| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shuhei Tomimoto, Hitoshi Hashimoto, Norihito Shintani, Akemichi Bab. [Transgenic mice overexpressing PACAP in pancreatic beta-cells: acute and chronic effects on insulin and glucose homeostasis]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. vol 123. issue 4. 2004-06-10. PMID:15056941. |
as an approach to understanding pacap's pancreatic function in vivo, we have recently generated transgenic mice overexpressing pacap in islet beta cells under the control of human insulin promoter (tg mice). |
2004-06-10 |
2023-08-12 |
mouse |
| Michael J LaMonte, Barbara E Ainsworth, Katrina D DuBose, Peter W Grandjean, Paul G Davis, Frank G Yanowitz, J Larry Durstin. The hypertriglyceridemic waist phenotype among women. Atherosclerosis. vol 171. issue 1. 2004-05-19. PMID:14642414. |
elevated plasma triglycerides (tg) and waist girth (hypertriglyceridemic waist (htgw)) has been associated with elevated insulin, small dense low-density lipoprotein (sldl) particles, and apo b in men. |
2004-05-19 |
2023-08-12 |
Not clear |
| Dongmei Jia, Mitsuyoshi Yamamoto, Munenori Otani, Makoto Otsuk. Bezafibrate on lipids and glucose metabolism in obese diabetic Otsuka Long-Evans Tokushima fatty rats. Metabolism: clinical and experimental. vol 53. issue 4. 2004-05-04. PMID:15045684. |
bezafibrate treatment significantly reduced serum triglyceride (tg) and free fatty acid (ffa) levels, suppressed the increase in islet size, and inhibited the expression of alpha-smooth muscle actin, a marker for activated pancreatic stellate cells that are involved in the fibrosis of the pancreas, in the islets in oletf rats, but had no influences on food intake, body weight gain, abdominal adipose depots, and pancreatic insulin content in both strains of rats. |
2004-05-04 |
2023-08-12 |
human |
| Tracey McLaughlin, Gregory Allison, Fahim Abbasi, Cindy Lamendola, Gerald Reave. Prevalence of insulin resistance and associated cardiovascular disease risk factors among normal weight, overweight, and obese individuals. Metabolism: clinical and experimental. vol 53. issue 4. 2004-05-04. PMID:15045698. |
thus, the higher the sspg concentration, the more the increase in plasma glucose, insulin, and triglyceride (tg) concentrations, whereas the greater the bmi, the higher the low-density lipoprotein concentration. |
2004-05-04 |
2023-08-12 |
human |
| Tomonari Koike, Jingyan Liang, Xiaofei Wang, Tomonaga Ichikawa, Masashi Shiomi, George Liu, Huijun Sun, Shuji Kitajima, Masatoshi Morimoto, Teruo Watanabe, Nobuhiro Yamada, Jianglin Fa. Overexpression of lipoprotein lipase in transgenic Watanabe heritable hyperlipidemic rabbits improves hyperlipidemia and obesity. The Journal of biological chemistry. vol 279. issue 9. 2004-05-03. PMID:14660566. |
in addition, overexpression of lpl significantly suppressed high fat diet-induced obesity and insulin resistance in tg whhl rabbits. |
2004-05-03 |
2023-08-12 |
human |
| André J Tremblay, Jean-Pierre Després, Marie-Eve Piché, André Nadeau, Jean Bergeron, Natalie Alméras, Angelo Tremblay, Simone Lemieu. Associations between the fatty acid content of triglyceride, visceral adipose tissue accumulation, and components of the insulin resistance syndrome. Metabolism: clinical and experimental. vol 53. issue 3. 2004-04-09. PMID:15015142. |
the main purpose of this study was to investigate the relationships between fatty acid content of triglyceride (tg), visceral adipose tissue (at) accumulation, and metabolic components of the insulin resistance syndrome in a group of 97 caucasian men with a mean age of 45.1 +/- 7.2 years (29 to 63 years). |
2004-04-09 |
2023-08-12 |
Not clear |
| André J Tremblay, Jean-Pierre Després, Marie-Eve Piché, André Nadeau, Jean Bergeron, Natalie Alméras, Angelo Tremblay, Simone Lemieu. Associations between the fatty acid content of triglyceride, visceral adipose tissue accumulation, and components of the insulin resistance syndrome. Metabolism: clinical and experimental. vol 53. issue 3. 2004-04-09. PMID:15015142. |
