| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ryoko Hiroi, Robert J Hand. Estrogen receptor-β regulates human tryptophan hydroxylase-2 through an estrogen response element in the 5' untranslated region. Journal of neurochemistry. vol 127. issue 4. 2014-01-06. PMID:24033289. |
a serotonergic cell line, b14, which endogenously expresses erβ was transiently transfected with a fragment of the human tph2 5'-untranslated region (5'-utr) cloned into a luciferase reporter vector (tph2-luc). |
2014-01-06 |
2023-08-12 |
human |
| Sebastiaan Engelborghs, Kristel Sleegers, Stefan Van der Mussele, Nathalie Le Bastard, Nathalie Brouwers, Christine Van Broeckhoven, Peter Paul De Dey. Brain-specific tryptophan hydroxylase, TPH2, and 5-HTTLPR are associated with frontal lobe symptoms in Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 35. issue 1. 2013-12-27. PMID:23334703. |
a prospective, longitudinal study was set up to investigate possible genetic associations of behavioral and psychological signs and symptoms of dementia (bpsd) in alzheimer's disease (ad) with two candidate genes in the serotonergic neurotransmitter pathway: serotonin transporter (slc6a4) and brain-specific tryptophan hydroxylase (tph2). |
2013-12-27 |
2023-08-12 |
Not clear |
| Sebastiaan Engelborghs, Kristel Sleegers, Stefan Van der Mussele, Nathalie Le Bastard, Nathalie Brouwers, Christine Van Broeckhoven, Peter Paul De Dey. Brain-specific tryptophan hydroxylase, TPH2, and 5-HTTLPR are associated with frontal lobe symptoms in Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 35. issue 1. 2013-12-27. PMID:23334703. |
the present prospective, longitudinal study showed that mainly frontal lobe symptoms were significantly associated with tph2 and 5-httlpr polymorphisms, pointing toward a role of the serotonergic neurotransmitter system in the pathophysiology of frontal lobe symptoms in ad. |
2013-12-27 |
2023-08-12 |
Not clear |
| Naozumi Araragi, Klaus-Peter Lesc. Serotonin (5-HT) in the regulation of depression-related emotionality: insight from 5-HT transporter and tryptophan hydroxylase-2 knockout mouse models. Current drug targets. vol 14. issue 5. 2013-10-29. PMID:23547810. |
moreover, the recent advent of knockout (ko) mice for tryptophan hydroxylase 2 (tph2 ko), which lacks the rate-limiting enzyme for 5-ht synthesis in the brain, has further provided insight to the brain serotonergic system and its role in emotion dysregulation. |
2013-10-29 |
2023-08-12 |
mouse |
| J L Lukkes, J M Kopelman, N C Donner, M W Hale, C A Lowr. Development × environment interactions control tph2 mRNA expression. Neuroscience. vol 237. 2013-09-23. PMID:23403177. |
these data suggest that adolescent social isolation alters tph2 expression in specific subregions of the dr and alters the effects of stress-related stimuli on behavior and serotonergic systems. |
2013-09-23 |
2023-08-12 |
rat |
| Lise Gutknecht, Naozumi Araragi, Sören Merker, Jonas Waider, Frank M J Sommerlandt, Boris Mlinar, Gilda Baccini, Ute Mayer, Florian Proft, Michel Hamon, Angelika G Schmitt, Renato Corradetti, Laurence Lanfumey, Klaus-Peter Lesc. Impacts of brain serotonin deficiency following Tph2 inactivation on development and raphe neuron serotonergic specification. PloS one. vol 7. issue 8. 2013-05-01. PMID:22912815. |
impacts of brain serotonin deficiency following tph2 inactivation on development and raphe neuron serotonergic specification. |
2013-05-01 |
2023-08-12 |
mouse |
| Lise Gutknecht, Naozumi Araragi, Sören Merker, Jonas Waider, Frank M J Sommerlandt, Boris Mlinar, Gilda Baccini, Ute Mayer, Florian Proft, Michel Hamon, Angelika G Schmitt, Renato Corradetti, Laurence Lanfumey, Klaus-Peter Lesc. Impacts of brain serotonin deficiency following Tph2 inactivation on development and raphe neuron serotonergic specification. PloS one. vol 7. issue 8. 2013-05-01. PMID:22912815. |
