| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| D Cota, G Marsicano, B Lutz, V Vicennati, G K Stalla, R Pasquali, U Pagott. Endogenous cannabinoid system as a modulator of food intake. International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity. vol 27. issue 3. 2003-04-17. PMID:12629555. |
later, the discovery of specific receptors and their endogenous ligands (endocannabinoids) suggested the existence of an endogenous cannabinoid system, providing a physiological basis for biological effects induced by marijuana and other cannabinoids. |
2003-04-17 |
2023-08-12 |
human |
| Roger G Pertwe. Cannabinoids and multiple sclerosis. Pharmacology & therapeutics. vol 95. issue 2. 2003-04-03. PMID:12182963. |
there is a growing amount of evidence to suggest that cannabis and individual cannabinoids may be effective in suppressing certain symptoms of multiple sclerosis and spinal cord injury, including spasticity and pain. |
2003-04-03 |
2023-08-12 |
mouse |
| Roger G Pertwe. Cannabinoids and multiple sclerosis. Pharmacology & therapeutics. vol 95. issue 2. 2003-04-03. PMID:12182963. |
future research should also be directed at obtaining more conclusive evidence about the efficacy of cannabis or individual cannabinoids against the signs and symptoms of these disorders, at devising better modes of administration for cannabinoids and at exploring strategies that maximize separation between the sought-after therapeutic effects and the unwanted effects of these drugs. |
2003-04-03 |
2023-08-12 |
mouse |
| Albert D Fraser, Lawrence Coffin, David Wort. Drug and chemical metabolites in clinical toxicology investigations: the importance of ethylene glycol, methanol and cannabinoid metabolite analyses. Clinical biochemistry. vol 35. issue 7. 2003-04-02. PMID:12493577. |
serial monitoring of the major urinary cannabinoid metabolite (delta(9)-thc-cooh) to creatinine ratios in paired urine specimens (collected at least 24 h apart) could differentiate new marijuana or hashish use from residual cannabinoid metabolite excretion in urine after drug use according to huestis. |
2003-04-02 |
2023-08-12 |
human |
| Albert D Fraser, Lawrence Coffin, David Wort. Drug and chemical metabolites in clinical toxicology investigations: the importance of ethylene glycol, methanol and cannabinoid metabolite analyses. Clinical biochemistry. vol 35. issue 7. 2003-04-02. PMID:12493577. |
the second objective is to demonstrate that creatinine corrected urine specimens positive for cannabinoids may help differentiate new marijuana use from the excretion of residual delta(9) -thc-cooh in chronic users of marijuana or hashish. |
2003-04-02 |
2023-08-12 |
human |
| Cristina Blázquez, M Llanos Casanova, Anna Planas, Teresa Gómez Del Pulgar, Concepción Villanueva, María J Fernández-Aceñero, Julián Aragonés, John W Huffman, José L Jorcano, Manuel Guzmá. Inhibition of tumor angiogenesis by cannabinoids. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 17. issue 3. 2003-04-01. PMID:12514108. |
cannabinoids, the active components of marijuana and their derivatives, induce tumor regression in rodents (8). |
2003-04-01 |
2023-08-12 |
mouse |
| Camila Scorticati, Claudia Mohn, Andrea De Laurentiis, Paula Vissio, Javier Fernández Solari, Adriana Seilicovich, Samuel M McCann, Valeria Rettor. The effect of anandamide on prolactin secretion is modulated by estrogen. Proceedings of the National Academy of Sciences of the United States of America. vol 100. issue 4. 2003-04-01. PMID:12578974. |
recent research has revealed that endogenous cannabinoid receptors (cb1 and cb2) react with the active ingredient of marijuana, delta(9)-tetrahydrocannabinol. |
2003-04-01 |
2023-08-12 |
rat |
| J Ludovic Croxfor. Therapeutic potential of cannabinoids in CNS disease. CNS drugs. vol 17. issue 3. 2003-03-31. PMID:12617697. |
the major psychoactive constituent of cannabis sativa, delta(9)-tetrahydrocannabinol (delta(9)-thc), and endogenous cannabinoid ligands, such as anandamide, signal through g-protein-coupled cannabinoid receptors localised to regions of the brain associated with important neurological processes. |
2003-03-31 |
2023-08-12 |
Not clear |
| J Ludovic Croxfor. Therapeutic potential of cannabinoids in CNS disease. CNS drugs. vol 17. issue 3. 2003-03-31. PMID:12617697. |
the use of nonpsychoactive cannabinoids such as cannabidiol and dexanabinol may allow the dissociation of unwanted psychoactive effects from potential therapeutic benefits. |
2003-03-31 |
2023-08-12 |
Not clear |
| Giulia Di Carlo, Angelo A Izz. Cannabinoids for gastrointestinal diseases: potential therapeutic applications. Expert opinion on investigational drugs. vol 12. issue 1. 2003-03-26. PMID:12517253. |
delta(9)-tetrahydrocannabinol (the active ingredient of marijuana), as well as endogenous and synthetic cannabinoids, exert many biological functions by activating two types of cannabinoid receptors, cb(1) and cb(2) receptors. |
2003-03-26 |
2023-08-12 |
Not clear |
