| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A Ota, A Nakashima, K Mori, T Nagats. Effects of dopamine on N-terminus-deleted human tyrosine hydroxylase type 1 expressed in Escherichia coli. Neuroscience letters. vol 229. issue 1. 1997-09-12. PMID:9224801. |
n-terminus-deleted mutants and wild-type human tyrosine hydroxylase type 1 were expressed in escherichia coli (e. coli) and utilized to investigate the dopamine-induced decrease in the enzyme catalytic activity and also to identify the specific portion in the n-terminus that affects the efficiency of the inhibitory action of dopamine. |
1997-09-12 |
2023-08-12 |
human |
| A Ota, A Nakashima, K Mori, T Nagats. Effects of dopamine on N-terminus-deleted human tyrosine hydroxylase type 1 expressed in Escherichia coli. Neuroscience letters. vol 229. issue 1. 1997-09-12. PMID:9224801. |
these results suggest that the inhibition by dopamine of tyrosine hydroxylase activity is closely related to the amino acid sequence in the n-terminus of the enzyme. |
1997-09-12 |
2023-08-12 |
human |
| H Ichinose, T Nagats. Molecular genetics of hereditary dystonia--mutations in the GTP cyclohydrolase I gene. Brain research bulletin. vol 43. issue 1. 1997-09-04. PMID:9205791. |
we found that mutations of gtp cyclohydrolase i, the rate-limiting enzyme in the biosynthesis of tetrahydrobiopterin, which is the cofactor of dopamine-synthesizing tyrosine hydroxylase, cause dominantly inherited hereditary progressive dystonia with marked diurnal fluctuation (hpd, segawa's disease) probably owing to the decrease of dopamine in the basal ganglia. |
1997-09-04 |
2023-08-12 |
Not clear |
| H Ichinose, T Nagats. Molecular genetics of hereditary dystonia--mutations in the GTP cyclohydrolase I gene. Brain research bulletin. vol 43. issue 1. 1997-09-04. PMID:9205791. |
these results indicate that tyrosine hydroxylase in the nigrostriatal dopamine neurons may be most sensitive to tetrahydrobiopterin deficiency causing dystonia. |
1997-09-04 |
2023-08-12 |
Not clear |
| P M Carvey, S Pieri, Z D Lin. Attenuation of levodopa-induced toxicity in mesencephalic cultures by pramipexole. Journal of neural transmission (Vienna, Austria : 1996). vol 104. issue 2-3. 1997-09-03. PMID:9203083. |
the direct-acting dopamine (da) agonist pramipexole (2 amino-4,5,6,7-tetrahydro-6-propyl-amino-benzthiazole-dihydrochlori de) was evaluated for its ability to attenuate levodopa-induced loss of tyrosine hydroxylase immunoreactive (thir, a marker for dopamine neurons) cells in mesencephalic cultures. |
1997-09-03 |
2023-08-12 |
Not clear |
| C G Charlto. Depletion of nigrostriatal and forebrain tyrosine hydroxylase by S-adenosylmethionine: a model that may explain the occurrence of depression in Parkinson's disease. Life sciences. vol 61. issue 5. 1997-09-03. PMID:9247319. |
the loss of nigrostriatal tyrosine hydroxylase (th), dopamine and dopaminergic neurons are the major pathology of parkinson's disease (pd). |
1997-09-03 |
2023-08-12 |
rat |
| K Vrecko, D Storga, J G Birkmayer, R Möller, E Tafeit, R Horejsi, G Reibnegge. NADH stimulates endogenous dopamine biosynthesis by enhancing the recycling of tetrahydrobiopterin in rat phaeochromocytoma cells. Biochimica et biophysica acta. vol 1361. issue 1. 1997-08-22. PMID:9247090. |
treatment of parkinson patients with l-dopa (3,4-dihydroxy-l-phenylalanine) leads to endproduct inhibition of tyrosine hydroxylase, the key enzyme in dopamine biosynthesis and the enzyme needing tetrahydrobiopterin and iron as cofactors. |
1997-08-22 |
2023-08-12 |
rat |
| C P De la Cruz, E Revilla, J A Rodríguez-Gómez, M L Vizuete, J Cano, A Machad. (-)-Deprenyl treatment restores serum insulin-like growth factor-I (IGF-I) levels in aged rats to young rat level. European journal of pharmacology. vol 327. issue 2-3. 1997-08-18. PMID:9200562. |
the concentrations of dopamine, serotonin (5-ht) and their main metabolites were determined by high performance liquid chromatography (hplc) with electrochemical detection, and the tyrosine hydroxylase content in hypothalamus and hypophysis was determined by enzyme-linked immunoabsorbent assay (elisa). |
1997-08-18 |
2023-08-12 |
rat |
| K E Goodwill, C Sabatier, C Marks, R Raag, P F Fitzpatrick, R C Steven. Crystal structure of tyrosine hydroxylase at 2.3 A and its implications for inherited neurodegenerative diseases. Nature structural biology. vol 4. issue 7. 1997-08-13. PMID:9228951. |
tyrosine hydroxylase (tyroh) catalyzes the conversion of tyrosine to l-dopa, the rate-limiting step in the biosynthesis of the catecholamines dopamine, adrenaline, and noradrenaline. |
1997-08-13 |
2023-08-12 |
Not clear |
| L Iacovitti, N D Stul. Expression of tyrosine hydroxylase in newly differentiated neurons from a human cell line (hNT). Neuroreport. vol 8. issue 6. 1997-08-07. PMID:9172156. |
