| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| C J Heyser, R E Hampson, S A Deadwyle. Effects of delta-9-tetrahydrocannabinol on delayed match to sample performance in rats: alterations in short-term memory associated with changes in task specific firing of hippocampal cells. The Journal of pharmacology and experimental therapeutics. vol 264. issue 1. 1993-02-23. PMID:8380864. |
neither control injection of the vehicle nor equivalent concentrations of the nonpsychoactive cannabinoid, cannabidiol, produced alterations in dmts performance levels. |
1993-02-23 |
2023-08-12 |
rat |
| D B Houston, A C Howlet. Solubilization of the cannabinoid receptor from rat brain and its functional interaction with guanine nucleotide-binding proteins. Molecular pharmacology. vol 43. issue 1. 1993-02-23. PMID:8423766. |
the order of potency for cannabinoid agonists in heterologous equilibrium binding studies was cp-55244 > or = desacetyllevonantradol > delta 9-tetrahydrocannabinol > cannabinol >> cannabidiol, consistent with the relative affinities for these agonists in brain membrane preparations. |
1993-02-23 |
2023-08-12 |
rat |
| G Lercker, F Bocci, N Frega, R Bortolomeazz. Cannabinoid acids analysis. Farmaco (Societa chimica italiana : 1989). vol 47. issue 3. 1992-09-21. PMID:1503600. |
the cannabinoid pattern of vegetable preparations from cannabis sativa (hashish, marijuana) allows to recognize the phenotype of the plants, to be used as drug or for fiber. |
1992-09-21 |
2023-08-11 |
Not clear |
| D W Self, L Stei. Receptor subtypes in opioid and stimulant reward. Pharmacology & toxicology. vol 70. issue 2. 1992-09-18. PMID:1324497. |
the reward-relevant opioid and dopamine receptors, as well as the cannabinoid (marijuana) receptor, share the ability to couple gi proteins that mediate inhibition of adenylate cyclase and stimulation of k+ conductance. |
1992-09-18 |
2023-08-11 |
Not clear |
| J W Hayde. Passive inhalation of marijuana smoke: a critical review. Journal of substance abuse. vol 3. issue 1. 1992-08-18. PMID:1668226. |
a number of research studies have been published which have attempted to determine the relationship of the passive inhalation of marijuana smoke to the consequent production of urinary cannabinoids. |
1992-08-18 |
2023-08-11 |
Not clear |
| L D Chait, J P Zacn. Reinforcing and subjective effects of oral delta 9-THC and smoked marijuana in humans. Psychopharmacology. vol 107. issue 2-3. 1992-07-30. PMID:1319601. |
the experimental paradigm used here should prove useful for identifying factors that influence the self-administration of marijuana and other cannabinoids by humans. |
1992-07-30 |
2023-08-11 |
human |
| M E Abood, B R Marti. Neurobiology of marijuana abuse. Trends in pharmacological sciences. vol 13. issue 5. 1992-07-14. PMID:1604713. |
while marked tolerance develops to marijuana, it has been difficult to demonstrate physical dependence, and until recently the mechanisms by which cannabinoids produced their behavioral effects were poorly defined. |
1992-07-14 |
2023-08-11 |
Not clear |
| B Watzl, P Scuderi, R R Watso. Marijuana components stimulate human peripheral blood mononuclear cell secretion of interferon-gamma and suppress interleukin-1 alpha in vitro. International journal of immunopharmacology. vol 13. issue 8. 1992-06-22. PMID:1667651. |
concentrations of thc and cbd, comparable to plasma levels found after smoking marijuana (10-100 ng/ml), increased the concentration of measurable ifn (139 and 68%), while high concentrations of both cannabinoids (5-20 micrograms/ml) completely blocked synthesis and/or release of this cytokine. |
1992-06-22 |
2023-08-11 |
human |
| A Charalambous, G Marciniak, C Y Shiue, S L Dewey, D J Schlyer, A P Wolf, A Makriyanni. PET studies in the primate brain and biodistribution in mice using (-)-5'-18F-delta 8-THC. Pharmacology, biochemistry, and behavior. vol 40. issue 3. 1992-05-14. PMID:1666914. |
cannabinoids, the active constituents of marijuana, are known to have many therapeutic properties; however, their exact mechanism of action is not well understood. |
1992-05-14 |
2023-08-11 |
mouse |
| P Consroe, K Kennedy, K Schra. Assay of plasma cannabidiol by capillary gas chromatography/ion trap mass spectroscopy following high-dose repeated daily oral administration in humans. Pharmacology, biochemistry, and behavior. vol 40. issue 3. 1992-05-14. PMID:1666917. |
