| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M Ellgren, A Artmann, O Tkalych, A Gupta, H S Hansen, S H Hansen, L A Devi, Y L Hur. Dynamic changes of the endogenous cannabinoid and opioid mesocorticolimbic systems during adolescence: THC effects. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 18. issue 11. 2008-12-16. PMID:18674887. |
these findings emphasize the dynamic nature of the mesocorticolimbic endocannabinoid system during adolescence and the selective mesocorticolimbic disturbance as a consequence of adolescent cannabis exposure. |
2008-12-16 |
2023-08-12 |
rat |
| Giovanni Appendino, Simon Gibbons, Anna Giana, Alberto Pagani, Gianpaolo Grassi, Michael Stavri, Eileen Smith, M Mukhlesur Rahma. Antibacterial cannabinoids from Cannabis sativa: a structure-activity study. Journal of natural products. vol 71. issue 8. 2008-12-05. PMID:18681481. |
antibacterial cannabinoids from cannabis sativa: a structure-activity study. |
2008-12-05 |
2023-08-12 |
Not clear |
| Giovanni Appendino, Simon Gibbons, Anna Giana, Alberto Pagani, Gianpaolo Grassi, Michael Stavri, Eileen Smith, M Mukhlesur Rahma. Antibacterial cannabinoids from Cannabis sativa: a structure-activity study. Journal of natural products. vol 71. issue 8. 2008-12-05. PMID:18681481. |
marijuana (cannabis sativa) has long been known to contain antibacterial cannabinoids, whose potential to address antibiotic resistance has not yet been investigated. |
2008-12-05 |
2023-08-12 |
Not clear |
| Giovanni Appendino, Simon Gibbons, Anna Giana, Alberto Pagani, Gianpaolo Grassi, Michael Stavri, Eileen Smith, M Mukhlesur Rahma. Antibacterial cannabinoids from Cannabis sativa: a structure-activity study. Journal of natural products. vol 71. issue 8. 2008-12-05. PMID:18681481. |
all five major cannabinoids (cannabidiol (1b), cannabichromene (2), cannabigerol (3b), delta (9)-tetrahydrocannabinol (4b), and cannabinol (5)) showed potent activity against a variety of methicillin-resistant staphylococcus aureus (mrsa) strains of current clinical relevance. |
2008-12-05 |
2023-08-12 |
Not clear |
| Robert S Goodwin, William D Darwin, C Nora Chiang, Ming Shih, Shou-Hua Li, Marilyn A Huesti. Urinary elimination of 11-nor-9-carboxy-delta9-tetrahydrocannnabinol in cannabis users during continuously monitored abstinence. Journal of analytical toxicology. vol 32. issue 8. 2008-12-04. PMID:19007504. |
these data provide guidelines for interpreting urine cannabinoid test results and suggest appropriate detection windows for differentiating new cannabis use from residual drug excretion. |
2008-12-04 |
2023-08-12 |
Not clear |
| Carsten Hjorthøj, Merete Nordentoft, Anders Fink-Jense. [Cannabis and cannabinoid receptors--abuse and psychosis]. Ugeskrift for laeger. vol 170. issue 46. 2008-11-25. PMID:19014732. |
[cannabis and cannabinoid receptors--abuse and psychosis]. |
2008-11-25 |
2023-08-12 |
Not clear |
| Marcus S Delatte, Carol A Paroni. Evaluation of cannabinoid agonists using punished responding and midazolam discrimination procedures in squirrel monkeys. Psychopharmacology. vol 198. issue 4. 2008-11-17. PMID:17882403. |
clinical studies have suggested that marijuana and nabilone have anxiolytic effects in humans, yet studies of anxiolytic-like effects of cannabinoid agonists in mice and rats have yielded mixed results. |
2008-11-17 |
2023-08-12 |
mouse |
| Gil Galanti, Tamar Fisher, Iris Kventsel, Jacob Shoham, Ruth Gallily, Raphael Mechoulam, Gad Lavie, Ninette Amariglio, Gideon Rechavi, Amos Tore. Delta 9-tetrahydrocannabinol inhibits cell cycle progression by downregulation of E2F1 in human glioblastoma multiforme cells. Acta oncologica (Stockholm, Sweden). vol 47. issue 6. 2008-11-17. PMID:17934890. |
the active components of cannabis sativa l., cannabinoids, traditionally used in the field of cancer for alleviation of pain, nausea, wasting and improvement of well-being have received renewed interest in recent years due to their diverse pharmacologic activities such as cell growth inhibition, anti-inflammatory activity and induction of tumor regression. |
2008-11-17 |
2023-08-12 |
human |
| Viviana Trezza, Patrizia Campolongo, Tommaso Cassano, Teresa Macheda, Pasqua Dipasquale, Maria Rosaria Carratù, Silvana Gaetani, Vincenzo Cuom. Effects of perinatal exposure to delta-9-tetrahydrocannabinol on the emotional reactivity of the offspring: a longitudinal behavioral study in Wistar rats. Psychopharmacology. vol 198. issue 4. 2008-11-17. PMID:18452035. |
the endocannabinoid system plays a crucial role in the control of emotionality and recent clinical findings have shown that heavy prenatal exposure to cannabis is significantly associated with self-reported anxiety symptoms in exposed children. |
2008-11-17 |
2023-08-12 |
rat |
| Tiziana Bisogno, Vincenzo Di Marz. The role of the endocannabinoid system in Alzheimer's disease: facts and hypotheses. Current pharmaceutical design. vol 14. issue 23. 2008-11-17. PMID:18781980. |
furthermore, plant and synthetic cannabinoids, and particularly the non-psychotropic cannabidiol, might also exert other, non-cannabinoid receptor-mediated protective effects, including, but not limited to, anti-oxidant actions. |
2008-11-17 |
2023-08-12 |
human |
