| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| George Kunos, Douglas Osei-Hyiaman, Sándor Bátkai, Keith A Sharkey, Alexandros Makriyanni. Should peripheral CB(1) cannabinoid receptors be selectively targeted for therapeutic gain? Trends in pharmacological sciences. vol 30. issue 1. 2009-04-14. PMID:19042036. |
endocannabinoids, endogenous lipid ligands of cannabinoid receptors, mediate a variety of effects similar to those of marijuana. |
2009-04-14 |
2023-08-12 |
Not clear |
| Chad R Edwards, Patrick D Skosni. Cerebellar-dependent learning as a neurobehavioral index of the cannabinoid system. Critical reviews in neurobiology. vol 19. issue 1. 2009-04-14. PMID:19166390. |
thus, there is a demand in contemporary clinical neuroscience for methods sensitive to cannabinoid system function, not only for assessing how cannabis use influences human information processing, but also to assess the involvement of the endocannabinoid system (ecs) in clinical disease and evaluate the effects of cb1-based drug therapies. |
2009-04-14 |
2023-08-12 |
mouse |
| Eva María Marco, Tiziana Rubino, Walter Adriani, María-Paz Viveros, Daniela Parolaro, Giovanni Laviol. Long-term consequences of URB597 administration during adolescence on cannabinoid CB1 receptor binding in brain areas. Brain research. vol 1257. 2009-04-01. PMID:19133243. |
despite the alarming increment in the use and abuse of cannabis preparations among young people, little is known about possible long-term consequences of targeting the endocannabinoid system during the critical developmental period of adolescence. |
2009-04-01 |
2023-08-12 |
rat |
| Hao Pan, Partha Mukhopadhyay, Mohanraj Rajesh, Vivek Patel, Bani Mukhopadhyay, Bin Gao, György Haskó, Pál Pache. Cannabidiol attenuates cisplatin-induced nephrotoxicity by decreasing oxidative/nitrosative stress, inflammation, and cell death. The Journal of pharmacology and experimental therapeutics. vol 328. issue 3. 2009-03-24. PMID:19074681. |
in this study, we have investigated the effects of a nonpsychoactive cannabinoid cannabidiol, which was reported to exert antioxidant effects and has recently been approved for the treatment of inflammation, pain, and spasticity associated with multiple sclerosis in patients in a mouse model of cisplatin-induced nephropathy. |
2009-03-24 |
2023-08-12 |
mouse |
| Lumír Ondrej Hanu. Pharmacological and therapeutic secrets of plant and brain (endo)cannabinoids. Medicinal research reviews. vol 29. issue 2. 2009-03-17. PMID:18777572. |
research on the chemistry and pharmacology of cannabinoids and endocannabinoids has reached enormous proportions, with approximately 15,000 articles on cannabis sativa l. and cannabinoids and over 2,000 articles on endocannabinoids. |
2009-03-17 |
2023-08-12 |
Not clear |
| Nico Wegener, Michael Koc. Behavioural disturbances and altered Fos protein expression in adult rats after chronic pubertal cannabinoid treatment. Brain research. vol 1253. 2009-03-17. PMID:19094973. |
however, little is known about long-lasting cellular and neurobehavioural effects of chronic cannabinoid intake, especially during puberty where cannabis use among humans is commonly initiated. |
2009-03-17 |
2023-08-12 |
rat |
| b' Krystyna Nadolska, Roman Go\\xc5\\x9. [The role of endocannabinoid system in physiological and pathological processes in the eye]. Klinika oczna. vol 110. issue 10-12. 2009-03-17. PMID:19195174.' |
investigations concerning biochemical mechanism of action of the main and most active pharmacological compound of cannabis sativa, cannabinoid 9-thc, contributed to the discovery of cannabinoid receptors both in the central nervous system (cns) and peripheral tissues, that mediated actions of this substance. |
2009-03-17 |
2023-08-12 |
Not clear |
| A Aversa, F Rossi, D Francomano, R Bruzziches, C Bertone, V Santiemma, G Sper. Early endothelial dysfunction as a marker of vasculogenic erectile dysfunction in young habitual cannabis users. International journal of impotence research. vol 20. issue 6. 2009-03-13. PMID:18997809. |
we conclude that early endothelial damage may be induced by chronic cannabis use (and endocannabinoid system activation); insulin resistance may be the hallmark of early endothelial dysfunction and may concur to determine vascular ed in the absence of obesity. |
2009-03-13 |
2023-08-12 |
human |
| A B El-Remessy, Y Tang, G Zhu, S Matragoon, Y Khalifa, E K Liu, J-Y Liu, E Hanson, S Mian, N Fatteh, G I Lio. Neuroprotective effects of cannabidiol in endotoxin-induced uveitis: critical role of p38 MAPK activation. Molecular vision. vol 14. 2009-03-11. PMID:19052649. |
the nonpsychoactive cannabinoid, cannabidiol (cbd), is an anti-inflammatory in models of diabetes and glaucoma. |
2009-03-11 |
2023-08-12 |
Not clear |
| Michel A Steiner, Carsten T Wotja. Role of the endocannabinoid system in regulation of the hypothalamic-pituitary-adrenocortical axis. Progress in brain research. vol 170. 2009-02-13. PMID:18655899. |
