| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M S Smith, Y Yamamoto, C Newton, H Friedman, T Klei. Psychoactive cannabinoids increase mortality and alter acute phase cytokine responses in mice sublethally infected with Legionella pneumophila. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.). vol 214. issue 1. 1997-02-20. PMID:9012363. |
mice given other cannabinoids, including cannabinol and cannabidiol, as well as the synthetic cp 55,940, showed no significant change in the level of mrna for any of the cytokines tested. |
1997-02-20 |
2023-08-12 |
mouse |
| M A Huestis, J M Mitchell, E J Con. Urinary excretion profiles of 11-nor-9-carboxy-delta 9-tetrahydrocannabinol in humans after single smoked doses of marijuana. Journal of analytical toxicology. vol 20. issue 6. 1997-01-30. PMID:8889681. |
these data provide a detailed complication of thccooh concentrations in urine after administration of marijuana that may aid in the interpretation of urine cannabinoid results. |
1997-01-30 |
2023-08-12 |
human |
| M F Ruh, J A Taylor, A C Howlett, W V Welshon. Failure of cannabinoid compounds to stimulate estrogen receptors. Biochemical pharmacology. vol 53. issue 1. 1997-01-09. PMID:8960061. |
compounds possessing the tricyclic cannabinoid structure, including delta 9-thc and cannabidiol, have been reported to interact with rodent uterine estrogen receptors in ligand binding assays. |
1997-01-09 |
2023-08-12 |
Not clear |
| M F Ruh, J A Taylor, A C Howlett, W V Welshon. Failure of cannabinoid compounds to stimulate estrogen receptors. Biochemical pharmacology. vol 53. issue 1. 1997-01-09. PMID:8960061. |
no response was observed with cannabidiol, a bicyclic cannabinoid compound that exhibits no cannabimimetic behavioral effects but has been reported to bind to the estrogen receptor in vitro. |
1997-01-09 |
2023-08-12 |
Not clear |
| E S Onaivi, A Chakrabarti, G Chaudhur. Cannabinoid receptor genes. Progress in neurobiology. vol 48. issue 4-5. 1996-12-05. PMID:8804112. |
cannabinoids are the constituents of the marijuana plant (cannabis sativa) of which the major active ingredient is delta-9-tetrahydrocannabinol (delta 9-thc). |
1996-12-05 |
2023-08-12 |
mouse |
| M A Huestis, J M Mitchell, E J Con. Detection times of marijuana metabolites in urine by immunoassay and GC-MS. Journal of analytical toxicology. vol 19. issue 6. 1996-11-21. PMID:8926739. |
detection times of marijuana metabolites in urine by immunoassay and gc-ms. reports of prolonged drug excretion have provided the basis for the common assumption that cannabinoid metabolites may he detected in urine for a week or longer. |
1996-11-21 |
2023-08-12 |
human |
| M A Huestis, J M Mitchell, E J Con. Detection times of marijuana metabolites in urine by immunoassay and GC-MS. Journal of analytical toxicology. vol 19. issue 6. 1996-11-21. PMID:8926739. |
however, monitoring acute marijuana usage with a commercial cannabinoid immunoassay that has a 50-ng/ml cutoff concentration provides only a narrow window of detection of 1-2 days. |
1996-11-21 |
2023-08-12 |
human |
| b' L Hanus, M Dost\\xc3\\xa1lov\\xc3\\xa. The effect of soil fertilization on the formation and the amount of cannabinoid substances in Cannabis sativa L. in the course of one vegetation period. Acta Universitatis Palackianae Olomucensis Facultatis Medicae. vol 138. 1996-10-09. PMID:8714084.' |
the effect of soil fertilization on the formation and the amount of cannabinoid substances in cannabis sativa l. in the course of one vegetation period. |
1996-10-09 |
2023-08-12 |
Not clear |
| X Q Xie, L S Melvin, A Makriyanni. The conformational properties of the highly selective cannabinoid receptor ligand CP-55,940. The Journal of biological chemistry. vol 271. issue 18. 1996-07-01. PMID:8631869. |
during a search for novel drugs possessing analgesic properties but devoid of the psychotropic effects of marijuana, a group of molecules designated as nonclassical cannabinoids was synthesized by pfizer. |
1996-07-01 |
2023-08-12 |
Not clear |
| J Romero, E García-Palomero, S Y Lin, J A Ramos, A Makriyannis, J J Fernández-Rui. Extrapyramidal effects of methanandamide, an analog of anandamide, the endogenous CB1 receptor ligand. Life sciences. vol 58. issue 15. 1996-06-03. PMID:8614278. |
recent evidence has demonstrated that arachidonylethanolamide ("anandamide", aea), the major endogenous ligand of cb1 receptors, inhibits motor behavior in rats, as does (-)delta 9-tetrahydrocannabinol (thc), the prototypical tricyclic cannabinoid derived from cannabis sativa preparations. |
