| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Christopher A Lowry, Matthew W Hale, Andrew K Evans, Jasper Heerkens, Daniel R Staub, Paul J Gasser, Anantha Shekha. Serotonergic systems, anxiety, and affective disorder: focus on the dorsomedial part of the dorsal raphe nucleus. Annals of the New York Academy of Sciences. vol 1148. 2009-01-23. PMID:19120094. |
here we review our current understanding of how genetic and environmental factors may influence tph2 mrna expression and serotonergic neurotransmission, focusing in particular on the dorsomedial part of the dorsal raphe nucleus. |
2009-01-23 |
2023-08-12 |
Not clear |
| Iris Manor, Efrat Laiba, Jacques Eisenberg, Sheera Meidad, Elad Lerer, Salomon Israel, Inga Gritsenko, Sam Tyano, Stephen V Faraone, Richard P Ebstei. Association between tryptophan hydroxylase 2, performance on a continuance performance test and response to methylphenidate in ADHD participants. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 147B. issue 8. 2009-01-06. PMID:18213624. |
the current investigation shows that risk for adhd conferred by tph2 variants is partially mediated by serotonergic mechanisms impacting some facets of executive function. |
2009-01-06 |
2023-08-12 |
human |
| Lise Gutknecht, Jonas Waider, Stefanie Kraft, Claudia Kriegebaum, Bettina Holtmann, Andreas Reif, Angelika Schmitt, Klaus-Peter Lesc. Deficiency of brain 5-HT synthesis but serotonergic neuron formation in Tph2 knockout mice. Journal of neural transmission (Vienna, Austria : 1996). vol 115. issue 8. 2008-10-24. PMID:18665319. |
the relative contribution of the two tryptophan hydroxylase (tph) isoforms, tph1 and tph2, to brain serotonergic system function is controversial. |
2008-10-24 |
2023-08-12 |
mouse |
| H Bach-Mizrachi, M D Underwood, A Tin, S P Ellis, J J Mann, V Arang. Elevated expression of tryptophan hydroxylase-2 mRNA at the neuronal level in the dorsal and median raphe nuclei of depressed suicides. Molecular psychiatry. vol 13. issue 5. 2008-07-03. PMID:18180753. |
localized changes in tph2 expression in specific subnuclei of the drn suggest that the serotonergic compensatory mechanism in depression and suicide is specifically regulated within the drn and has implications for regions innervated by this subnucleus. |
2008-07-03 |
2023-08-12 |
Not clear |
| Martin Reuter, Juergen Hennig, Manfred Amelang, Christian Montag, Tatjana Korkut, Anja Hueweler, Til Stürme. The role of the TPH1 and TPH2 genes for nicotine dependence: a genetic association study in two different age cohorts. Neuropsychobiology. vol 56. issue 1. 2008-01-04. PMID:17986837. |
based on pharmacological and genetic studies suggesting a role of the serotonergic system for nicotine dependence, two genetic variants, one on the tryptophan hydroxylase 1 (tph1) and one on the tph2 gene, were investigated. |
2008-01-04 |
2023-08-12 |
human |
| Federico Remes Lenicov, Sylvie Lemonde, Margaret Czesak, Tera M Mosher, Paul R Alber. Cell-type specific induction of tryptophan hydroxylase-2 transcription by calcium mobilization. Journal of neurochemistry. vol 103. issue 5. 2008-01-03. PMID:17868301. |
to study its regulation, we measured tph2 rna by quantitative rt-pcr in differentiated serotonergic rat raphe rn46a and gh4c1 pituitary cells, which express tph2. |
2008-01-03 |
2023-08-12 |
rat |
| Margaret Czesak, Ariel M Burns, Federico Remes Lenicov, Paul R Alber. Characterization of rat rostral raphe primary cultures: multiplex quantification of serotonergic markers. Journal of neuroscience methods. vol 164. issue 1. 2007-09-27. PMID:17498810. |
the relative abundances determined by q-pcr are consistent with the expression of tph2>deaf-1>5-ht1a receptor rna in serotonergic raphe cells. |
2007-09-27 |
2023-08-12 |
rat |
| Fabrice Jollant, Catherine Buresi, Sébastien Guillaume, Isabelle Jaussent, Frank Bellivier, Marion Leboyer, Didier Castelnau, Alain Malafosse, Philippe Courte. The influence of four serotonin-related genes on decision-making in suicide attempters. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 144B. issue 5. 2007-08-30. PMID:17221847. |
patients were genotyped for four serotonergic polymorphisms: 5httlpr, tph1 a218c, maoa u-vntr, and tph2 rs1118997. |
2007-08-30 |
2023-08-12 |
Not clear |
| Christina Lillesaar, Birgit Tannhäuser, Christian Stigloher, Elisabeth Kremmer, Laure Bally-Cui. The serotonergic phenotype is acquired by converging genetic mechanisms within the zebrafish central nervous system. Developmental dynamics : an official publication of the American Association of Anatomists. vol 236. issue 4. 2007-07-30. PMID:17304529. |
furthermore, by combining expression analyses of pet1 and the raphe tryptophan hydroxylase (tph2) with rhombomere identity markers, we show that anterior and posterior hindbrain clusters of serotonergic precursors are separated by r3, rather than r4 as in other vertebrates. |
