Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
Y Mikawa, S Matsuda, T Kanagawa, T Tajika, N Ueda, Y Mimur. Ocular activity of topically administered anandamide in the rabbit. Japanese journal of ophthalmology. vol 41. issue 4. 1997-10-27. PMID:9304433. |
marijuana and its psychoactive constituents, cannabinoids, reduce intraocular pressure (iop) in humans and animals. |
1997-10-27 |
2023-08-12 |
rabbit |
J Brodkin, J M Moerschbaeche. SR141716A antagonizes the disruptive effects of cannabinoid ligands on learning in rats. The Journal of pharmacology and experimental therapeutics. vol 282. issue 3. 1997-10-17. PMID:9316868. |
neither injections of the centrally inactive cannabinoid, cannabidiol (3.2-100 mg/kg i.p. |
1997-10-17 |
2023-08-12 |
rat |
P Consroe, R Musty, J Rein, W Tillery, R Pertwe. The perceived effects of smoked cannabis on patients with multiple sclerosis. European neurology. vol 38. issue 1. 1997-10-15. PMID:9252798. |
the survey findings will aid in the design of a clinical trial of cannabis or cannabinoid administration to ms patients or to other patients with similar signs or symptoms. |
1997-10-15 |
2023-08-12 |
human |
N Stella, P Schweitzer, D Piomell. A second endogenous cannabinoid that modulates long-term potentiation. Nature. vol 388. issue 6644. 1997-09-22. PMID:9285589. |
cannabinoid receptors are molecular targets for marijuana and hashish, the widespread drugs of abuse. |
1997-09-22 |
2023-08-12 |
Not clear |
G L Gessa, M S Mascia, M A Casu, G Cart. Inhibition of hippocampal acetylcholine release by cannabinoids: reversal by SR 141716A. European journal of pharmacology. vol 327. issue 1. 1997-07-29. PMID:9185841. |
the results also suggest that the negative effects of marijuana on learning and memory may depend on cannabinoid receptor-mediated inhibition of acetylcholine release. |
1997-07-29 |
2023-08-12 |
rat |
E D French, K Dillon, X W. Cannabinoids excite dopamine neurons in the ventral tegmentum and substantia nigra. Neuroreport. vol 8. issue 3. 1997-07-03. PMID:9106740. |
these results may provide a mechanism by which psychoactive cannabinoids increase extracellular dopamine levels in mesolimbic and striatal tissues, and thereby contribute to the reinforcing effects of marijuana. |
1997-07-03 |
2023-08-12 |
Not clear |
A Holdcroft, M Smith, A Jacklin, H Hodgson, B Smith, M Newton, F Evan. Pain relief with oral cannabinoids in familial Mediterranean fever. Anaesthesia. vol 52. issue 5. 1997-06-13. PMID:9165969. |
future study designs can now incorporate prescribable forms of cannabinoids but the choice of previous cannabis users only as patients has clinical limitations. |
1997-06-13 |
2023-08-12 |
Not clear |
M S Smith, Y Yamamoto, C Newton, H Friedman, T Klei. Psychoactive cannabinoids increase mortality and alter acute phase cytokine responses in mice sublethally infected with Legionella pneumophila. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.). vol 214. issue 1. 1997-02-20. PMID:9012363. |
marijuana contains both psychoactive and nonpsychoactive cannabinoids which have varying effects on the immune response system. |
1997-02-20 |
2023-08-12 |
mouse |
M S Smith, Y Yamamoto, C Newton, H Friedman, T Klei. Psychoactive cannabinoids increase mortality and alter acute phase cytokine responses in mice sublethally infected with Legionella pneumophila. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.). vol 214. issue 1. 1997-02-20. PMID:9012363. |
the present study compared the enhancement of legionella-induced mortality in mice due to two other major of marijuana components, cannabinol and cannabidiol, as well as the synthetic psychoactive cannabinoid cp 55,940. |
1997-02-20 |
2023-08-12 |
mouse |
M S Smith, Y Yamamoto, C Newton, H Friedman, T Klei. Psychoactive cannabinoids increase mortality and alter acute phase cytokine responses in mice sublethally infected with Legionella pneumophila. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.). vol 214. issue 1. 1997-02-20. PMID:9012363. |
mice given other cannabinoids, including cannabinol and cannabidiol, as well as the synthetic cp 55,940, showed no significant change in the level of mrna for any of the cytokines tested. |
1997-02-20 |
2023-08-12 |
mouse |
M A Huestis, J M Mitchell, E J Con. Urinary excretion profiles of 11-nor-9-carboxy-delta 9-tetrahydrocannabinol in humans after single smoked doses of marijuana. Journal of analytical toxicology. vol 20. issue 6. 1997-01-30. PMID:8889681. |