to further analyze the importance of brain 5-ht in somatic and brain development and function, and more specifically differentiation and specification of the serotonergic system itself, we generated a mouse model with brain-specific 5-ht deficiency resulting from a genetically driven constitutive inactivation of neuronal tryptophan hydroxylase-2 (tph2). |
2013-05-01 |
2023-08-12 |
mouse |
| Lise Gutknecht, Naozumi Araragi, Sören Merker, Jonas Waider, Frank M J Sommerlandt, Boris Mlinar, Gilda Baccini, Ute Mayer, Florian Proft, Michel Hamon, Angelika G Schmitt, Renato Corradetti, Laurence Lanfumey, Klaus-Peter Lesc. Impacts of brain serotonin deficiency following Tph2 inactivation on development and raphe neuron serotonergic specification. PloS one. vol 7. issue 8. 2013-05-01. PMID:22912815. |
the conserved expression pattern of the 5-ht neuron-specific markers (except tph2 and 5-ht) demonstrates that brain 5-ht synthesis is not a prerequisite for the proliferation, differentiation and survival of raphe neurons subjected to the developmental program of serotonergic specification. |
2013-05-01 |
2023-08-12 |
mouse |
| Kafui Dzirasa, Sunil Kumar, Benjamin D Sachs, Marc G Caron, Miguel A L Nicoleli. Cortical-amygdalar circuit dysfunction in a genetic mouse model of serotonin deficiency. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 10. 2013-04-26. PMID:23467366. |
although the majority of first-line antidepressants increase brain serotonin and rare polymorphisms in tryptophan hydroxlase-2 (tph2), the rate-limiting enzyme in the brain serotonin synthesis pathway, have been identified in cohorts of subjects with major depressive disorder, the circuit level alterations that results from serotonergic hypofunction remain poorly understood. |
2013-04-26 |
2023-08-12 |
mouse |
| Stefan M Berger, Tillmann Weber, Stephanie Perreau-Lenz, Miriam A Vogt, Sarah E Gartside, Christiane Maser-Gluth, Laurence Lanfumey, Peter Gass, Rainer Spanagel, Dusan Bartsc. A functional Tph2 C1473G polymorphism causes an anxiety phenotype via compensatory changes in the serotonergic system. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 37. issue 9. 2013-03-17. PMID:22491354. |
a functional tph2 c1473g polymorphism causes an anxiety phenotype via compensatory changes in the serotonergic system. |
2013-03-17 |
2023-08-12 |
mouse |
| Maria Teresa Gentile, Yukino Nawa, Gianluigi Lunardi, Tullio Florio, Hiroaki Matsui, Luca Colucci-D'Amat. Tryptophan hydroxylase 2 (TPH2) in a neuronal cell line: modulation by cell differentiation and NRSF/rest activity. Journal of neurochemistry. vol 123. issue 6. 2013-02-14. PMID:22958208. |
thus, insights into the mechanisms that specifically regulate tph2 expression and its modulation by exogenous stimuli may represent a new therapeutic approach to modify serotonergic neurotransmission. |
2013-02-14 |
2023-08-12 |
human |
| Zhi Xu, Zhijun Zhang, Yanyan Shi, Mengjia Pu, Yonggui Yuan, Xiangrong Zhang, Lingjiang Li, Gavin P Reynold. Influence and interaction of genetic polymorphisms in the serotonin system and life stress on antidepressant drug response. Journal of psychopharmacology (Oxford, England). vol 26. issue 3. 2012-08-03. PMID:21937687. |
in total, 14 single nucleotide polymorphisms (snps) in coding regions of 10 serotonergic genes (htr1a, htr1b, htr1d, htr2a, htr3a, htr3c, htr3d, htr3e, htr5a and tph2) were genotyped in 308 chinese han patients with major depressive disorder. |
2012-08-03 |
2023-08-12 |
human |
| Qi Wu, Michael S Clark, Richard D Palmite. Deciphering a neuronal circuit that mediates appetite. Nature. vol 483. issue 7391. 2012-05-08. PMID:22419158. |
blockade of serotonin (5-ht(3)) receptor signalling in the nts by either the chronic administration of ondansetron or the genetic inactivation of tph2 in caudal serotonergic neurons that project to the nts protects against starvation when agrp neurons are ablated. |
2012-05-08 |
2023-08-12 |
mouse |
