| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Seong W Kang, Karen D Christensen, Douglas Aldridge, Wayne J Kuenze. Effects of light intensity and dual light intensity choice on plasma corticosterone, central serotonergic and dopaminergic activities in birds, Gallus gallus. General and comparative endocrinology. vol 285. 2020-03-13. PMID:31557469. |
differential tph2 expression in the drn and crn observed in the dlic birds indicate a significant effect of dlic lighting program on the serotonergic activity in the avian brainstem. |
2020-03-13 |
2023-08-13 |
Not clear |
| Seong W Kang, Karen D Christensen, Douglas Aldridge, Wayne J Kuenze. Effects of light intensity and dual light intensity choice on plasma corticosterone, central serotonergic and dopaminergic activities in birds, Gallus gallus. General and comparative endocrinology. vol 285. 2020-03-13. PMID:31557469. |
taken together, temporal and spatial regulation of tph2 and th expression by dlic lighting program indicate that compensatory regulation of serotonergic and dopaminergic activities might be involved in the light intensity preference behavior of birds, suggesting a possible beneficial effect of the dlic lighting program on broiler welfare. |
2020-03-13 |
2023-08-13 |
Not clear |
| Afërdita Goçi Uka, Ferid Agani, Afrim Blyta, Blerina Hoxha, Shpend Haxhibeqiri, Valdete Haxhibeqiri, Emina Sabic Dzananovic, Sabina Kucukalic, Alma Bravo Mehmedbasic, Abdulah Kucukalic, Alma Dzubur-Kulenovic, Elma Feric Bojic, Damir Marjanovic, Nermina Kravic, Esmina Avdibegovic, Mirnesa Muminovic Umihanic, Nenad Jaksic, Ana Cima Franc, Dusko Rudan, Miro Jakovljevic, Romana Babic, Marko Pavlovic, Dragan Babic, Branka Aukst Margetic, Nada Bozina, Osman Sinanovic, Christiane Ziegler, Bodo Warrings, Katharina Domschke, Jürgen Deckert, Christiane Wol. Role of the Allelic Variation in the 5-Hydroxytryptamine Receptor 1A (HTR1A) and the Tryptophan Hydroxylase 2 (TPH2) Genes in the Development of PTSD. Psychiatria Danubina. vol 31. issue 2. 2019-09-16. PMID:31291234. |
the aim of this study was to investigate the potential role of single nucleotide polymorphisms (snps) of the two serotonergic candidate genes 5-hydroxytryptamine receptor 1a (htr1a) and tryptophan hydroxylase 2 (tph2) in the pathogenesis of ptsd and comorbid psychopathology. |
2019-09-16 |
2023-08-13 |
Not clear |
| Ryosuke Morinaga, Nobuaki Nakamuta, Yoshio Yamamot. Serotonergic projections to the ventral respiratory column from raphe nuclei in rats. Neuroscience research. vol 143. 2019-07-23. PMID:29803764. |
in the present study, to elucidate detailed distribution of serotonergic neurons in raphe nuclei projecting to the various rostrocaudal levels of vrc, we performed combination of retrograde tracing technique by cholera toxin b subunit (ctb) with immunohistochemistry for tryptophan hydroxylase 2 (tph2). |
2019-07-23 |
2023-08-13 |
rat |
| Marta Pratelli, Massimo Pasqualett. Serotonergic neurotransmission manipulation for the understanding of brain development and function: Learning from Tph2 genetic models. Biochimie. vol 161. 2019-07-08. PMID:30513372. |
serotonergic neurotransmission manipulation for the understanding of brain development and function: learning from tph2 genetic models. |
2019-07-08 |
2023-08-13 |
human |
| Marta Pratelli, Massimo Pasqualett. Serotonergic neurotransmission manipulation for the understanding of brain development and function: Learning from Tph2 genetic models. Biochimie. vol 161. 2019-07-08. PMID:30513372. |
in the present review we describe how the discovery of tph2 has improved our understanding on the role of serotonergic neurotransmission. |
2019-07-08 |
2023-08-13 |
human |
| Maria Teresa Plana, Teresa Torres, Natalia Rodríguez, Daniel Boloc, Patricia Gassó, Elena Moreno, Amalia Lafuente, Josefina Castro-Fornieles, Sergi Mas, Luisa Lazar. Genetic variability in the serotoninergic system and age of onset in anorexia nervosa and obsessive-compulsive disorder. Psychiatry research. vol 271. 2019-04-23. PMID:30554102. |
