| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jennifer L Stewart, Lance R McMaho. Rimonabant-induced Delta9-tetrahydrocannabinol withdrawal in rhesus monkeys: discriminative stimulus effects and other withdrawal signs. The Journal of pharmacology and experimental therapeutics. vol 334. issue 1. 2010-07-13. PMID:20375197. |
these results suggest that cannabinoid and noncannabinoid (alpha(2)-adrenergic) agonists are potentially useful therapeutics for marijuana dependence inasmuch as they attenuate the subjective experience of delta(9)-thc withdrawal. |
2010-07-13 |
2023-08-12 |
monkey |
| Erin L Karschner, Allan J Barnes, Ross H Lowe, Karl B Scheidweiler, Marilyn A Huesti. Validation of a two-dimensional gas chromatography mass spectrometry method for the simultaneous quantification of cannabidiol, Delta(9)-tetrahydrocannabinol (THC), 11-hydroxy-THC, and 11-nor-9-carboxy-THC in plasma. Analytical and bioanalytical chemistry. vol 397. issue 2. 2010-07-09. PMID:20306180. |
a sensitive analytical method for simultaneous quantification of sub-nanogram concentrations of cannabidiol (cbd), delta(9)-tetrahydrocannabinol (thc), 11-hydroxy-thc (11-oh-thc), and 11-nor-9-carboxy-thc (thccooh) in plasma is presented for monitoring cannabinoid pharmacotherapy and illicit cannabis use. |
2010-07-09 |
2023-08-12 |
Not clear |
| Stephen Sulliva. Cannabinoid hyperemesis. Canadian journal of gastroenterology = Journal canadien de gastroenterologie. vol 24. issue 5. 2010-07-06. PMID:20485701. |
cannabinoid hyperemesis syndrome is characterized by chronic, heavy use of cannabis, recurrent episodes of severe nausea and intractable vomiting, and abdominal pain. |
2010-07-06 |
2023-08-12 |
Not clear |
| Thomas J O'Connell, Ché B Bou-Mata. Long term marijuana users seeking medical cannabis in California (2001-2007): demographics, social characteristics, patterns of cannabis and other drug use of 4117 applicants. Harm reduction journal. vol 4. 2010-06-28. PMID:17980043. |
cannabinoid agonists are now attracting growing interest and there is also evidence that botanical cannabis is being used as self-medication for stress and anxiety as well as adjunctive therapy by the seriously ill and by patients with terminal illnesses. |
2010-06-28 |
2023-08-12 |
Not clear |
| Stephen M Eggan, Yoshito Mizoguchi, Samuel R Stoyak, David A Lewi. Development of cannabinoid 1 receptor protein and messenger RNA in monkey dorsolateral prefrontal cortex. Cerebral cortex (New York, N.Y. : 1991). vol 20. issue 5. 2010-06-28. PMID:19703937. |
the effects of cannabis are mediated by the cannabinoid 1 receptor (cb1r), which is present in high density in the primate dlpfc. |
2010-06-28 |
2023-08-12 |
monkey |
| B Pomahacova, F Van der Kooy, R Verpoort. Cannabis smoke condensate III: the cannabinoid content of vaporised Cannabis sativa. Inhalation toxicology. vol 21. issue 13. 2010-06-24. PMID:19852551. |
cannabis smoke condensate iii: the cannabinoid content of vaporised cannabis sativa. |
2010-06-24 |
2023-08-12 |
Not clear |
| B Pomahacova, F Van der Kooy, R Verpoort. Cannabis smoke condensate III: the cannabinoid content of vaporised Cannabis sativa. Inhalation toxicology. vol 21. issue 13. 2010-06-24. PMID:19852551. |
the worst ratio of cannabinoids:by-products was obtained from the vaporized cannabis sample at 170 degrees c. |
2010-06-24 |
2023-08-12 |
Not clear |
| Stefan W Toennes, Jörg Röhrich, Cora Wunde. [Interpretation of blood analysis data found after passive exposure to cannabis]. Archiv fur Kriminologie. vol 225. issue 3-4. 2010-06-16. PMID:20506708. |
