| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J Agata, Y Miyazaki, M Takada, H Murakami, A Masuda, T Miura, N Ura, K Shimamot. Association of insulin resistance and hyperinsulinemia with disturbed lipid metabolism in patients with essential hypertension. Hypertension research : official journal of the Japanese Society of Hypertension. vol 21. issue 1. 1998-06-15. PMID:9582109. |
in summary, (i) 33.3% of eht were found to be insulin resistant, when insulin resistance was defined as m value < 145.0 mg/m2/min, i.e., mean -isd of the m value of nt; (ii) these eht-r had higher levels of bs, insulin, ffa, and tg than did nt and eht-n; (iii) eht-n showed no difference in the levels of bs, insulin, or lipid, as compared with nt; and (iv) the levels of ffa and of tg correlated negatively with insulin sensitivity and positively with the insulin level during the ogtt. |
1998-06-15 |
2023-08-12 |
human |
| M D Kilby, R H Neary, M I Mackness, P N Durringto. Fetal and maternal lipoprotein metabolism in human pregnancy complicated by type I diabetes mellitus. The Journal of clinical endocrinology and metabolism. vol 83. issue 5. 1998-06-04. PMID:9589684. |
in type i dm, maternal tg and pl and fetal tc, tg, pl, ce, and fc were correlated to nefa levels (p < 0.05), but not to glucose, insulin secretion, or maternal control of type i dm. |
1998-06-04 |
2023-08-12 |
human |
| J F Ascaso, A Merchante, R I Lorente, J T Real, J Martinez-Valls, R Carmen. A study of insulin resistance using the minimal model in nondiabetic familial combined hyperlipidemic patients. Metabolism: clinical and experimental. vol 47. issue 5. 1998-05-28. PMID:9591739. |
in the fch group, the si value correlated significantly (p < .05) with the waist to hip ratio (whr), plasma triglycerides (tg), free fatty acids (ffa), and the area under the curve of glucose (aucg) and insulin (auci). |
1998-05-28 |
2023-08-12 |
human |
| W T Cefalu, S Werbel, A D Bell-Farrow, J G Terry, Z Q Wang, E C Opara, T Morgan, W H Hinson, J R Crous. Insulin resistance and fat patterning with aging: relationship to metabolic risk factors for cardiovascular disease. Metabolism: clinical and experimental. vol 47. issue 4. 1998-04-29. PMID:9550536. |
an index of central fat patterning (whr) added to the informativeness of the insulin area under the curve (iauc) in explaining 24% of the variability in plasma tg concentration, but measures of overall obesity were not independently related. |
1998-04-29 |
2023-08-12 |
human |
| M A Moussa, A A Shaltout, D Nkansa-Dwamena, M Mourad, N Al-Sheikh, N Agha, D O Gala. Association of fasting insulin with serum lipids and blood pressure in Kuwaiti children. Metabolism: clinical and experimental. vol 47. issue 4. 1998-04-29. PMID:9550539. |
fasting insulin levels were positively correlated (p < .001) with serum triglyceride (tg) and very-low-density lipoprotein (vldl) cholesterol levels and negatively correlated with high-density lipoprotein (hdl) cholesterol levels. |
1998-04-29 |
2023-08-12 |
Not clear |
| M A Moussa, A A Shaltout, D Nkansa-Dwamena, M Mourad, N Al-Sheikh, N Agha, D O Gala. Association of fasting insulin with serum lipids and blood pressure in Kuwaiti children. Metabolism: clinical and experimental. vol 47. issue 4. 1998-04-29. PMID:9550539. |
tg and hdl cholesterol levels and systolic blood pressure (sbp) were significantly different across insulin quartiles in boys and girls. |
1998-04-29 |
2023-08-12 |
Not clear |
| A Renauld, N V Gomez, J D Scaramal, D Garrido, M M Wank. Natural estrous cycle in normal and diabetic bitches. Basal serum total lipids and cholesterol. Serum triglycerides profiles during glucose and insulin tests. Acta physiologica, pharmacologica et therapeutica latinoamericana : organo de la Asociacion Latinoamericana de Ciencias Fisiologicas y [de] la Asociacion Latinoamericana de Farmacologia. vol 48. issue 1. 1998-04-10. PMID:9504192. |
mean serum, total triglycerides (tg) concentration in these animals at the same sex, stages, fasted and during intravenous glucose (ivgtt) and insulin (itt) tolerance tests, were studied. |
1998-04-10 |
2023-08-12 |
Not clear |
| A Renauld, N V Gomez, J D Scaramal, D Garrido, M M Wank. Natural estrous cycle in normal and diabetic bitches. Basal serum total lipids and cholesterol. Serum triglycerides profiles during glucose and insulin tests. Acta physiologica, pharmacologica et therapeutica latinoamericana : organo de la Asociacion Latinoamericana de Ciencias Fisiologicas y [de] la Asociacion Latinoamericana de Farmacologia. vol 48. issue 1. 1998-04-10. PMID:9504192. |
