| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A Amer. The effects of cannabinoids on the brain. Progress in neurobiology. vol 58. issue 4. 1999-07-22. PMID:10368032. |
since these dopaminergic circuits are known to play a pivotal role in mediating the reinforcing (rewarding) effects of the most drugs of abuse, the enhanced dopaminergic drive elicited by the cannabinoids is thought to underlie the reinforcing and abuse properties of marijuana. |
1999-07-22 |
2023-08-12 |
Not clear |
| M Diana, M Melis, G L Gess. Increase in meso-prefrontal dopaminergic activity after stimulation of CB1 receptors by cannabinoids. The European journal of neuroscience. vol 10. issue 9. 1999-06-07. PMID:9758152. |
the intravenous administration of the psychoactive constituent of marijuana, delta9-tetrahydrocannabinol (delta9-thc) (62.5-1000 microg/kg), and the synthetic cannabinoid agonist win 55212,2 (win) (62.5-500 microg/kg), produced a dose-related increase in the firing rate and burst firing in the majority of antidromically identified meso-prefrontal dopaminergic neurons. |
1999-06-07 |
2023-08-12 |
Not clear |
| H Ehrenreich, T Rinn, H J Kunert, M R Moeller, W Poser, L Schilling, G Gigerenzer, M R Hoeh. Specific attentional dysfunction in adults following early start of cannabis use. Psychopharmacology. vol 142. issue 3. 1999-05-26. PMID:10208322. |
the present study tested the hypothesis that chronic interference by cannabis with endogenous cannabinoid systems during peripubertal development causes specific and persistent brain alterations in humans. |
1999-05-26 |
2023-08-12 |
Not clear |
| C S Breivogel, S R Childer. The functional neuroanatomy of brain cannabinoid receptors. Neurobiology of disease. vol 5. issue 6 Pt B. 1999-05-06. PMID:9974175. |
the effects of the primary psychoactive constituent of marijuana, delta 9-tetrahydrocannabinol, are mediated by cannabinoid receptors, cb1 and cb2. |
1999-05-06 |
2023-08-12 |
Not clear |
| L L Murphy, R M Muñoz, B A Adrian, M A Villanú. Function of cannabinoid receptors in the neuroendocrine regulation of hormone secretion. Neurobiology of disease. vol 5. issue 6 Pt B. 1999-05-06. PMID:9974176. |
marijuana and its cannabinoid constituents have profound effects on anterior pituitary hormone secretion. |
1999-05-06 |
2023-08-12 |
Not clear |
| T Nagayama, A D Sinor, R P Simon, J Chen, S H Graham, K Jin, D A Greenber. Cannabinoids and neuroprotection in global and focal cerebral ischemia and in neuronal cultures. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 19. issue 8. 1999-04-27. PMID:10191316. |
marijuana and related drugs (cannabinoids) have been proposed as treatments for a widening spectrum of medical disorders. |
1999-04-27 |
2023-08-12 |
rat |
| M D Srivastava, B I Srivastava, B Brouhar. Delta9 tetrahydrocannabinol and cannabidiol alter cytokine production by human immune cells. Immunopharmacology. vol 40. issue 3. 1999-03-01. PMID:9858061. |
marijuana, a widely abused drug in the us, and its derivatives (cannabinoids) have been used in aids and cancer patients for treatment of intractable nausea and cachexia. |
1999-03-01 |
2023-08-12 |
human |
| P E Mallet, R J Beninge. The cannabinoid CB1 receptor antagonist SR141716A attenuates the memory impairment produced by delta9-tetrahydrocannabinol or anandamide. Psychopharmacology. vol 140. issue 1. 1999-02-25. PMID:9862397. |
the administration of delta9-tetrahydrocannabinol (thc), the principle psychoactive ingredient in marijuana, or the endogenous cannabinoid anandamide, has been shown to impair recent memory. |
1999-02-25 |
2023-08-12 |
rat |
| N Ueda, S K Goparaju, K Katayama, Y Kurahashi, H Suzuki, S Yamamot. A hydrolase enzyme inactivating endogenous ligands for cannabinoid receptors. The journal of medical investigation : JMI. vol 45. issue 1-4. 1999-02-16. PMID:9864962. |
cannabinoids are psychoactive components of marijuana, and bind to specific g protein-coupled receptors in the brain and other mammalian tissues. |
1999-02-16 |
2023-08-12 |
rat |
| J A Wagner, K Varga, G Kuno. Cardiovascular actions of cannabinoids and their generation during shock. Journal of molecular medicine (Berlin, Germany). vol 76. issue 12. 1999-02-11. PMID:9846953. |