the proportion of palmitic acid (16:0) in the tg fraction was positively associated with plasma fasting insulin (r =.25, p =.03), diastolic (r =.45, p <.001), and systolic (r =.29, p =.003) blood pressure. |
2004-04-09 |
2023-08-12 |
Not clear |
| André J Tremblay, Jean-Pierre Després, Marie-Eve Piché, André Nadeau, Jean Bergeron, Natalie Alméras, Angelo Tremblay, Simone Lemieu. Associations between the fatty acid content of triglyceride, visceral adipose tissue accumulation, and components of the insulin resistance syndrome. Metabolism: clinical and experimental. vol 53. issue 3. 2004-04-09. PMID:15015142. |
on the other hand, the proportion of alpha-linolenic acid (18:3n-3) was associated negatively with apolipoprotein (apo) b (r = -.29, p =.005) and positively with low-density lipoprotein (ldl) diameter (r =.29, p =.007), while the proportion of gamma-linolenic acid (18:3n-6) was associated negatively with plasma tg (r = -.33, p =.003), diastolic (r = -.29, p =.01), and systolic (r = -.35, p =.002) blood pressure and plasma fasting insulin (r = -.37, p =.0005) and positively with high-density lipoprotein (hdl)(2)-cholesterol (r =.27, p =.01) and ldl diameter (r =.25, p =.02). |
2004-04-09 |
2023-08-12 |
Not clear |
| André J Tremblay, Jean-Pierre Després, Marie-Eve Piché, André Nadeau, Jean Bergeron, Natalie Alméras, Angelo Tremblay, Simone Lemieu. Associations between the fatty acid content of triglyceride, visceral adipose tissue accumulation, and components of the insulin resistance syndrome. Metabolism: clinical and experimental. vol 53. issue 3. 2004-04-09. PMID:15015142. |
in summary, results of this study suggest that the fatty acid content of tg is associated with many metabolic variables of the insulin resistance syndrome independently of body fat mass or visceral at accumulation. |
2004-04-09 |
2023-08-12 |
Not clear |
| Tatsuo Yanagawa, Atsushi Araki, Kazuo Sasamoto, Shinichiro Shirabe, Toshikazu Yamanouch. Effect of antidiabetic medications on microalbuminuria in patients with type 2 diabetes. Metabolism: clinical and experimental. vol 53. issue 3. 2004-04-09. PMID:15015149. |
each patient received the designated drug for 12 weeks and their body weight, blood pressure (bp), fasting plasma glucose (fpg), hba(1c), lipids (triglycerides [tg], total, and high-density lipoprotein-cholesterol [hdl-c]), 1,5 anhidroglucitol (1,5-ag), immunoreactive insulin (iri), and urinary albumin to creatinine ratio (uacr) were measured every month. |
2004-04-09 |
2023-08-12 |
Not clear |
| Yi-fei Zhang, Jie Hong, Wei-qiong Gu, Shou-yue Sun, Jing-feng Tang, Ling Jiang, Meng Dai, Yong-ju Zhao, Guang Nin. [Fasting serum free fatty acid, insulin sensitivity index and serum lipid levels in individuals with different body mass index and glucose tolerance]. Zhonghua nei ke za zhi. vol 42. issue 11. 2004-04-08. PMID:14636469. |
to investigate the relationship among fasting serum free fatty acid (ffa), insulin sensitivity index (isi), serum triglyceride (tg) and total cholesterol (tc) levels in subjects with different body mass index (bmi) and glucose tolerance by using bergman's minimodel method. |
2004-04-08 |
2023-08-12 |
human |
| I J Jonkers, A H Smelt, A van der Laars. Hypertriglyceridemia: associated risks and effect of drug treatment. American journal of cardiovascular drugs : drugs, devices, and other interventions. vol 1. issue 6. 2004-04-08. PMID:14728004. |
this increased risk is probably substantially mediated through the metabolic interrelationships between serum triglyceride (tg) levels and other risk factors, such as the atherogenic lipid profile (low high density lipoprotein-cholesterol levels and elevated small dense low density lipoprotein levels), insulin resistance, a prothrombotic propensity and low grade systemic inflammation. |
2004-04-08 |
2023-08-12 |
Not clear |
| Hyean-Woo Lee, Yoon-Sun Park, Jong-Whan Choi, Sang-Yeop Yi, Woon-Seob Shi. Antidiabetic effects of chitosan oligosaccharides in neonatal streptozotocin-induced noninsulin-dependent diabetes mellitus in rats. Biological & pharmaceutical bulletin. vol 26. issue 8. 2004-04-07. PMID:12913258. |
in conclusion, these results indicate that cos can be used as an antidiabetic agent because it increases glucose tolerance and insulin secretion and decreases tg. |
