| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J L Mille. Panel sees medical potential in standardized cannabinoids but not in smoked marijuana. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists. vol 56. issue 10. 1999-09-10. PMID:10365716. |
panel sees medical potential in standardized cannabinoids but not in smoked marijuana. |
1999-09-10 |
2023-08-12 |
Not clear |
| D Parolar. Presence and functional regulation of cannabinoid receptors in immune cells. Life sciences. vol 65. issue 6-7. 1999-09-08. PMID:10462064. |
in the last 30 years studies on drug-abusing humans and animals injected with cannabinoids, as well as in vitro models employing immune cell cultures, have demonstrated that marijuana and cannabinoids are immunomodulators. |
1999-09-08 |
2023-08-12 |
Not clear |
| D L Misner, J M Sulliva. Mechanism of cannabinoid effects on long-term potentiation and depression in hippocampal CA1 neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 19. issue 16. 1999-09-01. PMID:10436037. |
cannabinoids, the active constituents of marijuana, are known to impair learning and memory. |
1999-09-01 |
2023-08-12 |
Not clear |
| D L Misner, J M Sulliva. Mechanism of cannabinoid effects on long-term potentiation and depression in hippocampal CA1 neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 19. issue 16. 1999-09-01. PMID:10436037. |
to investigate the possible contribution of cannabinoid receptor-mediated deficits in hippocampal function to the learning and memory impairments produced by marijuana, we studied the effects of cannabinoid receptor activation on two models of learning and memory, long-term potentiation (ltp) and long-term depression (ltd), in hippocampal slices. |
1999-09-01 |
2023-08-12 |
Not clear |
| C Hsieh, S Brown, C Derleth, K Macki. Internalization and recycling of the CB1 cannabinoid receptor. Journal of neurochemistry. vol 73. issue 2. 1999-08-13. PMID:10428044. |
tolerance develops rapidly to cannabis, cannabinoids, and related drugs acting at the cb1 cannabinoid receptor. |
1999-08-13 |
2023-08-12 |
Not clear |
| B N Zenor, G D Weesner, P V Malve. Endocrine and other responses to acute administration of cannabinoid compounds to non-stressed male calves. Life sciences. vol 65. issue 2. 1999-07-27. PMID:10416818. |
there is an abundance of cannabinoid (cb) receptors for derivatives of cannabis plants in the brain and throughout the body, and several naturally occurring arachidonic acid derivatives can activate these receptors. |
1999-07-27 |
2023-08-12 |
Not clear |
| N P Lemos, R A Anderson, J R Robertso. Nail analysis for drugs of abuse: extraction and determination of cannabis in fingernails by RIA and GC-MS. Journal of analytical toxicology. vol 23. issue 3. 1999-07-26. PMID:10369322. |
nail analysis for drugs of abuse: extraction and determination of cannabis in fingernails by ria and gc-ms. fingernail clippings were evaluated as analytical specimens for the detection and quantitation of cannabinoids. |
1999-07-26 |
2023-08-12 |
Not clear |
| A Amer. The effects of cannabinoids on the brain. Progress in neurobiology. vol 58. issue 4. 1999-07-22. PMID:10368032. |
since these dopaminergic circuits are known to play a pivotal role in mediating the reinforcing (rewarding) effects of the most drugs of abuse, the enhanced dopaminergic drive elicited by the cannabinoids is thought to underlie the reinforcing and abuse properties of marijuana. |
1999-07-22 |
2023-08-12 |
Not clear |
| M Diana, M Melis, G L Gess. Increase in meso-prefrontal dopaminergic activity after stimulation of CB1 receptors by cannabinoids. The European journal of neuroscience. vol 10. issue 9. 1999-06-07. PMID:9758152. |
the intravenous administration of the psychoactive constituent of marijuana, delta9-tetrahydrocannabinol (delta9-thc) (62.5-1000 microg/kg), and the synthetic cannabinoid agonist win 55212,2 (win) (62.5-500 microg/kg), produced a dose-related increase in the firing rate and burst firing in the majority of antidromically identified meso-prefrontal dopaminergic neurons. |
1999-06-07 |
2023-08-12 |
Not clear |
| H Ehrenreich, T Rinn, H J Kunert, M R Moeller, W Poser, L Schilling, G Gigerenzer, M R Hoeh. Specific attentional dysfunction in adults following early start of cannabis use. Psychopharmacology. vol 142. issue 3. 1999-05-26. PMID:10208322. |