cannabinoids, the active ingredients of marijuana, elicit their neurobehavioral effects by interacting with the cb1 cannabinoid receptor subtype, expressed primarily in the brain but also present in some peripheral tissues. |
1999-02-11 |
2023-08-12 |
human |
| T Matsunaga, K Watanabe, H Yoshimura, I Yamamot. [Quantitative analysis and pharmaco-toxicity of cannabinoids in commercially available cannabis seeds]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. vol 118. issue 9. 1999-01-22. PMID:9779001. |
[quantitative analysis and pharmaco-toxicity of cannabinoids in commercially available cannabis seeds]. |
1999-01-22 |
2023-08-12 |
mouse |
| M Egertová, D K Giang, B F Cravatt, M R Elphic. A new perspective on cannabinoid signalling: complementary localization of fatty acid amide hydrolase and the CB1 receptor in rat brain. Proceedings. Biological sciences. vol 265. issue 1410. 1998-12-22. PMID:9842734. |
cb1-type cannabinoid receptors in the brain mediate effects of the drug cannabis. |
1998-12-22 |
2023-08-12 |
rat |
| E J Cone, R Lange, W D Darwi. In vivo adulteration: excess fluid ingestion causes false-negative marijuana and cocaine urine test results. Journal of analytical toxicology. vol 22. issue 6. 1998-12-17. PMID:9788521. |
recovery of urine test measures to pre-treatment levels occurred over a period of 8-10 h. average detection times for marijuana metabolite appeared to be slightly shorter following ingestion of 1 gal of fluids compared with ingestion of 12 oz of water as a result of the time of testing being near the end of the cannabinoid metabolite excretion phase. |
1998-12-17 |
2023-08-12 |
human |
| K Gree. Marijuana smoking vs cannabinoids for glaucoma therapy. Archives of ophthalmology (Chicago, Ill. : 1960). vol 116. issue 11. 1998-11-25. PMID:9823341. |
marijuana smoking vs cannabinoids for glaucoma therapy. |
1998-11-25 |
2023-08-12 |
Not clear |
| K Gree. Marijuana smoking vs cannabinoids for glaucoma therapy. Archives of ophthalmology (Chicago, Ill. : 1960). vol 116. issue 11. 1998-11-25. PMID:9823341. |
a perspective is given on the use of marijuana and the cannabinoids in the treatment of glaucoma. |
1998-11-25 |
2023-08-12 |
Not clear |
| S R Childers, C S Breivoge. Cannabis and endogenous cannabinoid systems. Drug and alcohol dependence. vol 51. issue 1-2. 1998-11-12. PMID:9716939. |
cannabis and endogenous cannabinoid systems. |
1998-11-12 |
2023-08-12 |
Not clear |
| W Zhu, H Friedman, T W Klei. Delta9-tetrahydrocannabinol induces apoptosis in macrophages and lymphocytes: involvement of Bcl-2 and caspase-1. The Journal of pharmacology and experimental therapeutics. vol 286. issue 2. 1998-09-02. PMID:9694974. |
the marijuana cannabinoid, delta9tetrahydrocannabinol (thc), has been reported to suppress in culture the proliferation of splenocytes and increase the release of il-1 from macrophages; however, the mechanisms of these effects remain unclear. |
1998-09-02 |
2023-08-12 |
Not clear |
| A J Hampson, M Grimaldi, J Axelrod, D Win. Cannabidiol and (-)Delta9-tetrahydrocannabinol are neuroprotective antioxidants. Proceedings of the National Academy of Sciences of the United States of America. vol 95. issue 14. 1998-08-06. PMID:9653176. |
the neuroprotective actions of cannabidiol and other cannabinoids were examined in rat cortical neuron cultures exposed to toxic levels of the excitatory neurotransmitter glutamate. |
1998-08-06 |
2023-08-12 |
rat |
| A J Hampson, M Grimaldi, J Axelrod, D Win. Cannabidiol and (-)Delta9-tetrahydrocannabinol are neuroprotective antioxidants. Proceedings of the National Academy of Sciences of the United States of America. vol 95. issue 14. 1998-08-06. PMID:9653176. |
glutamate toxicity was reduced by both cannabidiol, a nonpsychoactive constituent of marijuana, and the psychotropic cannabinoid (-)delta9-tetrahydrocannabinol (thc). |
1998-08-06 |
2023-08-12 |
rat |
| A J Hampson, M Grimaldi, J Axelrod, D Win. Cannabidiol and (-)Delta9-tetrahydrocannabinol are neuroprotective antioxidants. Proceedings of the National Academy of Sciences of the United States of America. vol 95. issue 14. 1998-08-06. PMID:9653176. |
cannabidiol, thc and several synthetic cannabinoids all were demonstrated to be antioxidants by cyclic voltametry. |
1998-08-06 |
2023-08-12 |
rat |