| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jianmin Ran, Tsutomu Hirano, Mitsuru Adach. Angiotensin II type 1 receptor blocker ameliorates overproduction and accumulation of triglyceride in the liver of Zucker fatty rats. American journal of physiology. Endocrinology and metabolism. vol 287. issue 2. 2004-08-30. PMID:15082419. |
olmesartan treatment had no significant effects on tg metabolism or insulin sensitivity in the zl rats. |
2004-08-30 |
2023-08-12 |
rat |
| Jianmin Ran, Tsutomu Hirano, Mitsuru Adach. Angiotensin II type 1 receptor blocker ameliorates overproduction and accumulation of triglyceride in the liver of Zucker fatty rats. American journal of physiology. Endocrinology and metabolism. vol 287. issue 2. 2004-08-30. PMID:15082419. |
taken in sum, arb improves the overproduction and accumulation of tg in the liver associated with insulin resistance, and it does so through mechanisms independent of its hypotensive action. |
2004-08-30 |
2023-08-12 |
rat |
| Patricia Blackburn, Benoît Lamarche, Charles Couillard, Agnès Pascot, Nathalie Bergeron, Denis Prud'homme, Angelo Tremblay, Jean Bergeron, Isabelle Lemieux, Jean Pierre Despré. Postprandial hyperlipidemia: another correlate of the "hypertriglyceridemic waist" phenotype in men. Atherosclerosis. vol 171. issue 2. 2004-08-26. PMID:14644404. |
furthermore, subjects characterized by the "hypertriglyceridemic waist" phenotype displayed higher fasting insulin concentrations and postprandial insulin auc compared to men with low fasting plasma tg levels and low waist girth values. |
2004-08-26 |
2023-08-12 |
human |
| Martin Muurling, Ronald P Mensink, Hanno Pijl, Johannes A Romijn, Louis M Havekes, Peter J Vosho. A fish oil diet does not reverse insulin resistance despite decreased adipose tissue TNF-alpha protein concentration in ApoE-3*Leiden mice. The Journal of nutrition. vol 133. issue 11. 2004-08-24. PMID:14608043. |
we measured plasma glucose, insulin, free fatty acids (ffa) and triglyceride (tg) levels throughout the study. |
2004-08-24 |
2023-08-12 |
mouse |
| Tokuyuki Yamashita, Kazuhiro Eto, Yukiko Okazaki, Shigeo Yamashita, Toshimasa Yamauchi, Nobuo Sekine, Ryozo Nagai, Mitsuhiko Noda, Takashi Kadowak. Role of uncoupling protein-2 up-regulation and triglyceride accumulation in impaired glucose-stimulated insulin secretion in a beta-cell lipotoxicity model overexpressing sterol regulatory element-binding protein-1c. Endocrinology. vol 145. issue 8. 2004-08-17. PMID:15059954. |
triglyceride (tg) accumulation in pancreatic beta-cells is thought to be associated with impaired insulin secretory response to glucose (lipotoxicity). |
2004-08-17 |
2023-08-12 |
Not clear |
| Tokuyuki Yamashita, Kazuhiro Eto, Yukiko Okazaki, Shigeo Yamashita, Toshimasa Yamauchi, Nobuo Sekine, Ryozo Nagai, Mitsuhiko Noda, Takashi Kadowak. Role of uncoupling protein-2 up-regulation and triglyceride accumulation in impaired glucose-stimulated insulin secretion in a beta-cell lipotoxicity model overexpressing sterol regulatory element-binding protein-1c. Endocrinology. vol 145. issue 8. 2004-08-17. PMID:15059954. |
this treatment was associated with strong activation of transcription of the genes involved in fatty acid biosynthesis, increased cellular tg content, severely blunted glucose-stimulated insulin secretion, and enhanced expression of the uncoupling protein-2 (ucp-2), which supposedly dissipates the mitochondrial electrochemical potential. |
2004-08-17 |
2023-08-12 |
Not clear |
