| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tomohiro Miike, Kazuyoshi Kunishiro, Mamoru Kanda, Satoru Azukizawa, Kazuyoshi Kurahashi, Hiroaki Shirahas. Impairment of endothelium-dependent ACh-induced relaxation in aorta of diabetic db/db mice--possible dysfunction of receptor and/or receptor-G protein coupling. Naunyn-Schmiedeberg's archives of pharmacology. vol 377. issue 4-6. 2008-12-03. PMID:18228001. |
two-week treatment with kv-5070, a ppargamma agonist, lowered plasma glucose, triglyceride (tg), and insulin but not cholesterol, and reversed the reduced ach-induced relaxation. |
2008-12-03 |
2023-08-12 |
mouse |
| Shunji Kasai, Takashi Inoue, Hideki Yoshitomi, Taro Hihara, Fumiyoshi Matsuura, Hitoshi Harada, Masanobu Shinoda, Isao Tanak. Antidiabetic and hypolipidemic effects of a novel dual peroxisome proliferator-activated receptor (PPAR) alpha/gamma agonist, E3030, in db/db mice and beagle dogs. Journal of pharmacological sciences. vol 108. issue 1. 2008-11-17. PMID:18776709. |
in db/db mice orally administered e3030 decreased blood glucose, triglyceride (tg), non-esterified fatty acids (nefa), and insulin levels and increased blood adiponectin levels during a 14-day experimental period. |
2008-11-17 |
2023-08-12 |
mouse |
| Shunji Kasai, Takashi Inoue, Hideki Yoshitomi, Taro Hihara, Fumiyoshi Matsuura, Hitoshi Harada, Masanobu Shinoda, Isao Tanak. Antidiabetic and hypolipidemic effects of a novel dual peroxisome proliferator-activated receptor (PPAR) alpha/gamma agonist, E3030, in db/db mice and beagle dogs. Journal of pharmacological sciences. vol 108. issue 1. 2008-11-17. PMID:18776709. |
furthermore, significant effects on blood tg, nefa, and insulin levels were observed at doses of 1 mg/kg or more. |
2008-11-17 |
2023-08-12 |
mouse |
| Gustav Schonfeld, Pin Yue, Xiaobo Lin, Zhouji Che. Fatty liver and insulin resistance: not always linked. Transactions of the American Clinical and Climatological Association. vol 119. 2008-11-13. PMID:18596860. |
meanwhile, in human subjects with similar apob truncations, degree of obesity and insulin sensitivity, their liver triglyceride (tg) contents may vary considerably, suggesting that, in addition to defective apob, other genes may affect the magnitude of hepatic tg accumulation. |
2008-11-13 |
2023-08-12 |
mouse |
| Gustav Schonfeld, Pin Yue, Xiaobo Lin, Zhouji Che. Fatty liver and insulin resistance: not always linked. Transactions of the American Clinical and Climatological Association. vol 119. 2008-11-13. PMID:18596860. |
it is tempting to conclude that hepatic tg per se may not be responsible for the insulin resistance seen in fatty liver. |
2008-11-13 |
2023-08-12 |
mouse |
| Hyun Seob Um, Eun Bum Kang, Yea Hyun Leem, In Ho Cho, Chun Ho Yang, Kab Ryong Chae, Dae Youn Hwang, Joon Yong Ch. Exercise training acts as a therapeutic strategy for reduction of the pathogenic phenotypes for Alzheimer's disease in an NSE/APPsw-transgenic model. International journal of molecular medicine. vol 22. issue 4. 2008-10-31. PMID:18813861. |
the results indicated (i) that amyloid beta-42 (abeta-42) peptides were significantly decreased in the nse/appsw tg mice following exercise training; (ii) that exercise training inhibited the apoptotic biochemical cascades, including cytochrome c, caspase-9, caspase-3 and bax; (iii) that the glucose transporter-1 (glut-1) and brain-derived neurotrophic factor (bdnf) proteins induced by exercise training protected the neurons from injury by inducing the concomitant expression of genes that encode proteins such as superoxide dismutase-1 (sod-1), catalase and bcl-2, which suppress oxidative stress and excitotoxic injury; (iv) that heat-shock protein-70 (hsp-70) and glucose-regulated protein-78 (grp-78) were significantly increased in the exercise (exe) group when compared to the sedentary (sed) group, and that these proteins may benefit the brain by making it more resistant to stress-induced neuron cell damage; (v) and that exercise training contributed to the restoration of normal levels of serum total cholesterol, insulin and glucose. |
2008-10-31 |
