| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S Bhattacharyya, J A Crippa, R Martin-Santos, T Winton-Brown, P Fusar-Pol. Imaging the neural effects of cannabinoids: current status and future opportunities for psychopharmacology. Current pharmaceutical design. vol 15. issue 22. 2009-11-03. PMID:19689331. |
while cannabis has attracted the attention of mental health professionals because of accumulating evidence linking regular frequent use of cannabis to psychotic disorders like schizophrenia, neuroscientists and pharmacologists have focused their attention on the potential beneficial effects of cannabinoids in neuropsychiatric diseases. |
2009-11-03 |
2023-08-12 |
human |
| Mar Lorente, Arkaitz Carracedo, Sofía Torres, Francesco Natali, Ainara Egia, Sonia Hernández-Tiedra, María Salazar, Cristina Blázquez, Manuel Guzmán, Guillermo Velasc. Amphiregulin is a factor for resistance of glioma cells to cannabinoid-induced apoptosis. Glia. vol 57. issue 13. 2009-10-30. PMID:19229996. |
delta9-tetrahydrocannabinol (thc), the major active ingredient of marijuana, and other cannabinoids inhibit tumor growth in animal models of cancer, including glioma, an effect that relies, at least in part, on the ability of these compounds to induce apoptosis of tumor cells. |
2009-10-30 |
2023-08-12 |
Not clear |
| Enriqueta Ochoa-Mangado, Mónica Jiménez Giménez, Estrella Salvador Vadillo, Agustín Madoz-Gúrpid. [Cyclical hyperemesis secondary to cannabis abuse]. Gastroenterologia y hepatologia. vol 32. issue 6. 2009-10-21. PMID:19477551. |
cannabinoid hyperemesis is characterized by recurring episodes of nausea and vomiting, with a stereotyped pattern, related to cannabis consumption. |
2009-10-21 |
2023-08-12 |
Not clear |
| Ulrich S Zimmermann, Patricia R Winkelmann, Max Pilhatsch, Josef A Nees, Rainer Spanagel, Katja Schul. Withdrawal phenomena and dependence syndrome after the consumption of "spice gold". Deutsches Arzteblatt international. vol 106. issue 27. 2009-10-21. PMID:19652769. |
"spice" and other herbal blends were marketed in germany until january 2009 as substances purportedly exerting similar effects to cannabis, yet containing no cannabinoids. |
2009-10-21 |
2023-08-12 |
Not clear |
| Amy Alexander, Paul F Smith, Rhonda J Rosengre. Cannabinoids in the treatment of cancer. Cancer letters. vol 285. issue 1. 2009-10-14. PMID:19442435. |
cannabinoids, the active components of the hemp plant cannabis sativa, along with their endogenous counterparts and synthetic derivatives, have elicited anti-cancer effects in many different in vitro and in vivo models of cancer. |
2009-10-14 |
2023-08-12 |
Not clear |
| Zdenek Fisa. Phytocannabinoids and endocannabinoids. Current drug abuse reviews. vol 2. issue 1. 2009-10-12. PMID:19630737. |
progress in understanding the molecular mechanisms of cannabis action was made after discovery of cannabinoid receptors in the brain and the finding of endogenous metabolites with affinity to them. |
2009-10-12 |
2023-08-12 |
Not clear |
| Zdenek Fisa. Phytocannabinoids and endocannabinoids. Current drug abuse reviews. vol 2. issue 1. 2009-10-12. PMID:19630737. |
cannabis contains a large amount of substances with affinity for the cannabinoid receptors. |
2009-10-12 |
2023-08-12 |
Not clear |
| Sharon Anavi-Goffer, Jan Mulde. The polarised life of the endocannabinoid system in CNS development. Chembiochem : a European journal of chemical biology. vol 10. issue 10. 2009-10-08. PMID:19533710. |
furthermore, pharmacological experiments and transgenic animal models have shown the impact of disrupted ecb signalling on normal brain development and revealed the danger of both cannabis abuse and exposure to cannabinoid drugs during embryonic development, childhood and adolescence. |
2009-10-08 |
2023-08-12 |
Not clear |
| Eshwar Jagerdeo, Jason E Schaff, Madeline A Montgomery, Marc A LeBea. A semi-automated solid-phase extraction liquid chromatography/tandem mass spectrometry method for the analysis of tetrahydrocannabinol and metabolites in whole blood. Rapid communications in mass spectrometry : RCM. vol 23. issue 17. 2009-10-07. PMID:19630026. |
marijuana is one of the most commonly abused illicit substances in the usa, making cannabinoids important to detect in clinical and forensic toxicology laboratories. |
2009-10-07 |
2023-08-12 |
Not clear |
| Eshwar Jagerdeo, Jason E Schaff, Madeline A Montgomery, Marc A LeBea. A semi-automated solid-phase extraction liquid chromatography/tandem mass spectrometry method for the analysis of tetrahydrocannabinol and metabolites in whole blood. Rapid communications in mass spectrometry : RCM. vol 23. issue 17. 2009-10-07. PMID:19630026. |
the method has also been validated for cannabinol (cbd) and cannabidiol (cdn), two cannabinoids that were shown not to interfere with the method. |
2009-10-07 |
2023-08-12 |
Not clear |
| Lance R McMaho. Apparent affinity estimates of rimonabant in combination with anandamide and chemical analogs of anandamide in rhesus monkeys discriminating Delta9-tetrahydrocannabinol. Psychopharmacology. vol 203. issue 2. 2009-10-05. PMID:18592221. |
