| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Anke Witting, Lisa Walter, Jennifer Wacker, Thomas Möller, Nephi Stell. P2X7 receptors control 2-arachidonoylglycerol production by microglial cells. Proceedings of the National Academy of Sciences of the United States of America. vol 101. issue 9. 2004-06-17. PMID:14976257. |
endogenous cannabinoid ligands (endocannabinoids) produced by neurons, astrocytes, and microglial cells activate cannabinoid receptors, the molecular target for marijuana's bioactive ingredient delta(9)-tetrahydrocannabinol. |
2004-06-17 |
2023-08-12 |
Not clear |
| b' Marta Duran, Joan-Ramon Laporte, Dolors Capell\\xc3\\xa. [News about therapeutic use of Cannabis and endocannabinoid system]. Medicina clinica. vol 122. issue 10. 2004-06-10. PMID:15033046.' |
[news about therapeutic use of cannabis and endocannabinoid system]. |
2004-06-10 |
2023-08-12 |
Not clear |
| Linda A Parker, Raphael Mechoula. Cannabinoid agonists and antagonists modulate lithium-induced conditioned gaping in rats. Integrative physiological and behavioral science : the official journal of the Pavlovian Society. vol 38. issue 2. 2004-06-01. PMID:14527182. |
a series of experiments evaluated the potential of psychoactive cannabinoid agonists, delta-9-thc and hu-210, and non-psychoactive cannabinoids, cannabidiol (cbd) and its dimethylheptyl homolog (cbd-dmh), to interfere with the establishment and the expression of conditioned gaping in rats. |
2004-06-01 |
2023-08-12 |
rat |
| Emmanuel Contassot, Mirna Tenan, Valérie Schnüriger, Marie-Françoise Pelte, Pierre-Yves Dietric. Arachidonyl ethanolamide induces apoptosis of uterine cervix cancer cells via aberrantly expressed vanilloid receptor-1. Gynecologic oncology. vol 93. issue 1. 2004-05-20. PMID:15047233. |
delta(9)-tetrahydrocannabinol, the active agent of cannabis sativa, exhibits well-documented antitumor properties, but little is known about the possible effects mediated by endogenous cannabinoids on human tumors. |
2004-05-20 |
2023-08-12 |
human |
| P J McLaughlin, K Winston, L Swezey, A Wisniecki, J Aberman, D J Tardif, A J Betz, K Ishiwari, A Makriyannis, J D Salamon. The cannabinoid CB1 antagonists SR 141716A and AM 251 suppress food intake and food-reinforced behavior in a variety of tasks in rats. Behavioural pharmacology. vol 14. issue 8. 2004-05-19. PMID:14665975. |
cannabinoid cb1 receptor agonists, including delta-9-tetrahydrocannabinol (delta 9-thc) (the main psychoactive ingredient in marijuana) have been shown to increase feeding in rats and humans. |
2004-05-19 |
2023-08-12 |
rat |
| C Robin Hiley, William R For. Cannabinoid pharmacology in the cardiovascular system: potential protective mechanisms through lipid signalling. Biological reviews of the Cambridge Philosophical Society. vol 79. issue 1. 2004-05-19. PMID:15005177. |
cannabinoids include not only plant-derived compounds (of which delta9-tetrahydrocannabinol is the primary psychoactive ingredient of cannabis), but also synthetic agents and endogenous substances termed endocannabinoids which include anandamide (2-arachidonoylethanolamide) and 2-arachidonoylglycerol. |
2004-05-19 |
2023-08-12 |
human |
| María G Sánchez, Lidia Ruiz-Llorente, Ana M Sánchez, Inés Díaz-Laviad. Activation of phosphoinositide 3-kinase/PKB pathway by CB(1) and CB(2) cannabinoid receptors expressed in prostate PC-3 cells. Involvement in Raf-1 stimulation and NGF induction. Cellular signalling. vol 15. issue 9. 2004-05-05. PMID:12834810. |
treatment of pc-3 cells with either delta(9)-tetrahydrocannabinol (thc), the major psychoactive ingredient of marijuana, or r-(+)-methanandamide (met), an analogue of the endogenous cannabinoid anandamide, increased phosphorylation of pkb in thr308 and ser473. |
2004-05-05 |
2023-08-12 |
human |
| María Gómez, Mariluz Hernández, Björn Johansson, Rosario de Miguel, José Antonio Ramos, Javier Fernández-Rui. Prenatal cannabinoid and gene expression for neural adhesion molecule L1 in the fetal rat brain. Brain research. Developmental brain research. vol 147. issue 1-2. 2004-05-03. PMID:15068010. |
the consumption by women of cannabis derivatives during pregnancy and/or lactation affects the development of their offspring because like other psychoactive drugs, cannabinoids, the psychoactive ingredients of marijuana, can cross the placental barrier and be secreted into the maternal milk. |
2004-05-03 |
2023-08-12 |
rat |
| María Gómez, Mariluz Hernández, Björn Johansson, Rosario de Miguel, José Antonio Ramos, Javier Fernández-Rui. Prenatal cannabinoid and gene expression for neural adhesion molecule L1 in the fetal rat brain. Brain research. Developmental brain research. vol 147. issue 1-2. 2004-05-03. PMID:15068010. |
in summary, cannabinoids seem to influence the expression of l1 in specific brain structures during the prenatal period, which, considering the role played by this protein in different events related to neural development, might explain the neurotransmitter and behavioral disturbances reported after prenatal consumption of marijuana. |
