| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shunzhong Bao, David A Jacobson, Mary Wohltmann, Alan Bohrer, Wu Jin, Louis H Philipson, John Tur. Glucose homeostasis, insulin secretion, and islet phospholipids in mice that overexpress iPLA2beta in pancreatic beta-cells and in iPLA2beta-null mice. American journal of physiology. Endocrinology and metabolism. vol 294. issue 2. 2008-03-11. PMID:17895289. |
to determine whether similar effects occur in whole animals, we prepared transgenic (tg) mice in which the rat insulin 1 promoter (rip) drives ipla(2)beta overexpression, and two characterized tg mouse lines exhibit similar phenotypes. |
2008-03-11 |
2023-08-12 |
mouse |
| Shunzhong Bao, David A Jacobson, Mary Wohltmann, Alan Bohrer, Wu Jin, Louis H Philipson, John Tur. Glucose homeostasis, insulin secretion, and islet phospholipids in mice that overexpress iPLA2beta in pancreatic beta-cells and in iPLA2beta-null mice. American journal of physiology. Endocrinology and metabolism. vol 294. issue 2. 2008-03-11. PMID:17895289. |
male rip-ipla(2)beta-tg mice exhibit lower blood glucose and higher plasma insulin concentrations than wild-type (wt) mice when fasting and develop lower blood glucose levels in glucose tolerance tests, but wt and tg blood glucose levels do not differ in insulin tolerance tests. |
2008-03-11 |
2023-08-12 |
mouse |
| Antony D Karelis, Stephanie M Pasternyk, Lyne Messier, David H St-Pierre, Jean-Marc Lavoie, Dominique Garrel, Rémi Rabasa-Lhore. Relationship between insulin sensitivity and the triglyceride-HDL-C ratio in overweight and obese postmenopausal women: a MONET study. Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme. vol 32. issue 6. 2008-03-11. PMID:18059582. |
the objective of this cross-sectional study was to examine the relationship between the triglyceride-hdl-cholesterol ratio (tg:hdl-c) and insulin sensitivity in overweight and obese sedentary postmenopausal women. |
2008-03-11 |
2023-08-12 |
human |
| Antony D Karelis, Stephanie M Pasternyk, Lyne Messier, David H St-Pierre, Jean-Marc Lavoie, Dominique Garrel, Rémi Rabasa-Lhore. Relationship between insulin sensitivity and the triglyceride-HDL-C ratio in overweight and obese postmenopausal women: a MONET study. Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme. vol 32. issue 6. 2008-03-11. PMID:18059582. |
high levels of insulin sensitivity were associated with low levels of the tg:hdl-c. |
2008-03-11 |
2023-08-12 |
human |
| Sofiya Alhassan, Alexandre Kiazand, Raymond R Balise, Abby C King, Gerald M Reaven, Christopher D Gardne. Metabolic syndrome: do clinical criteria identify similar individuals among overweight premenopausal women? Metabolism: clinical and experimental. vol 57. issue 1. 2008-03-10. PMID:18078858. |
the purpose of this analysis was to determine to what extent the clinical criteria for metabolic syndrome (metsyn) proposed by the world health organization (who), the european group for study of insulin resistance (egir), the national cholesterol education program adult treatment panel iii (atp iii), and the international diabetes foundation (idf); triglyceride (tg)/high-density lipoprotein cholesterol (hdl-c) ratio >/=3.0; and enlarged waist circumference (>/=88 cm) and elevated tg (>/=129 mg/dl) (ewet) identified similar or different overweight women and, secondarily, to examine the effect of 7% weight reduction on metsyn status. |
2008-03-10 |
2023-08-12 |
human |
| Wei Cui, Sabina Paglialunga, David Kalant, Huiling Lu, Christian Roy, Mathieu Laplante, Yves Deshaies, Katherine Cianflon. Acylation-stimulating protein/C5L2-neutralizing antibodies alter triglyceride metabolism in vitro and in vivo. American journal of physiology. Endocrinology and metabolism. vol 293. issue 6. 2008-02-25. PMID:17711993. |
in vivo, neither anti-asp nor anti-c5l2-l1 altered body weight, adipose tissue mass, food intake, or hormone levels (insulin, leptin, and adiponectin), but they did induce a significant delay in tg clearance [p < 0.0001, 2-way repeated-measures (rm) anova] and nefa clearance (p < 0.0001, 2-way rm anova) after a fat load. |
