| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Claudia Kriegebaum, Ning-Ning Song, Lise Gutknecht, Ying Huang, Angelika Schmitt, Andreas Reif, Yu-Qiang Ding, Klaus-Peter Lesc. Brain-specific conditional and time-specific inducible Tph2 knockout mice possess normal serotonergic gene expression in the absence of serotonin during adult life. Neurochemistry international. vol 57. issue 5. 2010-12-22. PMID:20599453. |
brain-specific conditional and time-specific inducible tph2 knockout mice possess normal serotonergic gene expression in the absence of serotonin during adult life. |
2010-12-22 |
2023-08-12 |
mouse |
| Claudia Kriegebaum, Ning-Ning Song, Lise Gutknecht, Ying Huang, Angelika Schmitt, Andreas Reif, Yu-Qiang Ding, Klaus-Peter Lesc. Brain-specific conditional and time-specific inducible Tph2 knockout mice possess normal serotonergic gene expression in the absence of serotonin during adult life. Neurochemistry international. vol 57. issue 5. 2010-12-22. PMID:20599453. |
specifically, brain-specific conditional and time-specific inducible tph2 knockout (ko) models were generated and investigated for altered serotonergic neuron-specific gene expression. |
2010-12-22 |
2023-08-12 |
mouse |
| Claudia Kriegebaum, Ning-Ning Song, Lise Gutknecht, Ying Huang, Angelika Schmitt, Andreas Reif, Yu-Qiang Ding, Klaus-Peter Lesc. Brain-specific conditional and time-specific inducible Tph2 knockout mice possess normal serotonergic gene expression in the absence of serotonin during adult life. Neurochemistry international. vol 57. issue 5. 2010-12-22. PMID:20599453. |
these findings confirm the specificity of tph2 in brain 5-ht synthesis across the lifespan, yet also suggest that neither developmental nor adult 5-ht synthesis is required for the expression of genes specific for serotonergic signalling. |
2010-12-22 |
2023-08-12 |
mouse |
| S Kloiber, M A Kohli, T Brueckl, S Ripke, M Ising, M Uhr, A Menke, P G Unschuld, S Horstmann, D Salyakina, B Muller-Myhsok, E B Binder, F Holsboer, S Luca. Variations in tryptophan hydroxylase 2 linked to decreased serotonergic activity are associated with elevated risk for metabolic syndrome in depression. Molecular psychiatry. vol 15. issue 7. 2010-10-18. PMID:19125159. |
our findings suggest that tph2 polymorphisms characterize a subgroup of depressed patients who are especially prone to develop metabolic disorders induced by a genotype-dependent impairment of serotonergic neurotransmission. |
2010-10-18 |
2023-08-12 |
Not clear |
| Christian P Jacob, Thuy Trang Nguyen, Astrid Dempfle, Monika Heine, Christine Windemuth-Kieselbach, Katarina Baumann, Florian Jacob, Julian Prechtl, Maike Wittlich, Martin J Herrmann, Silke Gross-Lesch, Klaus-Peter Lesch, Andreas Rei. A gene-environment investigation on personality traits in two independent clinical sets of adult patients with personality disorder and attention deficit/hyperactive disorder. European archives of psychiatry and clinical neuroscience. vol 260. issue 4. 2010-08-24. PMID:19894072. |
the present study therefore aimed to detect main effects as well as interactions of serotonergic candidate genes (coding for the serotonin transporter, 5-htt; the serotonin autoreceptor, htr1a; and the enzyme which synthesizes serotonin in the brain, tph2) with the burden of life events (#le) in two independent samples consisting of 183 patients suffering from personality disorders and 123 patients suffering from adult attention deficit/hyperactivity disorder (aadhd). |
2010-08-24 |
2023-08-12 |
human |
| Gabriella Juhasz, Darragh Downey, Neal Hinvest, Emma Thomas, Diana Chase, Zoltan G Toth, Kathryn Lloyd-Williams, Krisztina Mekli, Hazel Platt, Antony Payton, Gyorgy Bagdy, Rebecca Elliott, J F William Deakin, Ian M Anderso. Risk-taking behavior in a gambling task associated with variations in the tryptophan hydroxylase 2 gene: relevance to psychiatric disorders. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 35. issue 5. 2010-06-21. PMID:20043001. |
