| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Erica J Carrier, John A Auchampach, Cecilia J Hillar. Inhibition of an equilibrative nucleoside transporter by cannabidiol: a mechanism of cannabinoid immunosuppression. Proceedings of the National Academy of Sciences of the United States of America. vol 103. issue 20. 2006-07-28. PMID:16672367. |
the plant-derived cannabinoids delta9-tetrahydrocannabinol (thc) and cannabidiol (cbd) both have immunosuppressive effects; although some effects of thc are mediated by the cb2 receptor, cb2 binds cbd weakly. |
2006-07-28 |
2023-08-12 |
mouse |
| Arno Hazekamp, Renee Ruhaak, Lineke Zuurman, Joop van Gerven, Rob Verpoort. Evaluation of a vaporizing device (Volcano) for the pulmonary administration of tetrahydrocannabinol. Journal of pharmaceutical sciences. vol 95. issue 6. 2006-07-27. PMID:16637053. |
cannabis "vaporization" is a technique aimed at suppressing irritating respiratory toxins by heating cannabis to a temperature where active cannabinoid vapors form, but below the point of combustion where smoke and associated toxins are produced. |
2006-07-27 |
2023-08-12 |
Not clear |
| Yara Ilias, Serge Rudaz, Patrick Mathieu, Philippe Christen, Jean-Luc Veuthe. Extraction and analysis of different Cannabis samples by headspace solid-phase microextraction combined with gas chromatography-mass spectrometry. Journal of separation science. vol 28. issue 17. 2006-07-21. PMID:16342794. |
a headspace solid-phase microextraction combined with gc-ms method was developed for the extraction and analysis of cannabinoids from cannabis samples. |
2006-07-21 |
2023-08-12 |
Not clear |
| Paul F Smith, John C Ashton, Cynthia L Darlingto. The endocannabinoid system: A new player in the neurochemical control of vestibular function? Audiology & neuro-otology. vol 11. issue 4. 2006-07-17. PMID:16601324. |
in this review, we consider the potential clinical significance of the endocannabinoid system for the development of vestibular disorders, the effects of recreational cannabis use and the therapeutic use of medicinal cannabinoids. |
2006-07-17 |
2023-08-12 |
Not clear |
| Alison J Drysdale, Duncan Ryan, Roger G Pertwee, Bettina Plat. Cannabidiol-induced intracellular Ca2+ elevations in hippocampal cells. Neuropharmacology. vol 50. issue 5. 2006-07-06. PMID:16386766. |
the phytocannabinoid cannabidiol (cbd) is at the forefront of therapeutic cannabinoid research due to its non-psychotropic properties. |
2006-07-06 |
2023-08-12 |
Not clear |
| Mareshige Kojoma, Hikaru Seki, Shigeo Yoshida, Toshiya Muranak. DNA polymorphisms in the tetrahydrocannabinolic acid (THCA) synthase gene in "drug-type" and "fiber-type" Cannabis sativa L. Forensic science international. vol 159. issue 2-3. 2006-07-05. PMID:16143478. |
dna polymorphisms in the tetrahydrocannabinolic acid (thca) synthase gene in "drug-type" and "fiber-type" cannabis sativa l. the cannabinoid content of 13 different strains of cannabis plant (cannabis sativa l.) was analyzed. |
2006-07-05 |
2023-08-12 |
Not clear |
| F Massa, K Monor. Endocannabinoids and the gastrointestinal tract. Journal of endocrinological investigation. vol 29. issue 3 Suppl. 2006-06-29. PMID:16751708. |
delta9-tetrahydrocannabinol (thc; the active component of marijuana), as well as endogenous and synthetic cannabinoids, exert their biological functions on the gastrointestinal tract by activating two types of cannabinoid receptors, cannabinoid type 1 receptor (cb1 receptor) and cannabinoid type 2 receptor (cb2 receptor). |
2006-06-29 |
2023-08-12 |
Not clear |
| Lumír O Hanus, Susanna Tchilibon, Datta E Ponde, Aviva Breuer, Ester Fride, Raphael Mechoula. Enantiomeric cannabidiol derivatives: synthesis and binding to cannabinoid receptors. Organic & biomolecular chemistry. vol 3. issue 6. 2006-06-15. PMID:15750656. |
enantiomeric cannabidiol derivatives: synthesis and binding to cannabinoid receptors. |
2006-06-15 |
2023-08-12 |
Not clear |
| Hao-Jie Zhu, Jun-Sheng Wang, John S Markowitz, Jennifer L Donovan, Bryan B Gibson, Holly A Gefroh, C Lindsay Devan. Characterization of P-glycoprotein inhibition by major cannabinoids from marijuana. The Journal of pharmacology and experimental therapeutics. vol 317. issue 2. 2006-06-09. PMID:16439618. |
characterization of p-glycoprotein inhibition by major cannabinoids from marijuana. |
2006-06-09 |
2023-08-12 |
rat |
| Ethan Russo, Geoffrey W Gu. A tale of two cannabinoids: the therapeutic rationale for combining tetrahydrocannabinol and cannabidiol. Medical hypotheses. vol 66. issue 2. 2006-06-08. PMID:16209908. |
a tale of two cannabinoids: the therapeutic rationale for combining tetrahydrocannabinol and cannabidiol. |
2006-06-08 |
2023-08-12 |
Not clear |
| Sharon Monterrubio, Nadia Solowij, Barbara J Meyer, Nigel Turne. Fatty acid relationships in former cannabis users with schizophrenia. Progress in neuro-psychopharmacology & biological psychiatry. vol 30. issue 2. 2006-06-08. PMID:16236415. |
abnormalities in the fatty acid (fa)-based endocannabinoid lipid signaller anandamide, and prevalent cannabis use, have been found to be associated with schizophrenia and may potentially alter stress mechanisms. |
