| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mihaela C Blendea, David Jacobs, Craig S Stump, Samy I McFarlane, Cristina Ogrin, Gul Bahtyiar, Samir Stas, Pawan Kumar, Quan Sha, Carlos M Ferrario, James R Sower. Abrogation of oxidative stress improves insulin sensitivity in the Ren-2 rat model of tissue angiotensin II overexpression. American journal of physiology. Endocrinology and metabolism. vol 288. issue 2. 2005-02-15. PMID:15494608. |
to evaluate the role of renin-angiotensin system (ras)-mediated oxidative stress in insulin resistance (ir), we compared the effects of the angiotensin ii (ang ii) receptor blocker (arb) valsartan and a superoxide dismutase (sod) mimetic, tempol, on whole body glucose tolerance and soleus muscle insulin-stimulated glucose uptake in transgenic hypertensive tg(mren-2)27 (ren-2) rats. |
2005-02-15 |
2023-08-12 |
rat |
| Hideo Kanehara, Jinya Suzuki, Yasuo Zenimaru, Sadao Takahashi, Koji Oida, Wen-Jun Shen, Fredric B Kraemer, Isamu Miyamor. Function of hormone-sensitive lipase in diacylglycerol-protein kinase C pathway. Diabetes research and clinical practice. vol 65. issue 3. 2005-02-11. PMID:15331200. |
[(14)c]glucose-incorporation into triglyceride (tg) was 75% lower in the presence or absence of insulin in cells expressing wt-hsl compared to ct or s423a. |
2005-02-11 |
2023-08-12 |
rat |
| Melania Manco, Menotti Calvani, Geltrude Mingron. Effects of dietary fatty acids on insulin sensitivity and secretion. Diabetes, obesity & metabolism. vol 6. issue 6. 2005-02-02. PMID:15479216. |
in pancreatic islets, tg accumulation causes impairment of insulin secretion. |
2005-02-02 |
2023-08-12 |
rat |
| Melania Manco, Menotti Calvani, Geltrude Mingron. Effects of dietary fatty acids on insulin sensitivity and secretion. Diabetes, obesity & metabolism. vol 6. issue 6. 2005-02-02. PMID:15479216. |
the decreased insulin gene promoter activity and binding of the pancreas-duodenum homeobox-1 (pdx-1) transcription factor to the insulin gene seem to mediate tg effect in islets. |
2005-02-02 |
2023-08-12 |
rat |
| Y Mori, Y Kitahara, K Miura, T Mine, N Tajim. Role of early insulin secretion in postglucose-loading hyperglycaemia and postfat-loading hyperlipidaemia: comparing nateglinide and glibenclamide for acute effects on insulin secretion in OLETF rats. Diabetes, obesity & metabolism. vol 6. issue 6. 2005-02-02. PMID:15479218. |
the aim of this study was to clarify the role of an early insulin secretion in postprandial hyperglycaemia and hyperlipidaemia; a study using spontaneously type 2 diabetic otsuka long-evans tokushima fatty rats with visceral obesity was performed to investigate the acute effect of nateglinide (nat) vs. glibenclamide (gb) on increases in glucose after glucose loading and on increases in triglyceride (tg) after fat loading. |
2005-02-02 |
2023-08-12 |
rat |
| Michela Novelli, Alessandro Pocai, Monika Skalicky, Andrus Viidik, Ettore Bergamini, Pellegrino Masiell. Effects of life-long exercise on circulating free fatty acids and muscle triglyceride content in ageing rats. Experimental gerontology. vol 39. issue 9. 2005-02-02. PMID:15489056. |
as muscle triglyceride (tg) accumulation is considered a reliable index of muscle insulin resistance, in this study we explored muscle tg content in 23-month-old male sprague-dawley rats subjected to life-long training. |
2005-02-02 |
2023-08-12 |
rat |
| Junji Matsui, Yasuo Terauchi, Naoto Kubota, Iseki Takamoto, Kazuhiro Eto, Tokuyuki Yamashita, Kajuro Komeda, Toshimasa Yamauchi, Junji Kamon, Shunbun Kita, Mitsuhiko Noda, Takashi Kadowak. Pioglitazone reduces islet triglyceride content and restores impaired glucose-stimulated insulin secretion in heterozygous peroxisome proliferator-activated receptor-gamma-deficient mice on a high-fat diet. Diabetes. vol 53. issue 11. 2005-01-12. PMID:15504964. |
administration of a ppar-gamma agonist, pioglitazone, reduced the islet tg content in ppargamma(+/-) mice on a high-fat diet and ameliorated the impaired insulin secretion in vitro. |
2005-01-12 |
2023-08-12 |
mouse |
