| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yoshitake Cho, Miyako Ariga, Yasunobu Uchijima, Kumi Kimura, Jeung-Yon Rho, Yasufumi Furuhata, Fumihiko Hakuno, Keitaro Yamanouchi, Masugi Nishihara, Shin-Ichiro Takahash. The novel roles of liver for compensation of insulin resistance in human growth hormone transgenic rats. Endocrinology. vol 147. issue 11. 2006-11-20. PMID:16916956. |
because the role of liver in gh-induced insulin resistance is poorly understood, we studied insulin signaling at early stages and insulin action in liver and primary cultures of hepatocytes prepared from tg rats. |
2006-11-20 |
2023-08-12 |
human |
| Yoshitake Cho, Miyako Ariga, Yasunobu Uchijima, Kumi Kimura, Jeung-Yon Rho, Yasufumi Furuhata, Fumihiko Hakuno, Keitaro Yamanouchi, Masugi Nishihara, Shin-Ichiro Takahash. The novel roles of liver for compensation of insulin resistance in human growth hormone transgenic rats. Endocrinology. vol 147. issue 11. 2006-11-20. PMID:16916956. |
there was no difference in insulin receptor kinase activity induced by insulin between tg and control rats; however, insulin-dependent insulin receptor substrate-2 tyrosine phosphorylation, glycogen synthase activation, and expression of enzymes that induce lipid synthesis were potentiated in hepatocytes of tg rats. |
2006-11-20 |
2023-08-12 |
human |
| Prem K Mamnoor, Pragathi Hegde, Srinivas R Datla, Ravi K B Damarla, Ramanujam Rajagopalan, Ranjan Chakrabart. Antihypertensive effect of ragaglitazar: a novel PPARalpha and gamma dual activator. Pharmacological research. vol 54. issue 2. 2006-10-17. PMID:16651004. |
ragaglitazar showed significant reduction (p<0.001) of systolic blood pressure (sbp) in insulin resistant fa/fa rats, with concomitant reduction in plasma triglycerides (tg) and insulin levels while pioglitazone (10 mg kg(-1)) showed significant (p<0.05) but comparatively less reduction. |
2006-10-17 |
2023-08-12 |
rat |
| Marnie L Gruen, Viswanathan Saraswathi, Alli M Nuotio-Antar, Michelle R Plummer, Kimberly R Coenen, Alyssa H Hast. Plasma insulin levels predict atherosclerotic lesion burden in obese hyperlipidemic mice. Atherosclerosis. vol 186. issue 1. 2006-09-12. PMID:16102772. |
plasma triglycerides (tg) were 55% lower (p<0.001), non-esterified fatty acids (nefa) were 1.5-fold higher (p<0.01), and insulin levels were 1.7-fold higher (ns) in ob/ob;apoe-/- mice compared to ob/ob;ldlr-/- mice. |
2006-09-12 |
2023-08-12 |
mouse |
| Rai Ajit K Srivastava, Ravi Jahagirdar, Salman Azhar, Somesh Sharma, Charles L Bisgaie. Peroxisome proliferator-activated receptor-alpha selective ligand reduces adiposity, improves insulin sensitivity and inhibits atherosclerosis in LDL receptor-deficient mice. Molecular and cellular biochemistry. vol 285. issue 1-2. 2006-08-31. PMID:16477380. |
the aim of this study was to delineate the mechanism of fenofibrate-mediated reductions in adiposity, improvements in insulin sensitivity, and lowering of triglycerides (tg) and free fatty acids (ffa) and to investigate if these favorable changes are related to the inhibition of lipid deposition in the aorta. |
2006-08-31 |
2023-08-12 |
mouse |
| Letizia Guiducci, Mikko Järvisalo, Jan Kiss, Kjell Någren, Antti Viljanen, Alexandru G Naum, Amalia Gastaldelli, Timo Savunen, Juhani Knuuti, Piero A Salvadori, Ele Ferrannini, Pirjo Nuutila, Patricia Iozz. [11C]palmitate kinetics across the splanchnic bed in arterial, portal and hepatic venous plasma during fasting and euglycemic hyperinsulinemia. Nuclear medicine and biology. vol 33. issue 4. 2006-08-31. PMID:16720244. |
the aim of the study was to investigate the appearance of labeled tg in the hepatic vascular bed after [11c]palmitate injection during fasting and insulin stimulation. |
2006-08-31 |
2023-08-12 |
Not clear |
