| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kayoko Okazawa, Yasunao Yoshimasa, Yoshihiro Miyamoto, Akiko Takahashi-Yasuno, Takashi Miyawaki, Hiroaki Masuzaki, Tatsuya Hayashi, Kiminori Hosoda, Gen Inoue, Kazuwa Naka. The haplotypes of the IRS-2 gene affect insulin sensitivity in Japanese patients with type 2 diabetes. Diabetes research and clinical practice. vol 68. issue 1. 2005-08-09. PMID:15811564. |
furthermore, we suggested that the tg and cg haplotypes might have a protective role against insulin resistance. |
2005-08-09 |
2023-08-12 |
human |
| Chun-che Lin, Mei-chin Yin, Cheng-chin Hsu, Meng-pei Li. Effect of five cysteine-containing compounds on three lipogenic enzymes in Balb/cA mice consuming a high saturated fat diet. Lipids. vol 39. issue 9. 2005-08-05. PMID:15669759. |
the influence of these agents on plasma levels of glucose, insulin, uric acid, tg, cholesterol, and the activity of three lipogenic enzymes--glucose-6-phosphate dehydrogenase, malic enzyme, and fa synthase--was determined. |
2005-08-05 |
2023-08-12 |
mouse |
| Jason K Kim, Hyo-Jeong Kim, So-Young Park, Anna Cederberg, Rickard Westergren, Daniel Nilsson, Takamasa Higashimori, You-Ree Cho, Zhen-Xiang Liu, Jianying Dong, Gary W Cline, Sven Enerback, Gerald I Shulma. Adipocyte-specific overexpression of FOXC2 prevents diet-induced increases in intramuscular fatty acyl CoA and insulin resistance. Diabetes. vol 54. issue 6. 2005-08-04. PMID:15919786. |
to understand the underlying mechanism, we examined the effects of chronic high-fat feeding on tissue-specific insulin action and glucose metabolism in the foxc2 transgenic (tg) mice. |
2005-08-04 |
2023-08-12 |
mouse |
| Jason K Kim, Hyo-Jeong Kim, So-Young Park, Anna Cederberg, Rickard Westergren, Daniel Nilsson, Takamasa Higashimori, You-Ree Cho, Zhen-Xiang Liu, Jianying Dong, Gary W Cline, Sven Enerback, Gerald I Shulma. Adipocyte-specific overexpression of FOXC2 prevents diet-induced increases in intramuscular fatty acyl CoA and insulin resistance. Diabetes. vol 54. issue 6. 2005-08-04. PMID:15919786. |
in contrast, foxc2 tg mice were completely protected from diet-induced insulin resistance and intramuscular accumulation of fatty acyl coa. |
2005-08-04 |
2023-08-12 |
mouse |
| Jason K Kim, Hyo-Jeong Kim, So-Young Park, Anna Cederberg, Rickard Westergren, Daniel Nilsson, Takamasa Higashimori, You-Ree Cho, Zhen-Xiang Liu, Jianying Dong, Gary W Cline, Sven Enerback, Gerald I Shulma. Adipocyte-specific overexpression of FOXC2 prevents diet-induced increases in intramuscular fatty acyl CoA and insulin resistance. Diabetes. vol 54. issue 6. 2005-08-04. PMID:15919786. |
high-fat feeding also blunted insulin-mediated suppression of hepatic glucose production in the wild-type mice, whereas foxc2 tg mice were protected from diet-induced hepatic insulin resistance. |
2005-08-04 |
2023-08-12 |
mouse |
| Carmine Morisco, Gerolama Condorelli, Valentina Trimarco, Alessandro Bellis, Chiara Marrone, Gianluigi Condorelli, Junichi Sadoshima, Bruno Trimarc. Akt mediates the cross-talk between beta-adrenergic and insulin receptors in neonatal cardiomyocytes. Circulation research. vol 96. issue 2. 2005-08-02. PMID:15591229. |
under basal conditions, e40k tg mice show increased levels of threonine phosphorylation of the beta subunit of the insulin receptor and blunted tyrosine autophosphorylation of the beta-subunit of the insulin receptor after insulin stimulation. |
2005-08-02 |
2023-08-12 |
mouse |
| Patricia J Manns, Jeffrey A McCubbin, Daniel P William. Fitness, inflammation, and the metabolic syndrome in men with paraplegia. Archives of physical medicine and rehabilitation. vol 86. issue 6. 2005-07-26. PMID:15954057. |
to determine the relations among peak aerobic capacity, physical activity, functional ability, components of the metabolic syndrome (high-density lipoprotein cholesterol [hdl-c], triglycerides [tg], glucose, insulin, abdominal obesity, high blood pressure), and inflammatory factors (interleukin-6 [il-6], c-reactive protein [crp]) in men with paraplegia. |
2005-07-26 |
