| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Benjamin De Backer, Benjamin Debrus, Pierre Lebrun, Laetitia Theunis, Nathalie Dubois, Lies Decock, Alain Verstraete, Philippe Hubert, Corinne Charlie. Innovative development and validation of an HPLC/DAD method for the qualitative and quantitative determination of major cannabinoids in cannabis plant material. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. vol 877. issue 32. 2010-02-05. PMID:19932642. |
by use of an innovative methodology for modelling chromatographic responses, a simple and accurate hplc/dad method was developed for the quantification of major neutral and acidic cannabinoids present in cannabis plant material: delta9-tetrahydrocannabinol (thc), thc acid (thca), cannabidiol (cbd), cbd acid (cbda), cannabigerol (cbg), cbg acid (cbga) and cannabinol (cbn). |
2010-02-05 |
2023-08-12 |
Not clear |
| Jaseena Elikkottil, Jaseena Elikottil, Pankaj Gupta, Kalpna Gupt. The analgesic potential of cannabinoids. Journal of opioid management. vol 5. issue 6. 2010-01-28. PMID:20073408. |
this review provides an overview of the history of cannabis use in medicine, cannabinoid signaling pathways, and current data from preclinical as well as clinical studies on using cannabinoids as potential analgesic agents. |
2010-01-28 |
2023-08-12 |
Not clear |
| Thomas Keller, Andrea Keller, Edith Tutsch-Bauer, Fabio Monticell. Driving under the influence of drugs and alcohol in Salzburg and Upper Austria during the years 2003-2007. Legal medicine (Tokyo, Japan). vol 11 Suppl 1. 2010-01-26. PMID:19282219. |
so far, it was not possible to draw any conclusions from a cannabinoid positive urine sample to the actual influence of a driver due to the previous consumption of cannabis. |
2010-01-26 |
2023-08-12 |
Not clear |
| Greg M Thaera, Kay E Wellik, Jonathan L Carter, Bart M Demaerschalk, Dean M Wingerchu. Do cannabinoids reduce multiple sclerosis-related spasticity? The neurologist. vol 15. issue 6. 2010-01-26. PMID:19901724. |
the plant cannabis sativa contains numerous cannabinoids, which are aromatic hydrocarbons that have central nervous system effects mediated through specific cannabinoid receptors. |
2010-01-26 |
2023-08-12 |
Not clear |
| Alline Cristina Campos, Francisco Silveira Guimarãe. Evidence for a potential role for TRPV1 receptors in the dorsolateral periaqueductal gray in the attenuation of the anxiolytic effects of cannabinoids. Progress in neuro-psychopharmacology & biological psychiatry. vol 33. issue 8. 2010-01-25. PMID:19735690. |
intra-cerebral administration of cannabidiol, a phytocannabinoid, or anandamide, an endocannabinoid, into the dorsolateral portion of periaqueductal gray (dlpag) promotes anxiolytic-like effects in several animal models of anxiety with bell-shaped dose-response curves. |
2010-01-25 |
2023-08-12 |
rat |
| Elizabeth J Rahn, Andrea G Hohman. Cannabinoids as pharmacotherapies for neuropathic pain: from the bench to the bedside. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. vol 6. issue 4. 2010-01-25. PMID:19789075. |
cannabinoids, drugs that share the same target as delta(9)-tetrahydrocannabinol (delta(9)-thc), the psychoactive ingredient in cannabis, have the potential to address this unmet need. |
2010-01-25 |
2023-08-12 |
human |
| Emmanuel S Onaiv. Cannabinoid receptors in brain: pharmacogenetics, neuropharmacology, neurotoxicology, and potential therapeutic applications. International review of neurobiology. vol 88. 2010-01-08. PMID:19897083. |
the remarkable progress in understanding the biological actions of marijuana and cannabinoids have provided much richer results than previously appreciated cannabinoid genomics and raised a number of critical issues on the molecular mechanisms of cannabinoid induced behavioral and biochemical alterations. |
2010-01-08 |
2023-08-12 |
human |
| Erin L Karschner, Eugene W Schwilke, Ross H Lowe, W David Darwin, Ronald I Herning, Jean Lud Cadet, Marilyn A Huesti. Implications of plasma Delta9-tetrahydrocannabinol, 11-hydroxy-THC, and 11-nor-9-carboxy-THC concentrations in chronic cannabis smokers. Journal of analytical toxicology. vol 33. issue 8. 2010-01-05. PMID:19874654. |
plasma cannabinoid concentrations were determined in 18 long-term heavy cannabis smokers residing on an in-patient research unit for seven days of monitored abstinence. |
2010-01-05 |
2023-08-12 |
human |
| Eugene W Schwilke, David M Schwope, Erin L Karschner, Ross H Lowe, William D Darwin, Deanna L Kelly, Robert S Goodwin, David A Gorelick, Marilyn A Huesti. Delta9-tetrahydrocannabinol (THC), 11-hydroxy-THC, and 11-nor-9-carboxy-THC plasma pharmacokinetics during and after continuous high-dose oral THC. Clinical chemistry. vol 55. issue 12. 2009-12-28. PMID:19833841. |
delta(9)-tetrahydrocannabinol (thc) is the primary psychoactive constituent of cannabis and an active cannabinoid pharmacotherapy component. |
2009-12-28 |
2023-08-12 |
Not clear |
| T C Kirkham, C M William. Endogenous cannabinoids and appetite. Nutrition research reviews. vol 14. issue 1. 2009-12-14. PMID:19087417. |