in order to understand the widespread use of cannabis and the therapeutic potential of cannabinoids, mechanisms responsible for behavioral effects need to be identified. |
2009-10-05 |
2023-08-12 |
monkey |
| Pablo Pandolfo, Leandro F Vendruscolo, Regina Sordi, Reinaldo N Takahash. Cannabinoid-induced conditioned place preference in the spontaneously hypertensive rat-an animal model of attention deficit hyperactivity disorder. Psychopharmacology. vol 205. issue 2. 2009-10-05. PMID:19407992. |
the prevalence of cannabis abuse is higher in patients with attention deficit/hyperactivity disorder (adhd) than in the general population, yet, knowledge about the motivational properties of cannabinoids in animal models of adhd are lacking. |
2009-10-05 |
2023-08-12 |
Not clear |
| Stefania Petrosino, Alessia Ligresti, Vincenzo Di Marz. Endocannabinoid chemical biology: a tool for the development of novel therapies. Current opinion in chemical biology. vol 13. issue 3. 2009-09-30. PMID:19457702. |
the identification of the major psychoactive constituent of cannabis and marijuana, delta(9)-tetrahydrocannabinol, opened the way first to the cloning of the g-protein-coupled cannabinoid cb(1) and cb(2) receptors, and then to the isolation and characterisation of their endogenous agonists, the endocannabinoids. |
2009-09-30 |
2023-08-12 |
Not clear |
| Stefania Petrosino, Alessia Ligresti, Vincenzo Di Marz. Endocannabinoid chemical biology: a tool for the development of novel therapies. Current opinion in chemical biology. vol 13. issue 3. 2009-09-30. PMID:19457702. |
however, it is still not fully understood how other plant cannabinoids, of which cannabidiol is the most studied representative, exert their pharmacological effects. |
2009-09-30 |
2023-08-12 |
Not clear |
| Anna Mazur, Cheryl F Lichti, Paul L Prather, Agnieszka K Zielinska, Stacie M Bratton, Anna Gallus-Zawada, Moshe Finel, Grover P Miller, Anna Radomińska-Pandya, Jeffery H Mora. Characterization of human hepatic and extrahepatic UDP-glucuronosyltransferase enzymes involved in the metabolism of classic cannabinoids. Drug metabolism and disposition: the biological fate of chemicals. vol 37. issue 7. 2009-09-28. PMID:19339377. |
the activities of 12 human recombinant ugts toward classic cannabinoids [cannabinol (cbn), cannabidiol (cbd), (-)-delta(8)-thc, (-)-delta(9)-thc, (+/-)-11-hydroxy-delta(9)-thc (thc-oh), and (-)-11-nor-9-carboxy-delta(9)-thc (thc-cooh)] were evaluated using high-performance liquid chromatography-tandem mass spectrometry and labeling assays. |
2009-09-28 |
2023-08-12 |
human |
| Boris D Heifets, Pablo E Castill. Endocannabinoid signaling and long-term synaptic plasticity. Annual review of physiology. vol 71. 2009-09-22. PMID:19575681. |
there is great interest in understanding how exogenous (e.g., cannabis) and endogenous cannabinoids affect behavior. |
2009-09-22 |
2023-08-12 |
Not clear |
| Ester Fride, Nikolai Gobshtis, Hodaya Dahan, Aron Weller, Andrea Giuffrida, Shimon Ben-Shaba. The endocannabinoid system during development: emphasis on perinatal events and delayed effects. Vitamins and hormones. vol 81. 2009-09-10. PMID:19647111. |
perinatal manipulation of the ecs, by administering cannabinoids or by maternal marijuana consumption, alters neurotransmitter and behavioral functions in the offspring. |
2009-09-10 |
2023-08-12 |
mouse |
| Vincenzo Di Marz. The endocannabinoid system: its general strategy of action, tools for its pharmacological manipulation and potential therapeutic exploitation. Pharmacological research. vol 60. issue 2. 2009-09-02. PMID:19559360. |
the endocannabinoid signalling system includes: (1) at least two g-protein-coupled receptors, known as the cannabinoid cb(1) and cb(2) receptors and discovered following studies on the mechanism of action of delta(9)-tetrahydrocannabinol, the major psychoactive principle of the hemp plant cannabis sativa; (2) the endogenous agonists at these receptors, known as endocannabinoids, of which anandamide and 2-arachidonoylglycerol are the best known; and (3) proteins and enzymes for the regulation of endocannabinoid levels and action at receptors. |
2009-09-02 |
2023-08-12 |
Not clear |
| N Realini, T Rubino, D Parolar. Neurobiological alterations at adult age triggered by adolescent exposure to cannabinoids. Pharmacological research. vol 60. issue 2. 2009-09-02. PMID:19559364. |
the endocannabinoid system plays an important role in this critical phase for cerebral development, therefore a strong stimulation by the psychoactive component of marijuana, delta-9-tetrahydrocanabinol, that acts through the cannabinoid system, might lead to subtle but lasting neurobiological changes that can affect adult brain functions and behaviour. |
2009-09-02 |
2023-08-12 |
Not clear |
| Sunil K Aggarwal, Gregory T Carter, Mark D Sullivan, Craig ZumBrunnen, Richard Morrill, Jonathan D Maye. Medicinal use of cannabis in the United States: historical perspectives, current trends, and future directions. Journal of opioid management. vol 5. issue 3. 2009-08-26. PMID:19662925. |
the recently discovered endocannabinoid system has greatly increased our understanding of the actions of exogenous cannabis. |
2009-08-26 |
2023-08-12 |
Not clear |