| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Camille M Lowy, Thordur Oskarsso. Tenascin C in metastasis: A view from the invasive front. Cell adhesion & migration. vol 9. issue 1-2. 2015-12-16. PMID:25738825. |
tnc is a compelling example of how an extracellular matrix protein can provide a molecular context that is imperative to cancer cell fitness in metastasis. |
2015-12-16 |
2023-08-13 |
mouse |
| Taizo Kimura, Kozoh Shiraishi, Aya Furusho, Sohei Ito, Saki Hirakata, Norifumi Nishida, Koichi Yoshimura, Kyoko Imanaka-Yoshida, Toshimichi Yoshida, Yasuhiro Ikeda, Takanobu Miyamoto, Takafumi Ueno, Kimikazu Hamano, Michiaki Hiroe, Kazutaka Aonuma, Masunori Matsuzaki, Tsutomu Imaizumi, Hiroki Aok. Tenascin C protects aorta from acute dissection in mice. Scientific reports. vol 4. 2015-10-07. PMID:24514259. |
deletion of tnc gene rendered mice susceptible to aad development upon the aortic stress, which was accompanied by impaired tgfβ signaling, insufficient induction of extracellular matrix proteins and exaggerated proinflammatory response. |
2015-10-07 |
2023-08-12 |
mouse |
| Alain Cuna, Brian Halloran, Ona Faye-Petersen, David Kelly, David K Crossman, Xiangqin Cui, Kusum Pandit, Naftali Kaminski, Soumyaroop Bhattacharya, Ausaf Ahmad, Thomas J Mariani, Namasivayam Ambalavana. Alterations in gene expression and DNA methylation during murine and human lung alveolar septation. American journal of respiratory cell and molecular biology. vol 53. issue 1. 2015-09-16. PMID:25387348. |
and its extracellular matrix (tnc, eln, etc. |
2015-09-16 |
2023-08-13 |
mouse |
| Y Shinohara, K Okamoto, Y Goh, N Kiga, I Tojyo, S Fujit. Inhibition of fibrous adhesion formation in the temporomandibular joint of tenascin-C knockout mice. European journal of histochemistry : EJH. vol 58. issue 4. 2015-09-16. PMID:25578971. |
tenascin-c (tnc) is a large hexameric extracellular matrix glycoprotein that is expressed in developing organs and tumors. |
2015-09-16 |
2023-08-13 |
mouse |
| Octavio Mercado-Gómez, Jorge Landgrave-Gómez, Virginia Arriaga-Avila, Adriana Nebreda-Corona, Rosalinda Guevara-Guzmá. Role of TGF-β signaling pathway on Tenascin C protein upregulation in a pilocarpine seizure model. Epilepsy research. vol 108. issue 10. 2015-08-04. PMID:25445237. |
tenascin c (tnc) is an extracellular matrix protein involved in several physiological roles and in pathological conditions. |
2015-08-04 |
2023-08-13 |
rat |
| Elena Jachetti, Sara Caputo, Stefania Mazzoleni, Chiara Svetlana Brambillasca, Sara Martina Parigi, Matteo Grioni, Ignazio Stefano Piras, Umberto Restuccia, Arianna Calcinotto, Massimo Freschi, Angela Bachi, Rossella Galli, Matteo Bellon. Tenascin-C Protects Cancer Stem-like Cells from Immune Surveillance by Arresting T-cell Activation. Cancer research. vol 75. issue 10. 2015-07-27. PMID:25808872. |
csc derived from either pdln or mpin used the extracellular matrix protein tenascin-c (tnc) to inhibit t-cell receptor-dependent t-cell activation, proliferation, and cytokine production. |
2015-07-27 |
2023-08-13 |
mouse |
| Yunhong Nong, Lang Bai, Hong Tan. [Advances in molecular mechanisms of tenascin-C in promoting tumor metastasis]. Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi. vol 32. issue 1. 2015-07-26. PMID:26040014. |
tenascin-c (tnc) is an extracellular matrix glycoprotein, which is usually highly expressed in embryonic tissues and tumor tissues, but is not expressed or just lowly expressed in mature tissues. |
2015-07-26 |
2023-08-13 |
Not clear |