the characterization of the psychoactive principals in cannabis (exogenous cannabinoids) and, more recently, the discovery of specific brain cannabinoid receptors and their endogenous ligands (endocannabinoids) has stimulated research into the physiological roles of endocannabinoid systems. |
2009-12-14 |
2023-08-12 |
human |
| Angelo A Izzo, Francesca Borrelli, Raffaele Capasso, Vincenzo Di Marzo, Raphael Mechoula. Non-psychotropic plant cannabinoids: new therapeutic opportunities from an ancient herb. Trends in pharmacological sciences. vol 30. issue 10. 2009-12-11. PMID:19729208. |
however, the plant cannabis contains many cannabinoids with weak or no psychoactivity that, therapeutically, might be more promising than delta(9)-tetrahydrocannabinol. |
2009-12-11 |
2023-08-12 |
Not clear |
| Aoife Gowran, Carrie E Murphy, Veronica A Campbel. Delta(9)-tetrahydrocannabinol regulates the p53 post-translational modifiers Murine double minute 2 and the Small Ubiquitin MOdifier protein in the rat brain. FEBS letters. vol 583. issue 21. 2009-12-03. PMID:19819240. |
the phytocannabinoid delta(9)-tetrahydrocannabinol (delta(9)-thc), the main psychoactive cannabinoid in cannabis, activates a number of signalling cascades including p53. |
2009-12-03 |
2023-08-12 |
rat |
| Caihua Liang, Michael D McClean, Carmen Marsit, Brock Christensen, Edward Peters, Heather H Nelson, Karl T Kelse. A population-based case-control study of marijuana use and head and neck squamous cell carcinoma. Cancer prevention research (Philadelphia, Pa.). vol 2. issue 8. 2009-11-30. PMID:19638490. |
cannabinoids, constituents of marijuana smoke, have been recognized to have potential antitumor properties. |
2009-11-30 |
2023-08-12 |
human |
| Lamont Booker, Pattipati S Naidu, Raj K Razdan, Anu Mahadevan, Aron H Lichtma. Evaluation of prevalent phytocannabinoids in the acetic acid model of visceral nociception. Drug and alcohol dependence. vol 105. issue 1-2. 2009-11-30. PMID:19679411. |
indeed, other plant-derived cannabinoids, including cannabidiol (cbd), cannabinol (cbn), and cannabichromene (cbc) elicit antinociceptive effects in some assays. |
2009-11-30 |
2023-08-12 |
Not clear |
| Didier Jutras-Aswad, Jennifer A DiNieri, Tibor Harkany, Yasmin L Hur. Neurobiological consequences of maternal cannabis on human fetal development and its neuropsychiatric outcome. European archives of psychiatry and clinical neuroscience. vol 259. issue 7. 2009-11-23. PMID:19568685. |
this review provides an overview of the endocannabinoid system and examines the neurobiological consequences of cannabis exposure in pregnancy and early life by addressing its impact on the development of neurotransmitters systems relevant to neuropsychiatric disorders and its association with these disorders later in life. |
2009-11-23 |
2023-08-12 |
human |
| Didier Jutras-Aswad, Jennifer A DiNieri, Tibor Harkany, Yasmin L Hur. Neurobiological consequences of maternal cannabis on human fetal development and its neuropsychiatric outcome. European archives of psychiatry and clinical neuroscience. vol 259. issue 7. 2009-11-23. PMID:19568685. |
it posits that studying in utero cannabis exposure in association with genetic mutations of neural systems that have strong relationships to endocannabinoid function, such as the dopamine, opioid, glutamate, and gaba, might help to identify individuals at risk. |
2009-11-23 |
2023-08-12 |
human |
| Piotr Kupczyk, Adam Reich, Jacek C Szepietowsk. Cannabinoid system in the skin - a possible target for future therapies in dermatology. Experimental dermatology. vol 18. issue 8. 2009-11-16. PMID:19664006. |
the major agent of exogenous cannabinoids is delta(9)-tetrahydrocannabinol (delta(9)-thc), natural psychoactive ingredient of marijuana. |
2009-11-16 |
2023-08-12 |
Not clear |
| Deepak Cyril D'Souz. Cannabinoids and psychosis. International review of neurobiology. vol 78. 2009-11-13. PMID:17349865. |
on the other hand, the large majority of individuals exposed to cannabinoids do not experience psychosis or develop schizophrenia and the rates of schizophrenia have not increased commensurate with the increase in rates of cannabis use. |
2009-11-13 |
2023-08-12 |
Not clear |
| Isvett Josefina Flores-Sanchez, Jaroslav Pec, Junni Fei, Young Hae Choi, Jaroslav Dusek, Robert Verpoort. Elicitation studies in cell suspension cultures of Cannabis sativa L. Journal of biotechnology. vol 143. issue 2. 2009-11-12. PMID:19500620. |
however, no cannabinoids were found in either control or elicited cannabis cell cultures. |
2009-11-12 |
2023-08-12 |
Not clear |
| Q-R Liu, C-H Pan, A Hishimoto, C-Y Li, Z-X Xi, A Llorente-Berzal, M-P Viveros, H Ishiguro, T Arinami, E S Onaivi, G R Uh. Species differences in cannabinoid receptor 2 (CNR2 gene): identification of novel human and rodent CB2 isoforms, differential tissue expression and regulation by cannabinoid receptor ligands. Genes, brain, and behavior. vol 8. issue 5. 2009-11-10. PMID:19496827. |
cannabinoids, endocannabinoids and marijuana activate two well-characterized cannabinoid receptors (cb-rs), cb1-rs and cb2-rs. |
2009-11-10 |
2023-08-12 |
mouse |