additionally, no plasma delta-1-thc, the major psychoactive cannabinoid of marijuana, was detected in any subject. |
1992-05-14 |
2023-08-11 |
human |
| Pharmacological, chemical, biochemical and behavioral research on cannabis and the cannabinoids. International conference, Kolympari, Crete, July 8-11, 1990. Issue dedicated to Professor Raphael Mechoulam. Pharmacology, biochemistry, and behavior. vol 40. issue 3. 1992-05-14. PMID:1687228. |
pharmacological, chemical, biochemical and behavioral research on cannabis and the cannabinoids. |
1992-05-14 |
2023-08-11 |
Not clear |
| E L Gardner, J H Lowinso. Marijuana's interaction with brain reward systems: update 1991. Pharmacology, biochemistry, and behavior. vol 40. issue 3. 1992-05-14. PMID:1806947. |
marijuana and other cannabinoids were long considered "anomalous" drugs of abuse, lacking pharmacological interaction with these brain reward substrates. |
1992-05-14 |
2023-08-11 |
Not clear |
| S K Tahir, A M Zimmerma. Influence of marihuana on cellular structures and biochemical activities. Pharmacology, biochemistry, and behavior. vol 40. issue 3. 1992-05-14. PMID:1806949. |
in this paper we review the current evidence describing cannabinoid effects on various levels of cellular structure and activity and we present our current studies on the influence of delta-9-tetrahydrocannabinol, cannabidiol and cannabinol on one cellular system, the cytoskeleton. |
1992-05-14 |
2023-08-11 |
Not clear |
| G Nahas, C Latou. The human toxicity of marijuana. The Medical journal of Australia. vol 156. issue 7. 1992-05-04. PMID:1313532. |
the pathophysiological effects of marijuana smoke and its constituent cannabinoids were reported first from in-vitro and in-vivo experimental studies. |
1992-05-04 |
2023-08-11 |
human |
| G Nahas, C Latou. The human toxicity of marijuana. The Medical journal of Australia. vol 156. issue 7. 1992-05-04. PMID:1313532. |
marijuana smoke is mutagenic in the ames test and in tissue culture and cannabinoids inhibit biosynthesis of macromolecules. |
1992-05-04 |
2023-08-11 |
human |
| R L Balster, W R Prescot. Delta 9-tetrahydrocannabinol discrimination in rats as a model for cannabis intoxication. Neuroscience and biobehavioral reviews. vol 16. issue 1. 1992-04-24. PMID:1313164. |
correlations between these values and potencies for cellular actions of cannabinoids can be used to establish the neural substrates of cannabis intoxication. |
1992-04-24 |
2023-08-11 |
rat |
| D R Compton, M R Johnson, L S Melvin, B R Marti. Pharmacological profile of a series of bicyclic cannabinoid analogs: classification as cannabimimetic agents. The Journal of pharmacology and experimental therapeutics. vol 260. issue 1. 1992-02-18. PMID:1309872. |
opening of the pyran ring of delta 9-tetrahydrocannabinol (thc) produces cannabidiol, a bicyclic cannabinoid devoid of many pharmacological properties produced by delta 8-thc or delta 9-thc. |
1992-02-18 |
2023-08-11 |
mouse |
| L M Shaw, J Edling-Owens, R Matte. Ultrasensitive measurement of delta-9-tetrahydrocannabinol with a high energy dynode detector and electron-capture negative chemical-ionization mass spectrometry. Clinical chemistry. vol 37. issue 12. 1992-02-18. PMID:1662560. |
plasma concentrations of delta-9-tetrahydrocannabinol, the principal psychoactive cannabinoid in marijuana, decline to values substantially less than 1 microgram/l within a few hours after a subject has smoked a marijuana cigarette. |
1992-02-18 |
2023-08-11 |
human |
| F J Evan. Cannabinoids: the separation of central from peripheral effects on a structural basis. Planta medica. vol 57. issue 7. 1992-01-02. PMID:1659702. |
a brief history of the therapeutic uses and legal problems of cannabis as well as the component cannabinoids is given. |
1992-01-02 |
2023-08-11 |
Not clear |
| H Gjerd. Screening for cannabinoids in blood using EMIT: concentrations of delta-9-tetrahydrocannabinol in relation to EMIT results. Forensic science international. vol 50. issue 1. 1991-12-23. PMID:1657743. |
cannabinoid assay of methanolic extracts of blood was found to be usable as a screening method in cases of suspected impairment by cannabis, when delta-9-tetrahydrocannabinol (thc) was analysed in the subsequent assay. |
1991-12-23 |
2023-08-11 |
Not clear |