| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Vincenzo Di Marzo, Maurizio Bifulco, Luciano De Petrocelli. The endocannabinoid system and its therapeutic exploitation. Nature reviews. Drug discovery. vol 3. issue 9. 2004-09-30. PMID:15340387. |
the term 'endocannabinoid' - originally coined in the mid-1990s after the discovery of membrane receptors for the psychoactive principle in cannabis, delta9-tetrahydrocannabinol and their endogenous ligands - now indicates a whole signalling system that comprises cannabinoid receptors, endogenous ligands and enzymes for ligand biosynthesis and inactivation. |
2004-09-30 |
2023-08-12 |
Not clear |
| Yoonkyung Do, Robert J McKallip, Mitzi Nagarkatti, Prakash S Nagarkatt. Activation through cannabinoid receptors 1 and 2 on dendritic cells triggers NF-kappaB-dependent apoptosis: novel role for endogenous and exogenous cannabinoids in immunoregulation. Journal of immunology (Baltimore, Md. : 1950). vol 173. issue 4. 2004-09-28. PMID:15294950. |
addition of delta(9)-tetrahydrocannabinol (thc), a major psychoactive component found in marijuana or anandamide, an endogenous cannabinoid, to dc cultures induced apoptosis in dcs. |
2004-09-28 |
2023-08-12 |
mouse |
| José M Oliva, Sergio Ortiz, Tomás Palomo, Jorge Manzanare. Spontaneous cannabinoid withdrawal produces a differential time-related responsiveness in cannabinoid CB1 receptor gene expression in the mouse brain. Journal of psychopharmacology (Oxford, England). vol 18. issue 1. 2004-08-30. PMID:15107186. |
these findings further suggest a time and regional differential role for cannabinoid receptors in short- and long-term neuroadaptations that occur after exposure to cannabis derivatives. |
2004-08-30 |
2023-08-12 |
mouse |
| Dirk W Lachenmeier, Lars Kroener, Frank Musshoff, Burkhard Made. Determination of cannabinoids in hemp food products by use of headspace solid-phase microextraction and gas chromatography-mass spectrometry. Analytical and bioanalytical chemistry. vol 378. issue 1. 2004-08-26. PMID:14598006. |
cannabinoids were detected in all of the samples and it was possible to differentiate between drug-type and fiber-type cannabis sativa l. in comparison with other studies relatively low thc concentrations between 0.01 and 15.53 mg kg(-1) were determined. |
2004-08-26 |
2023-08-12 |
Not clear |
| B Kraft, H G Kres. [Cannabinoids and the immune system. Of men, mice and cells]. Schmerz (Berlin, Germany). vol 18. issue 3. 2004-08-18. PMID:15221424. |
the medical use of cannabis or cannabinoid compounds is controversial. |
2004-08-18 |
2023-08-12 |
mouse |
| Boram Park, John M McPartland, Michelle Glas. Cannabis, cannabinoids and reproduction. Prostaglandins, leukotrienes, and essential fatty acids. vol 70. issue 2. 2004-08-17. PMID:14683692. |
cannabis, cannabinoids and reproduction. |
2004-08-17 |
2023-08-12 |
Not clear |
| Boram Park, John M McPartland, Michelle Glas. Cannabis, cannabinoids and reproduction. Prostaglandins, leukotrienes, and essential fatty acids. vol 70. issue 2. 2004-08-17. PMID:14683692. |
the purpose of this review is therefore twofold, to examine the impact that cannabis use may have on fertility and reproduction, and to review the potential role of the endocannabinoid system in hormonal regulation, embryo implantation and maintenance of pregnancy. |
2004-08-17 |
2023-08-12 |
Not clear |
| Silvana Gaetani, Vincenzo Cuomo, Daniele Piomell. Anandamide hydrolysis: a new target for anti-anxiety drugs? Trends in molecular medicine. vol 9. issue 11. 2004-08-12. PMID:14604824. |
the major psychoactive constituent of cannabis, delta(9)-tetrahydrocannabinol, affects emotional states in humans and laboratory animals by activating brain cannabinoid receptors. |
2004-08-12 |
2023-08-12 |
rat |
| Franjo Grotenherme. Pharmacology of cannabinoids. Neuro endocrinology letters. vol 25. issue 1-2. 2004-08-03. PMID:15159677. |
dronabinol (delta 9-tetrahydocannabinol, thc), the main source of the pharmacological effects caused by the use of cannabis, is an agonist to both the cb1 and the cb2 subtype of cannabinoid receptors. |
2004-08-03 |
2023-08-12 |
Not clear |
| Franjo Grotenherme. Pharmacology of cannabinoids. Neuro endocrinology letters. vol 25. issue 1-2. 2004-08-03. PMID:15159677. |
the non-psychotropic cannabidiol (cbd), some analogues of natural cannabinoids and their metabolites, antagonists at the cannabinoid receptors and modulators of the endogenous cannabinoid system are also promising candidates for clinical research and therapeutic uses. |
2004-08-03 |
2023-08-12 |
Not clear |
