| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J T Brozinick, S C McCoid, T H Reynolds, C M Wilson, R W Stevenson, S W Cushman, E M Gibb. Regulation of cell surface GLUT4 in skeletal muscle of transgenic mice. The Biochemical journal. vol 321 ( Pt 1). 1997-02-20. PMID:9003403. |
thus we have assessed cell surface glut4 by photolabelling with the membrane-impermeant reagent 2-n-[4-(1-azi-2,2,2-trifluoroethyl)benzoyl]-1, 3-bis(d-mannos-4-yloxy)-2-propylamine (atb-bmpa) and measured the corresponding glucose transport activity using 2-deoxyglucose in isolated extensor digitorum longus (edl) muscles from non-transgenic (ntg) and glut4 tg mice in the absence and presence of 13.3 nm (2000 mu units/ml) insulin, without or with hypoxia as a model of muscle contraction. |
1997-02-20 |
2023-08-12 |
mouse |
| J T Brozinick, S C McCoid, T H Reynolds, C M Wilson, R W Stevenson, S W Cushman, E M Gibb. Regulation of cell surface GLUT4 in skeletal muscle of transgenic mice. The Biochemical journal. vol 321 ( Pt 1). 1997-02-20. PMID:9003403. |
tg mice displayed elevated rates of glucose transport activity under basal and insulin-stimulated conditions, and in the presence of insulin plus hypoxia, compared with ntg mice. |
1997-02-20 |
2023-08-12 |
mouse |
| D Meirow, I Raz, O Yossepowitch, A Brzezinski, A Rosler, J G Schenker, E M Berr. Dyslipidaemia in polycystic ovarian syndrome: different groups, different aetiologies? Human reproduction (Oxford, England). vol 11. issue 9. 1997-02-18. PMID:8921052. |
pcos patients had higher fasting insulin concentrations, higher body mass indexes (bmi) and were hyperlipidaemic, with higher total cholesterol, low density lipoprotein (ldl) and triglyceride (tg) concentrations. |
1997-02-18 |
2023-08-12 |
human |
| D Meirow, I Raz, O Yossepowitch, A Brzezinski, A Rosler, J G Schenker, E M Berr. Dyslipidaemia in polycystic ovarian syndrome: different groups, different aetiologies? Human reproduction (Oxford, England). vol 11. issue 9. 1997-02-18. PMID:8921052. |
insulin and dhea-s concentrations were positively correlated with total cholesterol, ldl and tg, and negatively correlated with high density lipoprotein, in ir patients. |
1997-02-18 |
2023-08-12 |
human |
| P Legrand, D Catheline, E Le Bihan, P Lemarcha. Effect of insulin on triacylglycerol synthesis and secretion by chicken hepatocytes in primary culture. The international journal of biochemistry & cell biology. vol 28. issue 4. 1997-02-18. PMID:9026354. |
a primary culture system of chicken hepatocytes was developed to study the effects of genetic, hormonal and nutritional factors on hepatic triglyceride (tg) secretion in the chicken, and the effect of insulin on tg synthesis and secretion examined. |
1997-02-18 |
2023-08-12 |
chicken |
| P Legrand, D Catheline, E Le Bihan, P Lemarcha. Effect of insulin on triacylglycerol synthesis and secretion by chicken hepatocytes in primary culture. The international journal of biochemistry & cell biology. vol 28. issue 4. 1997-02-18. PMID:9026354. |
in contrast, the 10(-6) m concentration of insulin had no effect on tg secretion. |
1997-02-18 |
2023-08-12 |
chicken |
| P Legrand, D Catheline, E Le Bihan, P Lemarcha. Effect of insulin on triacylglycerol synthesis and secretion by chicken hepatocytes in primary culture. The international journal of biochemistry & cell biology. vol 28. issue 4. 1997-02-18. PMID:9026354. |
the use of an additional trypsinization step enhanced the findings obtained by simple removal of the culture medium: a clear stimulatory effect of insulin on tg synthesis was observed after both 24 and 48 hr of culture. |
1997-02-18 |
2023-08-12 |
chicken |
| P Legrand, D Catheline, E Le Bihan, P Lemarcha. Effect of insulin on triacylglycerol synthesis and secretion by chicken hepatocytes in primary culture. The international journal of biochemistry & cell biology. vol 28. issue 4. 1997-02-18. PMID:9026354. |
a high level of tg secretion was seen in these cells with or without exogenous fatty acid and this secretion was stimulated by insulin. |
1997-02-18 |
2023-08-12 |
chicken |
| M J Pagliassotti, P A Prach, T A Koppenhafer, D A Pa. Changes in insulin action, triglycerides, and lipid composition during sucrose feeding in rats. The American journal of physiology. vol 271. issue 5 Pt 2. 1997-01-03. PMID:8945970. |
in the present study, the time course of change in sucrose-induced insulin resistance, triglyceride (tg) concentration, and liver fatty acid composition was examined. |
1997-01-03 |
2023-08-12 |
rat |
| M J Pagliassotti, P A Prach, T A Koppenhafer, D A Pa. Changes in insulin action, triglycerides, and lipid composition during sucrose feeding in rats. The American journal of physiology. vol 271. issue 5 Pt 2. 1997-01-03. PMID:8945970. |
tg concentration appears to be related to sucrose-induced insulin resistance in liver and muscle. |
1997-01-03 |
2023-08-12 |
rat |
