| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Steven White, David B Bennett, Scot Cheu, Patrick W Conley, Donald B Guzek, Steven Gray, John Howard, Richard Malcolmson, Joann M Parker, Phil Roberts, Negar Sadrzadeh, Jacqueline D Schumacher, Sangita Seshadri, Gregory W Sluggett, Cynthia L Stevenson, Nancy J Harpe. EXUBERA: pharmaceutical development of a novel product for pulmonary delivery of insulin. Diabetes technology & therapeutics. vol 7. issue 6. 2006-02-28. PMID:16386095. |
the insulin drug is formulated using a novel excipient combination to create a powder with a high glass transition temperature (tg). |
2006-02-28 |
2023-08-12 |
Not clear |
| Steven White, David B Bennett, Scot Cheu, Patrick W Conley, Donald B Guzek, Steven Gray, John Howard, Richard Malcolmson, Joann M Parker, Phil Roberts, Negar Sadrzadeh, Jacqueline D Schumacher, Sangita Seshadri, Gregory W Sluggett, Cynthia L Stevenson, Nancy J Harpe. EXUBERA: pharmaceutical development of a novel product for pulmonary delivery of insulin. Diabetes technology & therapeutics. vol 7. issue 6. 2006-02-28. PMID:16386095. |
the high tg minimizes insulin mobility (thus reactivity), enabling ambient storage conditions. |
2006-02-28 |
2023-08-12 |
Not clear |
| Masamichi Inami, Ikuo Kawamura, Susumu Tsujimoto, Tohru Yasuno, Elizabeth Lacey, Jiro Hirosumi, Shoji Takakura, Fusako Nishigaki, Yoshinori Naoe, Toshitaka Manda, Seitaro Muto. FR177391, a new anti-hyperlipidemic agent from Serratia. II. Pharmacological activity of FR177391. The Journal of antibiotics. vol 58. issue 10. 2006-02-27. PMID:16392680. |
severely elevated levels of tg in db/db mice, an insulin resistant diabetic animal model, also significantly decreased from 14 days of treatment with fr177391. |
2006-02-27 |
2023-08-12 |
mouse |
| Robert C Cooksey, Sumitha Pusuluri, Mark Hazel, Donald A McClai. Hexosamines regulate sensitivity of glucose-stimulated insulin secretion in beta-cells. American journal of physiology. Endocrinology and metabolism. vol 290. issue 2. 2006-02-22. PMID:16188910. |
young (2-mo-old) tg animals had enhanced sensitivity to glucose of insulin secretion. |
2006-02-22 |
2023-08-12 |
mouse |
| Robert C Cooksey, Sumitha Pusuluri, Mark Hazel, Donald A McClai. Hexosamines regulate sensitivity of glucose-stimulated insulin secretion in beta-cells. American journal of physiology. Endocrinology and metabolism. vol 290. issue 2. 2006-02-22. PMID:16188910. |
insulin secretion was maximal at 20 mm and half maximal at 9.9 +/- 0.5 mm glucose in tg islets compared with maximal at 30 mm and half maximal at 13.5 +/- 0.7 mm glucose in wild type (wt; p < 0.005). |
2006-02-22 |
2023-08-12 |
mouse |
| Robert C Cooksey, Sumitha Pusuluri, Mark Hazel, Donald A McClai. Hexosamines regulate sensitivity of glucose-stimulated insulin secretion in beta-cells. American journal of physiology. Endocrinology and metabolism. vol 290. issue 2. 2006-02-22. PMID:16188910. |
young tg animals secreted more insulin in response to 20 mm glucose (tg, 1,254 +/- 311; wt, 425 +/- 231 pg x islet(-1) x 35 min(-1); p < 0.01). |
2006-02-22 |
2023-08-12 |
mouse |
| Robert C Cooksey, Sumitha Pusuluri, Mark Hazel, Donald A McClai. Hexosamines regulate sensitivity of glucose-stimulated insulin secretion in beta-cells. American journal of physiology. Endocrinology and metabolism. vol 290. issue 2. 2006-02-22. PMID:16188910. |
older tg mice secreted less insulin in response to 20 mm glucose (tg, 2,256 +/- 342; wt, 3,493 +/- 367 pg x islet(-1) x 35 min(-1); p < 0.05). |
2006-02-22 |
2023-08-12 |
mouse |
