| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ying Lan, Chi Wang, Cheng Zhang, Pengju Li, Jinding Zhang, Hong Ji, Haibo Y. Dietary sea buckthorn polysaccharide reduced lipid accumulation, alleviated inflammation and oxidative stress, and normalized imbalance of intestinal microbiota that was induced by high-fat diet in zebrafish Danio rerio. Fish physiology and biochemistry. 2022-07-25. PMID:35879492. |
results showed that adding 2 and 4 g/kg of sp in the hfd significantly improved the survival rate of zebrafish; reduced the levels of serum triglyceride (tg), total cholesterol (tc), aspartate aminotransferase (ast), and alanine transaminase (alt); and alleviated the lipid accumulation in the liver of zebrafish. |
2022-07-25 |
2023-08-14 |
zebrafish |
| Wenjie Zhu, Meizhu Yan, Haibin Cao, Jun Zhou, Zhongqing X. Effects of Clostridium butyricum Capsules Combined with Rosuvastatin on Intestinal Flora, Lipid Metabolism, Liver Function and Inflammation in NAFLD Patients. Cellular and molecular biology (Noisy-le-Grand, France). vol 68. issue 2. 2022-07-23. PMID:35869734. |
moreover, the observation group had remarkably lower levels of total cholesterol (tc), triglyceride (tg), free fatty acids (ffa), total bilirubin (tbil), direct bilirubin (dbil), alanine aminotransferase (alt), aspartate aminotransferase (ast), procollagen iii peptide (piiip), collagen-iv (c-iv), hyaluronicacid (ha) and laminin (ln) as well as lower levels of tumor necrosis factor-alpha (tnf-α), catabolite activator protein (cap) and interleukin-6 (il-6) in serum than the control group (p<0.05). |
2022-07-23 |
2023-08-14 |
human |
| Zhicheng Li, Biao Jiang, Zhihong Zhong, Jizhen Cao, Han Li, Chenxi Wang, Anxing L. Skin transcriptomic analysis and immune-related gene expression of golden pompano (Trachinotus ovatus) after Amyloodinium ocellatum infection. Fish & shellfish immunology. 2022-07-23. PMID:35870749. |
in addition, the serum of the primary infection group had significantly higher concentrations of triglyceride (tg), higher alanine transaminase (alt), aspartate transaminase (ast), and lactate dehydrogenase (ldh) activities than the control group. |
2022-07-23 |
2023-08-14 |
Not clear |
| Yong Zheng, Hongning Shi, Yahao Zhou, Ayong Wang, Dufu Kang, Limin Kan. Effects of endoplasmic reticulum stress, liver function, insulin resistance and vascular endothelial function in patients with nonalcoholic fatty liver disease. Cellular and molecular biology (Noisy-le-Grand, France). vol 67. issue 5. 2022-07-12. PMID:35818251. |
the expression level of glucose-regulated protein 94 (grp94) and biochemical indicators such as alanine aminotransferase (alt), free fatty acids (ffa), triglycerides (tg), gamma-glutamyl transferase (ggt), aspartate aminotransferase (ast), fasting blood glucose (fbg), and fasting insulin (fins) were measured. |
2022-07-12 |
2023-08-14 |
Not clear |
| Qingyu Zhao, Zhenyu Liu, Yiqing Zhu, Han Wang, Zijian Dai, Xuehao Yang, Xin Ren, Yong Xue, Qun She. Cooked Adzuki Bean Reduces High-Fat Diet-Induced Body Weight Gain, Ameliorates Inflammation, and Modulates Intestinal Homeostasis in Mice. Frontiers in nutrition. vol 9. 2022-07-05. PMID:35782919. |
cooked adzuki bean significantly inhibited weight gain and hepatic steatosis, reduced high levels of serum triacylglycerol (tg), alanine aminotransferase (alt), and aspartate aminotransferase (ast), and alleviated systemic inflammation and metabolic endotoxemia in mice fed a hfd. |
2022-07-05 |
2023-08-14 |
mouse |
| Shuang Wei, Ji Li, Dong-Wei Han, Qiang Fu, Feng Ha. [Mechanism of Astragali Radix-Puerariae Lobatae Radix combination in regulating type 2 diabetes mellitus through AMPK signaling pathway: based on network pharmacology and experimental verification]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 47. issue 10. 2022-06-19. PMID:35718494. |