2008-02-25 |
2023-08-12 |
mouse |
| Megan L Diaz, Bruce A Watkins, Yong Li, Richard A Anderson, Wayne W Campbel. Chromium picolinate and conjugated linoleic acid do not synergistically influence diet- and exercise-induced changes in body composition and health indexes in overweight women. The Journal of nutritional biochemistry. vol 19. issue 1. 2008-02-04. PMID:17531459. |
fasting blood hemoglobin a1c, plasma glucose and insulin, a homeostatic assessment of insulin resistance, serum total cholesterol (chol), high-density lipoprotein cholesterol (hdl), low-density lipoprotein cholesterol, triacylglycerol (tg), chol/hdl ratio, tg/hdl ratio and sitting systolic and diastolic blood pressures were not changed over time or influenced by cp-cla. |
2008-02-04 |
2023-08-12 |
Not clear |
| Yu Gao, Guang-Yao Song, Hui-Juan Ma, Wen-Jie Zhang, Yu Zho. Effects of long-term high-saturated and unsaturated fatty acid diets on relaxation and contraction of renal arteries in insulin resistant rats. Sheng li xue bao : [Acta physiologica Sinica]. vol 59. issue 3. 2008-01-08. PMID:17579794. |
body weight (bw), plasma total triglyceride (tg), free fatty acid (ffa), insulin, fasting blood glucose (fbg) and nitric oxide metabolite (no2(-)/no3(-)) were compared among the three groups. |
2008-01-08 |
2023-08-12 |
rat |
| Yu Gao, Guang-Yao Song, Hui-Juan Ma, Wen-Jie Zhang, Yu Zho. Effects of long-term high-saturated and unsaturated fatty acid diets on relaxation and contraction of renal arteries in insulin resistant rats. Sheng li xue bao : [Acta physiologica Sinica]. vol 59. issue 3. 2008-01-08. PMID:17579794. |
there were no significant differences in bw, fbg, tg, insulin and ffa between saturated and unsaturated fatty acid-fed rats. |
2008-01-08 |
2023-08-12 |
rat |
| Akari Inada, Hidenori Arai, Kojiro Nagai, Jun-ichi Miyazaki, Yuichiro Yamada, Yutaka Seino, Atsushi Fukats. Gender difference in ICER Igamma transgenic diabetic mouse. Bioscience, biotechnology, and biochemistry. vol 71. issue 8. 2007-12-20. PMID:17690470. |
both male and female tg mice developed severe diabetes early in life due to severely impaired insulin synthesis and decreased beta-cell numbers, but only female tg mice became less hyperglycemic later in life, and most female tg mice did not develop diabetic nephropathy. |
2007-12-20 |
2023-08-12 |
mouse |
| John Q Zhang, Lisa L Ji, Donovan L Fogt, Vicki S Fretwel. Effect of exercise duration on postprandial hypertriglyceridemia in men with metabolic syndrome. Journal of applied physiology (Bethesda, Md. : 1985). vol 103. issue 4. 2007-12-06. PMID:17641215. |
subjects were 10 hypertriglyceridemic men with insulin resistance [age = 35.0 +/- 1.8 yr, body weight = 90.7 +/- 3.3 kg, fasting triglyceride (tg) = 2.6 +/- 0.4 mmol/l, peak oxygen consumption ((. |
2007-12-06 |
2023-08-12 |
human |
| Nobuharu Fujii, Matthew M Seifert, Erin M Kane, Lauren E Peter, Richard C Ho, Schuyler Winstead, Michael F Hirshman, Laurie J Goodyea. Role of AMP-activated protein kinase in exercise capacity, whole body glucose homeostasis, and glucose transport in skeletal muscle -insight from analysis of a transgenic mouse model-. Diabetes research and clinical practice. vol 77 Suppl 1. 2007-11-13. PMID:17452058. |
while, alpha2 activation was severely blunted and alpha1 activation was only slightly reduced in alpha2i tg mice by these insulin independent stimuli compared to wild type mice. |
2007-11-13 |
2023-08-12 |
mouse |
| Jianguo Li, Marta Bosch-Marce, Ashika Nanayakkara, Vladimir Savransky, Susan K Fried, Gregg L Semenza, Vsevolod Y Polotsk. Altered metabolic responses to intermittent hypoxia in mice with partial deficiency of hypoxia-inducible factor-1alpha. Physiological genomics. vol 25. issue 3. 2007-11-08. PMID:16507783. |