| Chad M Paton, Josef Brandauer, Edward P Weiss, Michael D Brown, F M Ivey, Stephen M Roth, James M Hagber. Hemostatic response to postprandial lipemia before and after exercise training. Journal of applied physiology (Bethesda, Md. : 1985). vol 101. issue 1. 2006-08-28. PMID:16497841. |
blood samples were obtained for measurement of free fatty acid (ffa), triglycerides (tg), insulin (ins), and glucose (glu). |
2006-08-28 |
2023-08-12 |
human |
| Toshiyuki Hayashi, Tsutomu Hirano, Takeshi Yamamoto, Yasuki Ito, Mitsuru Adach. Intensive insulin therapy reduces small dense low-density lipoprotein particles in patients with type 2 diabetes mellitus: relationship to triglyceride-rich lipoprotein subspecies. Metabolism: clinical and experimental. vol 55. issue 7. 2006-08-09. PMID:16784958. |
we examined the effect of intensive insulin therapy on sd-ldl particles and triglyceride (tg)-rich lipoprotein subspecies. |
2006-08-09 |
2023-08-12 |
Not clear |
| Toshiyuki Hayashi, Tsutomu Hirano, Takeshi Yamamoto, Yasuki Ito, Mitsuru Adach. Intensive insulin therapy reduces small dense low-density lipoprotein particles in patients with type 2 diabetes mellitus: relationship to triglyceride-rich lipoprotein subspecies. Metabolism: clinical and experimental. vol 55. issue 7. 2006-08-09. PMID:16784958. |
these results suggest that intensive insulin therapy decreases atherogenic sd-ldl particles by reducing tg in tg-rich lipoproteins. |
2006-08-09 |
2023-08-12 |
Not clear |
| B Ahrén, G Pacin. A novel approach to assess insulin sensitivity reveals no increased insulin sensitivity in mice with a dominant-negative mutant hepatocyte nuclear factor-1alpha. American journal of physiology. Regulatory, integrative and comparative physiology. vol 291. issue 1. 2006-07-26. PMID:16469839. |
with dsgit, we evaluated dynamic insulin sensitivity in mice with a rat insulin promoter (beta-cell-targeted) dominant-negative mutation of hepatic nuclear factor (hnf)-1alpha [rip-dn hnf-1alpha (tg) mice]. |
2006-07-26 |
2023-08-12 |
mouse |
| B Ahrén, G Pacin. A novel approach to assess insulin sensitivity reveals no increased insulin sensitivity in mice with a dominant-negative mutant hepatocyte nuclear factor-1alpha. American journal of physiology. Regulatory, integrative and comparative physiology. vol 291. issue 1. 2006-07-26. PMID:16469839. |
when insulin was administered exogenously at the same dose in tg and wild-type (wt) mice, plasma insulin levels were higher in wt, indicating an increased insulin clearance in tg mice. |
2006-07-26 |
2023-08-12 |
mouse |
| B Ahrén, G Pacin. A novel approach to assess insulin sensitivity reveals no increased insulin sensitivity in mice with a dominant-negative mutant hepatocyte nuclear factor-1alpha. American journal of physiology. Regulatory, integrative and comparative physiology. vol 291. issue 1. 2006-07-26. PMID:16469839. |
when the diazoxide test was used, different doses of insulin were therefore administered (0.1 and 0.15 u/kg in wt and 0.2 and 0.25 u/kg in tg) to achieve similar insulin levels in the groups. |
2006-07-26 |
2023-08-12 |
mouse |
| B Ahrén, G Pacin. A novel approach to assess insulin sensitivity reveals no increased insulin sensitivity in mice with a dominant-negative mutant hepatocyte nuclear factor-1alpha. American journal of physiology. Regulatory, integrative and comparative physiology. vol 291. issue 1. 2006-07-26. PMID:16469839. |
we conclude that 1) the dsgit technique determines the in vivo dynamic insulin action in mice, 2) insulin clearance is increased in tg mice, and 3) chronic islet dysfunction in rip-dn hnf-1alpha mice is not compensated with increased insulin sensitivity. |
2006-07-26 |
2023-08-12 |
mouse |
| Dimple Aggarwal, Maria Luz Fernandez, Ghada A Solima. Rapamycin, an mTOR inhibitor, disrupts triglyceride metabolism in guinea pigs. Metabolism: clinical and experimental. vol 55. issue 6. 2006-07-12. PMID:16713440. |
these results suggest that rapa interferes with tg metabolism by altering the insulin signaling pathway, inducing increased secretion of very low density lipoprotein and promoting deposition of tg in the aorta. |