during ivgtt and itt, the mean serum tg levels were influenced by sex stages and also by time elapsed either from glucose or insulin load. |
1998-04-10 |
2023-08-12 |
Not clear |
| A Renauld, N V Gomez, J D Scaramal, D Garrido, M M Wank. Natural estrous cycle in normal and diabetic bitches. Basal serum total lipids and cholesterol. Serum triglycerides profiles during glucose and insulin tests. Acta physiologica, pharmacologica et therapeutica latinoamericana : organo de la Asociacion Latinoamericana de Ciencias Fisiologicas y [de] la Asociacion Latinoamericana de Farmacologia. vol 48. issue 1. 1998-04-10. PMID:9504192. |
dm intensely increased the serum tg response to insulin load in the bitches at a whereas such response was moderately decreasing at the end of itt in the diabetic bitches at lp. |
1998-04-10 |
2023-08-12 |
Not clear |
| M Shimabukuro, Y T Zhou, Y Lee, R H Unge. Troglitazone lowers islet fat and restores beta cell function of Zucker diabetic fatty rats. The Journal of biological chemistry. vol 273. issue 6. 1998-03-05. PMID:9452481. |
the 52% decrease in islet tg was accompanied by >30- and 2-fold improvements in glucose- and arginine-stimulated insulin secretion, respectively. |
1998-03-05 |
2023-08-12 |
rat |
| W J Chen, S L Yeh, Y P W. Effects of MCT/LCT and LCT emulsions on plasma lipids and nitrogen retention in streptozotocin-induced diabetic rats receiving total parenteral nutrition. Nutrition (Burbank, Los Angeles County, Calif.). vol 13. issue 10. 1998-01-28. PMID:9357025. |
the results showed that plasma triacylglycerol (tg), nonesterified fatty acids (nefa), and beta-hydroxybutyrate levels were higher in diabetic rats compared with control rats, whereas plasma insulin levels and nitrogen retention were lower. |
1998-01-28 |
2023-08-12 |
rat |
| G De Pergola, V De Mitrio, M Sciaraffia, N Pannacciulli, A Minenna, F Giorgino, M Petronelli, E Laudadio, R Giorgin. Lower androgenicity is associated with higher plasma levels of prothrombotic factors irrespective of age, obesity, body fat distribution, and related metabolic parameters in men. Metabolism: clinical and experimental. vol 46. issue 11. 1997-12-02. PMID:9361687. |
sixty-four apparently healthy men, 40 with a body mass index (bmi) greater than 25 kg/m2 (overweight and obese [oo]) and 24 non-obese controls with a bmi less than 25, were selected and evaluated for (1) plasma concentrations of plasminogen activator inhibitor-1 (pai-1) antigen, pai-1 activity, fibrinogen, von willebrand factor (vwf) antigen, vwf activity, and factor vii (fvii) as the prothrombotic factors; (2) plasma levels of tissue plasminogen activator (tpa) antigen, protein c, and antithrombin iii as the antithrombotic factors; (3) fasting plasma concentrations of insulin and glucose and the lipid pattern (triglycerides [tg] and total and high-density lipoprotein [hdl] cholesterol) as the metabolic parameters; and (4) free testosterone (ft), dehydroepiandrosterone sulfate (dheas), and sex hormone-binding globulin (shbg) serum levels as the parameters of androgenicity. |
1997-12-02 |
2023-08-12 |
human |
| S Bao, W T Garve. Exercise in transgenic mice overexpressing GLUT4 glucose transporters: effects on substrate metabolism and glycogen regulation. Metabolism: clinical and experimental. vol 46. issue 11. 1997-12-02. PMID:9361698. |
in conclusion, (1) tg overexpressing glut4 exhibit greater muscle glycogen content at rest than wt; (2) during exercise, tg metabolize more carbohydrate, made possible by increased glycogenolysis in muscle and liver, and this predominates as a fuel source despite hypoglycemia and increased availability of ffa; (3) increased carbohydrate metabolism is linked to a decrease in lipid metabolism such that there is no change in overall energy expenditure; and (4) glycogen synthase i activity is inversely proportional to tissue glycogen content despite differences in circulating glucose, insulin, and ffa concentrations, indicating that glycogen content has an overriding regulatory influence on glycogen synthase. |
1997-12-02 |
2023-08-12 |
mouse |
