| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M R Hoehe, L Caenazzo, M M Martinez, W T Hsieh, W S Modi, E S Gershon, T I Bonne. Genetic and physical mapping of the human cannabinoid receptor gene to chromosome 6q14-q15. The New biologist. vol 3. issue 9. 1991-12-23. PMID:1931832. |
a cdna encoding a g protein-coupled receptor that appears to mediate the behavioral effects of cannabinoids, the psychoactive ingredients of marijuana, has recently been cloned from rat cerebral cortex and expressed. |
1991-12-23 |
2023-08-11 |
human |
| P Lafolie, O Beck, G Blennow, L Boréus, S Borg, C E Elwin, L Karlsson, G Odelius, P Hjemdah. Importance of creatinine analyses of urine when screening for abused drugs. Clinical chemistry. vol 37. issue 11. 1991-12-23. PMID:1934467. |
in a formerly heavy smoker of cannabis, the excretion of cannabinoids and creatinine was monitored for 93 days. |
1991-12-23 |
2023-08-11 |
Not clear |
| P Lafolie, O Beck, G Blennow, L Boréus, S Borg, C E Elwin, L Karlsson, G Odelius, P Hjemdah. Importance of creatinine analyses of urine when screening for abused drugs. Clinical chemistry. vol 37. issue 11. 1991-12-23. PMID:1934467. |
the substances showed very good correlation throughout this period (r = 0.93, p less than 0.001), whereas simple measurements of cannabinoid concentrations would have falsely indicated several relapses of cannabis abuse. |
1991-12-23 |
2023-08-11 |
Not clear |
| J C Eldridge, L L Murphy, P W Landfiel. Cannabinoids and the hippocampal glucocorticoid receptor: recent findings and possible significance. Steroids. vol 56. issue 5. 1991-09-24. PMID:1652167. |
it has long been recognized that cannabinoids, including delta 9-tetrahydrocannabinol (thc), the major psychoactive substance of marijuana, bear structural similarities to steroid hormones. |
1991-09-24 |
2023-08-11 |
rat |
| J C Eldridge, L L Murphy, P W Landfiel. Cannabinoids and the hippocampal glucocorticoid receptor: recent findings and possible significance. Steroids. vol 56. issue 5. 1991-09-24. PMID:1652167. |
cannabidiol, a nonpsychoactive cannabinoid, displayed less competition than thc in all parameters. |
1991-09-24 |
2023-08-11 |
rat |
| L M Bornheim, M A Correi. Purification and characterization of the major hepatic cannabinoid hydroxylase in the mouse: a possible member of the cytochrome P-450IIC subfamily. Molecular pharmacology. vol 40. issue 2. 1991-09-24. PMID:1875910. |
acute cannabidiol treatment of mice inactivated hepatic microsomal cytochrome p-450iiia (p-450iiia) and markedly inhibited in vitro cannabinoid metabolism. |
1991-09-24 |
2023-08-11 |
mouse |
| L M Bornheim, M A Correi. Purification and characterization of the major hepatic cannabinoid hydroxylase in the mouse: a possible member of the cytochrome P-450IIC subfamily. Molecular pharmacology. vol 40. issue 2. 1991-09-24. PMID:1875910. |
thus, cannabidiol treatment of mice resulted in the inactivation of at least two constitutive p-450 isozymes, which together account for the majority of the detected cannabinoid metabolites. |
1991-09-24 |
2023-08-11 |
mouse |
| T M Westlake, A C Howlett, S F Ali, M G Paule, A C Scallet, W Slikke. Chronic exposure to delta 9-tetrahydrocannabinol fails to irreversibly alter brain cannabinoid receptors. Brain research. vol 544. issue 1. 1991-08-29. PMID:1649662. |
similarly, the cannabinoid receptors in the caudate, prefrontal cortex, and cerebellum of the monkey do not appear to be irreversibly altered by chronic exposure to marijuana smoke. |
1991-08-29 |
2023-08-11 |
rat |
| H Schuel, D Berkery, R Schuel, M C Chang, A M Zimmerman, S Zimmerma. Reduction of the fertilizing capacity of sea urchin sperm by cannabinoids derived from marihuana. I. Inhibition of the acrosome reaction induced by egg jelly. Molecular reproduction and development. vol 29. issue 1. 1991-07-31. PMID:1647172. |
delta 9-tetrahydrocannabinol (thc) and two other major cannabinoids derived from marihuana--cannabidiol (cbd) and cannabinol (cbn)--inhibit fertilization in the sea urchin strongylocentrotus purpuratus by reducing the fertilizing capacity of sperm (schuel et al., 1987). |
1991-07-31 |
2023-08-11 |
Not clear |
| D B Menkes, R C Howard, G F Spears, E R Cairn. Salivary THC following cannabis smoking correlates with subjective intoxication and heart rate. Psychopharmacology. vol 103. issue 2. 1991-06-12. PMID:1851311. |
salivary thc levels are a sensitive index of recent cannabis smoking, and appear more closely linked with the effects of intoxication than do either blood or urine cannabinoid levels. |
