| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Krishna Prasad Bastola, Arno Hazekamp, Robert Verpoort. Synthesis and spectroscopic characterization of cannabinolic acid. Planta medica. vol 73. issue 3. 2007-06-20. PMID:17354173. |
cannabinoids, the main constituents of the cannabis plant, are being increasingly studied for their medicinal properties. |
2007-06-20 |
2023-08-12 |
Not clear |
| C Coetzee, R-A Levendal, M van de Venter, C L Fros. Anticoagulant effects of a Cannabis extract in an obese rat model. Phytomedicine : international journal of phytotherapy and phytopharmacology. vol 14. issue 5. 2007-06-19. PMID:16644197. |
blood coagulation studies were conducted to determine the possible anti-/prothrombotic effect of an organic cannabis extract and the three major cannabinoids, thc, cbd and cbn. |
2007-06-19 |
2023-08-12 |
rat |
| C Coetzee, R-A Levendal, M van de Venter, C L Fros. Anticoagulant effects of a Cannabis extract in an obese rat model. Phytomedicine : international journal of phytotherapy and phytopharmacology. vol 14. issue 5. 2007-06-19. PMID:16644197. |
the study thus shows that cannabis sativa and the cannabinoids, thc and cbn, display anticoagulant activity and may be useful in the treatment of diseases such as type 2 diabetes in which a hypercoagulable state exists. |
2007-06-19 |
2023-08-12 |
rat |
| Johannes Rentzsch, Almut Penzhorn, Kim Kernbichler, Doris Plöckl, Ana Gómez-Carrillo de Castro, Jürgen Gallinat, Maria C Jockers-Scherüb. Differential impact of heavy cannabis use on sensory gating in schizophrenic patients and otherwise healthy controls. Experimental neurology. vol 205. issue 1. 2007-06-18. PMID:17368620. |
cannabis abuse may precipitate the onset of schizophrenia and a dysfunction of the endocannabinoid system may be involved in the pathology of schizophrenia. |
2007-06-18 |
2023-08-12 |
human |
| Markus Kathmann, Karsten Flau, Agnes Redmer, Christian Tränkle, Eberhard Schlicke. Cannabidiol is an allosteric modulator at mu- and delta-opioid receptors. Naunyn-Schmiedeberg's archives of pharmacology. vol 372. issue 5. 2007-06-13. PMID:16489449. |
for comparison, (-)-delta9-tetrahydrocannabinol (thc; another major constituent of cannabis) and rimonabant (a cannabinoid cb1 receptor antagonist) were studied. |
2007-06-13 |
2023-08-12 |
rat |
| Emmanuel S Onaiv. Neuropsychobiological evidence for the functional presence and expression of cannabinoid CB2 receptors in the brain. Neuropsychobiology. vol 54. issue 4. 2007-06-13. PMID:17356307. |
for over a decade, until recently, it was thought that marijuana acts by activating brain-type cannabinoid receptors called cb1, and that a second type called cb2 cannabinoid receptor was found only in peripheral tissues. |
2007-06-13 |
2023-08-12 |
mouse |
| Vincenzo Di Marzo, Stefania Petrosin. Endocannabinoids and the regulation of their levels in health and disease. Current opinion in lipidology. vol 18. issue 2. 2007-06-06. PMID:17353660. |
endocannabinoids are defined as endogenous agonists of cannabinoid receptors, that is, of the two g-protein-coupled receptors for the cannabis psychoactive principle delta-tetra-hydrocannabinol. |
2007-06-06 |
2023-08-12 |
Not clear |
| Kazuhide Hayakawa, Kenichi Mishima, Masanori Nozako, Ayumi Ogata, Mai Hazekawa, An-Xin Liu, Masayuki Fujioka, Kohji Abe, Nobuyoshi Hasebe, Nobuaki Egashira, Katsunori Iwasaki, Michihiro Fujiwar. Repeated treatment with cannabidiol but not Delta9-tetrahydrocannabinol has a neuroprotective effect without the development of tolerance. Neuropharmacology. vol 52. issue 4. 2007-06-01. PMID:17320118. |
the neuroprotective effect of delta(9)-thc but not cannabidiol was inhibited by sr141716, cannabinoid cb(1) receptor antagonist. |
2007-06-01 |
2023-08-12 |
mouse |
| Yuki Hashimotodani, Takako Ohno-Shosaku, Masanobu Kan. Endocannabinoids and synaptic function in the CNS. The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry. vol 13. issue 2. 2007-05-25. PMID:17404373. |
marijuana affects neural functions through the binding of its active component (delta(9)-thc) to cannabinoid receptors in the cns. |
2007-05-25 |
2023-08-12 |
mouse |
| A Thomas, G L Baillie, A M Phillips, R K Razdan, R A Ross, R G Pertwe. Cannabidiol displays unexpectedly high potency as an antagonist of CB1 and CB2 receptor agonists in vitro. British journal of pharmacology. vol 150. issue 5. 2007-05-10. PMID:17245363. |
a nonpsychoactive constituent of the cannabis plant, cannabidiol has been demonstrated to have low affinity for both cannabinoid cb1 and cb2 receptors. |
2007-05-10 |
2023-08-12 |
mouse |
| A Thomas, G L Baillie, A M Phillips, R K Razdan, R A Ross, R G Pertwe. Cannabidiol displays unexpectedly high potency as an antagonist of CB1 and CB2 receptor agonists in vitro. British journal of pharmacology. vol 150. issue 5. 2007-05-10. PMID:17245363. |