2007-07-30 |
2023-08-12 |
zebrafish |
| J-E Lim, J Pinsonneault, W Sadee, D Saffe. Tryptophan hydroxylase 2 (TPH2) haplotypes predict levels of TPH2 mRNA expression in human pons. Molecular psychiatry. vol 12. issue 5. 2007-06-26. PMID:17453063. |
tryptophan hydroxylase isoform 2 (tph2) is expressed in serotonergic neurons in the raphe nuclei, where it catalyzes the rate-limiting step in the synthesis of the neurotransmitter serotonin. |
2007-06-26 |
2023-08-12 |
human |
| Martin J Herrmann, Theresa Huter, Frauke Müller, Andreas Mühlberger, Paul Pauli, Andreas Reif, Tobias Renner, Turhan Canli, Andreas J Fallgatter, Klaus-Peter Lesc. Additive effects of serotonin transporter and tryptophan hydroxylase-2 gene variation on emotional processing. Cerebral cortex (New York, N.Y. : 1991). vol 17. issue 5. 2007-05-31. PMID:16801378. |
prior studies reported that functional variants of both the serotonin transporter (5-htt) and tryptophan hydroxylase-2 genes (tph2), 2 key regulators of the serotonergic signaling pathway, modulate amygdala activation during emotional processing. |
2007-05-31 |
2023-08-12 |
Not clear |
| Martin J Herrmann, Theresa Huter, Frauke Müller, Andreas Mühlberger, Paul Pauli, Andreas Reif, Tobias Renner, Turhan Canli, Andreas J Fallgatter, Klaus-Peter Lesc. Additive effects of serotonin transporter and tryptophan hydroxylase-2 gene variation on emotional processing. Cerebral cortex (New York, N.Y. : 1991). vol 17. issue 5. 2007-05-31. PMID:16801378. |
our results indicate that both the 5-htt and the tph2 genotypes modulate the sensory encoding of affective stimuli during early steps of visual processing and reveal additive effects of 2 genes in the serotonergic control of emotion regulation. |
2007-05-31 |
2023-08-12 |
Not clear |
| Martin Reuter, Ulrich Ott, Dieter Vaitl, Jürgen Henni. Impaired executive control is associated with a variation in the promoter region of the tryptophan hydroxylase 2 gene. Journal of cognitive neuroscience. vol 19. issue 3. 2007-05-02. PMID:17335389. |
this single-nucleotide polymorphism on the tph2 gene explained more than 10% of the variance in both indicators of attention stressing the role of the serotonergic system for cognitive functions. |
2007-05-02 |
2023-08-12 |
human |
| Helene Bach-Mizrachi, Mark D Underwood, Suham A Kassir, Mihran J Bakalian, Etienne Sibille, Hadassah Tamir, J John Mann, Victoria Arang. Neuronal tryptophan hydroxylase mRNA expression in the human dorsal and median raphe nuclei: major depression and suicide. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 31. issue 4. 2006-05-25. PMID:16192985. |
higher tph2 mrna expression may explain more tph protein observed in depressed suicides and reflect a homeostatic response to deficient brain serotonergic transmission. |
2006-05-25 |
2023-08-12 |
human |
| Zeina S Malek, Hugues Dardente, Paul Pevet, Sylvie Raiso. Tissue-specific expression of tryptophan hydroxylase mRNAs in the rat midbrain: anatomical evidence and daily profiles. The European journal of neuroscience. vol 22. issue 4. 2005-10-18. PMID:16115212. |
these data show that the circadian 5-ht synthesis within the serotonergic neurons projecting to the circadian system might be explained by the rhythmic transcription of the tph2 gene in raphe nuclei. |
2005-10-18 |
2023-08-12 |
rat |
| Alon Shamir, Galit Shaltiel, Itzhak Levi, R H Belmaker, Galila Aga. Postmortem parietal cortex TPH2 expression is not altered in schizophrenic, unipolar-depressed, and bipolar patients vs control subjects. Journal of molecular neuroscience : MN. vol 26. issue 1. 2005-10-14. PMID:15968084. |
the discovery of the brain-abundant tph2 gene justifies a new concept of the cns serotonergic system. |
2005-10-14 |
2023-08-12 |
human |
| P Zill, T C Baghai, P Zwanzger, C Schüle, D Eser, R Rupprecht, H-J Möller, B Bondy, M Ackenhei. SNP and haplotype analysis of a novel tryptophan hydroxylase isoform (TPH2) gene provide evidence for association with major depression. Molecular psychiatry. vol 9. issue 11. 2005-01-31. PMID:15124006. |
our findings provide evidence for an involvement of genetic variants of the tph2 gene in the pathogenesis of md and might be a hint on the repeatedly discussed duality of the serotonergic system. |
2005-01-31 |
2023-08-12 |
mouse |
| David Sugde. Comparison of circadian expression of tryptophan hydroxylase isoform mRNAs in the rat pineal gland using real-time PCR. Journal of neurochemistry. vol 86. issue 5. 2003-11-12. PMID:12911638. |
a second gene encoding a functional tryptophan hydroxylase activity has recently been described (tph2), which is expressed abundantly in brainstem, the primary site of serotonergic neurons in the cns. |
2003-11-12 |
2023-08-12 |
rat |