| Yunhong Nong, Lang Bai, Hong Tan. [Advances in molecular mechanisms of tenascin-C in promoting tumor metastasis]. Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi. vol 32. issue 1. 2015-07-26. PMID:26040014. |
tnc is involved in various complex signaling pathways during tumor metastasis, especially through modulating fak, rhoa, wnt and notch pathways by interacting with syndecan-4, integrin α5β1, matrix metalloproteinases (mmps) and vascular endothelial growth factor (vegf). |
2015-07-26 |
2023-08-13 |
Not clear |
| Junichi Taki, Anri Inaki, Hiroshi Wakabayashi, Ichiro Matsunari, Kyoko Imanaka-Yoshida, Kazuma Ogawa, Michiaki Hiroe, Kazuhiro Shiba, Toshimichi Yoshida, Seigo Kinuy. Effect of postconditioning on dynamic expression of tenascin-C and left ventricular remodeling after myocardial ischemia and reperfusion. EJNMMI research. vol 5. 2015-04-17. PMID:25883880. |
tenascin-c (tnc), an extracellular matrix glycoprotein, is expressed transiently in distinct areas in association with active tissue remodeling. |
2015-04-17 |
2023-08-13 |
rat |
| Zhixiang Tong, Aidan B Zerdoum, Randall L Duncan, Xinqiao Ji. Dynamic vibration cooperates with connective tissue growth factor to modulate stem cell behaviors. Tissue engineering. Part A. vol 20. issue 13-14. 2015-03-04. PMID:24456068. |
the initial 3-day vibratory culture resulted in an increased production of hyaluronic acids (ha), tenascin-c (tnc), decorin (dcn), and matrix metalloproteinase-1 (mmp1). |
2015-03-04 |
2023-08-12 |
Not clear |
| Falk Saupe, Anja Schwenzer, Yundan Jia, Isabelle Gasser, Caroline Spenlé, Benoit Langlois, Martial Kammerer, Olivier Lefebvre, Ruslan Hlushchuk, Tristan Rupp, Marija Marko, Michael van der Heyden, Gérard Cremel, Christiane Arnold, Annick Klein, Patricia Simon-Assmann, Valentin Djonov, Agnès Neuville-Méchine, Irene Esposito, Julia Slotta-Huspenina, Klaus-Peter Janssen, Olivier de Wever, Gerhard Christofori, Thomas Hussenet, Gertraud Oren. Tenascin-C downregulates wnt inhibitor dickkopf-1, promoting tumorigenesis in a neuroendocrine tumor model. Cell reports. vol 5. issue 2. 2015-01-09. PMID:24139798. |
the extracellular matrix molecule tenascin-c (tnc) is a major component of the cancer-specific matrix, and high tnc expression is linked to poor prognosis in several cancers. |
2015-01-09 |
2023-08-12 |
mouse |
| Kumiko I Claycomb, Paige N Winokur, Kasey M Johnson, Alexandra M Nicaise, Anthony W Giampetruzzi, Anthony V Sacino, Evan Y Snyder, Elisa Barbarese, Ernesto R Bongarzone, Stephen J Crocke. Aberrant production of tenascin-C in globoid cell leukodystrophy alters psychosine-induced microglial functions. Journal of neuropathology and experimental neurology. vol 73. issue 10. 2014-11-21. PMID:25192051. |
microglial responses to psychosine were enhanced by tnc, as determined by an increase in globoid-like cell formation, matrix metalloproteinase-3 mrna expression, and higher toxicity toward oligodendrocytes in culture. |
2014-11-21 |
2023-08-13 |
mouse |
| Tastekin Didem, Tas Faruk, Karabulut Senem, Duranyildiz Derya, Serilmez Murat, Guveli Murat, Kaynur Oznu. Clinical significance of serum tenascin-c levels in epithelial ovarian cancer. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 35. issue 7. 2014-10-06. PMID:24722824. |
tenascin-c (tnc) is an extracellular matrix protein that is expressed at low levels in normal adult tissue but is highly expressed around many tumors including ovarian tumors. |
2014-10-06 |
2023-08-13 |
Not clear |