we tested the hypothesis that variations in serotonergic genes (tph2, tph1, slc6a4, htr1a), which influence serotonin availability, affect choice behavior in a probabilistic gambling task. |
2010-06-21 |
2023-08-12 |
human |
| Tobias Banaschewski, Katja Becker, Susann Scherag, Barbara Franke, David Coghil. Molecular genetics of attention-deficit/hyperactivity disorder: an overview. European child & adolescent psychiatry. vol 19. issue 3. 2010-06-14. PMID:20145962. |
genes associated with the noradrenergic (such as net1/slc6a2, adra2a, adra2c) and serotonergic systems (such as 5-htt/slc6a4, htr1b, htr2a, tph2) have also received considerable interest. |
2010-06-14 |
2023-08-12 |
Not clear |
| Kathrin Scheuch, Markus Höltje, Holger Budde, Marion Lautenschlager, Andreas Heinz, Gudrun Ahnert-Hilger, Josef Prille. Lithium modulates tryptophan hydroxylase 2 gene expression and serotonin release in primary cultures of serotonergic raphe neurons. Brain research. vol 1307. 2010-03-08. PMID:19840776. |
our results suggest that lithium can modify tph2 gene expression and 5-ht release in raphe neurons, providing new insight into the serotonergic mechanisms of action of lithium. |
2010-03-08 |
2023-08-12 |
rat |
| K L Gardner, M W Hale, S Oldfield, S L Lightman, P M Plotsky, C A Lowr. Adverse experience during early life and adulthood interact to elevate tph2 mRNA expression in serotonergic neurons within the dorsal raphe nucleus. Neuroscience. vol 163. issue 4. 2010-02-12. PMID:19647049. |
adverse experience during early life and adulthood interact to elevate tph2 mrna expression in serotonergic neurons within the dorsal raphe nucleus. |
2010-02-12 |
2023-08-12 |
rat |
| John Jacob, Robert Storm, Diogo S Castro, Christopher Milton, Patrick Pla, François Guillemot, Carmen Birchmeier, James Brisco. Insm1 (IA-1) is an essential component of the regulatory network that specifies monoaminergic neuronal phenotypes in the vertebrate hindbrain. Development (Cambridge, England). vol 136. issue 14. 2009-09-24. PMID:19542360. |
nevertheless, serotonergic precursors begin to differentiate in insm1 mutants, but fail to produce serotonin because of a failure to activate expression of tryptophan hydroxylase 2 (tph2), the key enzyme of serotonin biosynthesis. |
2009-09-24 |
2023-08-12 |
mouse |
| A Heck, R Lieb, A Ellgas, H Pfister, S Lucae, D Roeske, B Pütz, B Müller-Myhsok, M Uhr, F Holsboer, M Isin. Investigation of 17 candidate genes for personality traits confirms effects of the HTR2A gene on novelty seeking. Genes, brain, and behavior. vol 8. issue 4. 2009-09-11. PMID:19566713. |
to overcome this limitation, we performed an extended genetic association study analyzing 17 serotonergic (slc6a4, htr1a, htr1b, htr2a, htr2c, htr3a, htr6, maoa, tph1, tph2) and dopaminergic genes (slc6a3, drd2, drd3, drd4, comt, maoa, th, dbh), which have been previously reported to be implicated with personality traits. |
2009-09-11 |
2023-08-12 |
Not clear |
| P Zill, A Büttner, W Eisenmenger, J Müller, H-J Möller, B Bond. Predominant expression of tryptophan hydroxylase 1 mRNA in the pituitary: a postmortem study in human brain. Neuroscience. vol 159. issue 4. 2009-08-20. PMID:19233335. |
the results of the present study extended our previous findings by the additional immunohistochemical determination of the neuronal tph1 and tph2 protein expression in the anterior pituitary and provide evidence against a strictly separated duality of the serotonergic system. |
2009-08-20 |
2023-08-12 |
human |
| Karen Sugden, Ales Tichopad, Nadeem Khan, Ian W Craig, Ursula M D'Souz. Genes within the serotonergic system are differentially expressed in human brain. BMC neuroscience. vol 10. 2009-08-17. PMID:19445671. |
