| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| David A Gorelick, Stephen J Heishman, Kenzie L Preston, Richard A Nelson, Eric T Moolchan, Marilyn A Huesti. The cannabinoid CB1 receptor antagonist rimonabant attenuates the hypotensive effect of smoked marijuana in male smokers. American heart journal. vol 151. issue 3. 2006-03-21. PMID:16504646. |
the cannabinoid cb1 receptor antagonist rimonabant attenuates the hypotensive effect of smoked marijuana in male smokers. |
2006-03-21 |
2023-08-12 |
human |
| Uberto Pagotto, Giovanni Marsicano, Daniela Cota, Beat Lutz, Renato Pasqual. The emerging role of the endocannabinoid system in endocrine regulation and energy balance. Endocrine reviews. vol 27. issue 1. 2006-03-16. PMID:16306385. |
cannabinoid receptors, named cb1 receptor and cb2 receptor, first discovered as the molecular targets of the psychotropic component of the plant cannabis sativa, participate in the physiological modulation of many central and peripheral functions. |
2006-03-16 |
2023-08-12 |
Not clear |
| Daniel Zamora-Valdés, Guadalupe Ponciano-Rodríguez, Norberto C Chávez-Tapia, Nahum Méndez-Sánche. The endocannabinoid system in chronic liver disease. Annals of hepatology. vol 4. issue 4. 2006-03-16. PMID:16432489. |
despite the public concern about the controversial use and abuse of marijuana, the scientific community has focused on the therapeutic potentials of cannabinoid compounds and had highlighted the importance of endocannabinoids and their receptors in physiology and disease. |
2006-03-16 |
2023-08-12 |
Not clear |
| Daniel Thomas Malone, David Alan Taylo. The effect of Delta9-tetrahydrocannabinol on sensorimotor gating in socially isolated rats. Behavioural brain research. vol 166. issue 1. 2006-03-14. PMID:16143410. |
in this study, we investigate the effect of the major psychoactive constituent of cannabis and partial cannabinoid cb(1) receptor agonist delta(9)-tetrahydrocannabinol (thc) on prepulse inhibition (%ppi) of the acoustic startle reflex and on habituation in socially isolated and grouped rats. |
2006-03-14 |
2023-08-12 |
rat |
| Linda A Parker, Magdalena Kwiatkowska, Raphael Mechoula. Delta-9-tetrahydrocannabinol and cannabidiol, but not ondansetron, interfere with conditioned retching reactions elicited by a lithium-paired context in Suncus murinus: An animal model of anticipatory nausea and vomiting. Physiology & behavior. vol 87. issue 1. 2006-03-09. PMID:16197970. |
the expression of this conditioned retching reaction was completely suppressed by pretreatment with each of the principal cannabinoids found in marijuana, delta(9)-tetrahydrocannabinol or cannabidiol, at a dose that did not suppress general activity. |
2006-03-09 |
2023-08-12 |
Not clear |
| Carl L Har. Increasing treatment options for cannabis dependence: a review of potential pharmacotherapies. Drug and alcohol dependence. vol 80. issue 2. 2006-02-24. PMID:15899556. |
this paper reviews data from recent research on cannabinoids that may be relevant for the development of pharmacotherapies for cannabis dependence. |
2006-02-24 |
2023-08-12 |
human |
| Zuzana Justinova, Marcello Solinas, Gianluigi Tanda, Godfrey H Redhi, Steven R Goldber. The endogenous cannabinoid anandamide and its synthetic analog R(+)-methanandamide are intravenously self-administered by squirrel monkeys. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 25. issue 23. 2006-02-17. PMID:15944392. |
anandamide, an endogenous ligand for brain cannabinoid cb(1) receptors, produces many behavioral effects similar to those of delta(9)-tetrahydrocannabinol (thc), the main psychoactive ingredient in marijuana. |
2006-02-17 |
2023-08-12 |
monkey |
| Daniela Parolaro, Daniela Viganò, Tiziana Rubin. Endocannabinoids and drug dependence. Current drug targets. CNS and neurological disorders. vol 4. issue 6. 2006-02-07. PMID:16375682. |
this review will discuss the latest advances on the mechanisms of cannabinoid dependence and the possible role of the endocannabinoid system in the treatment of addiction, not only to marijuana but also to the other common illicit drugs. |
2006-02-07 |
2023-08-12 |
Not clear |
| Yosef Sarne, Raphael Mechoula. Cannabinoids: between neuroprotection and neurotoxicity. Current drug targets. CNS and neurological disorders. vol 4. issue 6. 2006-02-07. PMID:16375685. |
cannabinoids, such as the delta9-tetrahydrocannabinol (thc), present in the cannabis plant, as well as anandamide and 2-arachidonoyl glycerol, produced by the mammalian body, have been shown to protect the brain from various insults and to improve several neurodegenerative diseases. |
2006-02-07 |
2023-08-12 |
Not clear |
| Christopher J Fowle. Pharmacological properties and therapeutic possibilities for drugs acting upon endocannabinoid receptors. Current drug targets. CNS and neurological disorders. vol 4. issue 6. 2006-02-07. PMID:16375686. |
these negative aspects constrain the doses of cannabis extracts and psychoactive cannabinoids that can be given to patients, and raise the risk that properly conducted clinical trials with too low dosages will impact negatively on subsequent drug development in this field. |
