| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| W M Duan, P Brundin, H Widne. Addition of allogeneic spleen cells causes rejection of intrastriatal embryonic mesencephalic allografts in the rat. Neuroscience. vol 77. issue 2. 1998-03-11. PMID:9472415. |
six weeks after transplantation, brain sections were processed immunocytochemically for tyrosine hydroxylase, specific for grafted dopamine neurons, and a bank of markers for various components in the immune and inflammatory responses. |
1998-03-11 |
2023-08-12 |
rat |
| T Hag. Neurotrophins prevent death and differentially affect tyrosine hydroxylase of adult rat nigrostriatal neurons in vivo. Experimental neurology. vol 149. issue 1. 1998-03-06. PMID:9454627. |
measurements of tyrosine hydroxylase immunoreactivity suggest that bdnf and nt-4 (presumably through their trkb receptor) reduce the synthesis of this rate-limiting enzyme for dopamine synthesis in rescued as well as in normal neurons. |
1998-03-06 |
2023-08-12 |
rat |
| L Kung, M Force, D J Chute, R C Robert. Immunocytochemical localization of tyrosine hydroxylase in the human striatum: a postmortem ultrastructural study. The Journal of comparative neurology. vol 390. issue 1. 1998-03-03. PMID:9456175. |
an electron microscopic evaluation of tyrosine hydroxylase (th) immunocytochemistry was used to describe the synaptic organization of dopamine innervation of the striatum in postmortem human brain tissue. |
1998-03-03 |
2023-08-12 |
human |
| D E Schmidt, M H Ebert, J C Lynn, W O Whetsel. Attenuation of 1-methyl-4-phenylpyridinium (MPP+) neurotoxicity by deprenyl in organotypic canine substantia nigra cultures. Journal of neural transmission (Vienna, Austria : 1996). vol 104. issue 8-9. 1998-02-26. PMID:9451719. |
thus the neuroprotective effects of deprenyl on mpp(+)-induced reduction of hva levels in living cultures appears similar to the effects of deprenyl on dopamine levels and tyrosine hydroxylase activity reported by others in cultures previously exposed to deprenyl and mpp+. |
1998-02-26 |
2023-08-12 |
Not clear |
| K Y Pau, Y J Ma, J H Yu, S P Yang, N Airhart, H G Spie. Topographic comparison of the expression of norepinephrine transporter, tyrosine hydroxylase and neuropeptide Y mRNA in association with dopamine beta-hydroxylase neurons in the rabbit brainstem. Brain research. Molecular brain research. vol 48. issue 2. 1998-02-17. PMID:9332734. |
topographic comparison of the expression of norepinephrine transporter, tyrosine hydroxylase and neuropeptide y mrna in association with dopamine beta-hydroxylase neurons in the rabbit brainstem. |
1998-02-17 |
2023-08-12 |
human |
| J N Joyce, G Smutzer, C J Whitty, A Myers, M J Banno. Differential modification of dopamine transporter and tyrosine hydroxylase mRNAs in midbrain of subjects with Parkinson's, Alzheimer's with parkinsonism, and Alzheimer's disease. Movement disorders : official journal of the Movement Disorder Society. vol 12. issue 6. 1998-02-10. PMID:9399211. |
differential modification of dopamine transporter and tyrosine hydroxylase mrnas in midbrain of subjects with parkinson's, alzheimer's with parkinsonism, and alzheimer's disease. |
1998-02-10 |
2023-08-12 |
human |
| J N Joyce, G Smutzer, C J Whitty, A Myers, M J Banno. Differential modification of dopamine transporter and tyrosine hydroxylase mRNAs in midbrain of subjects with Parkinson's, Alzheimer's with parkinsonism, and Alzheimer's disease. Movement disorders : official journal of the Movement Disorder Society. vol 12. issue 6. 1998-02-10. PMID:9399211. |