2006-06-08 |
2023-08-12 |
Not clear |
| Nancy E Buckley, Diep Burbridge, Manop Buranapramest, Tanya Ferguson, Renee Y Paa. Experimental methods to study the role of the peripheral cannabinoid receptor in immune function. Methods in molecular medicine. vol 123. 2006-05-26. PMID:16506400. |
marijuana components, such as delta-9-tetrahydrocannabinol, and endogenous cannabinoids, such as anandamide and 2-arachydonoylglycerol, alter diverse immune functions. |
2006-05-26 |
2023-08-12 |
mouse |
| Adèle Thomas, Roger G Pertwe. The bioassay of cannabinoids using the mouse isolated vas deferens. Methods in molecular medicine. vol 123. 2006-05-26. PMID:16506409. |
the mouse vas deferens has also been used to measure the ability of anandamide to activate vanilloid (trpv1) receptors, to monitor modulation by cannabinoids such as 6"-azido-2"-yne-cannabidiol and abnormal cannabidiol of contractions elicited in electrically unstimulated tissues by agonists for p2x purinoceptors or alpha1-adrenoceptors, and as a bioassay for the nonpsychoactive plant cannabinoid cannabidiol. |
2006-05-26 |
2023-08-12 |
mouse |
| Ester Fride, Alex Perchuk, F Scott Hall, George R Uhl, Emmanuel S Onaiv. Behavioral methods in cannabinoid research. Methods in molecular medicine. vol 123. 2006-05-26. PMID:16506414. |
in view of (1) the addictive/reward potential of cannabis and the cannabinoids and (2) the multiple roles of the endocannabinoid physiological control system (epcs) in behavioral functions, including memory, emotionality, and feeding, a number of behavioral techniques have been used to assess the effects of cannabinoids in these functions. |
2006-05-26 |
2023-08-12 |
mouse |
| Leonora E Long, Daniel T Malone, David A Taylo. Cannabidiol reverses MK-801-induced disruption of prepulse inhibition in mice. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 31. issue 4. 2006-05-25. PMID:16052245. |
cannabidiol, a nonpsychoactive constituent of the cannabis sativa plant, has been reported to act as an agonist of the vanilloid 1 channel in the transient receptor potential family (trpv1) and also to inhibit the hydrolysis and cellular uptake of the endogenous cannabinoid anandamide. |
2006-05-25 |
2023-08-12 |
mouse |
| M Bari, N Battista, F Fezza, V Gasperi, M Maccarron. New insights into endocannabinoid degradation and its therapeutic potential. Mini reviews in medicinal chemistry. vol 6. issue 3. 2006-05-25. PMID:16515464. |
anandamide (n-arachidonoylethanolamine; aea) and 2-arachidonoylglycerol (2-ag) are the main endogenous agonists of cannabinoid receptors, able to mimic several pharmacological effects of (-)-delta9-tetrahydrocannabinol (thc), the active principle of cannabis sativa preparations like hashish and marijuana. |
2006-05-25 |
2023-08-12 |
human |
| Vincenzo Di Marz. A brief history of cannabinoid and endocannabinoid pharmacology as inspired by the work of British scientists. Trends in pharmacological sciences. vol 27. issue 3. 2006-05-05. PMID:16476494. |
such research has progressed from the first crucial evaluation of the medicinal properties of cannabis sativa in the western world to pioneering studies of the chemical constituents of this plant, the development of in vitro biological assays to study cannabinoids, the identification of the mechanism of action of cannabinoids, the discovery of endocannabinoids and the assessment of their therapeutic implications. |
2006-05-05 |
2023-08-12 |
Not clear |
| Vincenzo Di Marzo, Luciano De Petrocelli. Plant, synthetic, and endogenous cannabinoids in medicine. Annual review of medicine. vol 57. 2006-05-04. PMID:16409166. |
although used for more than 4000 years for recreational and medicinal purposes, cannabis and its best-known pharmacologically active constituents, the cannabinoids, became a protagonist in medical research only recently. |
2006-05-04 |
2023-08-12 |
Not clear |
| Lara Teare, John Zajice. The use of cannabinoids in multiple sclerosis. Expert opinion on investigational drugs. vol 14. issue 7. 2006-04-25. PMID:16022575. |
naturally occurring cannabinoids including delta9-tetrahydrocannabinol and cannabidiol as well as endocannabinoids and synthetic cannabinoids may have a role in modulating experimental models of multiple sclerosis. |
2006-04-25 |
2023-08-12 |
Not clear |
| M L Holland, J A Panetta, J M Hoskins, M Bebawy, B D Roufogalis, J D Allen, J C Arnol. The effects of cannabinoids on P-glycoprotein transport and expression in multidrug resistant cells. Biochemical pharmacology. vol 71. issue 8. 2006-04-25. PMID:16458258. |
unlike the known p-gp inhibitor, psc833, short 1h exposure to three plant-derived cannabinoids, cannabinol (cbn), cannabidiol (cbd) and delta(9)-tetrahydrocannabinol (thc) and the synthetic cannabinoid receptor agonist, win55, 212-2 (win) did not inhibit the efflux of the p-gp substrate rhodamine 123 (rh123) in either a drug-selected human t lymphoblastoid leukaemia cell line (cem/vlb(100)) or in a mouse fibroblast mdr1 transfected cell line (77.1). |
2006-04-25 |
2023-08-12 |
mouse |