| Margaret Czesak, Brice Le François, Anne M Millar, Mariam Deria, Mireille Daigle, Jane E Visvader, Hymie Anisman, Paul R Alber. Increased serotonin-1A (5-HT1A) autoreceptor expression and reduced raphe serotonin levels in deformed epidermal autoregulatory factor-1 (Deaf-1) gene knock-out mice. The Journal of biological chemistry. vol 287. issue 9. 2012-04-25. PMID:22232550. |
in the dorsal raphe, deaf-1 knock-out mice displayed increased 5-ht1a mrna, protein, and 5-ht1a-positive cell counts but reduced 5-ht levels, whereas other serotonergic markers, such as tryptophan hydroxylase (tph)- or 5-ht-positive cells and tph2 rna levels, were unchanged. |
2012-04-25 |
2023-08-12 |
mouse |
| X Zhang, P J Nicholls, G Laje, T D Sotnikova, R R Gainetdinov, P R Albert, G Rajkowska, C A Stockmeier, M C Speer, D C Steffens, M C Austin, F J McMahon, K R R Krishnan, M A Garcia-Blanco, M G Caro. A functional alternative splicing mutation in human tryptophan hydroxylase-2. Molecular psychiatry. vol 16. issue 12. 2012-03-27. PMID:20856248. |
the tryptophan hydroxylase-2 (tph2) gene is the rate-limiting enzyme in brain 5-ht synthesis, and thus is an ideal candidate gene for understanding the role of dysregulation of brain serotonergic homeostasis. |
2012-03-27 |
2023-08-12 |
human |
| Ali Jahanshahi, Erwan Le Maitre, Yasin Temel, Laurence Lanfumey, Michel Hamon, Klaus-Peter Lesch, Rosa M Tordera, Joaquín Del Río, Ester Aso, Rafael Maldonado, Tomas Hökfelt, Harry W M Steinbusc. Altered expression of neuronal tryptophan hydroxylase-2 mRNA in the dorsal and median raphe nuclei of three genetically modified mouse models relevant to depression and anxiety. Journal of chemical neuroanatomy. vol 41. issue 4. 2012-02-22. PMID:21704153. |
our results show quantitative modifications in tph2 mrna expression in the three main subregions of the drn as well as the mrn in relation to changes in serotonergic, glutamatergic and endocannabinoid neurotransmission systems. |
2012-02-22 |
2023-08-12 |
mouse |
| Elisabeth M Dykens, Elizabeth Roof, Douglas Bittel, Merlin G Butle. TPH2 G/T polymorphism is associated with hyperphagia, IQ, and internalizing problems in Prader-Willi syndrome. Journal of child psychology and psychiatry, and allied disciplines. vol 52. issue 5. 2011-08-18. PMID:21418060. |
as aberrant serotonergic functioning is strongly implicated in pws, we examined associations between the pws phenotype and polymorphisms in tryptophan hydroxylase 2 (tph2), the rate-limiting enzyme in the biosynthesis of serotonin in the brain. |
2011-08-18 |
2023-08-12 |
Not clear |
| Nurgul Carkaci-Salli, Ugur Salli, Kara L Kuntz-Melcavage, Michael M Pennock, Hande Ozgen, Izel Tekin, Willard M Freeman, Kent E Vran. TPH2 in the ventral tegmental area of the male rat brain. Brain research bulletin. vol 84. issue 6. 2011-07-18. PMID:21272616. |
the results of this study indicate that tph2 and serotonergic signaling may play an important role in the mesolimbic/mesocortical reward pathway. |
2011-07-18 |
2023-08-12 |
rat |
| Jonas Waider, Naozumi Araragi, Lise Gutknecht, Klaus-Peter Lesc. Tryptophan hydroxylase-2 (TPH2) in disorders of cognitive control and emotion regulation: a perspective. Psychoneuroendocrinology. vol 36. issue 3. 2011-06-21. PMID:21257271. |
findings from psychophysiological and functional imaging studies are indicative of various tph2 polymorphisms directly influencing serotonergic function and thus impacting on mood disorders and on the response to antidepressant treatment. |
2011-06-21 |
2023-08-12 |
mouse |
| Tomaž Zupanc, Peter Pregelj, Martina Tomori, Radovan Komel, Alja Videtič Pask. TPH2 polymorphisms and alcohol-related suicide. Neuroscience letters. vol 490. issue 1. 2011-05-04. PMID:21182896. |
in conclusion, our results suggest implication of polymorphisms in suicide and alcohol-related suicide, but further studies are needed to clarify the interplay among serotonergic system disfunction, suicide, alcohol dependence, impulsivity and the role of tph2 enzyme. |
2011-05-04 |
2023-08-12 |
Not clear |