| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sumie Yoshioka, Yukio As. A quantitative assessment of the significance of molecular mobility as a determinant for the stability of lyophilized insulin formulations. Pharmaceutical research. vol 22. issue 8. 2005-10-13. PMID:16078146. |
degradation of insulin in lyophilized formulations containing trehalose and poly(vinylpyrrolidone)(pvp) was chosen as a model system, and the temperature- and glass transition temperature (tg)-dependence of the degradation rate was analyzed to obtain the relative contributions of molecular mobility and that of the chemical activational barrier reflected in the energy of activation. |
2005-10-13 |
2023-08-12 |
Not clear |
| Sébastien Vankoningsloo, Marie Piens, Christophe Lecocq, Audrey Gilson, Aurélia De Pauw, Patricia Renard, Catherine Demazy, Andrée Houbion, Martine Raes, Thierry Arnoul. Mitochondrial dysfunction induces triglyceride accumulation in 3T3-L1 cells: role of fatty acid beta-oxidation and glucose. Journal of lipid research. vol 46. issue 6. 2005-09-22. PMID:15741651. |
although the uptake of tg precursors is not stimulated in 3t3-l1 cells with impaired mitochondrial activity, we found a strong stimulation of glucose uptake in aa-treated cells mediated by calcium and phosphatidylinositol 3-kinase/akt1/glycogen synthase kinase 3beta, a pathway known to trigger the translocation of glucose transporter 4 to the plasma membrane in response to insulin. |
2005-09-22 |
2023-08-12 |
Not clear |
| Andrew M Lemieux, Cody J Diehl, Julie A Sloniger, Erik J Henrikse. Voluntary exercise training enhances glucose transport but not insulin signaling capacity in muscle of hypertensive TG(mREN2)27 rats. Journal of applied physiology (Bethesda, Md. : 1985). vol 99. issue 1. 2005-09-19. PMID:15718410. |
voluntary exercise training enhances glucose transport but not insulin signaling capacity in muscle of hypertensive tg(mren2)27 rats. |
2005-09-19 |
2023-08-12 |
rat |
| Andrew M Lemieux, Cody J Diehl, Julie A Sloniger, Erik J Henrikse. Voluntary exercise training enhances glucose transport but not insulin signaling capacity in muscle of hypertensive TG(mREN2)27 rats. Journal of applied physiology (Bethesda, Md. : 1985). vol 99. issue 1. 2005-09-19. PMID:15718410. |
male heterozygous tg(mren2)27 rats (tgr) overexpress a murine renin transgene, display marked hypertension, and have insulin resistance of skeletal muscle glucose transport and insulin signaling. |
2005-09-19 |
2023-08-12 |
rat |
| Henry N Ginsberg, Yuan-Li Zhang, Antonio Hernandez-On. Regulation of plasma triglycerides in insulin resistance and diabetes. Archives of medical research. vol 36. issue 3. 2005-09-16. PMID:15925013. |
increased plasma levels of triglycerides (tg) in very low density lipoproteins (vldl) are not only common characteristics of the dyslipidemia associated with insulin resistance and type 2 diabetes mellitus (t2dm) but are the central pathophysiologic feature of the abnormal lipid profile. |
2005-09-16 |
2023-08-12 |
Not clear |
| Henry N Ginsberg, Yuan-Li Zhang, Antonio Hernandez-On. Regulation of plasma triglycerides in insulin resistance and diabetes. Archives of medical research. vol 36. issue 3. 2005-09-16. PMID:15925013. |
the major sources of tg in the liver: uptake of fatty acids (fa) released by lipolysis of adipose tissue tg, uptake of tgfa in vldl and chylomicrons remnants, and hepatic de novo lipogenesis (the synthesis of fa from glucose) are all abnormally increased in insulin resistance. |
2005-09-16 |
2023-08-12 |
Not clear |
