| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| T Nagatsu, H Ichinos. [Autosomal-dominant DOPA-responsive dystonia, caused by mutations in the GTP-cyclohydrolase I gene]. Voprosy meditsinskoi khimii. vol 44. issue 3. 1998-09-21. PMID:9703621. |
its deficiency in nigrostriatal dopaminergic neurons cause a decrease in tyrosine hydroxylase activity and therefore dopamine deficiency. |
1998-09-21 |
2023-08-12 |
Not clear |
| S M Williams, P S Goldman-Raki. Widespread origin of the primate mesofrontal dopamine system. Cerebral cortex (New York, N.Y. : 1991). vol 8. issue 4. 1998-09-11. PMID:9651129. |
we have employed a combination of retrograde tracing, using fluorescent dyes, and tyrosine hydroxylase (th) immunohistochemistry to amplify knowledge of frontal cortex-projecting dopamine (da) neurons in non-human primates. |
1998-09-11 |
2023-08-12 |
monkey |
| J S Dixon, P Y Jen, J A Goslin. Immunohistochemical characteristics of human paraganglion cells and sensory corpuscles associated with the urinary bladder. A developmental study in the male fetus, neonate and infant. Journal of anatomy. vol 192 ( Pt 3). 1998-09-11. PMID:9688506. |
triple label immunohistochemistry was used to study the coexistence of the catecholamine-synthesising enzymes dopamine beta-hydroxylase (dbh) and tyrosine hydroxylase (th) and several neuropeptides including neuropeptide y (npy), vasoactive intestinal polypeptide (vip), substance p (sp), calcitonin gene-related peptide (cgrp), somatostatin (som) and galanin (gal) as well as nitric oxide synthase (nos) in developing pelvic paraganglion cells in a series of human male fetal, neonatal and infant specimens ranging in age from 13 wk of gestation to 3 y postnatal. |
1998-09-11 |
2023-08-12 |
human |
| L P Liang, S Kaufma. The regulation of dopamine release from striatum slices by tetrahydrobiopterin and L-arginine-derived nitric oxide. Brain research. vol 800. issue 2. 1998-09-04. PMID:9685635. |
adding exogenous bh4 directly to the superfusion fluid leads to a massive increase in [3h] dopamine release which can be inhibited 75% by superoxide dismutase and catalase, but is not inhibited by ng-nitro-arginine, a no synthase inhibitor, or alpha-methyl-p-tyrosine, a tyrosine hydroxylase inhibitor. |
1998-09-04 |
2023-08-12 |
rat |
| L P Liang, S Kaufma. The regulation of dopamine release from striatum slices by tetrahydrobiopterin and L-arginine-derived nitric oxide. Brain research. vol 800. issue 2. 1998-09-04. PMID:9685635. |
it is suggested that the increase of dopamine release stimulated by an enhancement of intracellular bh4 is dependent on its cofactor activity with no synthase and tyrosine hydroxylase. |
1998-09-04 |
2023-08-12 |
rat |
| J F Bowyer, L T Frame, P Clausing, K Nagamoto-Combs, C A Osterhout, C R Sterling, A W Tan. Long-term effects of amphetamine neurotoxicity on tyrosine hydroxylase mRNA and protein in aged rats. The Journal of pharmacology and experimental therapeutics. vol 286. issue 2. 1998-09-02. PMID:9694971. |
four injections (intraperitoneal) of 3 mg/kg amphetamine (2 hr apart) produced pronounced hyperthermia and sustained decreases in dopamine levels and tyrosine hydroxylase (th) protein levels in the striatum of 15-month-old male rats. |
1998-09-02 |
2023-08-12 |
rat |
| M Jabe. [Dopamine control of neuroendocrine functions. New findings based on the study of transgenic animals]. Annales d'endocrinologie. vol 58. issue 6. 1998-09-01. PMID:9686001. |
this technique has been applied recently to inactivate the expression of tyrosine hydroxylase, dopamine, monoamine oxidase, three of the five dopamine receptors, the monoamines vesicular transporter and the plasma membrane dopamine transporter. |
1998-09-01 |
2023-08-12 |
mouse |
| D Lu, H Yang, R H Lenox, M K Raizad. Regulation of angiotensin II-induced neuromodulation by MARCKS in brain neurons. The Journal of cell biology. vol 142. issue 1. 1998-08-20. PMID:9660875. |
angiotensin ii (ang ii) exerts chronic stimulatory actions on tyrosine hydroxylase (th), dopamine beta-hydroxylase (dbetah), and the norepinephrine transporter (net), in part, by influencing the transcription of their genes. |
1998-08-20 |
2023-08-12 |
Not clear |
| S F Ali, Y Itzha. Effects of 7-nitroindazole, an NOS inhibitor on methamphetamine-induced dopaminergic and serotonergic neurotoxicity in mice. Annals of the New York Academy of Sciences. vol 844. 1998-08-13. PMID:9668670. |
methamphetamine (meth) is one of the major drugs of abuse that is postulated to cause neurotoxicity by depleting dopamine (da) and its metabolites, high-affinity da uptake sites, and the activity of tyrosine hydroxylase. |
1998-08-13 |
2023-08-12 |
mouse |
| C A Cooney, C K Wise, L A Poirier, S F Al. Methamphetamine treatment affects blood and liver S-adenosylmethionine (SAM) in mice. Correlation with dopamine depletion in the striatum. Annals of the New York Academy of Sciences. vol 844. 1998-08-13. PMID:9668677. |
methamphetamine (meth) is a major drug of abuse which causes neurotoxicity by depleting dopamine, its metabolites, high-affinity dopamine uptake sites and tyrosine hydroxylase activity in the striatum. |
1998-08-13 |
2023-08-12 |
mouse |
