| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Andrew J Irving, Mark G Rae, Angela A Coutt. Cannabinoids on the brain. TheScientificWorldJournal. vol 2. 2004-03-23. PMID:12805989. |
recently there have been significant advances in our understanding of how cannabis and related compounds (cannabinoids) affect the brain and this review addresses the current state of knowledge of these effects. |
2004-03-23 |
2023-08-12 |
Not clear |
| Thomas W Klein, Cathy Newton, Kellie Larsen, Joe Chou, Izabella Perkins, Lily Lu, Liang Nong, Herman Friedma. Cannabinoid receptors and T helper cells. Journal of neuroimmunology. vol 147. issue 1-2. 2004-03-15. PMID:14741435. |
we have reported that injection of marijuana cannabinoids, such as delta(9)-tetrahydrocannabinol (thc), into mice, followed by infection with legionella pneumophila (lp), suppresses the development of cell-mediated immunity t helper 1 (th1) activity. |
2004-03-15 |
2023-08-12 |
mouse |
| Franjo Grotenhermen, Kirsten Müller-Vah. IACM 2nd Conference on Cannabinoids in Medicine. Expert opinion on pharmacotherapy. vol 4. issue 12. 2004-03-12. PMID:14640935. |
the international association for cannabis as medicine 2nd conference on cannabinoids in medicine focused on new clinical research with cannabis and single cannabinoids (delta(9)-tetrahydrocannabinol, ct-3) and on animal research with possible therapeutic implications. |
2004-03-12 |
2023-08-12 |
Not clear |
| Attila Losonczy, Agota A Biró, Zoltan Nusse. Persistently active cannabinoid receptors mute a subpopulation of hippocampal interneurons. Proceedings of the National Academy of Sciences of the United States of America. vol 101. issue 5. 2004-03-09. PMID:14734812. |
here, we report that persistently active cannabinoid receptors, the site of action of endocannabinoids, and the psychostimulants marijuana and hashish, switch off the output (mute) of a unique class of hippocampal ins. |
2004-03-09 |
2023-08-12 |
Not clear |
| Margaret Haney, Carl L Hart, Suzanne K Vosburg, Jennifer Nasser, Andrew Bennett, Carlos Zubaran, Richard W Folti. Marijuana withdrawal in humans: effects of oral THC or divalproex. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 29. issue 1. 2004-02-17. PMID:14560320. |
two placebo-controlled, within-subject studies investigated the effects of a cannabinoid agonist, delta-9-tetrahydrocannabinol (thc: study 1), and a mood stabilizer, divalproex (study 2), on symptoms of marijuana withdrawal. |
2004-02-17 |
2023-08-12 |
human |
| David Robbe, Gerard Alonso, Oliver J Manzon. Exogenous and endogenous cannabinoids control synaptic transmission in mice nucleus accumbens. Annals of the New York Academy of Sciences. vol 1003. 2004-02-13. PMID:14684448. |
the fact that this new form of ltd was occluded by an exogenous cannabinoid suggested that cannabis derivatives, such as marijuana, may alter normal ecb-mediated synaptic plasticity. |
2004-02-13 |
2023-08-12 |
mouse |
| Zuzana Justinova, Gianluigi Tanda, Godfrey H Redhi, Steven R Goldber. Self-administration of delta9-tetrahydrocannabinol (THC) by drug naive squirrel monkeys. Psychopharmacology. vol 169. issue 2. 2004-02-10. PMID:12827345. |
interest in therapeutic activities of cannabinoids has been restrained by the fact that they are most often mediated through activation of cannabinoid cb1 receptors, the same receptors that mediate the effects of delta9-tetrahydrocannabinol (thc) and are responsible for the abuse liability of marijuana. |
2004-02-10 |
2023-08-12 |
monkey |
| Alison J Drysdale, Bettina Plat. Cannabinoids: mechanisms and therapeutic applications in the CNS. Current medicinal chemistry. vol 10. issue 24. 2004-02-02. PMID:14529462. |
cannabinoids comprise three classes of compounds, the active components of marijuana (cannabis sativa), as well as endogenous and synthetic derivatives. |
2004-02-02 |
2023-08-12 |
Not clear |
| Malcolm Begg, Fong-Ming Mo, László Offertaler, Sándor Bátkai, Pál Pacher, Raj K Razdan, David M Lovinger, George Kuno. G protein-coupled endothelial receptor for atypical cannabinoid ligands modulates a Ca2+-dependent K+ current. The Journal of biological chemistry. vol 278. issue 46. 2003-12-24. PMID:12952947. |
the cannabinoid analog "abnormal cannabidiol" (abn-cbd) causes endothelium-dependent vasodilation in rat isolated mesenteric arteries through a g protein-coupled receptor distinct from cb1 or cb2. |
2003-12-24 |
2023-08-12 |
human |
| Kirsten R Müller-Vah. Cannabinoids reduce symptoms of Tourette's syndrome. Expert opinion on pharmacotherapy. vol 4. issue 10. 2003-12-18. PMID:14521482. |
at present, it remains unclear whether herbal cannabis, different natural or synthetic cannabinoid cb1-receptor agonists or agents that interfere with the inactivation of endocannabinoids, may have the best adverse effect profile in ts. |