we have also shown that cannabidiol can antagonize cannabinoid receptor agonists in this tissue with a greater potency than we would expect from its poor affinity for cannabinoid receptors. |
2007-05-10 |
2023-08-12 |
mouse |
| Judy Y Su, Anhkiet C V. 2-Arachidonylglyceryl ether and abnormal cannabidiol-induced vascular smooth muscle relaxation in rabbit pulmonary arteries via receptor-pertussis toxin sensitive G proteins-ERK1/2 signaling. European journal of pharmacology. vol 559. issue 2-3. 2007-05-09. PMID:17292352. |
here, we investigated the effects of 2-arachidonylglyceryl ether (2-ag ether), a metabolically stable endocannabinoid, and abnormal cannabidiol (abn-cbd) on relaxation of permeabilized pulmonary arterial strips monitored with force, and on extracellular signal-regulated mitogen-activated protein kinases (erk1/2) phosphorylation in permeabilized vascular smooth muscle cells using immunoblotting. |
2007-05-09 |
2023-08-12 |
rabbit |
| Carolina Dizioli Rodrigues de Oliveira, Mauricio Yonamine, Regina Lucia de Moraes Morea. Headspace solid-phase microextraction of cannabinoids in human head hair samples. Journal of separation science. vol 30. issue 1. 2007-05-09. PMID:17313152. |
a fast method was optimized and validated with the aim to detect cannabinoids (cannabidiol, cannabinol, and delta-9-tetrahydrocannabinol) in human head hair samples. |
2007-05-09 |
2023-08-12 |
human |
| Moisés García-Arencibia, Sara González, Eva de Lago, José A Ramos, Raphael Mechoulam, Javier Fernández-Rui. Evaluation of the neuroprotective effect of cannabinoids in a rat model of Parkinson's disease: importance of antioxidant and cannabinoid receptor-independent properties. Brain research. vol 1134. issue 1. 2007-04-05. PMID:17196181. |
we have recently demonstrated that two plant-derived cannabinoids, delta9-tetrahydrocannabinol and cannabidiol (cbd), are neuroprotective in an animal model of parkinson's disease (pd), presumably because of their antioxidant properties. |
2007-04-05 |
2023-08-12 |
rat |
| Jonathan D Wilkinson, Elizabeth M Williamso. Cannabinoids inhibit human keratinocyte proliferation through a non-CB1/CB2 mechanism and have a potential therapeutic value in the treatment of psoriasis. Journal of dermatological science. vol 45. issue 2. 2007-03-27. PMID:17157480. |
cannabinoids from cannabis (cannabis sativa) are anti-inflammatory and have inhibitory effects on the proliferation of a number of tumorigenic cell lines, some of which are mediated via cannabinoid receptors. |
2007-03-27 |
2023-08-12 |
human |
| Hassan Z Khiabani, Jørg Mørlan. [Cannabis and cannabinoids as drugs]. Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke. vol 127. issue 5. 2007-03-14. PMID:17332810. |
[cannabis and cannabinoids as drugs]. |
2007-03-14 |
2023-08-12 |
human |
| Mohini Ranganathan, Deepak Cyril D'Souz. The acute effects of cannabinoids on memory in humans: a review. Psychopharmacology. vol 188. issue 4. 2007-03-13. PMID:17019571. |
cannabis and its constituent cannabinoids are known to impair several aspects of cognitive function, with the most robust effects on short-term episodic and working memory in humans. |
2007-03-13 |
2023-08-12 |
Not clear |
| Lene Martini, Maria Waldhoer, Margareta Pusch, Viktor Kharazia, Jamie Fong, Josephine H Lee, Clarissa Freissmuth, Jennifer L Whistle. Ligand-induced down-regulation of the cannabinoid 1 receptor is mediated by the G-protein-coupled receptor-associated sorting protein GASP1. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 21. issue 3. 2007-03-08. PMID:17197383. |
the cannabinoid 1 receptor (cb1r) is one of the most abundant seven transmembrane (7tm) spanning/g-protein-coupled receptors in the central nervous system and plays an important role in pain transmission, feeding, and the rewarding effects of cannabis. |
2007-03-08 |
2023-08-12 |
human |
| Jürg Gertsch, Stefan Raduner, Karl-Heinz Altman. New natural noncannabinoid ligands for cannabinoid type-2 (CB2) receptors. Journal of receptor and signal transduction research. vol 26. issue 5-6. 2007-03-06. PMID:17118807. |
since the discovery that delta 9-tetrahydrocannabinol and related cannabinoids from cannabis sativa l. act on specific physiological receptors in the human body and the subsequent elucidation of the mammalian endogenous cannabinoid system, no other natural product class has been reported to mimic the effects of cannabinoids. |
2007-03-06 |
2023-08-12 |
human |
| Maria-Paz Viveros, Eva M Marco, Sandra E Fil. Nicotine and cannabinoids: parallels, contrasts and interactions. Neuroscience and biobehavioral reviews. vol 30. issue 8. 2007-02-20. PMID:17049986. |
after a brief outline of the nicotinic and cannabinoid systems, we review the interactions between the pharmacological effects of nicotine and cannabis, two of the most widely used drugs of dependence. |
2007-02-20 |
2023-08-12 |
Not clear |