| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| K Gree. Marijuana smoking vs cannabinoids for glaucoma therapy. Archives of ophthalmology (Chicago, Ill. : 1960). vol 116. issue 11. 1998-11-25. PMID:9823341. |
a perspective is given on the use of marijuana and the cannabinoids in the treatment of glaucoma. |
1998-11-25 |
2023-08-12 |
Not clear |
| S R Childers, C S Breivoge. Cannabis and endogenous cannabinoid systems. Drug and alcohol dependence. vol 51. issue 1-2. 1998-11-12. PMID:9716939. |
cannabis and endogenous cannabinoid systems. |
1998-11-12 |
2023-08-12 |
Not clear |
| W Zhu, H Friedman, T W Klei. Delta9-tetrahydrocannabinol induces apoptosis in macrophages and lymphocytes: involvement of Bcl-2 and caspase-1. The Journal of pharmacology and experimental therapeutics. vol 286. issue 2. 1998-09-02. PMID:9694974. |
the marijuana cannabinoid, delta9tetrahydrocannabinol (thc), has been reported to suppress in culture the proliferation of splenocytes and increase the release of il-1 from macrophages; however, the mechanisms of these effects remain unclear. |
1998-09-02 |
2023-08-12 |
Not clear |
| A J Hampson, M Grimaldi, J Axelrod, D Win. Cannabidiol and (-)Delta9-tetrahydrocannabinol are neuroprotective antioxidants. Proceedings of the National Academy of Sciences of the United States of America. vol 95. issue 14. 1998-08-06. PMID:9653176. |
the neuroprotective actions of cannabidiol and other cannabinoids were examined in rat cortical neuron cultures exposed to toxic levels of the excitatory neurotransmitter glutamate. |
1998-08-06 |
2023-08-12 |
rat |
| A J Hampson, M Grimaldi, J Axelrod, D Win. Cannabidiol and (-)Delta9-tetrahydrocannabinol are neuroprotective antioxidants. Proceedings of the National Academy of Sciences of the United States of America. vol 95. issue 14. 1998-08-06. PMID:9653176. |
glutamate toxicity was reduced by both cannabidiol, a nonpsychoactive constituent of marijuana, and the psychotropic cannabinoid (-)delta9-tetrahydrocannabinol (thc). |
1998-08-06 |
2023-08-12 |
rat |
| A J Hampson, M Grimaldi, J Axelrod, D Win. Cannabidiol and (-)Delta9-tetrahydrocannabinol are neuroprotective antioxidants. Proceedings of the National Academy of Sciences of the United States of America. vol 95. issue 14. 1998-08-06. PMID:9653176. |
cannabidiol, thc and several synthetic cannabinoids all were demonstrated to be antioxidants by cyclic voltametry. |
1998-08-06 |
2023-08-12 |
rat |
| A J Hampson, M Grimaldi, J Axelrod, D Win. Cannabidiol and (-)Delta9-tetrahydrocannabinol are neuroprotective antioxidants. Proceedings of the National Academy of Sciences of the United States of America. vol 95. issue 14. 1998-08-06. PMID:9653176. |
these data also suggest that the naturally occurring, nonpsychotropic cannabinoid, cannabidiol, may be a potentially useful therapeutic agent for the treatment of oxidative neurological disorders such as cerebral ischemia. |
1998-08-06 |
2023-08-12 |
rat |
| N A Patel, R L Moldow, J A Patel, G Wu, S L Chan. Arachidonylethanolamide (AEA) activation of FOS proto-oncogene protein immunoreactivity in the rat brain. Brain research. vol 797. issue 2. 1998-08-06. PMID:9666136. |
these findings provide valuable information on the response to aea at the level of neuronal activation and provide the basis for a broader understanding of the possible role of cb receptors in the modulation of motor and endocrine function associated with the use of exogenous cannabinoids, such as marijuana. |
1998-08-06 |
2023-08-12 |
rat |
| F Petitet, B Jeantaud, M Reibaud, A Imperato, M C Dubroeuc. Complex pharmacology of natural cannabinoids: evidence for partial agonist activity of delta9-tetrahydrocannabinol and antagonist activity of cannabidiol on rat brain cannabinoid receptors. Life sciences. vol 63. issue 1. 1998-07-23. PMID:9667767. |
complex pharmacology of natural cannabinoids: evidence for partial agonist activity of delta9-tetrahydrocannabinol and antagonist activity of cannabidiol on rat brain cannabinoid receptors. |
1998-07-23 |
2023-08-12 |
rat |
| F Petitet, B Jeantaud, M Reibaud, A Imperato, M C Dubroeuc. Complex pharmacology of natural cannabinoids: evidence for partial agonist activity of delta9-tetrahydrocannabinol and antagonist activity of cannabidiol on rat brain cannabinoid receptors. Life sciences. vol 63. issue 1. 1998-07-23. PMID:9667767. |
delta9-tetrahydrocannabinol (delta9-thc), cannabinol and cannabidiol are three important natural cannabinoids from the marijuana plant (cannabis sativa). |
1998-07-23 |
2023-08-12 |
rat |