2004-05-03 |
2023-08-12 |
rat |
| Allyn Franklin, Nephi Stell. Arachidonylcyclopropylamide increases microglial cell migration through cannabinoid CB2 and abnormal-cannabidiol-sensitive receptors. European journal of pharmacology. vol 474. issue 2-3. 2004-04-23. PMID:12921861. |
two antagonists of cannabinoid cb(2) receptors n-(1,s)-endo-1,3,3-trimethyl bicyclo(2,2,1)heptan-2-yl)-5-(4-chloro-3-methylphenyl)-1-(4-methylbenzyl)-pyrazole-3-carboxamide (sr144528) and cannabinol, as well as two antagonists of the newly identified "abnormal-cannabidiol-sensitive" (abn-cbd) receptors (o-1918 and cannabidiol) prevented this response. |
2004-04-23 |
2023-08-12 |
mouse |
| b' M Maccarrone, A Finazzi-Agr\\xc3\\xb. The endocannabinoid system, anandamide and the regulation of mammalian cell apoptosis. Cell death and differentiation. vol 10. issue 9. 2004-04-16. PMID:12934069.' |
anandamide (n-arachidonoylethanolamine; aea) and 2-arachidonoylglycerol (2-ag) are the main endogenous agonists of cannabinoid receptors able to mimic several pharmacological effects of delta-9-tetrahydrocannabinol, the active principle of cannabis sativa preparations like hashish and marijuana. |
2004-04-16 |
2023-08-12 |
Not clear |
| Aquiles J Roncoron. [Medical use of cannabis and synthetic cannabinoids]. Medicina. vol 63. issue 6. 2004-04-09. PMID:14719320. |
[medical use of cannabis and synthetic cannabinoids]. |
2004-04-09 |
2023-08-12 |
Not clear |
| Giovanni Diana, Massimiliano Malloni, Massimo Pier. Effects of the synthetic cannabinoid nabilone on spatial learning and hippocampal neurotransmission. Pharmacology, biochemistry, and behavior. vol 75. issue 3. 2004-04-08. PMID:12895676. |
cannabinoids, the active components of marijuana, affect memory and hippocampal neurotransmission. |
2004-04-08 |
2023-08-12 |
rat |
| Stefan Hart, Oliver M Fischer, Axel Ullric. Cannabinoids induce cancer cell proliferation via tumor necrosis factor alpha-converting enzyme (TACE/ADAM17)-mediated transactivation of the epidermal growth factor receptor. Cancer research. vol 64. issue 6. 2004-04-08. PMID:15026328. |
cannabinoids, the active components of marijuana and their endogenous counterparts were reported as useful analgetic agents to accompany primary cancer treatment by preventing nausea, vomiting, and pain and by stimulating appetite. |
2004-04-08 |
2023-08-12 |
Not clear |
| Paola Massi, Angelo Vaccani, Stefania Ceruti, Arianna Colombo, Maria P Abbracchio, Daniela Parolar. Antitumor effects of cannabidiol, a nonpsychoactive cannabinoid, on human glioma cell lines. The Journal of pharmacology and experimental therapeutics. vol 308. issue 3. 2004-04-06. PMID:14617682. |
antitumor effects of cannabidiol, a nonpsychoactive cannabinoid, on human glioma cell lines. |
2004-04-06 |
2023-08-12 |
mouse |
| Paola Massi, Angelo Vaccani, Stefania Ceruti, Arianna Colombo, Maria P Abbracchio, Daniela Parolar. Antitumor effects of cannabidiol, a nonpsychoactive cannabinoid, on human glioma cell lines. The Journal of pharmacology and experimental therapeutics. vol 308. issue 3. 2004-04-06. PMID:14617682. |
because the psychoactivity of cannabinoid compounds limits their medicinal usage, we undertook the present study to evaluate the in vitro antiproliferative ability of cannabidiol (cbd), a nonpsychoactive cannabinoid compound, on u87 and u373 human glioma cell lines. |
2004-04-06 |
2023-08-12 |
mouse |
| Gisela Skopp, Barbara Richter, Lucia Pötsc. [Serum cannabinoid levels 24 to 48 hours after cannabis smoking]. Archiv fur Kriminologie. vol 212. issue 3-4. 2004-03-29. PMID:14639811. |
[serum cannabinoid levels 24 to 48 hours after cannabis smoking]. |
2004-03-29 |
2023-08-12 |
Not clear |
| Jana Thorspecken, Gisela Skopp, Lucia Pötsc. In vitro contamination of hair by marijuana smoke. Clinical chemistry. vol 50. issue 3. 2004-03-24. PMID:14726468. |
we studied external uptake of cannabinoids from marijuana smoke, investigating possible influencing factors on drug uptake and the efficiency of decontamination procedures. |
2004-03-24 |
2023-08-12 |
Not clear |
| Robert B Zurie. Prospects for cannabinoids as anti-inflammatory agents. Journal of cellular biochemistry. vol 88. issue 3. 2004-03-23. PMID:12532323. |
it is likely that the therapeutic benefits of smoked marijuana are due to some combination of its more than 60 cannabinoids and 200-250 non-cannabinoid constituents. |
2004-03-23 |
2023-08-12 |
Not clear |
| Robert B Zurie. Prospects for cannabinoids as anti-inflammatory agents. Journal of cellular biochemistry. vol 88. issue 3. 2004-03-23. PMID:12532323. |
understanding the mechanisms of the therapeutic effects of nonpsychoactive cannabinoids should lead to development of safe effective treatment for several diseases, and may render moot the debate about "medical marijuana". |
2004-03-23 |
2023-08-12 |
Not clear |