| Henry N Ginsberg, Yuan-Li Zhang, Antonio Hernandez-On. Regulation of plasma triglycerides in insulin resistance and diabetes. Archives of medical research. vol 36. issue 3. 2005-09-16. PMID:15925013. |
treatment of the dyslipidemia in insulin resistant individuals and patients with t2dm has been successful in reducing cardiovascular disease; ldl cholesterol, tg, and hdl cholesterol are all appropriate targets for therapy when diet, exercise, and weight loss do not achieve goals. |
2005-09-16 |
2023-08-12 |
Not clear |
| Aldo Grefhorst, Jildou Hoekstra, Terry G J Derks, D Margriet Ouwens, Julius F W Baller, Rick Havinga, Louis M Havekes, Johannes A Romijn, Folkert Kuiper. Acute hepatic steatosis in mice by blocking beta-oxidation does not reduce insulin sensitivity of very-low-density lipoprotein production. American journal of physiology. Gastrointestinal and liver physiology. vol 289. issue 3. 2005-09-13. PMID:15817811. |
accumulation of triglycerides (tg) in the liver is generally associated with hepatic insulin resistance. |
2005-09-13 |
2023-08-12 |
mouse |
| Annemieke C Heijboer, Esther Donga, Peter J Voshol, Zhi-Chao Dang, Louis M Havekes, Johannes A Romijn, Eleonora P M Corssmi. Sixteen hours of fasting differentially affects hepatic and muscle insulin sensitivity in mice. Journal of lipid research. vol 46. issue 3. 2005-09-07. PMID:15576835. |
sixteen hours of fasting did not show an effect on hepatic insulin sensitivity in terms of glucose production in the presence of increased hepatic tg content. |
2005-09-07 |
2023-08-12 |
mouse |
| Annemieke C Heijboer, Esther Donga, Peter J Voshol, Zhi-Chao Dang, Louis M Havekes, Johannes A Romijn, Eleonora P M Corssmi. Sixteen hours of fasting differentially affects hepatic and muscle insulin sensitivity in mice. Journal of lipid research. vol 46. issue 3. 2005-09-07. PMID:15576835. |
in muscle, however, fasting resulted in increased insulin sensitivity, with increased muscle glucose uptake without changes in muscle tg content. |
2005-09-07 |
2023-08-12 |
mouse |
| Annemieke C Heijboer, Esther Donga, Peter J Voshol, Zhi-Chao Dang, Louis M Havekes, Johannes A Romijn, Eleonora P M Corssmi. Sixteen hours of fasting differentially affects hepatic and muscle insulin sensitivity in mice. Journal of lipid research. vol 46. issue 3. 2005-09-07. PMID:15576835. |
in conclusion, 16 h of fasting does not induce hepatic insulin resistance, although it causes liver steatosis, whereas muscle insulin sensitivity increases without changes in muscle tg content. |
2005-09-07 |
2023-08-12 |
mouse |
| Annemieke C Heijboer, Esther Donga, Peter J Voshol, Zhi-Chao Dang, Louis M Havekes, Johannes A Romijn, Eleonora P M Corssmi. Sixteen hours of fasting differentially affects hepatic and muscle insulin sensitivity in mice. Journal of lipid research. vol 46. issue 3. 2005-09-07. PMID:15576835. |
therefore, fasting induces differential changes in tissue-specific insulin sensitivity, and liver and muscle tg contents are unlikely to be involved in these changes. |
2005-09-07 |
2023-08-12 |
mouse |
| Wei-Dong Li, Chuanhui Dong, Ding Li, Cathleen Garrigan, R Arlen Pric. A genome scan for serum triglyceride in obese nuclear families. Journal of lipid research. vol 46. issue 3. 2005-09-07. PMID:15604520. |
serum triglyceride (tg) levels are increased in extremely obese individuals, indicating abnormalities in lipid metabolism and insulin resistance. |
2005-09-07 |
2023-08-12 |
Not clear |