in this study, we report expression patterns of five serotonergic genes (tph1, tph2, 5-ht2a, 5-ht2c, 5-htt) in seven different human post-mortem brain regions (superior frontal gyrus, superior temporal gyrus, striatum, cerebellum, hippocampus, midbrain and thalamus) using taqman real-time quantitative pcr. |
2009-08-17 |
2023-08-12 |
human |
| Maria Nobile, Marianna Rusconi, Monica Bellina, Cecilia Marino, Roberto Giorda, Ombretta Carlet, Laura Vanzin, Massimo Molteni, Marco Battagli. The influence of family structure, the TPH2 G-703T and the 5-HTTLPR serotonergic genes upon affective problems in children aged 10-14 years. Journal of child psychology and psychiatry, and allied disciplines. vol 50. issue 3. 2009-08-07. PMID:19175813. |
the influence of family structure, the tph2 g-703t and the 5-httlpr serotonergic genes upon affective problems in children aged 10-14 years. |
2009-08-07 |
2023-08-12 |
Not clear |
| Anne Must, Gunnar Tasa, Aavo Lang, Eero Vasar, Sulev Kõks, Eduard Maron, Marika Väl. Variation in tryptophan hydroxylase-2 gene is not associated to male completed suicide in Estonian population. Neuroscience letters. vol 453. issue 2. 2009-06-12. PMID:19356604. |
tryptophan hydroxylase isoform 2 (tph2) is the rate-limiting enzyme in the biosynthetic pathway of serotonin, being expressed in serotonergic neurons of raphe nuclei. |
2009-06-12 |
2023-08-12 |
human |
| Paul Gacek, Tamlin S Conner, Howard Tennen, Henry R Kranzler, Jonathan Covaul. Tryptophan hydroxylase 2 gene and alcohol use among college students. Addiction biology. vol 13. issue 3-4. 2009-03-05. PMID:18782386. |
tryptophan hydroxylase (tph2) plays an important role in serotonergic neurotransmission by serving as the rate-limiting enzyme for serotonin biosynthesis in the midbrain and serotonergic neurons. |
2009-03-05 |
2023-08-12 |
human |
| Paul Gacek, Tamlin S Conner, Howard Tennen, Henry R Kranzler, Jonathan Covaul. Tryptophan hydroxylase 2 gene and alcohol use among college students. Addiction biology. vol 13. issue 3-4. 2009-03-05. PMID:18782386. |
despite the link between tph2 and serotonergic function, tph2's role in the pathogenesis of alcohol-use disorders remains unclear. |
2009-03-05 |
2023-08-12 |
human |
| S W Kang, B Leclerc, L J Mauro, M E El Halawan. Serotonergic and catecholaminergic interactions with co-localised dopamine-melatonin neurones in the hypothalamus of the female turkey. Journal of neuroendocrinology. vol 21. issue 1. 2009-02-03. PMID:19094089. |
changes in the activities of serotonergic, dopaminergic, adrenergic and noradrenergic neuronal systems projecting to the pmm were measured at different reproductive states with in situ hybridisation (ish) techniques, using tryptophan hydroxylase 2 (tph2) and th mrna expression, respectively. |
2009-02-03 |
2023-08-12 |
Not clear |
| Christopher A Lowry, Matthew W Hale, Andrew K Evans, Jasper Heerkens, Daniel R Staub, Paul J Gasser, Anantha Shekha. Serotonergic systems, anxiety, and affective disorder: focus on the dorsomedial part of the dorsal raphe nucleus. Annals of the New York Academy of Sciences. vol 1148. 2009-01-23. PMID:19120094. |
depressed suicide patients have elevated expression of neuronal tryptophan hydroxylase 2 (tph2) mrna and protein in midbrain serotonergic neurons, as well as increases in brain serotonin turnover. |
2009-01-23 |
2023-08-12 |
Not clear |
| Christopher A Lowry, Matthew W Hale, Andrew K Evans, Jasper Heerkens, Daniel R Staub, Paul J Gasser, Anantha Shekha. Serotonergic systems, anxiety, and affective disorder: focus on the dorsomedial part of the dorsal raphe nucleus. Annals of the New York Academy of Sciences. vol 1148. 2009-01-23. PMID:19120094. |
the mechanisms underlying these changes are uncertain, but increased tph2 expression and serotonin turnover could result from genetic influences, adverse early life experiences, or acute stressful life events, all of which can alter serotonergic neurotransmission and have been implicated in determining vulnerability to major depression. |
2009-01-23 |
2023-08-12 |
Not clear |