we examined the levels of tyrosine hydroxylase (th) protein, and the expression of th and dopamine transporter (dat) mrnas, in midbrain neurons of pd, ad, and ad/park cases. |
1998-02-10 |
2023-08-12 |
human |
| A M Sullivan, J Opacka-Juffry, G Hötten, J Pohl, S B Blun. Growth/differentiation factor 5 protects nigrostriatal dopaminergic neurones in a rat model of Parkinson's disease. Neuroscience letters. vol 233. issue 2-3. 1998-01-29. PMID:9350835. |
post-mortem studies showed that gdf5 spared dopamine levels in the striatum and tyrosine hydroxylase positive neurones in the midbrain. |
1998-01-29 |
2023-08-12 |
rat |
| L F Jarskog, H Xiao, M B Wilkie, J M Lauder, J H Gilmor. Cytokine regulation of embryonic rat dopamine and serotonin neuronal survival in vitro. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 15. issue 6. 1998-01-29. PMID:9402221. |
this study measured the effects of cytokines on the survival of tyrosine hydroxylase (th) immunoreactive dopamine neurons from the substantia nigra (sn), and 5-hydroxytryptamine (5-ht) immunoreactive serotonin neurons from the rostral raphe (rr), using cultures from embryonic day 14 (e14) rat brain. |
1998-01-29 |
2023-08-12 |
rat |
| H Garpenstrand, J Ekblom, J Hallman, L Orelan. Platelet monoamine oxidase activity in relation to alleles of dopamine D4 receptor and tyrosine hydroxylase genes. Acta psychiatrica Scandinavica. vol 96. issue 4. 1998-01-21. PMID:9350959. |
platelet monoamine oxidase activity in relation to alleles of dopamine d4 receptor and tyrosine hydroxylase genes. |
1998-01-21 |
2023-08-12 |
human |
| B Drukarch, E Schepens, C A Jongenelen, J C Stoof, C H Langevel. Astrocyte-mediated enhancement of neuronal survival is abolished by glutathione deficiency. Brain research. vol 770. issue 1-2. 1998-01-21. PMID:9372211. |
using tyrosine hydroxylase immunocytochemistry and radiolabeled dopamine uptake as parameters, an increase in the number and outgrowth of daergic neurons was noted in cocultures as compared to cultures of mesencephalic neurons alone. |
1998-01-21 |
2023-08-12 |
rat |
| N Y Choksi, P R Kodavanti, H A Tilson, R G Boot. Effects of polychlorinated biphenyls (PCBs) on brain tyrosine hydroxylase activity and dopamine synthesis in rats. Fundamental and applied toxicology : official journal of the Society of Toxicology. vol 39. issue 1. 1998-01-20. PMID:9325030. |
effects of polychlorinated biphenyls (pcbs) on brain tyrosine hydroxylase activity and dopamine synthesis in rats. |
1998-01-20 |
2023-08-12 |
rat |
| N Y Choksi, P R Kodavanti, H A Tilson, R G Boot. Effects of polychlorinated biphenyls (PCBs) on brain tyrosine hydroxylase activity and dopamine synthesis in rats. Fundamental and applied toxicology : official journal of the Society of Toxicology. vol 39. issue 1. 1998-01-20. PMID:9325030. |
this report tested the hypothesis that ortho-substituted pcbs can selectively (vs para-substituted congeners) decrease dopamine synthesis in mammalian forebrain by inhibiting the activity of tyrosine hydroxylase, the rate-limiting enzyme in dopamine biosynthesis. |
1998-01-20 |
2023-08-12 |
rat |
| N Y Choksi, P R Kodavanti, H A Tilson, R G Boot. Effects of polychlorinated biphenyls (PCBs) on brain tyrosine hydroxylase activity and dopamine synthesis in rats. Fundamental and applied toxicology : official journal of the Society of Toxicology. vol 39. issue 1. 1998-01-20. PMID:9325030. |