when defendants are confronted with evidence of cannabinoids in their blood suggesting consumption of cannabis they sometimes argue that this could only be due to a passive exposure. |
2010-06-16 |
2023-08-12 |
Not clear |
| A Castillo, M R Tolón, J Fernández-Ruiz, J Romero, J Martinez-Orgad. The neuroprotective effect of cannabidiol in an in vitro model of newborn hypoxic-ischemic brain damage in mice is mediated by CB(2) and adenosine receptors. Neurobiology of disease. vol 37. issue 2. 2010-06-15. PMID:19900555. |
to investigate the mechanisms involved in cannabidiol (cbd)-induced neuroprotection in hypoxic-ischemic (hi) immature brain, forebrain slices from newborn mice underwent oxygen and glucose deprivation in the presence of vehicle, or cbd alone or with selective antagonists of cannabinoid cb(1) and cb(2), and adenosine a(1) and a(2) receptors. |
2010-06-15 |
2023-08-12 |
mouse |
| Julieta Aisemberg, Claudia Vercelli, Manuel Wolfson, Ana Inés Salazar, Claudia Osycka-Salut, Silvia Billi, María Laura Ribeiro, Mariana Farina, Ana María Franch. Inflammatory agents involved in septic miscarriage. Neuroimmunomodulation. vol 17. issue 3. 2010-06-14. PMID:20134189. |
since an association between chronic marijuana smoking and early miscarriage has been shown in women, we studied the participation of anandamide (aea), the principal endocannabinoid, on the mechanism of action of lps. |
2010-06-14 |
2023-08-12 |
Not clear |
| Patrik Roser, Franz X Vollenweider, Wolfram Kawoh. Potential antipsychotic properties of central cannabinoid (CB1) receptor antagonists. The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry. vol 11. issue 2 Pt 2. 2010-06-14. PMID:20218784. |
delta(9)-tetrahydrocannabinol (delta(9)-thc), the principal psychoactive constituent of the cannabis sativa plant, and other agonists at the central cannabinoid (cb(1)) receptor may induce characteristic psychomotor effects, psychotic reactions and cognitive impairment resembling schizophrenia. |
2010-06-14 |
2023-08-12 |
human |
| Patrik Roser, Franz X Vollenweider, Wolfram Kawoh. Potential antipsychotic properties of central cannabinoid (CB1) receptor antagonists. The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry. vol 11. issue 2 Pt 2. 2010-06-14. PMID:20218784. |
these effects of delta(9)-thc can be reduced in animal and human models of psychopathology by two exogenous cannabinoids, cannabidiol (cbd) and sr141716. |
2010-06-14 |
2023-08-12 |
human |
| J Manzanares, Md Julian, A Carrascos. Role of the cannabinoid system in pain control and therapeutic implications for the management of acute and chronic pain episodes. Current neuropharmacology. vol 4. issue 3. 2010-06-10. PMID:18615144. |
cannabis extracts and synthetic cannabinoids are still widely considered illegal substances. |
2010-06-10 |
2023-08-12 |
Not clear |
| Volker Auwärter, Ariane Wohlfarth, Jessica Traber, Detlef Thieme, Wolfgang Weinman. Hair analysis for Delta9-tetrahydrocannabinolic acid A--new insights into the mechanism of drug incorporation of cannabinoids into hair. Forensic science international. vol 196. issue 1-3. 2010-06-10. PMID:20129747. |
in hair analysis for cannabinoids the most common target is delta9-tetrahydrocannabinol (thc), sometimes cannabidiol (cbd) and cannabinol (cbn) are determined additionally. |
2010-06-10 |
2023-08-12 |
Not clear |
