| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yun-Ai Su, Ji-Tao Li, Wen-Ji Dai, Xue-Mei Liao, Li-Cai Dong, Tian-Lan Lu, Chad Bousman, Tian-Mei S. Genetic variation in the tryptophan hydroxylase 2 gene moderates depressive symptom trajectories and remission over 8 weeks of escitalopram treatment. International clinical psychopharmacology. vol 31. issue 3. 2016-12-22. PMID:26745768. |
the aim of this study was to investigate the relationship between genotypic variation in six candidate serotonergic genes (adcy9, htr1b, gnb3, htr2a, tph2, slc6a4) and depressive and anxiety symptom severity trajectories as well as remission following escitalopram treatment. |
2016-12-22 |
2023-08-13 |
Not clear |
| Nina C Donner, Philip H Siebler, Danté T Johnson, Marcos D Villarreal, Sofia Mani, Allison J Matti, Christopher A Lowr. Serotonergic systems in the balance: CRHR1 and CRHR2 differentially control stress-induced serotonin synthesis. Psychoneuroendocrinology. vol 63. 2016-10-19. PMID:26454419. |
anxiety and affective disorders are often associated with hypercortisolism and dysfunctional serotonergic systems, including increased expression of tph2, the gene encoding the rate-limiting enzyme of neuronal serotonin synthesis. |
2016-10-19 |
2023-08-13 |
rat |
| Nina C Donner, Philip H Siebler, Danté T Johnson, Marcos D Villarreal, Sofia Mani, Allison J Matti, Christopher A Lowr. Serotonergic systems in the balance: CRHR1 and CRHR2 differentially control stress-induced serotonin synthesis. Psychoneuroendocrinology. vol 63. 2016-10-19. PMID:26454419. |
in response to stress, a multitude of serotonergic systems reacted with increased tph2 activity, but the stress-, anxiety-, and learned helplessness-related dorsal and caudal dr (drd/drc) displayed stress-induced increases in tph2 activity only after chronic cort-treatment. |
2016-10-19 |
2023-08-13 |
rat |
| Boris Mlinar, Alberto Montalbano, Lukasz Piszczek, Cornelius Gross, Renato Corradett. Firing Properties of Genetically Identified Dorsal Raphe Serotonergic Neurons in Brain Slices. Frontiers in cellular neuroscience. vol 10. 2016-08-18. PMID:27536220. |
in order to examine in an unbiased manner whether serotonergic neurons of the dorsal raphe nucleus (drn) are heterogeneous, we used a non-invasive loose-seal cell-attached method to record α1 adrenergic receptor-stimulated spiking of a large sample of neurons in brain slices obtained from transgenic mice lines that express fluorescent marker proteins under the control of serotonergic system-specific tph2 and pet-1 promoters. |
2016-08-18 |
2023-08-13 |
mouse |
| Karlene T Barrett, Ryan T Dosumu-Johnson, J Andrew Daubenspeck, Rachael D Brust, Vasileios Kreouzis, Jun Chul Kim, Aihua Li, Susan M Dymecki, Eugene E Natti. Partial Raphe Dysfunction in Neurotransmission Is Sufficient to Increase Mortality after Anoxic Exposures in Mice at a Critical Period in Postnatal Development. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 36. issue 14. 2016-08-15. PMID:27053202. |
these used recombinase drivers targeted different portions of medullary raphe serotonergic, tryptophan hydroxylase 2 (tph2)(+) neurons by postnatal day (p) 5 through p12: approximately one-third in triple transgenic pet1::flpe, hβactin::cre, rc::pftox mice; approximately three-fourths inslc6a4::cre, rc::ptox mice; with the first model capturing a near equal number of pet1(+),tph2(+) versus pet1(+),tph2(low or negative) raphe cells. |
2016-08-15 |
2023-08-13 |
mouse |
| Maria Nobile, Valentina Bianchi, Dario Monzani, Silvana Beri, Monica Bellina, Andrea Greco, Paola Colombo, Alessandra Tesei, Daniela Caldirola, Roberto Giorda, Giampaolo Perna, Massimo Molten. Effect of family structure and TPH2 G-703T on the stability of dysregulation profile throughout adolescence. Journal of affective disorders. vol 190. 2016-08-09. PMID:26583347. |