following on from previous work by our group where we showed that early onset anorexia nervosa (an) and obsessive-compulsive disorder (ocd) shared a common genetic background, the aim of the present study is to assess genetic pleiotropy related to the serotonergic system (slc6a4, 5htr2a, 5htr2c, tph2, slc18a1), in a common phenotype such as very-early age of onset. |
2019-04-23 |
2023-08-13 |
Not clear |
| Jennyfer M Payet, Eliza Burnie, Nick J Sathananthan, Adrian M Russo, Adam J Lawther, Stephen Kent, Christopher A Lowry, Matthew W Hal. Exposure to Acute and Chronic Fluoxetine has Differential Effects on Sociability and Activity of Serotonergic Neurons in the Dorsal Raphe Nucleus of Juvenile Male BALB/c Mice. Neuroscience. vol 386. 2019-03-11. PMID:29940216. |
for the second cohort, brain tissue was collected ninety minutes after the onset of the social phase of the sat and prepared for immunohistochemical staining for c-fos and tph2 to measure the activation of serotonergic neurons within subregions of the dr. |
2019-03-11 |
2023-08-13 |
mouse |
| Jennyfer M Payet, Eliza Burnie, Nick J Sathananthan, Adrian M Russo, Adam J Lawther, Stephen Kent, Christopher A Lowry, Matthew W Hal. Exposure to Acute and Chronic Fluoxetine has Differential Effects on Sociability and Activity of Serotonergic Neurons in the Dorsal Raphe Nucleus of Juvenile Male BALB/c Mice. Neuroscience. vol 386. 2019-03-11. PMID:29940216. |
furthermore, acute and chronic fluoxetine treatments were without effect on tph2 activity but differentially affected populations of serotonergic neurons in the dr. |
2019-03-11 |
2023-08-13 |
mouse |
| Mihye Ko, Smi Choi-Kwon, Sang-Eun Jun, Ju Han Kim, Kyung-Hee Cho, Hyun-Wook Nah, Hasup Song, Jong S Ki. Poststroke emotional disturbances and a tryptophan hydroxylase 2 gene polymorphism. Brain and behavior. vol 8. issue 2. 2019-02-11. PMID:29484259. |
despite reports on serotonergic involvement in the etiology of poststroke emotional dysfunction (psed), the role of serotonin synthesizing tryptophan hydroxylase 2 (tph2) genes in the development of psed remains unclear. |
2019-02-11 |
2023-08-13 |
Not clear |
| Koen Willem Ottenhof, Mari Sild, Mélissa Luce Lévesque, Henricus Gerardus Ruhé, Linda Booi. TPH2 polymorphisms across the spectrum of psychiatric morbidity: A systematic review and meta-analysis. Neuroscience and biobehavioral reviews. vol 92. 2019-02-11. PMID:29775696. |
characterizing how exactly the different tph2 variants influence the serotonergic neurotransmission is a next necessary step in understanding the psychiatric disorders where serotonin is implicated. |
2019-02-11 |
2023-08-13 |
Not clear |
| J H Piel, T A Lett, C Wackerhagen, M M Plichta, S Mohnke, O Grimm, N Romanczuk-Seiferth, F Degenhardt, H Tost, S Witt, M Nöthen, M Rietschel, A Heinz, A Meyer-Lindenberg, H Walter, S Er. The effect of 5-HTTLPR and a serotonergic multi-marker score on amygdala, prefrontal and anterior cingulate cortex reactivity and habituation in a large, healthy fMRI cohort. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 28. issue 3. 2019-01-29. PMID:29358097. |
while effects of 5-httlpr and of a serotonergic multi-marker score (5-httlpr, tph1(rs1800532), tph2(rs4570625), htr1a(rs6295) and htr2a(rs6311)) on amygdala activation did not withstand correction for multiple regions of interest, we observed a strong correlation of the multi-marker score and habituation in the amygdala, dlpfc, and acc. |
2019-01-29 |
2023-08-13 |
human |
| R Slopień, A Rózycka, A Slopień, M Pawlak, A Warenik-Szymankiewicz, S Sajdak, P Jagodzińsk. The genetic background of climacteric symptoms in women during menopause. Clinical and experimental obstetrics & gynecology. vol 43. issue 4. 2018-06-20. PMID:29734534. |
among the candidate genes in the aetiology of depression the following were selected for the research: the serotonergic system receptor genes: 5htr2a, 5htr1b, 5htr2c, tph 1, tph2, and mao-a; the genes of noradrenergic and dopaminergic systems (comt, net), the genes of the gabaergic (gabrbl) system, a gene of the estrogen receptor (esr1), and the genes of the enzymes crucial in the methyl cycle (mthrf, mtr, and mthfd1). |