it was found that certain ortho-substituted pcb congeners (e.g., 2,2'-dcb) can inhibit tyrosine hydroxylase activity and dopamine synthesis by nearly 40% in minces of corpus striatum prepared from sprague-dawley and long-evans hooded rats. |
1998-01-20 |
2023-08-12 |
rat |
| N Y Choksi, P R Kodavanti, H A Tilson, R G Boot. Effects of polychlorinated biphenyls (PCBs) on brain tyrosine hydroxylase activity and dopamine synthesis in rats. Fundamental and applied toxicology : official journal of the Society of Toxicology. vol 39. issue 1. 1998-01-20. PMID:9325030. |
comparatively, the ortho, meta-substituted pcb congener 2,2',5,5'-tecb inhibited tyrosine hydroxylase activity only in striatal minces obtained from sprague-dawley rats, suggesting that genetic factors may influence the susceptibility of mammals to effects of pcbs that compromise brain dopamine synthesis. |
1998-01-20 |
2023-08-12 |
rat |
| C Tönshoff, L Hemmick, M J Evinge. Pituitary adenylate cyclase activating polypeptide (PACAP) regulates expression of catecholamine biosynthetic enzyme genes in bovine adrenal chromaffin cells. Journal of molecular neuroscience : MN. vol 9. issue 2. 1998-01-20. PMID:9407393. |
pituitary adenylate cyclase activating polypeptide (pacap) elevates levels of the mrnas encoding the catecholamine synthesizing enzymes tyrosine hydroxylase (th), dopamine beta-hydroxylase (dbh), and phenylethanolamine n-methyltransferase (pnmt) in primary cultures of bovine adrenal chromaffin cells. |
1998-01-20 |
2023-08-12 |
cattle |
| M L Hâkansson, H Brown, N Ghilardi, R C Skoda, B Meiste. Leptin receptor immunoreactivity in chemically defined target neurons of the hypothalamus. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 18. issue 1. 1998-01-16. PMID:9412531. |
in the dorsomedial arcuate nucleus, few tyrosine hydroxylase (dopamine)-containing neurons were seen to have lr-li. |
1998-01-16 |
2023-08-12 |
rat |
| X Lu, T Hag. Glial cell line-derived neurotrophic factor prevents death, but not reductions in tyrosine hydroxylase, of injured nigrostriatal neurons in adult rats. The Journal of comparative neurology. vol 388. issue 3. 1998-01-14. PMID:9368855. |
measurements of tyrosine hydroxylase (th) immunoreactivity of the rescued neuronal cell bodies suggest that gdnf cannot prevent the lesion-induced loss of this rate-limiting enzyme for dopamine synthesis. |
1998-01-14 |
2023-08-12 |
rat |
| M Laruelle, C D D'Souza, R M Baldwin, A Abi-Dargham, S J Kanes, C L Fingado, J P Seibyl, S S Zoghbi, M B Bowers, P Jatlow, D S Charney, R B Inni. Imaging D2 receptor occupancy by endogenous dopamine in humans. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 17. issue 3. 1998-01-08. PMID:9272483. |
dopamine depletion was achieved by administration of the tyrosine hydroxylase inhibitor alpha-methyl-para-tyrosine (ampt), given orally at a dose of 1 g every six hours for two days. |
1998-01-08 |
2023-08-12 |
human |
| W Kloas, M Reinecke, W Hank. Stage-dependent changes in adrenal steroids and catecholamines during development in Xenopus laevis. General and comparative endocrinology. vol 108. issue 3. 1997-12-31. PMID:9405118. |
in addition, the catecholamine-synthesizing enzymes tyrosine hydroxylase, dopamine beta-hydroxylase, and phenylethanolamine n-methyltransferase were immunocytochemically localized for the characterization of chromaffin adrenal cells. |
1997-12-31 |
2023-08-12 |
xenopus_laevis |