1991-06-12 |
2023-08-11 |
human |
| D J Harvey, E Samara, R Mechoula. Urinary metabolites of cannabidiol in dog, rat and man and their identification by gas chromatography-mass spectrometry. Journal of chromatography. vol 562. issue 1-2. 1991-06-10. PMID:2026700. |
urinary metabolites of cannabidiol (cbd), a non-psychoactive cannabinoid of potential therapeutic interest, were extracted from dog, rat and human urine, concentrated by chromatography on sephadex lh-20 and examined by gas chromatography-mass spectrometry as trimethylsilyl (tms), [2h9]tms, methyl ester-tms and methyloxime-tms derivatives. |
1991-06-10 |
2023-08-11 |
human |
| J C Eldridge, P W Landfiel. Cannabinoid interactions with glucocorticoid receptors in rat hippocampus. Brain research. vol 534. issue 1-2. 1991-04-18. PMID:1963558. |
binding of [3h]dexamethasone (dex) to hippocampal cytosol, in vitro, was inhibited partially, but not completely, by 100-fold excess unlabeled thc and cannabidiol (cbd), a non-psychoactive cannabinoid. |
1991-04-18 |
2023-08-11 |
rat |
| M A ElSohly, A B Jones, H N ElSohl. Cross-reactivity of selected compounds in the Abbott TDx cannabinoid assay. Journal of analytical toxicology. vol 14. issue 5. 1991-02-01. PMID:2175818. |
this cross-reactivity was evaluated against a group of cannabinoids and noncannabinoid phenolic constituents of cannabis, some cannabinoid metabolites, and other agents that appear in normal urine samples. |
1991-02-01 |
2023-08-11 |
Not clear |
| S Zimmerman, A M Zimmerma. Genetic effects of marijuana. The International journal of the addictions. vol 25. issue 1A. 1991-01-09. PMID:2174024. |
marijuana and its constitutive cannabinoids--tetrahydrocannabinol (thc), cannabinol (cbn), and cannabidiol (cbd)--markedly affect mammalian cells. |
1991-01-09 |
2023-08-11 |
Not clear |
| L A Matsuda, S J Lolait, M J Brownstein, A C Young, T I Bonne. Structure of a cannabinoid receptor and functional expression of the cloned cDNA. Nature. vol 346. issue 6284. 1990-09-06. PMID:2165569. |
marijuana and many of its constituent cannabinoids influence the central nervous system (cns) in a complex and dose-dependent manner. |
1990-09-06 |
2023-08-11 |
Not clear |
| R H Schwartz, S Bogema, M M Thorn. Evaluation of the EZ-SCREEN enzyme immunoassay test for detection of cocaine and marijuana metabolites in urine specimens. Pediatric emergency care. vol 6. issue 2. 1990-08-23. PMID:2196539. |
we compared the results of the ez-screen test with results of specimens analyzed by gas chromatography/mass spectrometry (gc/ms) for 36 clinical specimens positive for cannabinoids (marijuana), 38 clinical specimens positive for benzoylecgonine (cocaine), and 33 drug-free specimens. |
1990-08-23 |
2023-08-11 |
Not clear |
| C J Hillard, J J Pounds, D R Boyer, A S Bloo. Studies of the role of membrane lipid order in the effects of delta 9-tetrahydrocannabinol on adenylate cyclase activation in heart. The Journal of pharmacology and experimental therapeutics. vol 252. issue 3. 1990-05-03. PMID:2156989. |
cannabidiol, cannabinol and (+)-delta 9-thc were all without effect, indicating that this effect of delta 9-thc is stereoselective and specific for cannabinoids with psychoactive potency. |
1990-05-03 |
2023-08-11 |
rat |
| D J Harve. Stability of cannabinoids in dried samples of cannabis dating from around 1896-1905. Journal of ethnopharmacology. vol 28. issue 1. 1990-04-25. PMID:2314109. |
stability of cannabinoids in dried samples of cannabis dating from around 1896-1905. |
1990-04-25 |
2023-08-11 |
Not clear |
| D J Harve. Stability of cannabinoids in dried samples of cannabis dating from around 1896-1905. Journal of ethnopharmacology. vol 28. issue 1. 1990-04-25. PMID:2314109. |
cannabinoids from three samples of cannabis obtained from the pitt-rivers museum, oxford, and dating from the turn of the century were examined by gas chromatography and mass spectometry for the presence of cannabinoids. |
1990-04-25 |
2023-08-11 |
Not clear |
| E A Formukong, A T Evans, F J Evan. The inhibitory effects of cannabinoids, the active constituents of Cannabis sativa L. on human and rabbit platelet aggregation. The Journal of pharmacy and pharmacology. vol 41. issue 10. 1990-02-20. PMID:2575149. |
the inhibitory effects of cannabinoids, the active constituents of cannabis sativa l. on human and rabbit platelet aggregation. |
1990-02-20 |
2023-08-11 |
human |