2018-06-20 |
2023-08-13 |
human |
| James H Fox, James E Hassell, Philip H Siebler, Mathew R Arnold, Andrew K Lamb, David G Smith, Heidi E W Day, Tessa M Smith, Emma M Simmerman, Alexander A Outzen, Kaley S Holmes, Christopher J Brazell, Christopher A Lowr. Preimmunization with a heat-killed preparation of Mycobacterium vaccae enhances fear extinction in the fear-potentiated startle paradigm. Brain, behavior, and immunity. vol 66. 2018-06-06. PMID:28888667. |
rats were euthanized on day 11 and brain tissue was sectioned for analysis of mrna expression for genes important in control of brain serotonergic signaling, including tph2, htr1a, slc6a4, and slc22a3, throughout the brainstem dorsal and median raphe nuclei. |
2018-06-06 |
2023-08-13 |
mouse |
| Patricia Gassó, Natalia Rodríguez, Daniel Boloc, Ana Blázquez, Teresa Torres, Ana Gortat, Maria Teresa Plana, Amalia Lafuente, Sergi Mas, Joan Albert Arnaiz, Luisa Lázar. Association of regulatory TPH2 polymorphisms with higher reduction in depressive symptoms in children and adolescents treated with fluoxetine. Progress in neuro-psychopharmacology & biological psychiatry. vol 77. 2018-03-05. PMID:28456685. |
tph2 is one of the most important serotonergic candidate genes in selective serotonin reuptake inhibitors (ssris) pharmacogenetic studies. |
2018-03-05 |
2023-08-13 |
human |
| Tomas Furmark, Ina Marteinsdottir, Andreas Frick, Kerstin Heurling, Maria Tillfors, Lieuwe Appel, Gunnar Antoni, Per Hartvig, Håkan Fischer, Bengt Långström, Elias Eriksson, Mats Fredrikso. Serotonin synthesis rate and the tryptophan hydroxylase-2: G-703T polymorphism in social anxiety disorder. Journal of psychopharmacology (Oxford, England). vol 30. issue 10. 2017-12-28. PMID:27189957. |
our results support that social anxiety disorder entails an overactive presynaptic serotonergic system that, in turn, seems functionally influenced by the tph2 g-703t polymorphism in emotionally relevant brain regions. |
2017-12-28 |
2023-08-13 |
Not clear |
| Victoria S Marshe, Malgorzata Maciukiewicz, Soham Rej, Arun K Tiwari, Etienne Sibille, Daniel M Blumberger, Jordan F Karp, Eric J Lenze, Charles F Reynolds, James L Kennedy, Benoit H Mulsant, Daniel J Mülle. Norepinephrine Transporter Gene Variants and Remission From Depression With Venlafaxine Treatment in Older Adults. The American journal of psychiatry. vol 174. issue 5. 2017-06-19. PMID:28068779. |
a secondary objective was to analyze 17 other variants in serotonergic system genes (htr1a, htr2a, htr1b, htr2c, tph1, tph2) potentially involved in the mechanism of action of venlafaxine. |
2017-06-19 |
2023-08-13 |
Not clear |
| Maeson S Latsko, T Lee Gilman, Lindsey M Matt, K Maria Nylocks, Karin G Coifman, Aaron M Jasno. A Novel Interaction between Tryptophan Hydroxylase 2 (TPH2) Gene Polymorphism (rs4570625) and BDNF Val66Met Predicts a High-Risk Emotional Phenotype in Healthy Subjects. PloS one. vol 11. issue 10. 2017-06-14. PMID:27695066. |
moreover, polymorphisms in the tph2 gene may have greater influence on serotonergic function than other more commonly studied polymorphisms (e.g., 5-httlpr). |
2017-06-14 |
2023-08-13 |
mouse |
| Ruey-Kuang Cheng, Seetha Krishnan, Suresh Jesuthasa. Activation and inhibition of tph2 serotonergic neurons operate in tandem to influence larval zebrafish preference for light over darkness. Scientific reports. vol 6. 2016-12-30. PMID:26868164. |
activation and inhibition of tph2 serotonergic neurons operate in tandem to influence larval zebrafish preference for light over darkness. |
2016-12-30 |
2023-08-13 |
zebrafish |
| Ruey-Kuang Cheng, Seetha Krishnan, Suresh Jesuthasa. Activation and inhibition of tph2 serotonergic neurons operate in tandem to influence larval zebrafish preference for light over darkness. Scientific reports. vol 6. 2016-12-30. PMID:26868164. |
in particular, these results suggest that fish prefer swimming in conditions that elicits lower activity in tph2 serotonergic neurons in the rostral raphe. |
2016-12-30 |
2023-08-13 |
zebrafish |