two different polymorphisms (tph2 g-703t and 5-httlpr) involved in the serotonergic pathway have been reported to play a role, both alone and in interaction with the environment, in early and adult emotion regulation. |
2016-08-09 |
2023-08-13 |
Not clear |
| Meiju Zhu, Hongzhu Zhu, Ninghua Tan, Hui Wang, Hongbiao Chu, Chonglin Zhan. Central anti-fatigue activity of verbascoside. Neuroscience letters. vol 616. 2016-08-04. PMID:26827721. |
in this study, the effects of verbascoside on treadmill exercise endurance, 5-hydroxytryptamine (5-ht) concentrations, the second isoforms of tryptophan hydroxylase (tph2) and serotonergic type 1b inhibitory autoreceptors (5-ht1b) protein expression in the caudate putamen of exercised rats were investigated. |
2016-08-04 |
2023-08-13 |
rat |
| Isabelle E Bauer, David P Graham, Jair C Soares, David A Nielse. Serotonergic gene variation in substance use pharmacotherapy: a systematic review. Pharmacogenomics. vol 16. issue 11. 2016-06-29. PMID:26265436. |
current evidence suggests that genetic variability of the serotonergic biosynthesis enzyme tryptophan hydroxylase 2 (tph2) and the serotonin transporter (slc6a4) genes mediates the efficacy of several addiction treatments, such as ondansetron and disulfiram, and the antidepressants bupropion, nortriptyline and sertraline. |
2016-06-29 |
2023-08-13 |
Not clear |
| Andras David Nagy, Ayaka Iwamoto, Misato Kawai, Ryosei Goda, Haruka Matsuo, Tsuyoshi Otsuka, Mao Nagasawa, Mitsuhiro Furuse, Shinobu Yasu. Melatonin adjusts the expression pattern of clock genes in the suprachiasmatic nucleus and induces antidepressant-like effect in a mouse model of seasonal affective disorder. Chronobiology international. vol 32. issue 4. 2016-02-16. PMID:25515595. |
melatonin treatments altered the expression of genes of serotonergic neurotransmission in the dorsal raphe (tph2, sert, vmat2 and 5ht1a) and serotonin contents in the amygdala. |
2016-02-16 |
2023-08-13 |
mouse |
| D A Nielsen, M J Harding, S C Hamon, W Huang, T R Koste. Modifying the role of serotonergic 5-HTTLPR and TPH2 variants on disulfiram treatment of cocaine addiction: a preliminary study. Genes, brain, and behavior. vol 11. issue 8. 2015-11-30. PMID:22925276. |
modifying the role of serotonergic 5-httlpr and tph2 variants on disulfiram treatment of cocaine addiction: a preliminary study. |
2015-11-30 |
2023-08-12 |
Not clear |
| Barbara Pelosi, Sara Migliarini, Giulia Pacini, Marta Pratelli, Massimo Pasqualett. Generation of Pet1210-Cre transgenic mouse line reveals non-serotonergic expression domains of Pet1 both in CNS and periphery. PloS one. vol 9. issue 8. 2015-11-30. PMID:25098329. |
in the mouse, pet1 mrna expression appears between 10 and 11 days post coitum (dpc) in serotonergic post-mitotic precursors and persists in serotonergic neurons up to adulthood, where it promotes the expression of genes defining the mature serotonergic phenotype such as tryptophan hydroxylase 2 (tph2) and serotonin transporter (sert). |
2015-11-30 |
2023-08-13 |
mouse |
| Ichiro Kaneko, Marya S Sabir, Christopher M Dussik, G Kerr Whitfield, Amitis Karrys, Jui-Cheng Hsieh, Mark R Haussler, Mark B Meyer, J Wesley Pike, Peter W Jurutk. 1,25-Dihydroxyvitamin D regulates expression of the tryptophan hydroxylase 2 and leptin genes: implication for behavioral influences of vitamin D. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 29. issue 9. 2015-11-25. PMID:26071405. |
brain tph2 mrna, encoding the rate-limiting enzyme in serotonin synthesis, was induced 2.2-fold by 10 nm 1,25d in human u87 glioblastoma cells and 47.8-fold in rat serotonergic rn46a-b14 cells. |
2015-11-25 |
2023-08-13 |
mouse |
| Peiyan Wong, Ying Sze, Laura Jane Gray, Cecilia Chin Roei Chang, Shiwei Cai, Xiaodong Zhan. Early life environmental and pharmacological stressors result in persistent dysregulations of the serotonergic system. Frontiers in behavioral neuroscience. vol 9. 2015-05-12. PMID:25964750. |