| Lianne Robinson, Anushka V Goonawardena, Roger Pertwee, Robert E Hampson, Bettina Platt, Gernot Riede. WIN55,212-2 induced deficits in spatial learning are mediated by cholinergic hypofunction. Behavioural brain research. vol 208. issue 2. 2010-05-25. PMID:20079375. |
however, the identification of novel non-cb(1) receptors which are insensitive to the psychoactive ingredient of marijuana, delta(9)-tetrahydrocannabinol (delta(9)-thc) but sensitive to synthetic cannabinoids such as win55,212-2 (win-2) or endocannabinoids like anandamide lead us to question whether win-2 induced learning and memory deficits are indeed mediated by cb(1) receptor activation. |
2010-05-25 |
2023-08-12 |
rat |
| Luciano De Petrocellis, Vincenzo Di Marz. Non-CB1, non-CB2 receptors for endocannabinoids, plant cannabinoids, and synthetic cannabimimetics: focus on G-protein-coupled receptors and transient receptor potential channels. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. vol 5. issue 1. 2010-05-11. PMID:19847654. |
the molecular mechanism of action of delta(9)-tetrahydrocannabinol (thc), the psychotropic constituent of cannabis, has been a puzzle during the three decades separating its characterization, in 1964, and the cloning, in the 1990s, of cannabinoid cb1 and cb2 receptors. |
2010-05-11 |
2023-08-12 |
Not clear |
| Luciano De Petrocellis, Vincenzo Di Marz. Non-CB1, non-CB2 receptors for endocannabinoids, plant cannabinoids, and synthetic cannabimimetics: focus on G-protein-coupled receptors and transient receptor potential channels. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. vol 5. issue 1. 2010-05-11. PMID:19847654. |
in particular, the endocannabinoid anandamide, and the other most abundant cannabis constituent, cannabidiol, seem to be the most "promiscuous" of these compounds. |
2010-05-11 |
2023-08-12 |
Not clear |
| Keun-Hang Yang, Sehamuddin Galadari, Dmytro Isaev, Georg Petroianu, Toni S Shippenberg, Murat O. The nonpsychoactive cannabinoid cannabidiol inhibits 5-hydroxytryptamine3A receptor-mediated currents in Xenopus laevis oocytes. The Journal of pharmacology and experimental therapeutics. vol 333. issue 2. 2010-05-10. PMID:20160007. |
the nonpsychoactive cannabinoid cannabidiol inhibits 5-hydroxytryptamine3a receptor-mediated currents in xenopus laevis oocytes. |
2010-05-10 |
2023-08-12 |
xenopus_laevis |
| Keun-Hang Yang, Sehamuddin Galadari, Dmytro Isaev, Georg Petroianu, Toni S Shippenberg, Murat O. The nonpsychoactive cannabinoid cannabidiol inhibits 5-hydroxytryptamine3A receptor-mediated currents in Xenopus laevis oocytes. The Journal of pharmacology and experimental therapeutics. vol 333. issue 2. 2010-05-10. PMID:20160007. |
the effect of the plant-derived nonpsychotropic cannabinoid, cannabidiol (cbd), on the function of hydroxytryptamine (5-ht)3a receptors expressed in xenopus laevis oocytes was investigated using two-electrode voltage-clamp techniques. |
2010-05-10 |
2023-08-12 |
xenopus_laevis |
| Jeremy R Johnson, Mary Burnell-Nugent, Dominique Lossignol, Elena Doina Ganae-Motan, Richard Potts, Marie T Fallo. Multicenter, double-blind, randomized, placebo-controlled, parallel-group study of the efficacy, safety, and tolerability of THC:CBD extract and THC extract in patients with intractable cancer-related pain. Journal of pain and symptom management. vol 39. issue 2. 2010-05-04. PMID:19896326. |
this study compared the efficacy of a tetrahydrocannabinol:cannabidiol (thc:cbd) extract, a nonopioid analgesic endocannabinoid system modulator, and a thc extract, with placebo, in relieving pain in patients with advanced cancer. |
2010-05-04 |
2023-08-12 |
Not clear |