| Elena Sanguino, Núria Roglans, Marta Alegret, Rosa M Sánchez, Manuel Vázquez-Carrera, Juan C Lagun. Different response of senescent female Sprague-Dawley rats to gemfibrozil and rosiglitazone administration. Experimental gerontology. vol 40. issue 7. 2006-02-09. PMID:15998575. |
we determined in 18-month-old female sprague-dawley rats treated for 21 days with a daily dose of 3mg gemfibrozil/kg or 3mg rosiglitazone/kg: (i) plasma concentrations of total cholesterol (tc), triglycerides (tg), nonesterified fatty acids (nefa), glucose, insulin and leptin, (ii) hepatic concentrations of tg, nefa and cholesteryl esters (ce), and (iii) the liver expression and binding activity of peroxisome proliferator-activated receptor alpha (pparalpha), and several of its target genes, hepatic nuclear factor-4 (hnf-4), and liver x receptor alpha (lxralpha). |
2006-02-09 |
2023-08-12 |
rat |
| Elena Sanguino, Núria Roglans, Marta Alegret, Rosa M Sánchez, Manuel Vázquez-Carrera, Juan C Lagun. Different response of senescent female Sprague-Dawley rats to gemfibrozil and rosiglitazone administration. Experimental gerontology. vol 40. issue 7. 2006-02-09. PMID:15998575. |
although gemfibrozil induced mild effects on hepatic pparalpha, hnf-4, and lxralpha, only rosiglitazone significantly reduced plasma tg (59%), glucose (19%), insulin (61%), and leptin (66%), and liver tg (43%), ce (49%), and nefa (27%). |
2006-02-09 |
2023-08-12 |
rat |
| Shu Feng, Natalia V Bogatcheva, Aparna A Kamat, Anne Truong, Alexander I Agoulni. Endocrine effects of relaxin overexpression in mice. Endocrinology. vol 147. issue 1. 2006-02-03. PMID:16223865. |
to investigate the systemic endocrine effects of relaxin, we produced mice with transgenic overexpression of the rln1 gene, tg(rln1), driven by rat insulin 2 promoter. |
2006-02-03 |
2023-08-12 |
mouse |
| Mei-Ling Chang, Hui-Ling Chen, Shao-Chun L. Possible role of triacylglycerol-rich lipoproteins in the down-regulation of adipose obese mRNA expression in rats re-fed a high-fat diet. Journal of biomedical science. vol 12. issue 4. 2006-01-26. PMID:16132107. |
adult male wistar rats were fasted for 48 h and re-fed either a fat-free/high-carbohydrate diet or a high-fat diet for 2, 4, or 8 h and plasma glucose, insulin, tg, and leptin as well as ob mrna expression in epididymal fat pads were examined. |
2006-01-26 |
2023-08-12 |
rat |
| Mei-Ling Chang, Hui-Ling Chen, Shao-Chun L. Possible role of triacylglycerol-rich lipoproteins in the down-regulation of adipose obese mRNA expression in rats re-fed a high-fat diet. Journal of biomedical science. vol 12. issue 4. 2006-01-26. PMID:16132107. |
rats re-fed the high-fat diet had significantly higher plasma tg (p < 0.05) and lower plasma leptin and adipose ob mrna (p < 0.05) than those fed the fat-free/high-carbohydrate diet; however, plasma glucose and insulin concentrations were not significantly different between the two groups. |
2006-01-26 |
2023-08-12 |
rat |
| Julie A Sloniger, Vitoon Saengsirisuwan, Cody J Diehl, John S Kim, Erik J Henrikse. Selective angiotensin II receptor antagonism enhances whole-body insulin sensitivity and muscle glucose transport in hypertensive TG(mREN2)27 rats. Metabolism: clinical and experimental. vol 54. issue 12. 2006-01-24. PMID:16311101. |
selective angiotensin ii receptor antagonism enhances whole-body insulin sensitivity and muscle glucose transport in hypertensive tg(mren2)27 rats. |
2006-01-24 |
2023-08-12 |
mouse |