2023-08-12 |
mouse |
| Guang-Wei He, Wei-Jing Qu, Bin Fan, Rong Jing, Rong H. The protective effect of Yi-Qi-Yang-Yin-Ye, a compound of traditional Chinese herbal medicine in diet-induced obese rats. The American journal of Chinese medicine. vol 36. issue 4. 2008-10-28. PMID:18711768. |
the results showed that y-q-y-y-y treatment decreased the levels of body weight, total cholesterol (tc), triglycerides (tg), low density lipoprotein-cholesterol (ldl-c), free fatty acid (ffa), insulin (ins) and fast blood glucose (fbg) and increased the level of high density lipoprotein-cholesterol (hdl-c) in the diet-induced obese rats. |
2008-10-28 |
2023-08-12 |
rat |
| Débora Vieira Soares, Luciana Diniz Carneiro Spina, Rosane Resende de Lima Oliveira Brasil, Priscila Marise Lobo, Elizabeth Salles, Claúdia Medina Coeli, Flávia Lúcia Conceição, Mario Vaisma. Two years of growth hormone replacement therapy in a group of patients with Sheehan's syndrome. Pituitary. vol 9. issue 2. 2008-09-23. PMID:16944044. |
total cholesterol, triglycerides (tg), hdl-c, ldl-c, apolipoprotein a and b (apoa and apob) and lipoprotein (a), serum igf-1, ultrasonography of the carotid arteries, oral glucose tolerance test (ogtt), homa insulin resistance index, insulin sensitivity index (isi)-composite and abdominal ct scan were performed. |
2008-09-23 |
2023-08-12 |
Not clear |
| Débora Vieira Soares, Luciana Diniz Carneiro Spina, Rosane Resende de Lima Oliveira Brasil, Priscila Marise Lobo, Elizabeth Salles, Claúdia Medina Coeli, Flávia Lúcia Conceição, Mario Vaisma. Two years of growth hormone replacement therapy in a group of patients with Sheehan's syndrome. Pituitary. vol 9. issue 2. 2008-09-23. PMID:16944044. |
when compared to a control group, patients presented lower hdl concentrations (p=0.05) and 2-h ogtt insulin levels (p<0.04) and increased tg levels (p<0.04). |
2008-09-23 |
2023-08-12 |
Not clear |
| Alberto Cordero, Martín Laclaustra, Montserrat León, José A Casasnovas, Alberto Grima, Emilio Luengo, Beatriz Ordoñez, Clara Bergua, María Bes, Isaac Pascual, Eduardo Alegrí. Comparison of serum lipid values in subjects with and without the metabolic syndrome. The American journal of cardiology. vol 102. issue 4. 2008-09-19. PMID:18678299. |
the ratio of triglyceride (tg) to high-density lipoprotein (hdl) has been proposed as a surrogate marker of insulin resistance in overweight subjects. |
2008-09-19 |
2023-08-12 |
human |
| G Derosa, I Ferrari, A D'Angelo, C Tinelli, S A T Salvadeo, L Ciccarelli, M N Piccinni, A Gravina, F Ramondetti, P Maffioli, A F G Cicer. Matrix metalloproteinase-2 and -9 levels in obese patients. Endothelium : journal of endothelial cell research. vol 15. issue 4. 2008-09-17. PMID:18663625. |
the following were measured: body mass index (bmi), waist circumference (wc), fasting plasma glucose (fpg), fasting plasma insulin (fpi), homeostasis model assessment (homa) index, systolic blood pressure (sbp), diastolic blood pressure (dbp), total cholesterol (tc), low-density lipoprotein cholesterol (ldl-c), high-density lipoprotein cholesterol (hdl-c), triglycerides (tg), lipoprotein(a) (lp(a)), and plasma levels of mmp-2 and mmp-9. |
2008-09-17 |
2023-08-12 |
human |
| Yoshie Yamamoto, Fumitoshi Ishino, Tomoko Kaneko-Ishino, Hirosuke Shiura, Kozue Uchio-Yamada, Junichiro Matsuda, Osamu Suzuki, Katsunori Sat. Type 2 diabetes mellitus in a non-obese mouse model induced by Meg1/Grb10 overexpression. Experimental animals. vol 57. issue 4. 2008-09-11. PMID:18633161. |
the glucose tolerance test and insulin tolerance test showed that meg1 tg mice had reduced ability to normalize the blood glucose level. |
2008-09-11 |
2023-08-12 |
mouse |
| Yoshie Yamamoto, Fumitoshi Ishino, Tomoko Kaneko-Ishino, Hirosuke Shiura, Kozue Uchio-Yamada, Junichiro Matsuda, Osamu Suzuki, Katsunori Sat. Type 2 diabetes mellitus in a non-obese mouse model induced by Meg1/Grb10 overexpression. Experimental animals. vol 57. issue 4. 2008-09-11. PMID:18633161. |