| Tokuyuki Yamashita, Kazuhiro Eto, Yukiko Okazaki, Shigeo Yamashita, Toshimasa Yamauchi, Nobuo Sekine, Ryozo Nagai, Mitsuhiko Noda, Takashi Kadowak. Role of uncoupling protein-2 up-regulation and triglyceride accumulation in impaired glucose-stimulated insulin secretion in a beta-cell lipotoxicity model overexpressing sterol regulatory element-binding protein-1c. Endocrinology. vol 145. issue 8. 2004-08-17. PMID:15059954. |
introduction of the small interfering rna increased the atp/adp ratio and partially rescued the glucose-stimulated insulin secretion in the cells overexpressing srebp-1c, but did not affect the cellular tg content. |
2004-08-17 |
2023-08-12 |
Not clear |
| Tokuyuki Yamashita, Kazuhiro Eto, Yukiko Okazaki, Shigeo Yamashita, Toshimasa Yamauchi, Nobuo Sekine, Ryozo Nagai, Mitsuhiko Noda, Takashi Kadowak. Role of uncoupling protein-2 up-regulation and triglyceride accumulation in impaired glucose-stimulated insulin secretion in a beta-cell lipotoxicity model overexpressing sterol regulatory element-binding protein-1c. Endocrinology. vol 145. issue 8. 2004-08-17. PMID:15059954. |
exposure of the cells with lipotoxicity to 5-amino-4-imidazolecarboxamide riboside increased free fatty acid oxidation, partially reversed the tg accumulation, phosphorylated ampk and acetyl-coenzyme a carboxylase, and improved the impaired glucose-stimulated insulin secretion. |
2004-08-17 |
2023-08-12 |
Not clear |
| Guo-Qing Chang, Olga Karatayev, Zoya Davydova, Sarah F Leibowit. Circulating triglycerides impact on orexigenic peptides and neuronal activity in hypothalamus. Endocrinology. vol 145. issue 8. 2004-08-17. PMID:15117877. |
in normal weight rats, ip injection of intralipid (20%, 5 ml) during the first 4 h after injection produced a robust increase in tg levels and nonesterified fatty acids, but had no impact on glucose, insulin, or leptin levels. |
2004-08-17 |
2023-08-12 |
rat |
| M den Boer, P J Voshol, F Kuipers, L M Havekes, J A Romij. Hepatic steatosis: a mediator of the metabolic syndrome. Lessons from animal models. Arteriosclerosis, thrombosis, and vascular biology. vol 24. issue 4. 2004-08-05. PMID:14715643. |
several lines of evidence indicate that hepatic tg accumulation is also a causative factor involved in hepatic insulin resistance. |
2004-08-05 |
2023-08-12 |
human |
| C Verseyden, S Meijssen, H van Dijk, H Jansen, M Castro Cabeza. Effects of atorvastatin on fasting and postprandial complement component 3 response in familial combined hyperlipidemia. Journal of lipid research. vol 44. issue 11. 2004-08-03. PMID:12923226. |
fasting tg and insulin sensitivity were the best predictors of fasting and postprandial c3. |
2004-08-03 |
2023-08-12 |
Not clear |
| Meng H Tan, Don Johns, N Bradly Glaze. Pioglitazone reduces atherogenic index of plasma in patients with type 2 diabetes. Clinical chemistry. vol 50. issue 7. 2004-07-29. PMID:15117857. |
insulin resistance is often associated with increased triglyceride (tg) and decreased hdl-cholesterol (hdl-c) concentrations and increased small ldl particles. |
2004-07-29 |
2023-08-12 |
Not clear |
| Allison W Miller, Christina D Tulbert, David W Busij. Rosuvastatin treatment reverses impaired coronary artery vasodilation in fructose-fed, insulin-resistant rats. American journal of physiology. Regulatory, integrative and comparative physiology. vol 287. issue 1. 2004-07-13. PMID:15044186. |
fasting insulin and triglyceride (tg) levels were markedly increased in ff-placebo rats compared with other groups. |
2004-07-13 |
2023-08-12 |
rat |
| Allison W Miller, Christina D Tulbert, David W Busij. Rosuvastatin treatment reverses impaired coronary artery vasodilation in fructose-fed, insulin-resistant rats. American journal of physiology. Regulatory, integrative and comparative physiology. vol 287. issue 1. 2004-07-13. PMID:15044186. |