| M S Islam, M Kusakabe, K Horiguchi, S Iino, T Nakamura, K Iwanaga, H Hashimoto, S Matsumoto, T Murata, M Hori, H Ozak. PDGF and TGF-β promote tenascin-C expression in subepithelial myofibroblasts and contribute to intestinal mucosal protection in mice. British journal of pharmacology. vol 171. issue 2. 2014-08-26. PMID:24116743. |
tenascin-c (tnc) is a multi-domain extracellular matrix glycoprotein that is expressed at a high level during embryogenesis but is almost absent during normal postnatal life. |
2014-08-26 |
2023-08-12 |
mouse |
| Zehra Karatas, Tamer Baysal, Hayrullah Alp, Aysun Toke. Serum tenascin-C: a novel biomarker for diagnosis and predicting prognosis of rheumatic carditis? Journal of tropical pediatrics. vol 59. issue 6. 2014-04-07. PMID:23868575. |
tenascin-c (tnc) is an extracellular matrix glycoprotein that has a major role in tissue remodeling. |
2014-04-07 |
2023-08-12 |
Not clear |
| Yali Zhao, Feifan Zhao, Liang Zong, Peng Zhang, Liping Guan, Jianguo Zhang, Dayong Wang, Jing Wang, Wei Chai, Lan Lan, Qian Li, Bing Han, Ling Yang, Xin Jin, Weiyan Yang, Xiaoxiang Hu, Xiaoning Wang, Ning Li, Yingrui Li, Christine Petit, Jun Wang, Huanming Yang Jian Wang, Qiuju Wan. Exome sequencing and linkage analysis identified tenascin-C (TNC) as a novel causative gene in nonsyndromic hearing loss. PloS one. vol 8. issue 7. 2014-04-01. PMID:23936043. |
tnc encodes tenascin-c, a member of the extracellular matrix (ecm), is present in the basilar membrane (bm), and the osseous spiral lamina of the cochlea. |
2014-04-01 |
2023-08-12 |
human |
| Kan Xie, Yang Liu, Wenlin Hao, Silke Walter, Botond Penke, Tobias Hartmann, Melitta Schachner, Klaus Fassbende. Tenascin-C deficiency ameliorates Alzheimer's disease-related pathology in mice. Neurobiology of aging. vol 34. issue 10. 2014-03-25. PMID:23673309. |
tenascin-c (tnc) is an extracellular matrix protein that is upregulated in inflammation and induces further inflammatory responses. |
2014-03-25 |
2023-08-12 |
mouse |
| Masahisa Ohtsuka, Hirofumi Yamamoto, Ryota Oshiro, Hidekazu Takahashi, Toru Masuzawa, Mamoru Uemura, Naotsugu Haraguchi, Junichi Nishimura, Taishi Hata, Makoto Yamasaki, Ichiro Takemasa, Hiroshi Miyata, Tsunekazu Mizushima, Shuji Takiguchi, Yuichiro Doki, Masaki Mor. Concurrent expression of C4.4A and Tenascin-C in tumor cells relates to poor prognosis of esophageal squamous cell carcinoma. International journal of oncology. vol 43. issue 2. 2014-03-20. PMID:23708783. |
to uncover this, we performed pcr array analysis using the hct116 cell line, a positive control for c4.4a expression and we found that tenascin-c (tnc) among the many adhesion molecules and extracellular matrix proteins was the best candidate for c4.4a molecule induction. |
2014-03-20 |
2023-08-12 |
human |
| Melanie Rodrigues, Cecelia C Yates, Austin Nuschke, Linda Griffith, Alan Well. The matrikine tenascin-C protects multipotential stromal cells/mesenchymal stem cells from death cytokines such as FasL. Tissue engineering. Part A. vol 19. issue 17-18. 2014-03-13. PMID:23541003. |
interestingly, during wound repair, an extracellular matrix (ecm) component tenascin-c (tnc) containing egf-like repeats (egfl) and fibronectin-like repeats (fnl) is upregulated. |
2014-03-13 |
2023-08-12 |
Not clear |
| Sarah L Ellis, Shen Y Heazlewood, Brenda Williams, Andrea J Reitsma, Jochen Grassinger, Judy Borg, Chad K Heazlewood, Ann P Chidgey, Susan K Nilsso. The role of Tenascin C in the lymphoid progenitor cell niche. Experimental hematology. vol 41. issue 12. 2014-02-07. PMID:24084079. |
mice devoid of the extracellular matrix molecule tenascin-c (tnc) were reported to develop normally. |
2014-02-07 |
2023-08-12 |
mouse |