| G Aviello, B Romano, A A Izz. Cannabinoids and gastrointestinal motility: animal and human studies. European review for medical and pharmacological sciences. vol 12 Suppl 1. 2008-11-14. PMID:18924447. |
delta9-tetrahydrocannabinol, the main psychotropic component of cannabis, acts via at least two types of cannabinoid receptors, named cb1 and cb2 receptors. |
2008-11-14 |
2023-08-12 |
human |
| Anna E Sanford, Elizabeth Castillo, Robert L Ganno. Cannabinoids and hamster circadian activity rhythms. Brain research. vol 1222. 2008-11-12. PMID:18582849. |
altogether these data indicate that the endocannabinoid system has the capability to modulate circadian rhythms in the hamster and cannabis use should be evaluated for adverse effects on circadian rhythms in humans. |
2008-11-12 |
2023-08-12 |
Not clear |
| Patrik Roser, Georg Juckel, Johannes Rentzsch, Thomas Nadulski, Jürgen Gallinat, Andreas M Stadelman. Effects of acute oral Delta9-tetrahydrocannabinol and standardized cannabis extract on the auditory P300 event-related potential in healthy volunteers. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 18. issue 8. 2008-11-05. PMID:18544469. |
this prospective, double-blind, placebo-controlled cross-over study investigated the acute effects of cannabinoids on p300 amplitude in 20 healthy volunteers (age 28.2+/-3.1 years, 10 male) by comparing delta9-thc and standardized cannabis extract containing delta9-thc and cannabidiol (cbd). |
2008-11-05 |
2023-08-12 |
human |
| M Isabel Martín Fontelles, Carlos Goicoechea Garcí. Role of cannabinoids in the management of neuropathic pain. CNS drugs. vol 22. issue 8. 2008-11-05. PMID:18601303. |
the treatment of pain, particularly neuropathic pain, is one of the therapeutic applications of cannabis and cannabinoids that is currently under investigation and that stimulates interest among clinicians and basic researchers. |
2008-11-05 |
2023-08-12 |
Not clear |
| John Ashto. Pro-drugs for indirect cannabinoids as therapeutic agents. Current drug delivery. vol 5. issue 4. 2008-11-04. PMID:18855592. |
medicinal cannabis, cannabis extracts, and other cannabinoids are currently in use or under clinical trial investigation for the control of nausea, emesis and wasting in patients undergoing chemotherapy, the control of neuropathic pain and arthritic pain, and the control of the symptoms of multiple sclerosis. |
2008-11-04 |
2023-08-12 |
Not clear |
| D Parolaro, T Rubin. The role of the endogenous cannabinoid system in drug addiction. Drug news & perspectives. vol 21. issue 3. 2008-11-03. PMID:18560613. |
for a long time, dopamine has been consistently associated with the reinforcing effects of most drugs of abuse but, recently, pharmacological evidence points to the possibility that pharmacological management of the endocannabinoid system might not only block the direct reinforcing effect of cannabis, opioids, nicotine and ethanol, but also prevent the relapse to various drugs of abuse including opioids, cocaine, nicotine, alcohol and amphetamine. |
2008-11-03 |
2023-08-12 |
Not clear |
| D de Filippis, T Iuvone, A d'amico, G Esposito, L Steardo, A G Herman, P A Pelckmans, B Y de Winter, J G de Ma. Effect of cannabidiol on sepsis-induced motility disturbances in mice: involvement of CB receptors and fatty acid amide hydrolase. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society. vol 20. issue 8. 2008-10-27. PMID:18373655. |
cannabidiol, a non-psychotropic component of cannabis sativa, exerts strong anti-oxidant and anti-inflammatory effects without binding to cannabinoid cb(1) or cb(2) receptors. |
2008-10-27 |
2023-08-12 |
mouse |
| D de Filippis, T Iuvone, A d'amico, G Esposito, L Steardo, A G Herman, P A Pelckmans, B Y de Winter, J G de Ma. Effect of cannabidiol on sepsis-induced motility disturbances in mice: involvement of CB receptors and fatty acid amide hydrolase. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society. vol 20. issue 8. 2008-10-27. PMID:18373655. |
cannabidiol also regulates the activity of fatty acid amide hydrolase (faah) which is the main enzyme involved in endocannabinoid breakdown and which modulates gastrointestinal motility. |
2008-10-27 |
2023-08-12 |
mouse |
| Stefan W Toennes, Johannes G Ramaekers, Eef L Theunissen, Manfred R Moeller, Gerold F Kauer. Comparison of cannabinoid pharmacokinetic properties in occasional and heavy users smoking a marijuana or placebo joint. Journal of analytical toxicology. vol 32. issue 7. 2008-10-17. PMID:18713514. |
comparison of cannabinoid pharmacokinetic properties in occasional and heavy users smoking a marijuana or placebo joint. |
2008-10-17 |
2023-08-12 |
Not clear |
| Stefan W Toennes, Johannes G Ramaekers, Eef L Theunissen, Manfred R Moeller, Gerold F Kauer. Comparison of cannabinoid pharmacokinetic properties in occasional and heavy users smoking a marijuana or placebo joint. Journal of analytical toxicology. vol 32. issue 7. 2008-10-17. PMID:18713514. |
from the results, it must be cautioned that cannabinoid blood concentrations from heavy users in a late elimination phase may be difficult to distinguish from concentrations measured in occasional users after acute cannabis use. |
2008-10-17 |
2023-08-12 |
Not clear |