| Z W Man, M Zhu, Y Noma, K Toide, T Sato, Y Asahi, T Hirashima, S Mori, K Kawano, A Mizuno, T Sano, K Shim. Impaired beta-cell function and deposition of fat droplets in the pancreas as a consequence of hypertriglyceridemia in OLETF rat, a model of spontaneous NIDDM. Diabetes. vol 46. issue 11. 1997-11-21. PMID:9356017. |
therefore, the islets from 6-week-old rats were cultured with either free fatty acids (ffas; 1.0 mmol/l sodium oleate) or tg (5.0 mmol/l intralipide) for 72 h. several abnormalities in oletf rats were evident, in contrast to the results from control leto rats: 1) glucose-induced insulin secretion was more inhibited by either ffas or tgs in the presence of 27.7 mmol/l glucose, a result associated, at least in part, with reduced glucokinase activity in the islets; 2) a marked elevation in tg content was found in the islets; and 3) the deposition of fat droplets in the enlarged islets, even in the beta-cells, was found by oil red o-insulin double staining at age 30 weeks. |
1997-11-21 |
2023-08-12 |
rat |
| Z W Man, M Zhu, Y Noma, K Toide, T Sato, Y Asahi, T Hirashima, S Mori, K Kawano, A Mizuno, T Sano, K Shim. Impaired beta-cell function and deposition of fat droplets in the pancreas as a consequence of hypertriglyceridemia in OLETF rat, a model of spontaneous NIDDM. Diabetes. vol 46. issue 11. 1997-11-21. PMID:9356017. |
in conclusion, hypertriglyceridemia resulted in significant tg stores in the islets, which subsequently inhibited glucose-induced insulin secretion, at least in part, via reduced glucokinase activity in the islets. |
1997-11-21 |
2023-08-12 |
rat |
| K Koyama, G Chen, Y Lee, R H Unge. Tissue triglycerides, insulin resistance, and insulin production: implications for hyperinsulinemia of obesity. The American journal of physiology. vol 273. issue 4. 1997-11-21. PMID:9357799. |
to determine whether both insulin resistance and hyperinsulinemia might be secondary to increased tissue tg, we studied correlations between tg content of skeletal muscle, liver, and pancreas and plasma insulin, plasma [insulin] x [glucose], and beta-cell function in four rat models with widely varying fat content: obese zucker diabetic fatty rats, free-feeding lean wistar rats, hyperleptinemic wistar rats with profound tissue lipopenia, and rats pair fed to hyperleptinemics. |
1997-11-21 |
2023-08-12 |
rat |
| K Koyama, G Chen, Y Lee, R H Unge. Tissue triglycerides, insulin resistance, and insulin production: implications for hyperinsulinemia of obesity. The American journal of physiology. vol 273. issue 4. 1997-11-21. PMID:9357799. |
correlation coefficients >0.9 (p < 0.05) were obtained among tg of skeletal muscle, liver, and pancreas and among plasma insulin, [insulin] x [glucose] product, and beta-cell function as gauged by basal, glucose-stimulated, and arginine-stimulated insulin secretion by the isolated perfused pancreas. |
1997-11-21 |
2023-08-12 |
rat |
| K Koyama, G Chen, Y Lee, R H Unge. Tissue triglycerides, insulin resistance, and insulin production: implications for hyperinsulinemia of obesity. The American journal of physiology. vol 273. issue 4. 1997-11-21. PMID:9357799. |
although these correlations cannot prove cause and effect, they are consistent with the hypothesis that the tg content of tissues sets the level of both insulin resistance and insulin production. |
1997-11-21 |
2023-08-12 |
rat |
| A C Rustan, M S Nenseter, C A Drevo. Omega-3 and omega-6 fatty acids in the insulin resistance syndrome. Lipid and lipoprotein metabolism and atherosclerosis. Annals of the New York Academy of Sciences. vol 827. 1997-11-13. PMID:9329764. |
omega-3 pufa reduce fasting and postprandial tg, may improve insulin sensitivity (as shown in animal experiments), decrease platelet and leukocyte reactivity, alter immunological functions, and may slightly decrease blood pressure. |
1997-11-13 |
2023-08-12 |
Not clear |
| P Bohov, E Seböková, D Gasperíková, P Langer, I Klime. Fatty acid composition in fractions of structural and storage lipids in liver and skeletal muscle of hereditary hypertriglyceridemic rats. Annals of the New York Academy of Sciences. vol 827. 1997-11-13. PMID:9329780. |
the fatty acid (fa) compositions of liver and skeletal muscle structural lipids, overall phospholipids and phosphatidylcholine, and triglycerides (tg) were determined in the hereditary hypertriglyceridemic (htg) rat, a nonobese animal model of the insulin resistance syndrome. |
1997-11-13 |
2023-08-12 |
rat |