2003-12-18 |
2023-08-12 |
Not clear |
| B Park, H M Gibbons, M D Mitchell, M Glass. Identification of the CB1 cannabinoid receptor and fatty acid amide hydrolase (FAAH) in the human placenta. Placenta. vol 24. issue 5. 2003-12-10. PMID:12744923. |
synthetic cannabinoids, the psychoactive components of the cannabis sativa (marijuana) and their endogenous counterparts, act through two g protein-coupled receptors, cb1 and cb2. |
2003-12-10 |
2023-08-12 |
human |
| B Park, H M Gibbons, M D Mitchell, M Glass. Identification of the CB1 cannabinoid receptor and fatty acid amide hydrolase (FAAH) in the human placenta. Placenta. vol 24. issue 5. 2003-12-10. PMID:12744923. |
this is consistent with a placental site of action of endocannabinoids and cannabis being responsible, at least in part, for the poor outcomes associated with cannabis consumption and pathology in the endocannabinoid system during pregnancy. |
2003-12-10 |
2023-08-12 |
human |
| Shih-Fang Fan, Stephen Yazull. Biphasic modulation of voltage-dependent currents of retinal cones by cannabinoid CB1 receptor agonist WIN 55212-2. Visual neuroscience. vol 20. issue 2. 2003-11-28. PMID:12916739. |
thus, neuronal excitability appears to be affected by cannabinoids at the first synapse of the visual pathway and could account for some of the visual effects of marijuana. |
2003-11-28 |
2023-08-12 |
Not clear |
| Thomas W Klein, Cathy Newton, Kellie Larsen, Lily Lu, Izabella Perkins, Liang Nong, Herman Friedma. The cannabinoid system and immune modulation. Journal of leukocyte biology. vol 74. issue 4. 2003-11-18. PMID:12960289. |
studies on the effects of marijuana smoking have evolved into the discovery and description of the endocannabinoid system. |
2003-11-18 |
2023-08-12 |
Not clear |
| Manuel Guzmá. Cannabinoids: potential anticancer agents. Nature reviews. Cancer. vol 3. issue 10. 2003-11-04. PMID:14570037. |
cannabinoids - the active components of cannabis sativa and their derivatives - exert palliative effects in cancer patients by preventing nausea, vomiting and pain and by stimulating appetite. |
2003-11-04 |
2023-08-12 |
Not clear |
| Jenny L Wiley, Billy R Marti. Cannabinoid pharmacology: implications for additional cannabinoid receptor subtypes. Chemistry and physics of lipids. vol 121. issue 1-2. 2003-08-22. PMID:12505690. |
delta(9)-tetrahydrocannabinol (delta(9)-thc), the primary psychoactive constituent of marijuana (cannabis sativa), is known to bind to two cannabinoid receptors: cb(1) receptors, located primarily in the brain, and cb(2) receptors, located primarily in the periphery. |
2003-08-22 |
2023-08-12 |
mouse |
| Herbert Schuel, Lani J Burkman, Jack Lippes, Kent Crickard, Ellyn Forester, Daniele Piomelli, Andrea Giuffrid. N-Acylethanolamines in human reproductive fluids. Chemistry and physics of lipids. vol 121. issue 1-2. 2003-08-22. PMID:12505702. |
collectively, these findings suggest that naes in human reproductive fluids may help regulate multiple physiological and pathological processes in the reproductive system, and imply that exogenous cannabinoids delivered by marijuana smoke might impact these processes. |
2003-08-22 |
2023-08-12 |
human |
| Herbert Schuel, Lani J Burkman, Jack Lippes, Kent Crickard, Ellyn Forester, Daniele Piomelli, Andrea Giuffrid. N-Acylethanolamines in human reproductive fluids. Chemistry and physics of lipids. vol 121. issue 1-2. 2003-08-22. PMID:12505702. |
this study has potential medical and public policy ramifications because of the incidence of marijuana abuse by adolescents and adults in our society, previously documented reproductive effects of marijuana, and the ongoing debate about medicinal use of marijuana and cannabinoids. |
2003-08-22 |
2023-08-12 |
human |
| Alexander F Hoffman, Murat Oz, Tara Caulder, Carl R Lupic. Functional tolerance and blockade of long-term depression at synapses in the nucleus accumbens after chronic cannabinoid exposure. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 12. 2003-08-05. PMID:12832502. |
the rewarding properties of the psychoactive constituents of marijuana, termed "cannabinoids," may reflect actions on synaptic transmission in the nucleus accumbens (nac). |
2003-08-05 |
2023-08-12 |
rat |
| Alexander F Hoffman, Murat Oz, Tara Caulder, Carl R Lupic. Functional tolerance and blockade of long-term depression at synapses in the nucleus accumbens after chronic cannabinoid exposure. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 12. 2003-08-05. PMID:12832502. |
because humans often use marijuana for prolonged periods, we examined the impact of long-term cannabinoid exposure on synaptic processes in an animal model. |
2003-08-05 |
2023-08-12 |
rat |