| Ethan B Russ. Clinical endocannabinoid deficiency (CECD): can this concept explain therapeutic benefits of cannabis in migraine, fibromyalgia, irritable bowel syndrome and other treatment-resistant conditions? Neuro endocrinology letters. vol 25. issue 1-2. 2004-08-03. PMID:15159679. |
clinical endocannabinoid deficiency (cecd): can this concept explain therapeutic benefits of cannabis in migraine, fibromyalgia, irritable bowel syndrome and other treatment-resistant conditions? |
2004-08-03 |
2023-08-12 |
Not clear |
| Ethan B Russ. Clinical endocannabinoid deficiency (CECD): can this concept explain therapeutic benefits of cannabis in migraine, fibromyalgia, irritable bowel syndrome and other treatment-resistant conditions? Neuro endocrinology letters. vol 25. issue 1-2. 2004-08-03. PMID:15159679. |
this study examines the concept of clinical endocannabinoid deficiency (cecd), and the prospect that it could underlie the pathophysiology of migraine, fibromyalgia, irritable bowel syndrome, and other functional conditions alleviated by clinical cannabis. |
2004-08-03 |
2023-08-12 |
Not clear |
| Linda A Parker, Magdalena Kwiatkowska, Page Burton, Raphael Mechoula. Effect of cannabinoids on lithium-induced vomiting in the Suncus murinus (house musk shrew). Psychopharmacology. vol 171. issue 2. 2004-07-27. PMID:13680081. |
the principal cannabinoids found in marijuana include the psychoactive compound delta-9-tetrahydrocannabinol (thc) and the non-psychoactive compound cannabidiol (cbd). |
2004-07-27 |
2023-08-12 |
Not clear |
| Gregory T Carter, Patrick Weydt, Muraco Kyashna-Tocha, Donald I Abram. Medicinal cannabis: rational guidelines for dosing. IDrugs : the investigational drugs journal. vol 7. issue 5. 2004-07-21. PMID:15154108. |
cannabinoids, the active ingredients in cannabis, have many distinct pharmacological properties. |
2004-07-21 |
2023-08-12 |
Not clear |
| B Park, H M Gibbons, M D Mitchell, M Glas. Identification of the CB1 cannabinoid receptor and fatty acid amide hydrolase (FAAH) in the human placenta. Placenta. vol 24. issue 10. 2004-07-15. PMID:14580383. |
synthetic cannabinoids, the psychoactive components of the cannabis sativa (marijuana) plant and their endogenous counterparts, act through two g protein-coupled receptors, cb1 and cb2. |
2004-07-15 |
2023-08-12 |
human |
| B Park, H M Gibbons, M D Mitchell, M Glas. Identification of the CB1 cannabinoid receptor and fatty acid amide hydrolase (FAAH) in the human placenta. Placenta. vol 24. issue 10. 2004-07-15. PMID:14580383. |
this is consistent with a placental site of action of endocannabinoids and cannabis being responsible, at least in part, for the poor outcomes associated with cannabis consumption and pathology in the endocannabinoid system during pregnancy. |
2004-07-15 |
2023-08-12 |
human |
| Tri J Raharjo, Wen-Te Chang, Marianne C Verberne, Anja M G Peltenburg-Looman, Huub J M Linthorst, Robert Verpoort. Cloning and over-expression of a cDNA encoding a polyketide synthase from Cannabis sativa. Plant physiology and biochemistry : PPB. vol 42. issue 4. 2004-07-08. PMID:15120113. |
a polyketide synthase has been suggested to play an important role in cannabinoid biosynthesis in cannabis sativa l. this enzyme catalyzes the biosynthesis of olivetolic acid, one of the precursors for cannabinoid biosynthesis. |
2004-07-08 |
2023-08-12 |
Not clear |
| J P Jacques, S Zombek, Ch Guillain, P Due. [Cannabis: experts agree more than they admit]. Revue medicale de Bruxelles. vol 25. issue 2. 2004-06-29. PMID:15157061. |
the psychotropic effects of cannabis--the result of cannabinoids contained in its resin that activate specific receptors--include general euphoria, a mild release from inhibitions and, in certain cases, some distortion of sensory perception. |
2004-06-29 |
2023-08-12 |
human |
| Ruth Gallily, Tal Even-Chena, Galia Katzavian, Dan Lehmann, Arie Dagan, Raphael Mechoula. Gamma-irradiation enhances apoptosis induced by cannabidiol, a non-psychotropic cannabinoid, in cultured HL-60 myeloblastic leukemia cells. Leukemia & lymphoma. vol 44. issue 10. 2004-06-21. PMID:14692532. |
gamma-irradiation enhances apoptosis induced by cannabidiol, a non-psychotropic cannabinoid, in cultured hl-60 myeloblastic leukemia cells. |
2004-06-21 |
2023-08-12 |
human |
| Ruth Gallily, Tal Even-Chena, Galia Katzavian, Dan Lehmann, Arie Dagan, Raphael Mechoula. Gamma-irradiation enhances apoptosis induced by cannabidiol, a non-psychotropic cannabinoid, in cultured HL-60 myeloblastic leukemia cells. Leukemia & lymphoma. vol 44. issue 10. 2004-06-21. PMID:14692532. |
two non-psychotropic cannabinoids, cannabidiol (cbd) and cannabidiol-dimethylheptyl (cbd-dmh), induced apoptosis in a human acute myeloid leukemia (aml) hl-60 cell line. |
2004-06-21 |
2023-08-12 |
human |