accordingly, exogenous cannabinoids such as the major active component of marijuana, delta(9)-tetrahydrocannabinol, have long been known to activate the major neuroendocrine stress response system of mammals, the hypothalamic-pituitary-adrenocortical (hpa) axis. |
2009-02-13 |
2023-08-12 |
Not clear |
| S Gaetani, W H Kaye, V Cuomo, D Piomell. Role of endocannabinoids and their analogues in obesity and eating disorders. Eating and weight disorders : EWD. vol 13. issue 3. 2009-02-11. PMID:19011363. |
a member of this family, anandamide, is an endogenous ligand for cannabinoid receptors targeted by the marijuana constituent delta-9-tetrahydrocannabinol. |
2009-02-11 |
2023-08-12 |
mouse |
| Mohammad-Reza Zarrindast, Shadi Sarahroodi, Ardeshir Arzi, Mohammad Javad Khodayar, Saba Taheri-Shalmani, Ameneh Rezayo. Cannabinoid CB1 receptors of the rat central amygdala mediate anxiety-like behavior: interaction with the opioid system. Behavioural pharmacology. vol 19. issue 7. 2009-01-23. PMID:18797248. |
cannabinoids, which are the active compounds of marijuana, produce some pharmacological effects similar to the opioids. |
2009-01-23 |
2023-08-12 |
rat |
| Francisco J Alvarez, Hector Lafuente, M Carmen Rey-Santano, Victoria E Mielgo, Elena Gastiasoro, Miguel Rueda, Roger G Pertwee, Ana I Castillo, Julián Romero, José Martínez-Orgad. Neuroprotective effects of the nonpsychoactive cannabinoid cannabidiol in hypoxic-ischemic newborn piglets. Pediatric research. vol 64. issue 6. 2009-01-22. PMID:18679164. |
neuroprotective effects of the nonpsychoactive cannabinoid cannabidiol in hypoxic-ischemic newborn piglets. |
2009-01-22 |
2023-08-12 |
Not clear |
| Francisco J Alvarez, Hector Lafuente, M Carmen Rey-Santano, Victoria E Mielgo, Elena Gastiasoro, Miguel Rueda, Roger G Pertwee, Ana I Castillo, Julián Romero, José Martínez-Orgad. Neuroprotective effects of the nonpsychoactive cannabinoid cannabidiol in hypoxic-ischemic newborn piglets. Pediatric research. vol 64. issue 6. 2009-01-22. PMID:18679164. |
to test the neuroprotective effects of the nonpsychoactive cannabinoid cannabidiol (cbd), piglets received i.v. |
2009-01-22 |
2023-08-12 |
Not clear |
| Delphine Psychoyos, Basalingappa Hungund, Thomas Cooper, Richard H Finnel. A cannabinoid analogue of Delta9-tetrahydrocannabinol disrupts neural development in chick. Birth defects research. Part B, Developmental and reproductive toxicology. vol 83. issue 5. 2009-01-15. PMID:19040278. |
our results indicate that the administration of the cannabinoid o-2545 during early embryogenesis results in embryotoxic effects and serves to illuminate the risks of marijuana exposure during the second week of pregnancy, a time point at which most women are unaware of their pregnancies. |
2009-01-15 |
2023-08-12 |
chicken |
| Isvett Josefina Flores-Sanchez, Robert Verpoort. PKS activities and biosynthesis of cannabinoids and flavonoids in Cannabis sativa L. plants. Plant & cell physiology. vol 49. issue 12. 2009-01-06. PMID:18854334. |
pks activities and biosynthesis of cannabinoids and flavonoids in cannabis sativa l. plants. |
2009-01-06 |
2023-08-12 |
Not clear |
| Ashish Samat, Brian Tomlinson, Shahrad Taheri, G Neil Thoma. Rimonabant for the treatment of obesity. Recent patents on cardiovascular drug discovery. vol 3. issue 3. 2009-01-06. PMID:18991793. |
the endogenous cannabinoid or endocan-nabinoid system (ecs) was discovered in the early 1990s in relation to work on the action of components of marijuana. |
2009-01-06 |
2023-08-12 |
Not clear |
| Filomena Fezza, Chiara De Simone, Daniele Amadio, Mauro Maccarron. Fatty acid amide hydrolase: a gate-keeper of the endocannabinoid system. Sub-cellular biochemistry. vol 49. 2008-12-24. PMID:18751909. |
these compounds are the main endogenous agonists of cannabinoid receptors, able to mimic several pharmacological effects of delta9-tetrahydrocannabinol (delta9-thc), the active principle of cannabis sativa preparations like hashish and marijuana. |
2008-12-24 |
2023-08-12 |
human |
| Deepak Cyril D'Souza, Mohini Ranganathan, Gabriel Braley, Ralitza Gueorguieva, Zoran Zimolo, Thomas Cooper, Edward Perry, John Krysta. Blunted psychotomimetic and amnestic effects of delta-9-tetrahydrocannabinol in frequent users of cannabis. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 33. issue 10. 2008-12-22. PMID:18185500. |
these data suggest that frequent users of cannabis are either inherently blunted in their response to, and/or develop tolerance to the psychotomimetic, perceptual altering, amnestic, endocrine, and other effects of cannabinoids. |
2008-12-22 |
2023-08-12 |
Not clear |
| Heather M Haughey, Erin Marshall, Joseph P Schacht, Ashleigh Louis, Kent E Hutchiso. Marijuana withdrawal and craving: influence of the cannabinoid receptor 1 (CNR1) and fatty acid amide hydrolase (FAAH) genes. Addiction (Abingdon, England). vol 103. issue 10. 2008-12-19. PMID:18705688. |
two single nucleotide polymorphisms (snps) in the cnr1 (rs2023239) and faah (rs324420) genes, associated previously with substance abuse and functional changes in cannabinoid regulation, were examined in a sample of daily marijuana smokers. |
2008-12-19 |
2023-08-12 |
Not clear |