| Takayuki Sugiura, Keizo Wak. Cannabinoid receptors and their endogenous ligands. Journal of biochemistry. vol 132. issue 1. 2003-03-25. PMID:12097154. |
delta9-tetrahydrocannabinol, a major psychoactive component of marijuana, has been shown to interact with specific cannabinoid receptors, thereby eliciting a variety of pharmacological responses in experimental animals and human. |
2003-03-25 |
2023-08-12 |
human |
| Satish Kathuria, Silvana Gaetani, Darren Fegley, Fernando Valiño, Andrea Duranti, Andrea Tontini, Marco Mor, Giorgio Tarzia, Giovanna La Rana, Antonio Calignano, Arcangela Giustino, Maria Tattoli, Maura Palmery, Vincenzo Cuomo, Daniele Piomell. Modulation of anxiety through blockade of anandamide hydrolysis. Nature medicine. vol 9. issue 1. 2003-03-18. PMID:12461523. |
the psychoactive constituent of cannabis, delta(9)-tetrahydrocannabinol, produces in humans subjective responses mediated by cb1 cannabinoid receptors, indicating that endogenous cannabinoids may contribute to the control of emotion. |
2003-03-18 |
2023-08-12 |
rat |
| Maurice R Elphick, Yutaka Satou, Nori Sato. The invertebrate ancestry of endocannabinoid signalling: an orthologue of vertebrate cannabinoid receptors in the urochordate Ciona intestinalis. Gene. vol 302. issue 1-2. 2003-03-14. PMID:12527200. |
the g-protein coupled cannabinoid receptors cb(1) and cb(2) are activated by delta(9)-tetrahydrocannabinol, the psychoactive ingredient of cannabis, and mediate physiological effects of endogenous cannabinoids ('endocannabinoids'). |
2003-03-14 |
2023-08-12 |
human |
| Stephen Sidne. Cardiovascular consequences of marijuana use. Journal of clinical pharmacology. vol 42. issue S1. 2003-03-12. PMID:12412838. |
this review describes what is known about effects of marijuana and cannabinoids in relation to human physiological and disease outcomes. |
2003-03-12 |
2023-08-12 |
human |
| Stephen Sidne. Cardiovascular consequences of marijuana use. Journal of clinical pharmacology. vol 42. issue S1. 2003-03-12. PMID:12412838. |
research directions might include more studies of cardiovascular disease outcomes and relationships of marijuana with cardiovascular risk factors, studies of metabolic and physiologic effects of chronic marijuana use that may affect cardiovascular disease risk, increased understanding of the role of the cannabinoid receptor system in cardiovascular regulation, and studies to determine if there is a therapeutic role for cannabinoids in blood pressure control or for neuroprotection after stroke. |
2003-03-12 |
2023-08-12 |
human |
| Barry M Bredt, Dana Higuera-Alhino, Starley B Shade, Samuel J Hebert, Joseph M McCune, Donald I Abram. Short-term effects of cannabinoids on immune phenotype and function in HIV-1-infected patients. Journal of clinical pharmacology. vol 42. issue S1. 2003-03-12. PMID:12412840. |
cannabinoids, including smoked marijuana and delta9-tetrahydrocannabinol (thc) (dronabinol, marinol), have been used to treat human immunodeficiency virus-1 (hiv)-associated anorexia and weight loss. |
2003-03-12 |
2023-08-12 |
human |
| Herbert Schuel, Lani J Burkman, Jack Lippes, Kent Crickard, Mary C Mahony, Andrea Giuffrida, Robert P Picone, Alexandros Makriyanni. Evidence that anandamide-signaling regulates human sperm functions required for fertilization. Molecular reproduction and development. vol 63. issue 3. 2003-03-10. PMID:12237954. |
this study has potential medical and public policy ramifications because of the incidence of marijuana abuse by adults in our society, previously documented reproductive effects of marijuana, and the ongoing debate about medicinal use of marijuana and cannabinoids. |
2003-03-10 |
2023-08-12 |
human |
| Allan J Flac. Delta-9-tetrahydrocannabinol (THC) in the treatment of end-stage open-angle glaucoma. Transactions of the American Ophthalmological Society. vol 100. 2003-03-03. PMID:12545695. |
therefore, the research advisory panel of california instituted the cannabis therapeutic research program to permit compassionate access to cannabinoid derivatives. |
2003-03-03 |
2023-08-12 |
Not clear |
| Paul F Smit. Cannabinoids in the treatment of pain and spasticity in multiple sclerosis. Current opinion in investigational drugs (London, England : 2000). vol 3. issue 6. 2003-02-26. PMID:12137404. |
there is a large amount of evidence to support the view that the psychoactive ingredient in cannabis, delta9-tetrahydrocannabinol (delta9-thc), and cannabinoids in general, can reduce muscle spasticity and pain under some circumstances. |
2003-02-26 |
2023-08-12 |
Not clear |
| Paul F Smit. Cannabinoids in the treatment of pain and spasticity in multiple sclerosis. Current opinion in investigational drugs (London, England : 2000). vol 3. issue 6. 2003-02-26. PMID:12137404. |
whether or not cannabinoids do have therapeutic potential in the treatment of ms, a further issue will be whether synthetic cannabinoids should be used in preference to cannabis itself. |
2003-02-26 |
2023-08-12 |
Not clear |