| Junji Matsui, Yasuo Terauchi, Naoto Kubota, Iseki Takamoto, Kazuhiro Eto, Tokuyuki Yamashita, Kajuro Komeda, Toshimasa Yamauchi, Junji Kamon, Shunbun Kita, Mitsuhiko Noda, Takashi Kadowak. Pioglitazone reduces islet triglyceride content and restores impaired glucose-stimulated insulin secretion in heterozygous peroxisome proliferator-activated receptor-gamma-deficient mice on a high-fat diet. Diabetes. vol 53. issue 11. 2005-01-12. PMID:15504964. |
our results demonstrate that ppar-gamma protects islets from lipotoxicity by regulating tg partitioning among tissues and that a ppar-gamma agonist can restore impaired insulin secretion under conditions of islet fat accumulation. |
2005-01-12 |
2023-08-12 |
mouse |
| Jason M R Gill, Jacqueline C Brown, Dorothy Bedford, Dawn M Wright, Josephine Cooney, David A Hughes, Chris J Packard, Muriel J Caslak. Hepatic production of VLDL1 but not VLDL2 is related to insulin resistance in normoglycaemic middle-aged subjects. Atherosclerosis. vol 176. issue 1. 2004-12-30. PMID:15306174. |
insulin resistance is probably the defining feature of the metabolic syndrome and is an important determinant of plasma triglyceride (tg) concentrations. |
2004-12-30 |
2023-08-12 |
human |
| Yoshiko Kanezaki, Toshiyuki Obata, Rie Matsushima, Asako Minami, Tomoyuki Yuasa, Kazuhiro Kishi, Yoshimi Bando, Hisanori Uehara, Keisuke Izumi, Tasuku Mitani, Mitsuru Matsumoto, Yukari Takeshita, Yutaka Nakaya, Toshio Matsumoto, Yousuke Ebin. K(ATP) channel knockout mice crossbred with transgenic mice expressing a dominant-negative form of human insulin receptor have glucose intolerance but not diabetes. Endocrine journal. vol 51. issue 2. 2004-12-21. PMID:15118262. |
there are two kinds of diabetic model mice: one is a k(atp) channel knockout (kir6.2ko) mouse which is defective in glucose-induced insulin secretion, and the other is a transgenic mouse expressing the tyrosine kinase-deficient (dominant-negative form of) human insulin receptor (hir(km)tg), and which has insulin resistance in muscle and fat. |
2004-12-21 |
2023-08-12 |
mouse |
| Yoshiko Kanezaki, Toshiyuki Obata, Rie Matsushima, Asako Minami, Tomoyuki Yuasa, Kazuhiro Kishi, Yoshimi Bando, Hisanori Uehara, Keisuke Izumi, Tasuku Mitani, Mitsuru Matsumoto, Yukari Takeshita, Yutaka Nakaya, Toshio Matsumoto, Yousuke Ebin. K(ATP) channel knockout mice crossbred with transgenic mice expressing a dominant-negative form of human insulin receptor have glucose intolerance but not diabetes. Endocrine journal. vol 51. issue 2. 2004-12-21. PMID:15118262. |
to determine if the double mutant kir6.2ko/hir(km)tg mice would have diabetes, we generated mutant mice by crossbreeding, which would show both impaired glucose-induced insulin secretion and insulin resistance in muscle and fat. |
2004-12-21 |
2023-08-12 |
mouse |
| Yoshiko Kanezaki, Toshiyuki Obata, Rie Matsushima, Asako Minami, Tomoyuki Yuasa, Kazuhiro Kishi, Yoshimi Bando, Hisanori Uehara, Keisuke Izumi, Tasuku Mitani, Mitsuru Matsumoto, Yukari Takeshita, Yutaka Nakaya, Toshio Matsumoto, Yousuke Ebin. K(ATP) channel knockout mice crossbred with transgenic mice expressing a dominant-negative form of human insulin receptor have glucose intolerance but not diabetes. Endocrine journal. vol 51. issue 2. 2004-12-21. PMID:15118262. |
we report here that: 1) blood glucose levels of randomly fed and 6 h fasted double mutant (kir6.2ko/hir(km)tg) mice were comparable with those of wild type mice; 2) in intraperitoneal glucose tolerance test (ipgtt), kir6.2ko/hir(km)tg mice had an impaired glucose tolerance; and 3) during ipgtt, insulin secretion was not induced in either kir6.2ko/hir(km)tg or kir6.2ko mice, while the hir(km)tg mice showed a more prolonged insulin secretion than did wild type mice; 4) hyperinsulinemic euglycemic clamp test revealed that kir6.2ko, kir6.2ko/hir(km)tg and hir(km)tg mice, showed decreased whole-body glucose disposal compared with wild type mice; 5) kir6.2ko, but not kir6.2ko/hir(km)tg mice had some obesity and hyperleptinemia compared with wild type mice. |
2004-12-21 |
2023-08-12 |
mouse |
| Yoshiko Kanezaki, Toshiyuki Obata, Rie Matsushima, Asako Minami, Tomoyuki Yuasa, Kazuhiro Kishi, Yoshimi Bando, Hisanori Uehara, Keisuke Izumi, Tasuku Mitani, Mitsuru Matsumoto, Yukari Takeshita, Yutaka Nakaya, Toshio Matsumoto, Yousuke Ebin. K(ATP) channel knockout mice crossbred with transgenic mice expressing a dominant-negative form of human insulin receptor have glucose intolerance but not diabetes. Endocrine journal. vol 51. issue 2. 2004-12-21. PMID:15118262. |