2006-02-07 |
2023-08-12 |
Not clear |
| Silvia Ortega-Gutiérre. Therapeutic perspectives of inhibitors of endocannabinoid degradation. Current drug targets. CNS and neurological disorders. vol 4. issue 6. 2006-02-07. PMID:16375687. |
the study of the cannabinoids can be established in the middle sixties with the elucidation of the structure of the active principle of cannabis sativa plant, the delta9-tetrahydrocannabinol. |
2006-02-07 |
2023-08-12 |
Not clear |
| Soo Yeun Lee, Seung Min Oh, Sang Ki Lee, Kyu Hyuck Chun. Antiestrogenic effects of marijuana smoke condensate and cannabinoid compounds. Archives of pharmacal research. vol 28. issue 12. 2006-02-07. PMID:16392670. |
antiestrogenic effects of marijuana smoke condensate and cannabinoid compounds. |
2006-02-07 |
2023-08-12 |
human |
| Soo Yeun Lee, Seung Min Oh, Sang Ki Lee, Kyu Hyuck Chun. Antiestrogenic effects of marijuana smoke condensate and cannabinoid compounds. Archives of pharmacal research. vol 28. issue 12. 2006-02-07. PMID:16392670. |
the antiestrogenic effects of marijuana smoke condensate (msc) and three major cannabinoids, ie., delta9-tetrahydrocannabinol (thc), cannabidiol (cbd), and cannabinol (cbn), were evaluated using in vitro bioassays, viz., the human breast cancer cell proliferation assay, the recombinant human estrogen receptor (er) competitive binding assay, and the reporter gene assay. |
2006-02-07 |
2023-08-12 |
human |
| Jane E Lauckner, Bertil Hille, Ken Macki. The cannabinoid agonist WIN55,212-2 increases intracellular calcium via CB1 receptor coupling to Gq/11 G proteins. Proceedings of the National Academy of Sciences of the United States of America. vol 102. issue 52. 2006-02-06. PMID:16365309. |
the calcium rise was win-specific, being essentially absent in cells treated with other classes of cannabinoid agonists, including delta(9)-tetrahydrocannabinol, hu-210, cp55,940, 2-arachidonoylglycerol, methanandamide, and cannabidiol. |
2006-02-06 |
2023-08-12 |
human |
| Wen Jiang, Yun Zhang, Lan Xiao, Jamie Van Cleemput, Shao-Ping Ji, Guang Bai, Xia Zhan. Cannabinoids promote embryonic and adult hippocampus neurogenesis and produce anxiolytic- and antidepressant-like effects. The Journal of clinical investigation. vol 115. issue 11. 2006-02-03. PMID:16224541. |
most drugs of abuse examined to date decrease adult hippocampal neurogenesis, but the effects of cannabis (marijuana or cannabinoids) on hippocampal neurogenesis remain unknown. |
2006-02-03 |
2023-08-12 |
rat |
| Matthew H Jamerson, Joseph J McCue, Kevin L Klett. Urine pH, container composition, and exposure time influence adsorptive loss of 11-nor-delta9-tetrahydrocannabinol-9-carboxylic acid. Journal of analytical toxicology. vol 29. issue 7. 2006-02-03. PMID:16419391. |
11-nor-delta9-tetrahydrocannabinol-9-carboxylic acid (11-nor-delta9-thc-cooh) is the primary cannabinoid present in the urine of individuals who have used marijuana and is the target analyte identified at forensic urinalysis drug testing laboratories. |
2006-02-03 |
2023-08-12 |
human |
| G Gobbi, F R Bambico, R Mangieri, M Bortolato, P Campolongo, M Solinas, T Cassano, M G Morgese, G Debonnel, A Duranti, A Tontini, G Tarzia, M Mor, V Trezza, S R Goldberg, V Cuomo, D Piomell. Antidepressant-like activity and modulation of brain monoaminergic transmission by blockade of anandamide hydrolysis. Proceedings of the National Academy of Sciences of the United States of America. vol 102. issue 51. 2006-01-31. PMID:16352709. |
the active constituent of cannabis, delta9-tetrahydrocannabinol, acts by binding to brain cb1 cannabinoid receptors, but an alternative approach might be to develop agents that amplify the actions of endogenous cannabinoids by blocking their deactivation. |
2006-01-31 |
2023-08-12 |
mouse |
| Marilyn A Huestis, Allan Barnes, Michael L Smit. Estimating the time of last cannabis use from plasma delta9-tetrahydrocannabinol and 11-nor-9-carboxy-delta9-tetrahydrocannabinol concentrations. Clinical chemistry. vol 51. issue 12. 2006-01-27. PMID:16223887. |
two models for predicting time of last cannabis use from single plasma cannabinoid concentrations-model i, using delta(9)-tetrahydrocannabinol (thc), and model ii, using the concentration ratio of 11-nor-9-carboxy-thc (thccooh) to thc-were developed and validated from controlled drug administration studies. |
2006-01-27 |
2023-08-12 |
Not clear |
| R Rukwied, B Gauter, M Schley, C Konra. [Cannabinoids--signal transduction and mode of action]. Schmerz (Berlin, Germany). vol 19. issue 6. 2006-01-26. PMID:15549420. |
the therapeutic use of cannabinoids, the components of cannabis sativa l., was investigated in numerous researches in detail. |
2006-01-26 |
2023-08-12 |
Not clear |
| Ethan B Russo, Andrea Burnett, Brian Hall, Keith K Parke. Agonistic properties of cannabidiol at 5-HT1a receptors. Neurochemical research. vol 30. issue 8. 2006-01-24. PMID:16258853. |
finally, the results indicate that cannabidiol may have interesting and useful potential beyond the realm of cannabinoid receptors. |
2006-01-24 |
2023-08-12 |
human |