after 4 weeks of intragastric administration, serum fasting blood glucose(fbg), fasting insulin(fins), aspartate aminotransferase(ast), alanine aminotransferase(alt), triglyceride(tg), total cholesterol(tc), low-density lipoprotein cholesterol(ldl-c), high-density lipoprotein cholesterol(hdl-c), interleukin(il)-6, and tumor necrosis factor(tnf)-α of rats in each group were measured. |
2022-06-19 |
2023-08-14 |
rat |
| Yi-Hsieng Samuel Wu, Yi-Ling Lin, Wen-Yuan Yang, Sheng-Yao Wang, Yi-Chen Che. Pepsin-digested chicken-liver hydrolysate attenuates hepatosteatosis by relieving hepatic and peripheral insulin resistance in long-term high-fat dietary habit. Journal of food and drug analysis. vol 29. issue 2. 2022-06-13. PMID:35696203. |
elevated ( p < 0.05) serum aspartate aminotransferase (ast), alanine transaminase (alt), alkaline phosphatase (alp), free fatty acids (ffas), triglyceride (tg), total cholesterol (tc), and fasted glucose values in hfd-fed mice decreased ( p < 0.05) by supplementing clhs. |
2022-06-13 |
2023-08-14 |
mouse |
| Hongkang Zhu, Wenhao Jiang, Chang Liu, Cheng Wang, Bin Hu, Yahui Guo, Yuliang Cheng, He Qia. Ameliorative effects of chlorogenic acid on alcoholic liver injury in mice via gut microbiota informatics. European journal of pharmacology. 2022-06-13. PMID:35697148. |
experimental results showed the increased (p < 0.05) serum alanine aminotransferase (alt), aspartate aminotransferase (ast), low density lipoprotein (ldl), total cholesterol (tc) and triglyceride (tg) levels of mice fed with ethanol were ameliorated by supplementing with cga. |
2022-06-13 |
2023-08-14 |
mouse |
| Jin-Ke Zhang, Xiu-Li Zhou, Xiao-Qian Wang, Jia-Xiong Zhang, Mei-Lian Yang, Ya-Ping Liu, Jian-Xin Cao, Gui-Guang Chen. Que Zui tea ameliorates hepatic lipid accumulation and oxidative stress in high fat diet induced nonalcoholic fatty liver disease. Food research international (Ottawa, Ont.). vol 156. 2022-06-02. PMID:35651050. |
furthermore, the contents of tc, tg, nefa, alanine aminotransferase (alt) and aspartate aminotransferase (ast) in the liver tissues were inhibited after qw and qa administration. |
2022-06-02 |
2023-08-13 |
rat |
| Wenjing Ni, Yan Pan, Huijuan Yang, Wei Li, Yan Sun, Yu Xu, Weidong Che. [Saxagliptin alleviates kidney injury in diabetic rats by down-regulating the expression of mammalian target of rapamycin (mTOR)]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 38. issue 5. 2022-05-23. PMID:35603648. |
glucose (g1u), albumin (alb), aspartate transaminase (ast), alanine transaminase (alt), serum creatinine (scr), blood urea nitrogen (bun), uric acid (ua), serum total cholesterol (tc), triglycerides (tg) were detected by automatic biochemical analyzer. |
2022-05-23 |
2023-08-13 |
rat |
| Gaber E El-Desoky, Saikh M Wabaidur, Zeid A AlOthman, Mohamed A Habil. Evaluation of Nano-curcumin effects against Tartrazine-induced abnormalities in liver and kidney histology and other biochemical parameters. Food science & nutrition. vol 10. issue 5. 2022-05-20. PMID:35592283. |
the liver function biomarkers are (glutamate oxaloacetate transaminase (got), glutamate pyruvate transaminase (gpt), alanine aminotransferase (alt), aspartate aminotransferase (ast), gamma-glutamyl transaminase (ggt), alkaline phosphatase (alp), total bilirubin (t. bill)), whereas the kidney biomarkers are (creatinine, uric acid, urea, globulin, total protein (tp)), as well as blood parameters of (serum glucose (sglu), alpha-fetoprotein (afp), protein kinase-c (pkc)) and lipid profiles that include (total lipids (tl), triglyceride (tg), total cholesterol (tc), low-density lipoprotein-cholesterol (ldl-c), high-density l-c (hdl-c), and very-low-density l-c (vldl-c)). |
2022-05-20 |
2023-08-13 |
rat |
| Juan-Fen Mo, Jia-Yuan Wu, Li Zheng, Ya-Wei Yu, Tian-Xin Zhang, Li Guo, Yi Ba. Therapeutic efficacy of polydatin for nonalcoholic fatty liver disease RSC advances. vol 8. issue 54. 2022-05-13. PMID:35548751. |