here, we investigate the interactions between the stress and serotonergic systems by characterizing the behavioral and biochemical effects of chronic stress applied during early-life or adulthood in wild type (wt) mice and mice with deficient tryptophan hydroxylase 2 (tph2) function. |
2015-05-12 |
2023-08-13 |
mouse |
| Jonas Waider, Florian Proft, Georg Langlhofer, Esther Asan, Klaus-Peter Lesch, Lise Gutknech. GABA concentration and GABAergic neuron populations in limbic areas are differentially altered by brain serotonin deficiency in Tph2 knockout mice. Histochemistry and cell biology. vol 139. issue 2. 2014-12-17. PMID:23052836. |
while tryptophan hydroxylase-2 (tph2) null mutant (tph2(-/-)) mice are completely deficient in brain serotonin (5-ht) synthesis, the formation of serotonergic neurons and pathfinding of their projections are not impaired. |
2014-12-17 |
2023-08-12 |
mouse |
| Yun-Fang Jia, Ning-Ning Song, Rong-Rong Mao, Jin-Nan Li, Qiong Zhang, Ying Huang, Lei Zhang, Hui-Li Han, Yu-Qiang Ding, Lin X. Abnormal anxiety- and depression-like behaviors in mice lacking both central serotonergic neurons and pancreatic islet cells. Frontiers in behavioral neuroscience. vol 8. 2014-10-08. PMID:25294992. |
mice lacking either 5-ht or central serotonergic neurons were generated by conditional deletion of tph2 or lmx1b respectively. |
2014-10-08 |
2023-08-13 |
mouse |
| Joon W Shim, Todd R Dodge, Max A Hammond, Joseph M Wallace, Feng C Zhou, Hiroki Yokot. Physical weight loading induces expression of tryptophan hydroxylase 2 in the brain stem. PloS one. vol 9. issue 1. 2014-09-02. PMID:24416346. |
focusing on serotonergic signaling, we addressed a question: does local mechanical loading to the skeleton elevate expression of tryptophan hydroxylase 2 (tph2) that is a rate-limiting enzyme for brain serotonin? |
2014-09-02 |
2023-08-12 |
mouse |
| Joon W Shim, Todd R Dodge, Max A Hammond, Joseph M Wallace, Feng C Zhou, Hiroki Yokot. Physical weight loading induces expression of tryptophan hydroxylase 2 in the brain stem. PloS one. vol 9. issue 1. 2014-09-02. PMID:24416346. |
in this study we provided evidence that peripheral mechanical loading can activate central tph2 expression, suggesting that physical cues may mediate tph2-cathalyzed serotonergic signaling in the brain. |
2014-09-02 |
2023-08-12 |
mouse |
| Marta Sadkowski, Brittany Dennis, Robert C Clayden, Wala Elsheikh, Sumathy Rangarajan, Jane Dejesus, Zainab Samaa. The role of the serotonergic system in suicidal behavior. Neuropsychiatric disease and treatment. vol 9. 2014-06-24. PMID:24235834. |
these genes - tph1, tph2, slc6a4, slc18a2, htr1a, htr1b, htr2a, ddc, maoa, and maob - encode proteins that are vital to serotonergic function: tryptophan hydroxylase; the serotonin transporter 5-htt; the vesicular transporter vmat2; the htr1a, htr1b, and htr2a receptors; the l-amino acid decarboxylase; and the monoamine oxidases. |
2014-06-24 |
2023-08-12 |
Not clear |
| Niki Antypa, Alessandro Serretti, Dan Rujesc. Serotonergic genes and suicide: a systematic review. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 23. issue 10. 2014-04-24. PMID:23742855. |
in this paper, we review evidence from studies examining the association between various serotonergic genes (tryptophan hydroxylase genes: tph1; tph2, serotonin transporter gene: 5-httlpr in slc6a4, serotonin receptor genes: htr1a, htr2a, htr1b, htr2c and monoamine oxidase a gene: maoa) and suicidal behavior. |
2014-04-24 |
2023-08-12 |
Not clear |
| Ul'yana A Boyarskikh, Natalya P Bondar, Maxim L Filipenko, Natalia N Kudryavtsev. Downregulation of serotonergic gene expression in the Raphe nuclei of the midbrain under chronic social defeat stress in male mice. Molecular neurobiology. vol 48. issue 1. 2014-02-12. PMID:23392607. |
the serotonergic genes were the tph2, sert, maoa, and htr1a. |
2014-02-12 |
2023-08-12 |
mouse |