1996-06-03 |
2023-08-12 |
rat |
| B F Thomas, I B Adams, S W Mascarella, B R Martin, R K Razda. Structure-activity analysis of anandamide analogs: relationship to a cannabinoid pharmacophore. Journal of medicinal chemistry. vol 39. issue 2. 1996-02-28. PMID:8558515. |
anandamides are endogenous fatty acid ethanolamides that have been shown to bind to the cannabinoid receptor and possess cannabimimetic activity yet are structurally dissimilar from the classical cannabinoids found in cannabis sativa. |
1996-02-28 |
2023-08-12 |
Not clear |
| P M Kemp, I K Abukhalaf, J E Manno, B R Manno, D D Alford, G A Abusad. Cannabinoids in humans. I. Analysis of delta 9-tetrahydrocannabinol and six metabolites in plasma and urine using GC-MS. Journal of analytical toxicology. vol 19. issue 5. 1996-01-16. PMID:7500614. |
in addition, the method was designed to detect cannabidiol and cannabinol, two naturally occurring cannabinoids. |
1996-01-16 |
2023-08-12 |
Not clear |
| L M Bornheim, K Y Kim, J Li, B Y Perotti, L Z Bene. Effect of cannabidiol pretreatment on the kinetics of tetrahydrocannabinol metabolites in mouse brain. Drug metabolism and disposition: the biological fate of chemicals. vol 23. issue 8. 1996-01-11. PMID:7493549. |
cannabidiol (cbd), a nonpsychoactive cannabinoid, inhibits hepatic microsomal thc metabolism and also modulates subjective psychological responses to thc in humans. |
1996-01-11 |
2023-08-12 |
mouse |
| J L Wiley, J A Lowe, R L Balster, B R Marti. Antagonism of the discriminative stimulus effects of delta 9-tetrahydrocannabinol in rats and rhesus monkeys. The Journal of pharmacology and experimental therapeutics. vol 275. issue 1. 1995-11-21. PMID:7562536. |
this drug is the first reliable antagonist of cannabinoid discrimination and would be predicted to block or reverse cannabis intoxication in humans. |
1995-11-21 |
2023-08-12 |
rat |
| B C Paria, S K Das, S K De. The preimplantation mouse embryo is a target for cannabinoid ligand-receptor signaling. Proceedings of the National Academy of Sciences of the United States of America. vol 92. issue 21. 1995-11-14. PMID:7568154. |
however, the inactive cannabinoid cannabidiol (cbd) failed to influence this response. |
1995-11-14 |
2023-08-12 |
mouse |
| G Petri, S Nyiredy, P Veszki, P Oroszlán, G Turiá. [Gas chromatographic analysis of cannabinoids on tandem columns]. Acta pharmaceutica Hungarica. vol 65. issue 3. 1995-10-24. PMID:7572186. |
the psychotropic cannabinoids delta 1-tetrahydrocannabinol (delta 1-thc) and delta 1(6)-tetrahydrocannabionol (delta 1(6)-thc), as well as, their main metabolites cannabidiol (cbd) and cannabichromene (cbc) were baseline separated except the cannabigerol (cbg) and cannabinol (cbn) pair, however for these compounds the separation was also satisfactory for the quantitative determinations. |
1995-10-24 |
2023-08-12 |
Not clear |
| A H Lichtman, K R Dimen, B R Marti. Systemic or intrahippocampal cannabinoid administration impairs spatial memory in rats. Psychopharmacology. vol 119. issue 3. 1995-10-18. PMID:7675962. |
on the other hand, neither anandamide, the putative endogenous cannabinoid ligand, nor cannabidiol, an inactive naturally occurring cannabinoid, had any apparent effects on memory. |
1995-10-18 |
2023-08-12 |
rat |
| Y Daaka, T W Klein, H Friedma. Expression of cannabinoid receptor mRNA in murine and human leukocytes. Advances in experimental medicine and biology. vol 373. 1995-10-12. PMID:7545349. |
delta 9-tetrahydrocannabinol, the major psychoactive cannabinoid of marijuana modulates immune cells in vivo and in vitro. |
1995-10-12 |
2023-08-12 |
mouse |
| R Gillan, M D Cole, A Linacre, J W Thorpe, N D Watso. Comparison of Cannabis sativa by random amplification of polymorphic DNA (RAPD) and HPLC of cannabinoids: a preliminary study. Science & justice : journal of the Forensic Science Society. vol 35. issue 3. 1995-10-11. PMID:7663991. |
comparison of cannabis sativa by random amplification of polymorphic dna (rapd) and hplc of cannabinoids: a preliminary study. |
1995-10-11 |
2023-08-12 |
Not clear |
| J M Derocq, M Ségui, J Marchand, G Le Fur, P Casella. Cannabinoids enhance human B-cell growth at low nanomolar concentrations. FEBS letters. vol 369. issue 2-3. 1995-09-22. PMID:7544292. |
the two synthetic cannabinoids, cp55,940 and win55212-2, as well as delta 9-tetrahydrocannabinol (thc), the psychoactive component of marijuana, caused a dose-dependent increase of b-cell proliferation and displayed ec50 at low nanomolar concentrations. |
1995-09-22 |
2023-08-12 |
human |