L M Bornheim, K Y Kim, B Chen, M A Correi. The effect of cannabidiol on mouse hepatic microsomal cytochrome P450-dependent anandamide metabolism. Biochemical and biophysical research communications. vol 197. issue 2. 1994-01-25. PMID:8267610. |
we examined whether p450 would also metabolize anandamide, and whether cannabidiol (a cannabinoid which inactivates several p450s) would affect this metabolism. |
1994-01-25 |
2023-08-12 |
mouse |
| A Oviedo, J Glowa, M Herkenha. Chronic cannabinoid administration alters cannabinoid receptor binding in rat brain: a quantitative autoradiographic study. Brain research. vol 616. issue 1-2. 1993-09-30. PMID:8395305. |
to test the hypothesis that tolerance is mediated by changes in cannabinoid receptor binding characteristics, we used quantitative in vitro autoradiography of [3h]cp-55,940 binding to striatal brain sections from rats treated either chronically or acutely with delta 9-thc, cp-55,940, or the inactive natural cannabinoid cannabidiol. |
1993-09-30 |
2023-08-12 |
rat |
| J A Blanc, V A Manneh, R Ernst, D E Berger, S A de Keczer, C Chase, J M Centofanti, A J DeLizz. Adsorption losses from urine-based cannabinoid calibrators during routine use. Clinical chemistry. vol 39. issue 8. 1993-09-23. PMID:8394791. |
the major metabolite of cannabis found in urine, 11-nor-delta 9-tetrahydrocannabinol-9-carboxylic acid (delta 9-thc), is the compound most often used to calibrate cannabinoid immunoassays. |
1993-09-23 |
2023-08-12 |
Not clear |
| S Y Nah, D Saya, Z Voge. Cannabinoids inhibit agonist-stimulated formation of inositol phosphates in rat hippocampal cultures. European journal of pharmacology. vol 246. issue 1. 1993-09-17. PMID:8102606. |
addition of cannabinoids, such as delta 8-tetrahydrocannabinol, delta 9-tetrahydrocannabinol or the psychoinactive cannabidiol inhibited formation of inositol phosphates evoked by carbachol, glutamate or norepinephrine by 55-90%. |
1993-09-17 |
2023-08-12 |
rat |
| M Bouaboula, M Rinaldi, P Carayon, C Carillon, B Delpech, D Shire, G Le Fur, P Casella. Cannabinoid-receptor expression in human leukocytes. European journal of biochemistry. vol 214. issue 1. 1993-07-15. PMID:8508790. |
marijuana and many of its constituent cannabinoids influence the central nervous system (cns), probably through the cannabinoid receptor, which has recently been cloned in rat and human. |
1993-07-15 |
2023-08-12 |
human |
| M A Huestis, J E Henningfield, E J Con. Blood cannabinoids. I. Absorption of THC and formation of 11-OH-THC and THCCOOH during and after smoking marijuana. Journal of analytical toxicology. vol 16. issue 5. 1993-04-15. PMID:1338215. |
these findings have implications for understanding the mechanisms underlying the performance-impairing effects of marijuana, as well as for aiding forensic interpretation of cannabinoid blood levels. |
1993-04-15 |
2023-08-11 |
human |
| M A Huestis, J E Henningfield, E J Con. Blood cannabinoids. II. Models for the prediction of time of marijuana exposure from plasma concentrations of delta 9-tetrahydrocannabinol (THC) and 11-nor-9-carboxy-delta 9-tetrahydrocannabinol (THCCOOH) Journal of analytical toxicology. vol 16. issue 5. 1993-04-15. PMID:1338216. |
models for the prediction of time of marijuana exposure from plasma concentrations of delta 9-tetrahydrocannabinol (thc) and 11-nor-9-carboxy-delta 9-tetrahydrocannabinol (thccooh) two mathematical models are described for the prediction of time of marijuana use from the analysis of a single plasma sample for cannabinoids. |
1993-04-15 |
2023-08-11 |
Not clear |
| M A Huestis, J E Henningfield, E J Con. Blood cannabinoids. II. Models for the prediction of time of marijuana exposure from plasma concentrations of delta 9-tetrahydrocannabinol (THC) and 11-nor-9-carboxy-delta 9-tetrahydrocannabinol (THCCOOH) Journal of analytical toxicology. vol 16. issue 5. 1993-04-15. PMID:1338216. |
the models were derived from cannabinoid data obtained from a controlled clinical study of acute marijuana smoking. |
1993-04-15 |
2023-08-11 |
Not clear |
| L A Matsuda, T I Bonner, S J Lolai. Localization of cannabinoid receptor mRNA in rat brain. The Journal of comparative neurology. vol 327. issue 4. 1993-03-30. PMID:8440779. |
the localization of cannabinoid receptor mrna indicates that sensory, motor, cognitive, limbic, and autonomic systems should all be influenced by the activation of this receptor by either exogenous cannabimimetics, including marijuana, or the yet unknown endogenous "cannabinoid" ligand. |
1993-03-30 |
2023-08-12 |
rat |
| C J Heyser, R E Hampson, S A Deadwyle. Effects of delta-9-tetrahydrocannabinol on delayed match to sample performance in rats: alterations in short-term memory associated with changes in task specific firing of hippocampal cells. The Journal of pharmacology and experimental therapeutics. vol 264. issue 1. 1993-02-23. PMID:8380864. |
neither control injection of the vehicle nor equivalent concentrations of the nonpsychoactive cannabinoid, cannabidiol, produced alterations in dmts performance levels. |
1993-02-23 |
2023-08-12 |
rat |
| D B Houston, A C Howlet. Solubilization of the cannabinoid receptor from rat brain and its functional interaction with guanine nucleotide-binding proteins. Molecular pharmacology. vol 43. issue 1. 1993-02-23. PMID:8423766. |
the order of potency for cannabinoid agonists in heterologous equilibrium binding studies was cp-55244 > or = desacetyllevonantradol > delta 9-tetrahydrocannabinol > cannabinol >> cannabidiol, consistent with the relative affinities for these agonists in brain membrane preparations. |
1993-02-23 |
2023-08-12 |
rat |