thus, the defects in glucose-induced insulin secretion (kir6.2ko) and an insulin resistance in muscle and fat (hir(km)tg) were not sufficient to lead to overt diabetes. |
2004-12-21 |
2023-08-12 |
mouse |
| S R Sutradhar, L Ali, A K Khan, N I Siddiqui, C B Sarker, S Rahman, M H Huq, C R Debnat. Ketosis resistance in under thirty diabetic subjects. Mymensingh medical journal : MMJ. vol 13. issue 2. 2004-12-21. PMID:15284687. |
to understand this mechanism we have studied the serum responses of glucose, non-esterified fatty acid (nefa) and triglyceride (tg) to intravenous fat emulsion in newly diagnosed 8 fibrocalculous pancreatic diabetes (fcpd) and 11 low insulin secretory (lis) subjects under 30 years of age along with 27 age-matched non insulin dependent diabetes mellitus (niddm) subjects. |
2004-12-21 |
2023-08-12 |
human |
| S R Sutradhar, L Ali, A K Khan, N I Siddiqui, C B Sarker, S Rahman, M H Huq, C R Debnat. Ketosis resistance in under thirty diabetic subjects. Mymensingh medical journal : MMJ. vol 13. issue 2. 2004-12-21. PMID:15284687. |
the results suggest the following: (a) depleted body fat store do not lead to a decreased supply of nefa in fcpd and lis subjects at the fasting state; (b) increased supply of nefa in these subjects lead to a normal esterification response as evidenced by a parallel rise of tg; (c) inspite of markedly low level of the antilipolytic hormone insulin, fcpd and lis subjects are capable to maintain nefa and tg responses similar to niddm subjects. |
2004-12-21 |
2023-08-12 |
human |
| May Faraj, Allan D Sniderman, Katherine Cianflon. ASP enhances in situ lipoprotein lipase activity by increasing fatty acid trapping in adipocytes. Journal of lipid research. vol 45. issue 4. 2004-12-03. PMID:14703506. |
however, asp and insulin increased the v(max) of in situ lpl activity ([(3)h]tg synthetic lipoprotein hydrolysis and [(3)h]nefa incorporation into adipocytes) by 60% and 41%, respectively (p
| 2004-12-03 |
2023-08-12 |
Not clear |
| Gabriele E Sonnenberg, Glenn R Krakower, Lisa J Martin, Michael Olivier, Anne E Kwitek, Anthony G Comuzzie, John Blangero, Ahmed H Kisseba. Genetic determinants of obesity-related lipid traits. Journal of lipid research. vol 45. issue 4. 2004-12-03. PMID:14754912. |
covariates of the tg linkage included waist circumference, fasting insulin, and insulin:glucose, but not body mass index or hip circumference. |
2004-12-03 |
2023-08-12 |
Not clear |
| Santiago Rodríguez, Tom R Gaunt, Sandra D O'Dell, Xiao-He Chen, Dongfeng Gu, Emma Hawe, George J Miller, Stephen E Humphries, Ian N M Da. Haplotypic analyses of the IGF2-INS-TH gene cluster in relation to cardiovascular risk traits. Human molecular genetics. vol 13. issue 7. 2004-12-02. PMID:14749349. |
we propose that long repeat insertion in the insulin gene promoter ('class iii'), reported to result in low insulin production, predisposes to the metabolic syndrome features of elevated bp, fat mass or tg level, therefore appearing more frequently in type 2 diabetic, polycystic ovary syndrome and chd cases. |
2004-12-02 |
2023-08-12 |
Not clear |
| Jianmin Ran, Tsutomu Hirano, Mitsuru Adach. Chronic ANG II infusion increases plasma triglyceride level by stimulating hepatic triglyceride production in rats. American journal of physiology. Endocrinology and metabolism. vol 287. issue 5. 2004-12-02. PMID:15213064. |
we recently observed that ang ii receptor blocker therapy improved the overproduction of triglyceride (tg) in fructose-fed rats and zucker fatty rats with insulin resistance, which in turn suggests that ang ii may stimulate tg production. |
2004-12-02 |
2023-08-12 |
rat |
| Jianmin Ran, Tsutomu Hirano, Mitsuru Adach. Chronic ANG II infusion increases plasma triglyceride level by stimulating hepatic triglyceride production in rats. American journal of physiology. Endocrinology and metabolism. vol 287. issue 5. 2004-12-02. PMID:15213064. |
accordingly, we investigated the effects of ang ii on tg production and the association with insulin resistance in normal rats. |
2004-12-02 |
2023-08-12 |
rat |