2023-08-12 |
Not clear |
| Yutaka Mori, Genshin Kuriyama, Naoko Tajim. Effects of nateglinide on the elevation of postprandial remnant-like particle triglyceride levels in Japanese patients with type 2 diabetes assessment by meal tolerance test. Endocrine. vol 25. issue 3. 2005-07-25. PMID:15758246. |
to elucidate the role of early insulin response in post-prandial hyperlipidemia, we examined triglyceride (tg) and remnant-like particle triglyceride (rlp-tg) levels, using a meal tolerance test (mtt) with or without the administration of nateglinide (nat). |
2005-07-25 |
2023-08-12 |
Not clear |
| Anne E Sumner, Karl B Finley, David J Genovese, Michael H Criqui, Raymond C Bosto. Fasting triglyceride and the triglyceride-HDL cholesterol ratio are not markers of insulin resistance in African Americans. Archives of internal medicine. vol 165. issue 12. 2005-07-21. PMID:15983289. |
our goal was to determine whether tg levels or tg-hdl-c ratio predicted insulin resistance in african americans with a bmi of 25 kg/m(2) or more. |
2005-07-21 |
2023-08-12 |
Not clear |
| M A Montanaro, Y B Lombardo, M S González, A M Bernasconi, A Chicco, O J Rimoldi, J C Basabe, R R Brenne. Effect of troglitazone on the desaturases in a rat model of insulin-resistance induced by a sucrose-rich diet. Prostaglandins, leukotrienes, and essential fatty acids. vol 72. issue 4. 2005-07-20. PMID:15763435. |
after 8 month (mo) this diet evoked in the rat an increase of blood glucose, free fatty acids (ffa) and triacylycerides (tg) without insulin modification, an interruption of liver stearoyl-coa desaturase-1 (scd-1) mrna and activity increase found at 6 mo, and an enhacement of delta6 and delta5 desaturase mrna and delta6 activity. |
2005-07-20 |
2023-08-12 |
rat |
| Julie A Sloniger, Vitoon Saengsirisuwan, Cody J Diehl, Betsy B Dokken, Narissara Lailerd, Andrew M Lemieux, John S Kim, Erik J Henrikse. Defective insulin signaling in skeletal muscle of the hypertensive TG(mREN2)27 rat. American journal of physiology. Endocrinology and metabolism. vol 288. issue 6. 2005-06-16. PMID:15657091. |
defective insulin signaling in skeletal muscle of the hypertensive tg(mren2)27 rat. |
2005-06-16 |
2023-08-12 |
mouse |
| Julie A Sloniger, Vitoon Saengsirisuwan, Cody J Diehl, Betsy B Dokken, Narissara Lailerd, Andrew M Lemieux, John S Kim, Erik J Henrikse. Defective insulin signaling in skeletal muscle of the hypertensive TG(mREN2)27 rat. American journal of physiology. Endocrinology and metabolism. vol 288. issue 6. 2005-06-16. PMID:15657091. |
the male heterozygous tg(mren2)27 rat harbors the mouse transgene for renin, exhibits local elevations in angiotensin ii, and is an excellent model of both hypertension and insulin resistance. |
2005-06-16 |
2023-08-12 |
mouse |
| Julie A Sloniger, Vitoon Saengsirisuwan, Cody J Diehl, Betsy B Dokken, Narissara Lailerd, Andrew M Lemieux, John S Kim, Erik J Henrikse. Defective insulin signaling in skeletal muscle of the hypertensive TG(mREN2)27 rat. American journal of physiology. Endocrinology and metabolism. vol 288. issue 6. 2005-06-16. PMID:15657091. |
compared with nontransgenic, normotensive sprague-dawley control rats, male heterozygous tg(mren2)27 rats displayed elevated (p < 0.05) fasting plasma insulin (74%), an exaggerated insulin response (108%) during an oral glucose tolerance test, and reduced whole body insulin sensitivity. |
2005-06-16 |
2023-08-12 |
mouse |
| Julie A Sloniger, Vitoon Saengsirisuwan, Cody J Diehl, Betsy B Dokken, Narissara Lailerd, Andrew M Lemieux, John S Kim, Erik J Henrikse. Defective insulin signaling in skeletal muscle of the hypertensive TG(mREN2)27 rat. American journal of physiology. Endocrinology and metabolism. vol 288. issue 6. 2005-06-16. PMID:15657091. |
importantly, there were significant reductions (approximately 30-50%) in insulin stimulation of tyrosine phosphorylation of the insulin receptor beta-subunit and insulin receptor substrate-1 (irs-1), irs-1 associated with the p85 subunit of phosphatidylinositol 3-kinase, akt ser473 phosphorylation, and ser9 phosphorylation of glycogen synthase kinase-3beta in epitrochlearis and soleus muscles of tg(mren2)27 rats. |