previous studies have demonstrated that the synergistic interaction of acidic fibroblast growth factor (afgf) and a number of co-activator molecules (dopamine, tpa, ibmx/forskolin) can induce the novel expression of the catecholamine biosynthetic enzyme tyrosine hydroxylase (th) in non-th-expressing neurons. |
1997-08-07 |
2023-08-12 |
human |
| R Tomasini, I P Kema, F A Muskiet, G Meiborg, M J Staal, K G G. Catecholaminergic development of fetal rat ventral mesencephalon: characterization by high-performance liquid chromatography with electrochemical detection and immunohistochemistry. Experimental neurology. vol 145. issue 2 Pt 1. 1997-07-31. PMID:9217079. |
we determined dopamine (da), noradrenaline (na), and adrenaline (a), as well as immunohistochemically stained tyrosine hydroxylase (th) and da in dissected rat ventral mesencephalon (vm) tissue from embryonic day (ed) 14 to postnatal day (p) 17. |
1997-07-31 |
2023-08-12 |
rat |
| P Agrati, Z Q Ma, C Patrone, G B Picotti, C Pellicciari, G Bondiolotti, M G Bottone, A Magg. Dopaminergic phenotype induced by oestrogens in a human neuroblastoma cell line. The European journal of neuroscience. vol 9. issue 5. 1997-07-21. PMID:9182953. |
most importantly, we show that in the differentiated cells the content of tyrosine hydroxylase and na+-dependent dopamine uptake is significantly augmented, proving that the oestrogen-differentiated sk-er3 cells can synthesize and store a specific neurotransmitter. |
1997-07-21 |
2023-08-12 |
human |
| A McGroarty, S A Greenfiel. 6-Hydroxy dopamine lesions block a tolbutamide-sensitive K+ conductance in the guinea-pig substantia nigra. Neuroscience letters. vol 224. issue 3. 1997-07-18. PMID:9131673. |
these cells do not show positive immunoreactivity for tyrosine hydroxylase (th), but they are present in slices that contain th and release dopamine (da). |
1997-07-18 |
2023-08-12 |
Not clear |
| G D Zeevalk, L Manzino, J Hoppe, P Sonsall. In vivo vulnerability of dopamine neurons to inhibition of energy metabolism. European journal of pharmacology. vol 320. issue 2-3. 1997-07-14. PMID:9059843. |
intrastriatal injection of malonate produced a loss of both tyrosine hydroxylase activity and dopamine. |
1997-07-14 |
2023-08-12 |
rat |
| A Castaño, A Ayala, J A Rodríguez-Gómez, A J Herrera, J Cano, A Machad. Low selenium diet increases the dopamine turnover in prefrontal cortex of the rat. Neurochemistry international. vol 30. issue 6. 1997-07-07. PMID:9152996. |
the increase of dopamine turnover in experimental rats was accompanied by an increase in tyrosine hydroxylase activity. |
1997-07-07 |
2023-08-12 |
rat |
| R Martin-Fardon, F Sandillon, J Thibault, A Privat, J Vigno. Long-term monitoring of extracellular dopamine concentration in the rat striatum by a repeated microdialysis procedure. Journal of neuroscience methods. vol 72. issue 2. 1997-06-30. PMID:9133576. |
the histological analysis using glial fibrillary acidic protein (gfap), dopamine (da) and tyrosine hydroxylase (th) immunocytochemistry showed a moderate gliosis and a discrete increase of immunoreactivity of catecholaminergic fibres around the probe implantation site. |
1997-06-30 |
2023-08-12 |
rat |
| J A Maurer, S Wra. Neuronal dopamine subpopulations maintained in hypothalamic slice explant cultures exhibit distinct tyrosine hydroxylase mRNA turnover rates. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 17. issue 12. 1997-06-30. PMID:9169516. |
neuronal dopamine subpopulations maintained in hypothalamic slice explant cultures exhibit distinct tyrosine hydroxylase mrna turnover rates. |
1997-06-30 |
2023-08-12 |
rat |
| B A Pappas, D Zhang, C M Davidson, T Crowder, G A Park, T Forti. Perinatal manganese exposure: behavioral, neurochemical, and histopathological effects in the rat. Neurotoxicology and teratology. vol 19. issue 1. 1997-06-19. PMID:9088007. |
tyrosine hydroxylase immunohistochemistry showed that dopamine cells of the substantia nigra were intact. |
1997-06-19 |
2023-08-12 |
rat |
| L Oruc, G R Verheyen, I Furac, M Jakovljević, S Ivezić, P Raeymaekers, C Van Broeckhove. Analysis of the tyrosine hydroxylase and dopamine D4 receptor genes in a Croatian sample of bipolar I and unipolar patients. American journal of medical genetics. vol 74. issue 2. 1997-06-18. PMID:9129719. |
analysis of the tyrosine hydroxylase and dopamine d4 receptor genes in a croatian sample of bipolar i and unipolar patients. |
1997-06-18 |
2023-08-12 |
Not clear |
| L Oruc, G R Verheyen, I Furac, M Jakovljević, S Ivezić, P Raeymaekers, C Van Broeckhove. Analysis of the tyrosine hydroxylase and dopamine D4 receptor genes in a Croatian sample of bipolar I and unipolar patients. American journal of medical genetics. vol 74. issue 2. 1997-06-18. PMID:9129719. |
we selected 83 patients with bipolar disorder type i or unipolar recurrent major depression and 71 healthy controls for genetic analysis of the tyrosine hydroxylase and the dopamine d4 receptor gene. |
1997-06-18 |
2023-08-12 |
Not clear |