| Anne E Sumner, Gloria L Vega, David J Genovese, Karl B Finley, Richard N Bergman, Raymond C Bosto. Normal triglyceride levels despite insulin resistance in African Americans: role of lipoprotein lipase. Metabolism: clinical and experimental. vol 54. issue 7. 2005-08-23. PMID:15988699. |
in caucasians, postheparin-lpl (ph-lpl) activity is impaired in the presence of insulin resistance and leads to elevated tg levels. |
2005-08-23 |
2023-08-12 |
human |
| Anne E Sumner, Gloria L Vega, David J Genovese, Karl B Finley, Richard N Bergman, Raymond C Bosto. Normal triglyceride levels despite insulin resistance in African Americans: role of lipoprotein lipase. Metabolism: clinical and experimental. vol 54. issue 7. 2005-08-23. PMID:15988699. |
the lack of an effect of insulin resistance on ph-lpl could allow lpl to clear tg even in the presence of insulin resistance and explain the coexistence of insulin resistance and normotriglyceridemia in african americans. |
2005-08-23 |
2023-08-12 |
human |
| Cunzhi Han, Hong-Tao Zhang, Lili Du, Xiuying Liu, Jiexian Jing, Xianwen Zhao, Xuan Yang, Baoguo Tia. Serum levels of leptin, insulin, and lipids in relation to breast cancer in china. Endocrine. vol 26. issue 1. 2005-08-19. PMID:15805581. |
we found that the serum levels of leptin, insulin, and triglyceride (tg) were clearly higher in patients with breast cancer than in patients with benign breast disease and healthy controls, while serum hdl-c levels were lower in breast cancer patients (p < 0.03). |
2005-08-19 |
2023-08-12 |
human |
| Cunzhi Han, Hong-Tao Zhang, Lili Du, Xiuying Liu, Jiexian Jing, Xianwen Zhao, Xuan Yang, Baoguo Tia. Serum levels of leptin, insulin, and lipids in relation to breast cancer in china. Endocrine. vol 26. issue 1. 2005-08-19. PMID:15805581. |
furthermore, the serum levels of leptin and insulin were not associated with menopausal status in patients with mammary disease (p > 0.05); however, the serum levels of f-chol, t-chol, tg, ldl-c, and apob were significant higher in postmenopausal cases than those in premenopausal cases (p < 0.025). |
2005-08-19 |
2023-08-12 |
human |
| Cunzhi Han, Hong-Tao Zhang, Lili Du, Xiuying Liu, Jiexian Jing, Xianwen Zhao, Xuan Yang, Baoguo Tia. Serum levels of leptin, insulin, and lipids in relation to breast cancer in china. Endocrine. vol 26. issue 1. 2005-08-19. PMID:15805581. |
interestingly, logistic regression analysis showed that subjects with elevated serum levels of leptin, insulin, tg, apoa1, and reduced level of serum hdl-c displayed increased risk of developing breast cancer than those with the normal levels, respectively. |
2005-08-19 |
2023-08-12 |
human |
| Cunzhi Han, Hong-Tao Zhang, Lili Du, Xiuying Liu, Jiexian Jing, Xianwen Zhao, Xuan Yang, Baoguo Tia. Serum levels of leptin, insulin, and lipids in relation to breast cancer in china. Endocrine. vol 26. issue 1. 2005-08-19. PMID:15805581. |
the elevated serum levels of leptin, insulin, tg, apoa1, and reduced level of serum hdl-c may be correlated with increased risk of breast cancer, suggesting that one way of preventing breast cancer would be carried out by controlling the intake of food. |
2005-08-19 |
2023-08-12 |
human |
| Mei-Lian Liu, Xia Xu, Wei-Qing Rang, Yuan-Jian Li, Hui-Ping Son. Influence of ovariectomy and 17beta-estradiol treatment on insulin sensitivity, lipid metabolism and post-ischemic cardiac function. International journal of cardiology. vol 97. issue 3. 2005-08-16. PMID:15561337. |
within 3 months after operation, body weight, the serum levels of estrogen, glucose, insulin, total cholesterol (t-chol), hdl-chol, ldl-cholesterol (ldl-chol), triglycerides (tg) and lipoprotein a (lp(a)) were monitored. |
2005-08-16 |
2023-08-12 |
rat |