| Julie A Sloniger, Vitoon Saengsirisuwan, Cody J Diehl, John S Kim, Erik J Henrikse. Selective angiotensin II receptor antagonism enhances whole-body insulin sensitivity and muscle glucose transport in hypertensive TG(mREN2)27 rats. Metabolism: clinical and experimental. vol 54. issue 12. 2006-01-24. PMID:16311101. |
the male heterozygous tg(mren2)27 rat (tgr) harbors the mouse transgene for renin, exhibits local tissue elevations in angii and is an excellent model of both hypertension and insulin resistance associated with defective insulin signaling. |
2006-01-24 |
2023-08-12 |
mouse |
| Elena Sanguino, Nuria Roglans, Marta Alegret, Rosa M Sánchez, Manuel Vázquez-Carrera, Juan C Lagun. Atorvastatin reverses age-related reduction in rat hepatic PPARalpha and HNF-4. British journal of pharmacology. vol 145. issue 7. 2006-01-17. PMID:15912134. |
we measured fatty acid oxidation (fao), the expression of pparalpha-target genes, liver triglyceride (tg) and cholesteryl ester (ce) contents and plasma concentrations of tg, cholesterol, glucose, nonesterified fatty acids (nefa), insulin and leptin. |
2006-01-17 |
2023-08-12 |
rat |
| Liang Xi, Zhiyu Qian, Xiangchun Shen, Na Wen, Yabing Zhan. Crocetin prevents dexamethasone-induced insulin resistance in rats. Planta medica. vol 71. issue 10. 2005-12-19. PMID:16254822. |
in the dexamethasone-treated group, serum insulin, free fatty acids (ffa), triglyceride (tg) and tumor necrosis factor (tnf)-alpha levels were significantly increased at the end of the study. |
2005-12-19 |
2023-08-12 |
rat |
| Mi-Young Park, Kwang-Seung Lee, Mi-Kyung Sun. Effects of dietary mulberry, Korean red ginseng, and banaba on glucose homeostasis in relation to PPAR-alpha, PPAR-gamma, and LPL mRNA expressions. Life sciences. vol 77. issue 26. 2005-11-15. PMID:15979095. |
results indicated that mulberry leaf water extract, korean red ginseng, banaba leaf water extract, and the combination of above herbs effectively reduced blood glucose, insulin, tg, and percent hba1c in study animals (p<0.05). |
2005-11-15 |
2023-08-12 |
mouse |
| Nicholas D Oakes, Pia Thalén, Therese Hultstrand, Severina Jacinto, Germán Camejo, Boel Wallin, Bengt Ljun. Tesaglitazar, a dual PPAR{alpha}/{gamma} agonist, ameliorates glucose and lipid intolerance in obese Zucker rats. American journal of physiology. Regulatory, integrative and comparative physiology. vol 289. issue 4. 2005-11-07. PMID:16183630. |
the 2-h postload area under the curve values were greater for glucose (+19%), insulin (+849%), ffa (+53%), and tg (+413%) compared with untreated lean controls. |
2005-11-07 |
2023-08-12 |
rat |
| Nicholas D Oakes, Pia Thalén, Therese Hultstrand, Severina Jacinto, Germán Camejo, Boel Wallin, Bengt Ljun. Tesaglitazar, a dual PPAR{alpha}/{gamma} agonist, ameliorates glucose and lipid intolerance in obese Zucker rats. American journal of physiology. Regulatory, integrative and comparative physiology. vol 289. issue 4. 2005-11-07. PMID:16183630. |
treatment with tesaglitazar lowered fasting plasma glucose, improved glucose tolerance, substantially reduced fasting and postload insulin levels, and markedly lowered fasting tg and improved lipid tolerance. |
2005-11-07 |
2023-08-12 |
rat |
| Mihaela C Blendea, Mara Bard, James R Sowers, Nathaniel Wine. High-fat meal impairs vascular compliance in a subgroup of young healthy subjects. Metabolism: clinical and experimental. vol 54. issue 10. 2005-10-27. PMID:16154433. |
normal weight young subjects with an insulin resistance phenotype show significantly decreased vascular compliance, increased postprandial tg peaks, and markedly reduced plasma nitric oxide metabolites after a high-fat meal. |
2005-10-27 |
2023-08-12 |
human |