blood urea nitrogen (bun) in meg1 tg mice (19.6 +/- 1.2 mg/dl) was significantly lower than in controls (22.0 +/- 0.8 mg/dl), while plasma triglyceride, insulin, adiponectin, and resistin levels were significantly higher (202.0 +/- 23.4 mg/dl vs 146.3 +/- 23.4 mg/dl, 152.4 +/- 16.3 pg/ml vs 88.1 +/- 16.9 pg/ml, 74.4 +/- 10.9 microg/ml vs 48.3 +/- 7.0 microg/ml, and 4.0 +/- 0.2 ng/ml vs 3.6 +/- 0.2 ng/ml, respectively). |
2008-09-11 |
2023-08-12 |
mouse |
| Yoshie Yamamoto, Fumitoshi Ishino, Tomoko Kaneko-Ishino, Hirosuke Shiura, Kozue Uchio-Yamada, Junichiro Matsuda, Osamu Suzuki, Katsunori Sat. Type 2 diabetes mellitus in a non-obese mouse model induced by Meg1/Grb10 overexpression. Experimental animals. vol 57. issue 4. 2008-09-11. PMID:18633161. |
thus, hyperinsulinemia observed in meg1 tg mice indicates that their insulin signaling pathway is somehow inhibited. |
2008-09-11 |
2023-08-12 |
mouse |
| Viduranga Y Waisundara, Annie Hsu, Dejian Huang, Benny Kwong-Huat Ta. Scutellaria baicalensis enhances the anti-diabetic activity of metformin in streptozotocin-induced diabetic Wistar rats. The American journal of Chinese medicine. vol 36. issue 3. 2008-09-04. PMID:18543386. |
in addition, the combined treatment caused significant elevations of plasma and pancreatic insulin levels and reductions of plasma and hepatic triglycerides (tg) and cholesterol levels. |
2008-09-04 |
2023-08-12 |
rat |
| Tsutomu Shimada, Toshiyuki Kudo, Tomoko Akase, Masaki Aburad. Preventive effects of Bofutsushosan on obesity and various metabolic disorders. Biological & pharmaceutical bulletin. vol 31. issue 7. 2008-09-02. PMID:18591775. |
at 2 months after initiation of the study, the control tsod mice developed various metabolic disorders such as marked obesity and visceral fat accumulation, increases in the levels of blood glucose, insulin, total-cholesterol (tc) and triglyceride (tg), and abnormal glucose tolerance, hypertension and peripheral neuropathy as distinct from the control tsumura, suzuki, non-obesity (tsno) mice, which do not develop obesity and various metabolic disorders. |
2008-09-02 |
2023-08-12 |
mouse |
| Nicolas D Knuth, David B Remias, Jeffrey F Horowit. Adding carbohydrate to a high-fat meal blunts postprandial lipemia in women and reduces meal-derived fatty acids in systemic circulation. Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme. vol 33. issue 2. 2008-08-25. PMID:18347687. |
plasma concentrations of triglyceride (tg), fatty acids, insulin, and glucose were measured in blood samples taken hourly from 0 to 8 h after the meal. |
2008-08-25 |
2023-08-12 |
Not clear |
| Sebastiaan Hammer, Jacqueline T Jonker, Hildo J Lamb, Rutger W van der Meer, Wendy Zondag, Jan M Sepers, Albert de Roos, Johannes W A Smit, Johannes A Romij. Short-term hyperglycemic dysregulation in patients with type 1 diabetes does not change myocardial triglyceride content or myocardial function. Diabetes care. vol 31. issue 8. 2008-08-20. PMID:18458137. |
to evaluate the effects of hyperglycemia due to partial insulin deprivation on myocardial triglyceride (tg) content and myocardial function in patients with type 1 diabetes. |
2008-08-20 |
2023-08-12 |
Not clear |
| Jasem M K Abbas, Jagadish Chakraborty, Abayomi O Akanji, Suhail A R Do. Hypothyroidism results in small dense LDL independent of IRS traits and hypertriglyceridemia. Endocrine journal. vol 55. issue 2. 2008-08-18. PMID:18385530. |
after adjusting for tg levels, other insulin resistance syndrome (irs) traits were not associated with ldl size phenotype, suggesting that the irs related sdldl is linked most strongly to alterations in tg levels. |
2008-08-18 |
2023-08-12 |
Not clear |
| Martin R Salazar, Horacio A Carbajal, Jose O Curciarello, Marcelo Aizpurua, Raul E Adrover, Beatriz Rionde. Alanine-aminotransferase: an early marker for insulin resistance? Medicina. vol 67. issue 2. 2008-07-21. PMID:17593595. |
blood pressure, body mass index, waist circumference, cholesterol, hdl cholesterol (hdlc), triglyceride (tg), tg/hdlc ratio, glycemia and homeostasis model assessment of insulin resistance (homa-ir) were compared between those above and below each alt threshold. |
2008-07-21 |
2023-08-12 |
Not clear |