| S O Castillo, J S Baffi, M Palkovits, D S Goldstein, I J Kopin, J Witta, M A Magnuson, V M Nikode. Dopamine biosynthesis is selectively abolished in substantia nigra/ventral tegmental area but not in hypothalamic neurons in mice with targeted disruption of the Nurr1 gene. Molecular and cellular neurosciences. vol 11. issue 1-2. 1998-08-07. PMID:9608532. |
dopamine (da) was absent in the substantia nigra (sn) and ventral tegmental area (vta) of nurr1-null mice, consistent with absent tyrosine hydroxylase (th), l-aromatic amino acid decarboxylase, and other da neuron markers. |
1998-08-07 |
2023-08-12 |
mouse |
| E N Pothos, S Przedborski, V Davila, Y Schmitz, D Sulze. D2-Like dopamine autoreceptor activation reduces quantal size in PC12 cells. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 18. issue 15. 1998-08-07. PMID:9671649. |
together, these findings indicate effects on quantal neurotransmission by d2-like dopamine autoreceptors previously distinguished as synthesis-modulating autoreceptors that regulate tyrosine hydroxylase activity versus impulse-regulating autoreceptors that modulate membrane potential. |
1998-08-07 |
2023-08-12 |
Not clear |
| U J Kan. Potential of gene therapy for Parkinson's disease: neurobiologic issues and new developments in gene transfer methodologies. Movement disorders : official journal of the Movement Disorder Society. vol 13 Suppl 1. 1998-08-06. PMID:9613721. |
the gene for tyrosine hydroxylase, the rate-limiting step of dopamine synthesis, has been transferred into animal models by viral vectors or by implantable cells that have been modified by retrovirus vectors. |
1998-08-06 |
2023-08-12 |
Not clear |
| J Ara, S Przedborski, A B Naini, V Jackson-Lewis, R R Trifiletti, J Horwitz, H Ischiropoulo. Inactivation of tyrosine hydroxylase by nitration following exposure to peroxynitrite and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Proceedings of the National Academy of Sciences of the United States of America. vol 95. issue 13. 1998-08-06. PMID:9636206. |
herein, we report that the rate-limiting enzyme in dopamine synthesis, tyrosine hydroxylase (th), is a selective target for nitration following exposure of pc12 cells to either peroxynitrite or 1-methyl-4-phenylpyridiniun ion (mpp+). |
1998-08-06 |
2023-08-12 |
mouse |
| C E Sortwell, B C Blanchard, T J Collier, J D Elsworth, J R Taylor, R H Roth, D E Redmond, J R Slade. Pattern of synaptophysin immunoreactivity within mesencephalic grafts following transplantation in a parkinsonian primate model. Brain research. vol 791. issue 1-2. 1998-08-03. PMID:9593853. |
immunohistochemical staining with antibodies directed against sy and the dopamine synthetic enzyme tyrosine hydroxylase (th) was used to assess overall synaptic differentiation as well as the relationship between sy immunoreactivity and the distribution of grafted dopamine (da) neurons and processes in mesencephalic grafts and mesencephalic-striatal co-grafts implanted in the striatum of mptp-treated african green monkeys. |
1998-08-03 |
2023-08-12 |
monkey |
| O K Rønnekleiv, Y Fang, W S Choi, L Cha. Changes in the midbrain-rostral forebrain dopamine circuitry in the cocaine-exposed primate fetal brain. Annals of the New York Academy of Sciences. vol 846. 1998-07-31. PMID:9668406. |
however, by day 60 the midbrain of monkeys exposed to cocaine had significantly reduced expression of tyrosine hydroxylase, the rate-limiting enzyme in dopamine synthesis. |
1998-07-31 |
2023-08-12 |
monkey |
| A Serretti, F Macciardi, M Verga, C Cusin, S Pedrini, E Smerald. Tyrosine hydroxylase gene associated with depressive symptomatology in mood disorder. American journal of medical genetics. vol 81. issue 2. 1998-07-24. PMID:9613850. |
tyrosine hydroxylase (th) is the rate-limiting enzyme in the synthesis of dopamine and norepinephrine. |
1998-07-24 |
2023-08-12 |
human |
| H Wang, S Li, G Pelletie. Role of nitric oxide in the regulation of gonadotropin-releasing hormone and tyrosine hydroxylase gene expression in the male rat brain. Brain research. vol 792. issue 1. 1998-07-13. PMID:9593826. |
since the dopaminergic system can positively influence gnrh gene expression, we have also measured in the same animals tyrosine hydroxylase (th) mrna in tuberoinfundibular dopamine (tida) neurons. |
1998-07-13 |
2023-08-12 |
rat |
| J R Sladek, T J Collier, J D Elsworth, R H Roth, J R Taylor, D E Redmon. Intrastriatal grafts from multiple donors do not result in a proportional increase in survival of dopamine neurons in nonhuman primates. Cell transplantation. vol 7. issue 2. 1998-07-10. PMID:9588591. |
while well-developed grafts with several thousand dopamine neurons were found in most recipient animals, we observed a reduced total number of tyrosine hydroxylase positive neurons in the grafts in spite of the presence of some double grafts that were larger than normal. |
1998-07-10 |
2023-08-12 |
human |
| D Sulzer, M P Joyce, L Lin, D Geldwert, S N Haber, T Hattori, S Raypor. Dopamine neurons make glutamatergic synapses in vitro. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 18. issue 12. 1998-07-08. PMID:9614234. |
to examine this possibility, we double immunostained ventral midbrain sections from rat and monkey for the dopamine-synthetic enzyme tyrosine hydroxylase and for glutamate; we found that most dopamine neurons immunostained for glutamate, both in rat and monkey. |
1998-07-08 |
2023-08-12 |
rat |