the present study tested the hypothesis that chronic interference by cannabis with endogenous cannabinoid systems during peripubertal development causes specific and persistent brain alterations in humans. |
1999-05-26 |
2023-08-12 |
Not clear |
| C S Breivogel, S R Childer. The functional neuroanatomy of brain cannabinoid receptors. Neurobiology of disease. vol 5. issue 6 Pt B. 1999-05-06. PMID:9974175. |
the effects of the primary psychoactive constituent of marijuana, delta 9-tetrahydrocannabinol, are mediated by cannabinoid receptors, cb1 and cb2. |
1999-05-06 |
2023-08-12 |
Not clear |
| L L Murphy, R M Muñoz, B A Adrian, M A Villanú. Function of cannabinoid receptors in the neuroendocrine regulation of hormone secretion. Neurobiology of disease. vol 5. issue 6 Pt B. 1999-05-06. PMID:9974176. |
marijuana and its cannabinoid constituents have profound effects on anterior pituitary hormone secretion. |
1999-05-06 |
2023-08-12 |
Not clear |
| T Nagayama, A D Sinor, R P Simon, J Chen, S H Graham, K Jin, D A Greenber. Cannabinoids and neuroprotection in global and focal cerebral ischemia and in neuronal cultures. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 19. issue 8. 1999-04-27. PMID:10191316. |
marijuana and related drugs (cannabinoids) have been proposed as treatments for a widening spectrum of medical disorders. |
1999-04-27 |
2023-08-12 |
rat |
| M D Srivastava, B I Srivastava, B Brouhar. Delta9 tetrahydrocannabinol and cannabidiol alter cytokine production by human immune cells. Immunopharmacology. vol 40. issue 3. 1999-03-01. PMID:9858061. |
marijuana, a widely abused drug in the us, and its derivatives (cannabinoids) have been used in aids and cancer patients for treatment of intractable nausea and cachexia. |
1999-03-01 |
2023-08-12 |
human |
| P E Mallet, R J Beninge. The cannabinoid CB1 receptor antagonist SR141716A attenuates the memory impairment produced by delta9-tetrahydrocannabinol or anandamide. Psychopharmacology. vol 140. issue 1. 1999-02-25. PMID:9862397. |
the administration of delta9-tetrahydrocannabinol (thc), the principle psychoactive ingredient in marijuana, or the endogenous cannabinoid anandamide, has been shown to impair recent memory. |
1999-02-25 |
2023-08-12 |
rat |
| N Ueda, S K Goparaju, K Katayama, Y Kurahashi, H Suzuki, S Yamamot. A hydrolase enzyme inactivating endogenous ligands for cannabinoid receptors. The journal of medical investigation : JMI. vol 45. issue 1-4. 1999-02-16. PMID:9864962. |
cannabinoids are psychoactive components of marijuana, and bind to specific g protein-coupled receptors in the brain and other mammalian tissues. |
1999-02-16 |
2023-08-12 |
rat |
| J A Wagner, K Varga, G Kuno. Cardiovascular actions of cannabinoids and their generation during shock. Journal of molecular medicine (Berlin, Germany). vol 76. issue 12. 1999-02-11. PMID:9846953. |
cannabinoids, the active ingredients of marijuana, elicit their neurobehavioral effects by interacting with the cb1 cannabinoid receptor subtype, expressed primarily in the brain but also present in some peripheral tissues. |
1999-02-11 |
2023-08-12 |
human |
| T Matsunaga, K Watanabe, H Yoshimura, I Yamamot. [Quantitative analysis and pharmaco-toxicity of cannabinoids in commercially available cannabis seeds]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. vol 118. issue 9. 1999-01-22. PMID:9779001. |
[quantitative analysis and pharmaco-toxicity of cannabinoids in commercially available cannabis seeds]. |
1999-01-22 |
2023-08-12 |
mouse |
| M Egertová, D K Giang, B F Cravatt, M R Elphic. A new perspective on cannabinoid signalling: complementary localization of fatty acid amide hydrolase and the CB1 receptor in rat brain. Proceedings. Biological sciences. vol 265. issue 1410. 1998-12-22. PMID:9842734. |
cb1-type cannabinoid receptors in the brain mediate effects of the drug cannabis. |
1998-12-22 |
2023-08-12 |
rat |
| E J Cone, R Lange, W D Darwi. In vivo adulteration: excess fluid ingestion causes false-negative marijuana and cocaine urine test results. Journal of analytical toxicology. vol 22. issue 6. 1998-12-17. PMID:9788521. |
recovery of urine test measures to pre-treatment levels occurred over a period of 8-10 h. average detection times for marijuana metabolite appeared to be slightly shorter following ingestion of 1 gal of fluids compared with ingestion of 12 oz of water as a result of the time of testing being near the end of the cannabinoid metabolite excretion phase. |
1998-12-17 |
2023-08-12 |
human |