rosuvastatin treatment of ff rats normalized tg and modestly decreased insulin levels. |
2004-07-13 |
2023-08-12 |
rat |
| M Nagano, Y Kai, B Zou, T Hatayama, M Suwa, H Sasaki, S Kumaga. The contribution of cardiorespiratory fitness and visceral fat to risk factors in Japanese patients with impaired glucose tolerance and type 2 diabetes mellitus. Metabolism: clinical and experimental. vol 53. issue 5. 2004-07-08. PMID:15131771. |
the levels of fasting insulin, triglyceride (tg), total cholesterol (tc), high-density lipoprotein cholesterol (hdl-c), and resting blood pressure were assessed. |
2004-07-08 |
2023-08-12 |
human |
| Yangsoo Jang, Oh Yoen Kim, Ha Jung Ryu, Ji Young Kim, Sang Hoon Song, Jose M Ordovas, Jong Ho Le. Visceral fat accumulation determines postprandial lipemic response, lipid peroxidation, DNA damage, and endothelial dysfunction in nonobese Korean men. Journal of lipid research. vol 44. issue 12. 2004-07-01. PMID:12951360. |
men with hvfa showed higher tg, glucose, and insulin responses following fat and oral glucose tolerance tests respectively higher plasma concentrations of mda (p < 0.001), urinary pgf2alpha (p < 0.05), and lymphocytes deoxyribonucleic acid tail moments (p < 0.01). |
2004-07-01 |
2023-08-12 |
Not clear |
| Kenta Okada, Tsutomu Hirano, Jianmin Ran, Mitsuru Adach. Olmesartan medoxomil, an angiotensin II receptor blocker ameliorates insulin resistance and decreases triglyceride production in fructose-fed rats. Hypertension research : official journal of the Japanese Society of Hypertension. vol 27. issue 4. 2004-06-25. PMID:15127887. |
although angiotensin ii receptor blockers (arbs) have been recommended as a first line of anti-hypertensive agents in patients with diabetes, it remains unclear whether arbs have a favorable effect on insulin action and triglyceride (tg) metabolism, both of which are impaired in type 2 diabetes. |
2004-06-25 |
2023-08-12 |
rat |
| Kenta Okada, Tsutomu Hirano, Jianmin Ran, Mitsuru Adach. Olmesartan medoxomil, an angiotensin II receptor blocker ameliorates insulin resistance and decreases triglyceride production in fructose-fed rats. Hypertension research : official journal of the Japanese Society of Hypertension. vol 27. issue 4. 2004-06-25. PMID:15127887. |
in this study we addressed this issue by investigating how a newly developed arb, olmesartan medoxomil, influenced insulin sensitivity and tg metabolism in fructose-fed rats, a representative animal model of insulin resistance. |
2004-06-25 |
2023-08-12 |
rat |
| Kenta Okada, Tsutomu Hirano, Jianmin Ran, Mitsuru Adach. Olmesartan medoxomil, an angiotensin II receptor blocker ameliorates insulin resistance and decreases triglyceride production in fructose-fed rats. Hypertension research : official journal of the Japanese Society of Hypertension. vol 27. issue 4. 2004-06-25. PMID:15127887. |
olmesartan did not affect plasma parameters, insulin sensitivity or tg metabolism in chow-fed rats. |
2004-06-25 |
2023-08-12 |
rat |
| Kenta Okada, Tsutomu Hirano, Jianmin Ran, Mitsuru Adach. Olmesartan medoxomil, an angiotensin II receptor blocker ameliorates insulin resistance and decreases triglyceride production in fructose-fed rats. Hypertension research : official journal of the Japanese Society of Hypertension. vol 27. issue 4. 2004-06-25. PMID:15127887. |
olmesartan ameliorates insulin resistance and overproduction of tg in fructose-fed rats, and these effects appear to be independent of its hypotensive action. |
2004-06-25 |
2023-08-12 |
rat |