2004-04-07 |
2023-08-12 |
rat |
| Linda A Barbour, Jianhua Shao, Liping Qiao, Wayne Leitner, Marianne Anderson, Jacob E Friedman, Boris Drazni. Human placental growth hormone increases expression of the p85 regulatory unit of phosphatidylinositol 3-kinase and triggers severe insulin resistance in skeletal muscle. Endocrinology. vol 145. issue 3. 2004-03-23. PMID:14633976. |
we recently demonstrated that human placental gh (hpgh) can trigger severe insulin resistance in transgenic (tg) mice. |
2004-03-23 |
2023-08-12 |
mouse |
| Linda A Barbour, Jianhua Shao, Liping Qiao, Wayne Leitner, Marianne Anderson, Jacob E Friedman, Boris Drazni. Human placental growth hormone increases expression of the p85 regulatory unit of phosphatidylinositol 3-kinase and triggers severe insulin resistance in skeletal muscle. Endocrinology. vol 145. issue 3. 2004-03-23. PMID:14633976. |
in this study we sought to elucidate the cellular mechanisms by which hpgh interferes with insulin signaling in muscle in tg mice. |
2004-03-23 |
2023-08-12 |
mouse |
| Linda A Barbour, Jianhua Shao, Liping Qiao, Wayne Leitner, Marianne Anderson, Jacob E Friedman, Boris Drazni. Human placental growth hormone increases expression of the p85 regulatory unit of phosphatidylinositol 3-kinase and triggers severe insulin resistance in skeletal muscle. Endocrinology. vol 145. issue 3. 2004-03-23. PMID:14633976. |
although the levels of the p110 catalytic subunit protein of pi 3-kinase and irs-1 were unchanged in the tg mice, insulin's ability to stimulate p110 association with irs-1 was markedly reduced (p < 0.0001). |
2004-03-23 |
2023-08-12 |
mouse |
| Giuseppina Rosa, Melania Manco, Natalie Vega, Aldo V Greco, Marco Castagneto, Hubert Vidal, Geltrude Mingron. Decreased muscle acetyl-coenzyme A carboxylase 2 mRNA and insulin resistance in formerly obese subjects. Obesity research. vol 11. issue 11. 2004-03-19. PMID:14627750. |
a relationship between free fatty acids, intramuscular triglycerides (tg(m)s), and insulin resistance is widely accepted. |
2004-03-19 |
2023-08-12 |
human |
| Sang Ah Chang, Hee Seung Kim, Kun Ho Yoon, Seung Hyun Ko, Hyuk Sang Kwon, Sung Rae Kim, Won Chul Lee, Soon Jib Yoo, Hyun Sik Son, Bong Yun Cha, Kwang Woo Lee, Ho-Young Son, Sung Koo Kan. Body mass index is the most important determining factor for the degree of insulin resistance in non-obese type 2 diabetic patients in Korea. Metabolism: clinical and experimental. vol 53. issue 2. 2004-03-09. PMID:14767863. |
these results suggest that the bmi is the most important determinant of insulin resistance, while tg and hdl-c levels might be good markers of insulin resistance in non-obese patients with type 2 diabetes mellitus in korea. |
2004-03-09 |
2023-08-12 |
human |
| Fahim Abbasi, James W Chu, Tracey McLaughlin, Cindy Lamendola, Elizabeth T Leary, Gerald M Reave. Effect of metformin treatment on multiple cardiovascular disease risk factors in patients with type 2 diabetes mellitus. Metabolism: clinical and experimental. vol 53. issue 2. 2004-03-09. PMID:14767866. |
measurements were made of (1) fasting plasma glucose, hemoglobin a(1c) (hba(1c)), lipid, remnant lipoprotein cholesterol (rlp-c) levels, and low-density lipoprotein (ldl) particle size; (2) daylong plasma glucose, insulin, free fatty acid (ffa), triglyceride (tg), and rlp-c concentrations; and (3) fasting levels of soluble intercellular adhesion molecule-1 (sicam-1), soluble vascular cell adhesion molecule-1 (svcam-1), and soluble e-selectin (se-selectin). |
2004-03-09 |
2023-08-12 |
human |
| Fahim Abbasi, James W Chu, Tracey McLaughlin, Cindy Lamendola, Elizabeth T Leary, Gerald M Reave. Effect of metformin treatment on multiple cardiovascular disease risk factors in patients with type 2 diabetes mellitus. Metabolism: clinical and experimental. vol 53. issue 2. 2004-03-09. PMID:14767866. |
daylong concentrations of plasma glucose, ffa, tg, and rlp-c were lower to a similar degree in both treatment groups, whereas daylong plasma insulin concentrations were unchanged. |
2004-03-09 |
2023-08-12 |
human |