| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| John J Dube, Bankim A Bhatt, Nikolas Dedousis, Arend Bonen, Robert M O'Dohert. Leptin, skeletal muscle lipids, and lipid-induced insulin resistance. American journal of physiology. Regulatory, integrative and comparative physiology. vol 293. issue 2. 2007-10-10. PMID:17491114. |
these improvements in insulin action were associated with decreased skm triglycerides (tg; approximately 61%), elevated ceramides ( approximately 50%), and similar diacylglycerol (dag) levels in hl compared with cont. |
2007-10-10 |
2023-08-12 |
rat |
| John J Dube, Bankim A Bhatt, Nikolas Dedousis, Arend Bonen, Robert M O'Dohert. Leptin, skeletal muscle lipids, and lipid-induced insulin resistance. American journal of physiology. Regulatory, integrative and comparative physiology. vol 293. issue 2. 2007-10-10. PMID:17491114. |
we conclude that increases in insulin sensitivity induced by hl are associated with decreased levels of skm tg and pkc theta and increased skm insulin signaling, but not with decreases in other lipid metabolites implicated in altering skm insulin sensitivity (dag and ceramide). |
2007-10-10 |
2023-08-12 |
rat |
| Zafar H Israili, Badiâa Lyoussi, Rafael Hernández-Hernández, Manuel Velasc. Metabolic syndrome: treatment of hypertensive patients. American journal of therapeutics. vol 14. issue 4. 2007-10-09. PMID:17667215. |
metabolic syndrome (metsyndr), a constellation of abnormalities [obesity, glucose intolerance, insulin resistance (ir), dyslipidemia (low hdl-cholesterol, high ldl-cholesterol and triglycerides (tg)], and elevated blood pressure (bp)], increases the risk of cardiovascular (cv) disease and premature death. |
2007-10-09 |
2023-08-12 |
Not clear |
| Lixin Li, Mark Naples, Hui Song, Ronghua Yuan, Feilu Ye, Sharmi Shafi, Khosrow Adeli, Dominic S N. LCAT-null mice develop improved hepatic insulin sensitivity through altered regulation of transcription factors and suppressors of cytokine signaling. American journal of physiology. Endocrinology and metabolism. vol 293. issue 2. 2007-09-24. PMID:17551001. |
we previously reported that lcat-deficient mice develop not only low hdl-cholesterol but also hypertriglyceridemia, hepatic triglyceride (tg) overproduction, and, unexpectedly, improved hepatic insulin sensitivity and reduced hepatic tg content. |
2007-09-24 |
2023-08-12 |
mouse |
| Lixin Li, Mark Naples, Hui Song, Ronghua Yuan, Feilu Ye, Sharmi Shafi, Khosrow Adeli, Dominic S N. LCAT-null mice develop improved hepatic insulin sensitivity through altered regulation of transcription factors and suppressors of cytokine signaling. American journal of physiology. Endocrinology and metabolism. vol 293. issue 2. 2007-09-24. PMID:17551001. |
these data suggest that lcat deficiency induces complex alterations in hepatic signal transduction cascades, which explain, at least in part, the observed enhanced insulin signaling in association with hepatic tg overproduction and reduced hepatic tg content. |
2007-09-24 |
2023-08-12 |
mouse |
| Tadanori Morikawa, Tomoaki Toyama, Naomi Kudo, Yoichi Kawashim. Reducing effect of matrix metalloproteinase inhibitors on serum triacylglycerol in streptozotocin-induced diabetic rats and Zucker fa/fa rats. Biological & pharmaceutical bulletin. vol 30. issue 8. 2007-09-21. PMID:17666804. |
moreover, treatment of zucker fa/fa rats with fyk-1388 lowered serum levels of tg and cholesterol without changing blood levels of glucose and insulin. |
2007-09-21 |
2023-08-12 |
rat |
| Anne Liese Magnusson-Olsson, Susanne Lager, Bo Jacobsson, Thomas Jansson, Theresa L Powel. Effect of maternal triglycerides and free fatty acids on placental LPL in cultured primary trophoblast cells and in a case of maternal LPL deficiency. American journal of physiology. Endocrinology and metabolism. vol 293. issue 1. 2007-09-13. PMID:17299085. |