2006-07-12 |
2023-08-12 |
Not clear |
| Yutaka Mori, Yohta Itoh, Tohru Obata, Naoko Tajim. Effects of pioglitazone vs glibenclamide on postprandial increases in glucose and triglyceride levels and on oxidative stress in Japanese patients with type 2 diabetes. Endocrine. vol 29. issue 1. 2006-06-29. PMID:16622303. |
at mtt 6 mo after pg administration, insulin levels before and 4 h after mtt, free fatty acid (ffa) levels 1, 2, and 4 h after mtt, glucose, tg, and rlp-tg levels before and 1, 2, 4, and 6 h after mtt were significantly decreased compared to baseline. |
2006-06-29 |
2023-08-12 |
human |
| Yutaka Mori, Yohta Itoh, Tohru Obata, Naoko Tajim. Effects of pioglitazone vs glibenclamide on postprandial increases in glucose and triglyceride levels and on oxidative stress in Japanese patients with type 2 diabetes. Endocrine. vol 29. issue 1. 2006-06-29. PMID:16622303. |
our study results suggest that pg suppresses increases in postprandial glucose and tg levels, and improves insulin resistance; and, in addition, that pg may have a favorable impact on oxidative stress in type 2 diabetic patients. |
2006-06-29 |
2023-08-12 |
human |
| Ana Marice Ladeia, Luis Adan, Ana Claudia Couto-Silva, Angela Hiltner, Armênio C Guimarãe. Lipid profile correlates with glycemic control in young patients with type 1 diabetes mellitus. Preventive cardiology. vol 9. issue 2. 2006-06-28. PMID:16603826. |
duration of diabetes correlated with ldl (r=0.21; p=0.04) and insulin daily doses with tg (r=0.23; p=0.04) and body mass index expressed as z scores (r=-0.28; p=0.007). |
2006-06-28 |
2023-08-12 |
human |
| Elke Burgermeister, Astride Schnoebelen, Angele Flament, Jörg Benz, Martine Stihle, Bernard Gsell, Arne Rufer, Armin Ruf, Bernd Kuhn, Hans Peter Märki, Jacques Mizrahi, Elena Sebokova, Eric Niesor, Markus Meye. A novel partial agonist of peroxisome proliferator-activated receptor-gamma (PPARgamma) recruits PPARgamma-coactivator-1alpha, prevents triglyceride accumulation, and potentiates insulin signaling in vitro. Molecular endocrinology (Baltimore, Md.). vol 20. issue 4. 2006-06-23. PMID:16373399. |
partial agonists of peroxisome proliferator-activated receptor-gamma (ppargamma), also termed selective ppargamma modulators, are expected to uncouple insulin sensitization from triglyceride (tg) storage in patients with type 2 diabetes mellitus. |
2006-06-23 |
2023-08-12 |
human |
| Elke Burgermeister, Astride Schnoebelen, Angele Flament, Jörg Benz, Martine Stihle, Bernard Gsell, Arne Rufer, Armin Ruf, Bernd Kuhn, Hans Peter Märki, Jacques Mizrahi, Elena Sebokova, Eric Niesor, Markus Meye. A novel partial agonist of peroxisome proliferator-activated receptor-gamma (PPARgamma) recruits PPARgamma-coactivator-1alpha, prevents triglyceride accumulation, and potentiates insulin signaling in vitro. Molecular endocrinology (Baltimore, Md.). vol 20. issue 4. 2006-06-23. PMID:16373399. |
despite failing to promote tg loading, pa-082 induced mrnas of genes encoding components of insulin signaling and adipogenic differentiation pathways. |
2006-06-23 |
2023-08-12 |
human |
| Elke Burgermeister, Astride Schnoebelen, Angele Flament, Jörg Benz, Martine Stihle, Bernard Gsell, Arne Rufer, Armin Ruf, Bernd Kuhn, Hans Peter Märki, Jacques Mizrahi, Elena Sebokova, Eric Niesor, Markus Meye. A novel partial agonist of peroxisome proliferator-activated receptor-gamma (PPARgamma) recruits PPARgamma-coactivator-1alpha, prevents triglyceride accumulation, and potentiates insulin signaling in vitro. Molecular endocrinology (Baltimore, Md.). vol 20. issue 4. 2006-06-23. PMID:16373399. |
we thus propose that selective recruitment of pgc1alpha to favorable ppargamma-target genes provides a possible molecular mechanism whereby partial ppargamma agonists dissociate tg accumulation from insulin signaling. |
2006-06-23 |
2023-08-12 |
human |