ih increased fasting blood glucose, serum total cholesterol, and high-density lipoprotein-cholesterol, phospholipids, triglycerides (tg), and leptin in mice of both genotypes, whereas serum insulin and interleukin-6 were elevated only in wt mice. |
2007-11-08 |
2023-08-12 |
mouse |
| Tomoyuki Iwasaki, Masato Yoneda, Atsushi Nakajima, Yasuo Terauch. Serum butyrylcholinesterase is strongly associated with adiposity, the serum lipid profile and insulin resistance. Internal medicine (Tokyo, Japan). vol 46. issue 19. 2007-10-26. PMID:17917325. |
we investigated the association between the serum butyrylcholinesterase (bche) activity and parameters of adiposity, insulin resistance and the serum lipid profile, including the serum levels of triglyceride (tg), hdl-cholesterol (hdl-c) and ldl-cholesterol (ldl-c) in japanese patients with type 2 diabetes and non-diabetic subjects. |
2007-10-26 |
2023-08-12 |
human |
| Po-Shiuan Hsieh, Wei-Tung Cheng, Tse-Tsung Liu, Ching-Hui Loh, Bao-Chy Chan. Diminution of hypertriglyceridemia-induced pressor effect under hyperinsulinemic condition in normal and fructose-induced insulin resistant rats. The Chinese journal of physiology. vol 50. issue 3. 2007-10-19. PMID:17867429. |
after the basal period, somatostatin (1.3 microg/kg/ min) combined with regular insulin (0.6 or 4 mu/kg/min) and variable glucose infusion were given to clamp euglycemia and euinsulinemia in c and c(tg) or euglycemia and hyperinsulinemia in cins, c(ins+tg), f(ins) and f(ins+tg). |
2007-10-19 |
2023-08-12 |
rat |
| Po-Shiuan Hsieh, Wei-Tung Cheng, Tse-Tsung Liu, Ching-Hui Loh, Bao-Chy Chan. Diminution of hypertriglyceridemia-induced pressor effect under hyperinsulinemic condition in normal and fructose-induced insulin resistant rats. The Chinese journal of physiology. vol 50. issue 3. 2007-10-19. PMID:17867429. |
during the test period, low-dose insulin infusion kept plasma insulin at basal levels in c and c(tg) and high-dose insulin infusion increased plasma insulin levels about 6 times the baseline insulin level in c. glucose infusion rate (gir) was significantly higher in rats with high insulin infusion than those with low insulin infusion. |
2007-10-19 |
2023-08-12 |
rat |
| Erik J Henrikse. Improvement of insulin sensitivity by antagonism of the renin-angiotensin system. American journal of physiology. Regulatory, integrative and comparative physiology. vol 293. issue 3. 2007-10-17. PMID:17581838. |
further critical evidence has been obtained from the tg(mren2)27 rat, a model of ras overactivity and insulin resistance. |
2007-10-17 |
2023-08-12 |
rat |
| Erik J Henrikse. Improvement of insulin sensitivity by antagonism of the renin-angiotensin system. American journal of physiology. Regulatory, integrative and comparative physiology. vol 293. issue 3. 2007-10-17. PMID:17581838. |
the tg(mren2)27 rat displays whole body and skeletal muscle insulin resistance that is associated with local oxidative stress and a significant reduction in the functionality of the insulin receptor (ir)/irs-1-dependent insulin signaling. |
2007-10-17 |
2023-08-12 |
rat |
| Erik J Henrikse. Improvement of insulin sensitivity by antagonism of the renin-angiotensin system. American journal of physiology. Regulatory, integrative and comparative physiology. vol 293. issue 3. 2007-10-17. PMID:17581838. |
in addition, exercise training of tg(mren2)27 rats enhances whole body and skeletal muscle insulin action. |
2007-10-17 |
2023-08-12 |
rat |
| Robert Ostfeld, Disha Mookherjee, Michael Spinelli, Dvorah Holtzman, Abu Shoyeb, Michael Schaefer, Sanjay Doddamani, Daniel Spevack, Yunling D. A triglyceride/high-density lipoprotein ratio > or = 3.5 is associated with an increased burden of coronary artery disease on cardiac catheterization. Journal of the cardiometabolic syndrome. vol 1. issue 1. 2007-10-16. PMID:17675905. |
an elevated triglyceride (tg)/high-density lipoprotein (hdl) ratio has been described as a predictor of insulin resistance and cardiovascular events. |
2007-10-16 |
2023-08-12 |
Not clear |