| F Petitet, B Jeantaud, M Reibaud, A Imperato, M C Dubroeuc. Complex pharmacology of natural cannabinoids: evidence for partial agonist activity of delta9-tetrahydrocannabinol and antagonist activity of cannabidiol on rat brain cannabinoid receptors. Life sciences. vol 63. issue 1. 1998-07-23. PMID:9667767. |
cannabinol is a weak agonist on rat cerebellar cannabinoid receptors and cannabidiol behaves as an antagonist acting in the micromolar range. |
1998-07-23 |
2023-08-12 |
rat |
| J G van Amsterdam, J W van der Laan, J L Slange. [Cognitive and psychotic effects after cessation of chronic cannabis use]. Nederlands tijdschrift voor geneeskunde. vol 142. issue 10. 1998-07-02. PMID:9623095. |
establishment of residual cognitive and psychotic effects (effects present at the time that all active cannabinoids are eliminated from the body) putatively produced by prolonged heavy cannabis use is difficult, because of many confounding variables like slow elimination of active cannabinoids, lack of supervision during abstinence, poor use of well-matched control groups and the presence of withdrawal symptoms. |
1998-07-02 |
2023-08-12 |
Not clear |
| J Axelrod, C C Felde. Cannabinoid receptors and their endogenous agonist, anandamide. Neurochemical research. vol 23. issue 5. 1998-06-19. PMID:9566594. |
cannabinoids are a class of compound found in marijuana which have been known for their therapeutic and psychoactive properties for at least 4000 years. |
1998-06-19 |
2023-08-12 |
Not clear |
| M Fellermeier, M H Zen. Prenylation of olivetolate by a hemp transferase yields cannabigerolic acid, the precursor of tetrahydrocannabinol. FEBS letters. vol 427. issue 2. 1998-06-18. PMID:9607329. |
a new enzyme, geranylpyrophosphate:olivetolate geranyltransferase (got), the first enzyme in the biosynthesis of cannabinoids could be detected in extracts of young leaves of cannabis sativa. |
1998-06-18 |
2023-08-12 |
Not clear |
| T W Klein, H Friedman, S Specte. Marijuana, immunity and infection. Journal of neuroimmunology. vol 83. issue 1-2. 1998-06-12. PMID:9610678. |
the influence of marijuana cannabinoids on immune function has been examined extensively over the last 25 yr. |
1998-06-12 |
2023-08-12 |
human |
| T W Klein, H Friedman, S Specte. Marijuana, immunity and infection. Journal of neuroimmunology. vol 83. issue 1-2. 1998-06-12. PMID:9610678. |
various experimental models have been used employing drug-abusing human subjects, experimental animals exposed to marijuana smoke or injected with cannabinoids, and in vitro models employing immune cell cultures treated with various cannabinoids. |
1998-06-12 |
2023-08-12 |
human |
| B F Thomas, A F Gilliam, D F Burch, M J Roche, H H Seltzma. Comparative receptor binding analyses of cannabinoid agonists and antagonists. The Journal of pharmacology and experimental therapeutics. vol 285. issue 1. 1998-05-12. PMID:9536023. |
a series of alternatively halogenated analogs of sr141716a were synthesized and tested in rat brain membrane binding assays along with the classical cannabinoids, delta9-tetrahydrocannabinol, cannabinol, cannabidiol, the nonclassical cannabinoid cp-55,940, the aminoalkylindole win55212-2 and the endogenous fatty acid ethanolamide, anandamide. |
1998-05-12 |
2023-08-12 |
rat |
| B F Thomas, A F Gilliam, D F Burch, M J Roche, H H Seltzma. Comparative receptor binding analyses of cannabinoid agonists and antagonists. The Journal of pharmacology and experimental therapeutics. vol 285. issue 1. 1998-05-12. PMID:9536023. |
these results suggest that cp-55,940, win55212-2 and other agonists interact with cannabinoid binding sites within the brain which are distinguishable from the population of binding sites for sr141716a, its analogs and cannabidiol. |
1998-05-12 |
2023-08-12 |
rat |
| G L Gessa, M Melis, A L Muntoni, M Dian. Cannabinoids activate mesolimbic dopamine neurons by an action on cannabinoid CB1 receptors. European journal of pharmacology. vol 341. issue 1. 1998-04-29. PMID:9489854. |
these findings support the contention that cannabinoids regulate mesolimbic dopamine transmission and may help to explain the addictive properties of marijuana. |
1998-04-29 |
2023-08-12 |
rat |
| K R Müller-Vahl, H Kolbe, R Dengle. [Gilles de la Tourette syndrome. Effect of nicotine, alcohol and marihuana on clinical symptoms]. Der Nervenarzt. vol 68. issue 12. 1998-04-01. PMID:9465342. |
we suggest that marijuana influences an assumed interaction between cannabinoid and dopamine receptors and, by this, influences the dopaminergic processes in basal ganglia and motor activity. |
1998-04-01 |
2023-08-12 |
Not clear |