to further investigate the role of maternal lipids in placental lpl regulation, we isolated placental cytotrophoblasts from term placentas and studied lpl activity and protein and mrna expression after incubation in intralipid (as a source of tg) and oleic, linoleic, and a combination of oleic, linoleic, and arachidonic acids as well as insulin. |
2007-09-13 |
2023-08-12 |
Not clear |
| Melvin R Hayden, Nazif Chowdhury, Guru Govindarajan, Poorna R Karuparthi, Javad Habibi, James R Sower. Myocardial myocyte remodeling and fibrosis in the cardiometabolic syndrome. Journal of the cardiometabolic syndrome. vol 1. issue 5. 2007-08-24. PMID:17679785. |
the 11-week-old tg(mren-2)27 transgene rat model of tissue angiotensin ii overexpression, which develops hypertension and insulin resistance, was chosen to examine both myocyte hypertrophy and extracellular matrix fibrosis. |
2007-08-24 |
2023-08-12 |
rat |
| Latha P Palaniappan, Andrea C Kwan, Fahim Abbasi, Cindy Lamendola, Tracey L McLaughlin, Gerald M Reave. Lipoprotein abnormalities are associated with insulin resistance in South Asian Indian women. Metabolism: clinical and experimental. vol 56. issue 7. 2007-08-21. PMID:17570249. |
finally, a more extensive lipoprotein analysis indicated that the most insulin resistant tertile had higher tg concentrations, lower concentrations of hdl-c and hdl-c subclasses, and smaller and denser low-density lipoprotein particles than the most insulin sensitive tertile, despite the 2 groups not being different in age, bmi, or wc. |
2007-08-21 |
2023-08-12 |
Not clear |
| Elizabeth Stein, Harvey Kushner, Samuel Gidding, Bonita Falkne. Plasma lipid concentrations in nondiabetic African American adults: associations with insulin resistance and the metabolic syndrome. Metabolism: clinical and experimental. vol 56. issue 7. 2007-08-21. PMID:17570258. |
the purpose of the study was to examine the association between plasma lipid concentrations and insulin resistance in african americans and to determine if insulin resistance is present at a lower triglyceride (tg) threshold than is used for metabolic syndrome criteria. |
2007-08-21 |
2023-08-12 |
human |
| Elizabeth Stein, Harvey Kushner, Samuel Gidding, Bonita Falkne. Plasma lipid concentrations in nondiabetic African American adults: associations with insulin resistance and the metabolic syndrome. Metabolism: clinical and experimental. vol 56. issue 7. 2007-08-21. PMID:17570258. |
the relationship between lipids and insulin sensitivity was analyzed by correlation analysis and by comparing tg levels among tertiles of m. despite relatively low mean (+/- sd) tg level (87.8 +/- 55.2 mg/dl), there were statistically significant correlations of m with tg (r = -0.23, p < .002), high-density lipoprotein cholesterol (hdl-c; r = 0.19, p < .01), and tg/hdl-c ratio (r = -0.23, p < .002). |
2007-08-21 |
2023-08-12 |
human |
| Elizabeth Stein, Harvey Kushner, Samuel Gidding, Bonita Falkne. Plasma lipid concentrations in nondiabetic African American adults: associations with insulin resistance and the metabolic syndrome. Metabolism: clinical and experimental. vol 56. issue 7. 2007-08-21. PMID:17570258. |
subjects with tg in an intermediate range (110-149 mg/dl) had insulin resistance equivalent to that of the high-tg group (>/=150 mg/dl). |
2007-08-21 |
2023-08-12 |
human |
| Elizabeth Stein, Harvey Kushner, Samuel Gidding, Bonita Falkne. Plasma lipid concentrations in nondiabetic African American adults: associations with insulin resistance and the metabolic syndrome. Metabolism: clinical and experimental. vol 56. issue 7. 2007-08-21. PMID:17570258. |
in african americans, tg levels below the current metabolic syndrome threshold criterion are associated with insulin resistance. |
2007-08-21 |
2023-08-12 |
human |