| S Arslanian, C Suprasongsi. Insulin sensitivity, lipids, and body composition in childhood: is "syndrome X" present? The Journal of clinical endocrinology and metabolism. vol 81. issue 3. 1996-12-20. PMID:8772576. |
however, regardless of body composition, the basal insulin level was correlated with tg (r = 0.38; p = 0.04) and vldl (r = 0.40; p = 0.04) in tii-iv subjects. |
1996-12-20 |
2023-08-12 |
human |
| S Arslanian, C Suprasongsi. Insulin sensitivity, lipids, and body composition in childhood: is "syndrome X" present? The Journal of clinical endocrinology and metabolism. vol 81. issue 3. 1996-12-20. PMID:8772576. |
we conclude that 1) the primary correlate of insulin sensitivity is %bf in both prepubertal and pubertal subjects, with no relationship to plasma lipids; 2) in prepubertal children, diastolic blood pressure is negatively correlated with insulin sensitivity and positively with insulin levels, independent of adiposity; and 3) after the onset of puberty, basal insulin levels are positively correlated with vldl and tg regardless of the degree of adiposity. |
1996-12-20 |
2023-08-12 |
human |
| S Sreenan, J Sturis, W Pugh, C F Burant, K S Polonsk. Prevention of hyperglycemia in the Zucker diabetic fatty rat by treatment with metformin or troglitazone. The American journal of physiology. vol 271. issue 4 Pt 1. 1996-12-16. PMID:8897863. |
glucose, insulin, triglyceride (tg), and free fatty acid (ffa) levels and glucose stimulated insulin secretion by the perfused pancreas were measured. |
1996-12-16 |
2023-08-12 |
rat |
| D I Phillips, S Caddy, V Ilic, B A Fielding, K N Frayn, A C Borthwick, R Taylo. Intramuscular triglyceride and muscle insulin sensitivity: evidence for a relationship in nondiabetic subjects. Metabolism: clinical and experimental. vol 45. issue 8. 1996-12-10. PMID:8769349. |
however, recent evidence suggests that if muscle contains abnormally high tg stores its sensitivity to insulin may be reduced, and this could predispose to type ii diabetes. |
1996-12-10 |
2023-08-12 |
human |
| Y P Zhou, Z C Ling, V E Gril. Inhibitory effects of fatty acids on glucose-regulated B-cell function: association with increased islet triglyceride stores and altered effect of fatty acid oxidation on glucose metabolism. Metabolism: clinical and experimental. vol 45. issue 8. 1996-12-10. PMID:8769356. |
the dose-response for palmitate was similar for the increase in tg and inhibition of glucose-induced insulin secretion. |
1996-12-10 |
2023-08-12 |
rat |
| Y P Zhou, Z C Ling, V E Gril. Inhibitory effects of fatty acids on glucose-regulated B-cell function: association with increased islet triglyceride stores and altered effect of fatty acid oxidation on glucose metabolism. Metabolism: clinical and experimental. vol 45. issue 8. 1996-12-10. PMID:8769356. |
etomoxir enhanced glucose-induced insulin secretion from palmitate-cultured islets; however, this effect was lost when tg were normalized. |
1996-12-10 |
2023-08-12 |
rat |
| Y T Teng, D B Williams, N Hozumi, R M Gorczynsk. Multiple levels of regulation for self-tolerance in beef insulin transgenic mice. Cellular immunology. vol 173. issue 2. 1996-12-09. PMID:8912875. |
to characterize the mechanism(s) of tolerance toward soluble self-antigens (ags), beef insulin (bi) transgenic (tg) mice were generated in which the transgene was expressed in pancreatic beta-cells. |
1996-12-09 |
2023-08-12 |
mouse |
| F Kambe, H Se. Mediation of the hormone- and serum-dependent regulation of thyroglobulin gene expression by thyroid-transcription factors in rat thyroid FRTL-5 cells. The Journal of endocrinology. vol 150. issue 2. 1996-12-02. PMID:8869595. |
taken together, our results suggest that tsh, insulin and serum increase the binding activities of ttf-1 and pax-8 to the tg promoter presumably through the posttranslational modification of the factors, thereby enhancing tg gene transcription. |
1996-12-02 |
2023-08-12 |
rat |
| T Ramlal, H S Ewart, R Somwar, R O Deems, M A Valentin, D A Young, A Kli. Muscle subcellular localization and recruitment by insulin of glucose transporters and Na+-K+-ATPase subunits in transgenic mice overexpressing the GLUT4 glucose transporter. Diabetes. vol 45. issue 11. 1996-11-29. PMID:8866555. |
insulin injection (4.3 u/kg body wt) increased glut4 in the pm-rich fraction; the increase was threefold higher in tg than in non-tg mice. |
1996-11-29 |
2023-08-12 |
mouse |
| T Ramlal, H S Ewart, R Somwar, R O Deems, M A Valentin, D A Young, A Kli. Muscle subcellular localization and recruitment by insulin of glucose transporters and Na+-K+-ATPase subunits in transgenic mice overexpressing the GLUT4 glucose transporter. Diabetes. vol 45. issue 11. 1996-11-29. PMID:8866555. |
insulin decreased the glut4 content of the im in both animal groups and of a second, heavier intracellular membrane fraction only in tg mice. |
1996-11-29 |
2023-08-12 |
mouse |