these data provide a detailed complication of thccooh concentrations in urine after administration of marijuana that may aid in the interpretation of urine cannabinoid results. |
1997-01-30 |
2023-08-12 |
human |
M F Ruh, J A Taylor, A C Howlett, W V Welshon. Failure of cannabinoid compounds to stimulate estrogen receptors. Biochemical pharmacology. vol 53. issue 1. 1997-01-09. PMID:8960061. |
compounds possessing the tricyclic cannabinoid structure, including delta 9-thc and cannabidiol, have been reported to interact with rodent uterine estrogen receptors in ligand binding assays. |
1997-01-09 |
2023-08-12 |
Not clear |
M F Ruh, J A Taylor, A C Howlett, W V Welshon. Failure of cannabinoid compounds to stimulate estrogen receptors. Biochemical pharmacology. vol 53. issue 1. 1997-01-09. PMID:8960061. |
no response was observed with cannabidiol, a bicyclic cannabinoid compound that exhibits no cannabimimetic behavioral effects but has been reported to bind to the estrogen receptor in vitro. |
1997-01-09 |
2023-08-12 |
Not clear |
E S Onaivi, A Chakrabarti, G Chaudhur. Cannabinoid receptor genes. Progress in neurobiology. vol 48. issue 4-5. 1996-12-05. PMID:8804112. |
cannabinoids are the constituents of the marijuana plant (cannabis sativa) of which the major active ingredient is delta-9-tetrahydrocannabinol (delta 9-thc). |
1996-12-05 |
2023-08-12 |
mouse |
M A Huestis, J M Mitchell, E J Con. Detection times of marijuana metabolites in urine by immunoassay and GC-MS. Journal of analytical toxicology. vol 19. issue 6. 1996-11-21. PMID:8926739. |
detection times of marijuana metabolites in urine by immunoassay and gc-ms. reports of prolonged drug excretion have provided the basis for the common assumption that cannabinoid metabolites may he detected in urine for a week or longer. |
1996-11-21 |
2023-08-12 |
human |
M A Huestis, J M Mitchell, E J Con. Detection times of marijuana metabolites in urine by immunoassay and GC-MS. Journal of analytical toxicology. vol 19. issue 6. 1996-11-21. PMID:8926739. |
however, monitoring acute marijuana usage with a commercial cannabinoid immunoassay that has a 50-ng/ml cutoff concentration provides only a narrow window of detection of 1-2 days. |
1996-11-21 |
2023-08-12 |
human |
b' L Hanus, M Dost\\xc3\\xa1lov\\xc3\\xa. The effect of soil fertilization on the formation and the amount of cannabinoid substances in Cannabis sativa L. in the course of one vegetation period. Acta Universitatis Palackianae Olomucensis Facultatis Medicae. vol 138. 1996-10-09. PMID:8714084.' |
the effect of soil fertilization on the formation and the amount of cannabinoid substances in cannabis sativa l. in the course of one vegetation period. |
1996-10-09 |
2023-08-12 |
Not clear |
X Q Xie, L S Melvin, A Makriyanni. The conformational properties of the highly selective cannabinoid receptor ligand CP-55,940. The Journal of biological chemistry. vol 271. issue 18. 1996-07-01. PMID:8631869. |
during a search for novel drugs possessing analgesic properties but devoid of the psychotropic effects of marijuana, a group of molecules designated as nonclassical cannabinoids was synthesized by pfizer. |
1996-07-01 |
2023-08-12 |
Not clear |
J Romero, E García-Palomero, S Y Lin, J A Ramos, A Makriyannis, J J Fernández-Rui. Extrapyramidal effects of methanandamide, an analog of anandamide, the endogenous CB1 receptor ligand. Life sciences. vol 58. issue 15. 1996-06-03. PMID:8614278. |
recent evidence has demonstrated that arachidonylethanolamide ("anandamide", aea), the major endogenous ligand of cb1 receptors, inhibits motor behavior in rats, as does (-)delta 9-tetrahydrocannabinol (thc), the prototypical tricyclic cannabinoid derived from cannabis sativa preparations. |
1996-06-03 |
2023-08-12 |
rat |
B F Thomas, I B Adams, S W Mascarella, B R Martin, R K Razda. Structure-activity analysis of anandamide analogs: relationship to a cannabinoid pharmacophore. Journal of medicinal chemistry. vol 39. issue 2. 1996-02-28. PMID:8558515. |
anandamides are endogenous fatty acid ethanolamides that have been shown to bind to the cannabinoid receptor and possess cannabimimetic activity yet are structurally dissimilar from the classical cannabinoids found in cannabis sativa. |
1996-02-28 |
2023-08-12 |
Not clear |