| Mara Monetti, Malin C Levin, Matthew J Watt, Mini P Sajan, Stephen Marmor, Brian K Hubbard, Robert D Stevens, James R Bain, Christopher B Newgard, Robert V Farese, Andrea L Hevener, Robert V Fares. Dissociation of hepatic steatosis and insulin resistance in mice overexpressing DGAT in the liver. Cell metabolism. vol 6. issue 1. 2007-08-16. PMID:17618857. |
to test the causal relationship between hepatic steatosis and insulin resistance, we generated mice that overexpress acyl-coa:diacylglycerol acyltransferase 2 (dgat2), which catalyzes the final step of triacylglycerol (tg) biosynthesis, in the liver (liv-dgat2 mice). |
2007-08-16 |
2023-08-12 |
mouse |
| Akiko Nogi, Jianjun Yang, Limei Li, Masayuki Yamasaki, Mamiko Watanabe, Minako Watanabe, Michio Hashimoto, Kuninori Shiwak. Plasma n-3 polyunsaturated fatty acid and cardiovascular disease risk factors in Japanese, Korean and Mongolian workers. Journal of occupational health. vol 49. issue 3. 2007-08-15. PMID:17575401. |
we conducted a cross-sectional study in workplace settings and determined body mass index (bmi), blood pressure, total cholesterol, ldl-cholesterol, hdl-cholesterol, triglyceride (tg), glucose, insulin, homeostasis model assessment-insulin resistance (homa-ir) and fatty acid composition in plasma. |
2007-08-15 |
2023-08-12 |
Not clear |
| J A A Pires, A H Souza, R R Grumme. Induction of hyperlipidemia by intravenous infusion of tallow emulsion causes insulin resistance in Holstein cows. Journal of dairy science. vol 90. issue 6. 2007-08-09. PMID:17517713. |
the induction of insulin resistance by tg, nefa, or both may increase the availability of glucogenic nutrients to the periparturient dairy cow. |
2007-08-09 |
2023-08-12 |
Not clear |
| Yongzhong Wei, Adam T Whaley-Connell, Kemin Chen, Javad Habibi, Grace M-E Uptergrove, Suzanne E Clark, Craig S Stump, Carlos M Ferrario, James R Sower. NADPH oxidase contributes to vascular inflammation, insulin resistance, and remodeling in the transgenic (mRen2) rat. Hypertension (Dallas, Tex. : 1979). vol 50. issue 2. 2007-08-08. PMID:17533199. |
to explore the impact of angiotensin ii on insulin signaling, nadph oxidase-derived reactive oxygen species formation, vascular inflammation, apoptosis, and remodeling, we used transgenic tg(mren2)27 (ren2) rats, which harbor the mouse renin transgene and exhibits elevated tissue angiotensin ii levels. |
2007-08-08 |
2023-08-12 |
mouse |
| Fiona J Spargo, Sean L McGee, Nick Dzamko, Matthew J Watt, Bruce E Kemp, Steven L Britton, Lauren G Koch, Mark Hargreaves, John A Hawle. Dysregulation of muscle lipid metabolism in rats selectively bred for low aerobic running capacity. American journal of physiology. Endocrinology and metabolism. vol 292. issue 6. 2007-07-30. PMID:17284571. |
lcr animals had higher resting plasma glucose (6.58 +/- 0.45 vs. 6.09 +/- 0.45 mmol/l), insulin (0.48 +/- 0.03 vs. 0.32 +/- 0.02 ng/ml), nonesterified fatty acid (0.57 +/- 0.14 v 0.35 +/- 0.05 mm), and triglyceride (tg; 0.47 +/- 0.11 vs. 0.25 +/- 0.08 mmol/l) concentrations (all p < 0.05). |
2007-07-30 |
2023-08-12 |
rat |
| W John Kalk, Barry I Joff. Differences in coronary heart disease prevalence and risk factors in African and White patients with type 2 diabetes. Diabetes research and clinical practice. vol 77. issue 1. 2007-07-23. PMID:17141912. |
the a had significantly lower tg:hdl-c ratios (an index of insulin resistance) (p=0.004) and were less likely to have (estimated) small dense ldl-c particles (p< or =0.038). |
2007-07-23 |
2023-08-12 |
human |
| Jen-Der Lin, Wen-Ko Chiou, Hung-Yu Chang, Feng-Hsuan Liu, Hsiao-Fen Wen. Serum uric acid and leptin levels in metabolic syndrome: a quandary over the role of uric acid. Metabolism: clinical and experimental. vol 56. issue 6. 2007-07-20. PMID:17512306. |
uric acid appeared to be better correlated with tg, blood pressure (both systolic and diastolic), obesity, immunoreactive insulin, and homa-ir. |
2007-07-20 |
2023-08-12 |
human |