2005-06-16 |
2023-08-12 |
mouse |
| Julie A Sloniger, Vitoon Saengsirisuwan, Cody J Diehl, Betsy B Dokken, Narissara Lailerd, Andrew M Lemieux, John S Kim, Erik J Henrikse. Defective insulin signaling in skeletal muscle of the hypertensive TG(mREN2)27 rat. American journal of physiology. Endocrinology and metabolism. vol 288. issue 6. 2005-06-16. PMID:15657091. |
collectively, these data provide the first evidence that the insulin resistance of the hypertensive male heterozygous tg(mren2)27 rat can be attributed to specific defects in the insulin-signaling pathway in skeletal muscle. |
2005-06-16 |
2023-08-12 |
mouse |
| Hiroshi Iwakura, Kiminori Hosoda, Choel Son, Junji Fujikura, Tsutomu Tomita, Michio Noguchi, Hiroyuki Ariyasu, Kazuhiko Takaya, Hiroaki Masuzaki, Yoshihiro Ogawa, Tatsuya Hayashi, Gen Inoue, Takashi Akamizu, Hiroshi Hosoda, Masayasu Kojima, Hiroshi Itoh, Shinya Toyokuni, Kenji Kangawa, Kazuwa Naka. Analysis of rat insulin II promoter-ghrelin transgenic mice and rat glucagon promoter-ghrelin transgenic mice. The Journal of biological chemistry. vol 280. issue 15. 2005-06-07. PMID:15701644. |
we developed and analyzed two types of transgenic mice: rat insulin ii promoter-ghrelin transgenic (rip-g tg) and rat glucagon promoter-ghrelin transgenic mice (rgp-g tg). |
2005-06-07 |
2023-08-12 |
mouse |
| Hiroshi Iwakura, Kiminori Hosoda, Choel Son, Junji Fujikura, Tsutomu Tomita, Michio Noguchi, Hiroyuki Ariyasu, Kazuhiko Takaya, Hiroaki Masuzaki, Yoshihiro Ogawa, Tatsuya Hayashi, Gen Inoue, Takashi Akamizu, Hiroshi Hosoda, Masayasu Kojima, Hiroshi Itoh, Shinya Toyokuni, Kenji Kangawa, Kazuwa Naka. Analysis of rat insulin II promoter-ghrelin transgenic mice and rat glucagon promoter-ghrelin transgenic mice. The Journal of biological chemistry. vol 280. issue 15. 2005-06-07. PMID:15701644. |
rip-g tg showed suppression of glucose-stimulated insulin secretion. |
2005-06-07 |
2023-08-12 |
mouse |
| Hiroshi Iwakura, Kiminori Hosoda, Choel Son, Junji Fujikura, Tsutomu Tomita, Michio Noguchi, Hiroyuki Ariyasu, Kazuhiko Takaya, Hiroaki Masuzaki, Yoshihiro Ogawa, Tatsuya Hayashi, Gen Inoue, Takashi Akamizu, Hiroshi Hosoda, Masayasu Kojima, Hiroshi Itoh, Shinya Toyokuni, Kenji Kangawa, Kazuwa Naka. Analysis of rat insulin II promoter-ghrelin transgenic mice and rat glucagon promoter-ghrelin transgenic mice. The Journal of biological chemistry. vol 280. issue 15. 2005-06-07. PMID:15701644. |
arginine-stimulated insulin secretion, pancreatic insulin mrna and peptide levels, beta cell mass, islet architecture, and glut2 and pdx-1 immunoreactivity in rip-g tg pancreas were not significantly different from those of nontransgenic littermates. |
2005-06-07 |
2023-08-12 |
mouse |
| Hiroshi Iwakura, Kiminori Hosoda, Choel Son, Junji Fujikura, Tsutomu Tomita, Michio Noguchi, Hiroyuki Ariyasu, Kazuhiko Takaya, Hiroaki Masuzaki, Yoshihiro Ogawa, Tatsuya Hayashi, Gen Inoue, Takashi Akamizu, Hiroshi Hosoda, Masayasu Kojima, Hiroshi Itoh, Shinya Toyokuni, Kenji Kangawa, Kazuwa Naka. Analysis of rat insulin II promoter-ghrelin transgenic mice and rat glucagon promoter-ghrelin transgenic mice. The Journal of biological chemistry. vol 280. issue 15. 2005-06-07. PMID:15701644. |
islet batch incubation study did not show suppression of insulin secretion of rip-g tg in vitro. |
2005-06-07 |
2023-08-12 |
mouse |
| Hiroshi Iwakura, Kiminori Hosoda, Choel Son, Junji Fujikura, Tsutomu Tomita, Michio Noguchi, Hiroyuki Ariyasu, Kazuhiko Takaya, Hiroaki Masuzaki, Yoshihiro Ogawa, Tatsuya Hayashi, Gen Inoue, Takashi Akamizu, Hiroshi Hosoda, Masayasu Kojima, Hiroshi Itoh, Shinya Toyokuni, Kenji Kangawa, Kazuwa Naka. Analysis of rat insulin II promoter-ghrelin transgenic mice and rat glucagon promoter-ghrelin transgenic mice. The Journal of biological chemistry. vol 280. issue 15. 2005-06-07. PMID:15701644. |
the insulin tolerance test showed lower tendency of blood glucose levels in rip-g tg. |
2005-06-07 |
2023-08-12 |
mouse |