pd also downregulated the serum levels of triglyceride (tg), low density lipoprotein (ldl), aspartate aminotransferase (ast) and alanine aminotransferase (alt), and upregulated high density lipoprotein (hdl). |
2022-05-13 |
2023-08-13 |
mouse |
| Maryam Arabloei Sani, Parichehreh Yaghmaei, Zahra Hajebrahimi, Nasim Hayati Roodbar. Therapeutic Effect of P-Cymene on Lipid Profile, Liver Enzyme, and Akt/Mtor Pathway in Streptozotocin-Induced Diabetes Mellitus in Wistar Rats. Journal of obesity. vol 2022. 2022-05-09. PMID:35528246. |
data have shown that p-cymene can improve serum levels of glu, total cholesterol (tc), triglycerides (tg), high-density lipoprotein cholesterol (hdl-c), low-density lipoprotein (ldl), very-low-density lipoprotein (vldl), alkaline phosphatase (alp), alanine aminotransferase (alt), aspartate aminotransferase (ast), malondialdehyde (mda), and the expression of mtor, akt, and phospho-akt protein in diabetic animals. |
2022-05-09 |
2023-08-13 |
rat |
| Fang-Wei Zhong, Geng-Xi Li, Li Zen. [Gynostemma pentaphyllum saponins alleviate non-alcoholic fatty liver disease in rats by regulating intestinal flora and short-chain fatty acid metabolism]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 47. issue 9. 2022-05-09. PMID:35531697. |
after intragastric administration for 8 continuous weeks, we determined the body weight, liver weight, the levels of total cholesterol(tc), triglyceride(tg), low-density lipoprotein cholesterol(ldl-c), high-density lipoprotein cholesterol(hdl-c), alanine aminotransferase(alt), and aspartate aminotransferase(ast) in serum, and the levels of tc, tg, malondialdehyde(mda), superoxide dismutase(sod), catalase(cat), and interleukin 6(il-6) in the liver. |
2022-05-09 |
2023-08-13 |
rat |
| Cheng-Fang Jian, Bo-Yu Zhang, Cun-Ping Wang, Yu-Ru Sha, A-Rong Li, Pu-Yang Gong, Jian Gu, Rui Ta. [Mechanism of Tibetan medicine Ershiwuwei Songshi Pills in regulating intestinal flora and improving non-alcoholic steatohepatitis]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 47. issue 8. 2022-05-09. PMID:35531719. |
the levels of serum aspartate aminotransferase(ast) and alanine aminotransferase(alt) and triglyceride(tg) in liver tissue were measured. |
2022-05-09 |
2023-08-13 |
mouse |
| Pan Li, Yuwei Chen, Xiumei Ke, Ruoyu Zhang, Ling Zuo, Meng Wang, Zhiwei Chen, Xianqin Luo, Jianwei Wan. Baicalin ameliorates alcohol-induced hepatic steatosis by suppressing SREBP1c elicited PNPLA3 competitive binding to ATGL. Archives of biochemistry and biophysics. 2022-04-16. PMID:35429444. |
it was evident that baicalin treatment significantly normalized the serous contents of hepatic triglyceride (tg), alanine aminotransferase (alt), and aspartate aminotransferase (ast), and attenuated the increase of hepatic vacuolization and oil red o staining area caused by alcohol. |
2022-04-16 |
2023-08-13 |
rat |
| Shui-Fen Sun, Hui-Jie Zhong, Yun-Li Zhao, Xiu-Ying Ma, Jin-Bo Luo, Ling Zhu, Yu-Ting Zhang, Wen-Xue Wang, Xiao-Dong Luo, Jia-Wei Gen. Indole alkaloids of Alstonia scholaris (L.) R. Br. alleviated nonalcoholic fatty liver disease in mice fed with high-fat diet. Natural products and bioprospecting. vol 12. issue 1. 2022-04-02. PMID:35364708. |
the concentrations of low-density lipoprotein (ldl), triglyceride (tg), aspartate aminotransferase (ast) and alanine aminotransferase (alt) were also decreased significantly in ta-treated mice group, accompanied by an increase in high-density lipoprotein (hdl). |
2022-04-02 |
2023-08-13 |
mouse |
| Mohammad Moradzad, Mohammad Abdi, Farshad Sheikh Esmaeili, Dana Ghaderi, Khaled Rahmani, Mohammad Raman Moloudi, Zakaria Vahabzade. Possible correlation between high circulatory levels of trimethylamine-N-oxide and 2177G>C polymorphisms of hepatic flavin containing monooxygenase 3 in Kurdish Population with non-alcoholic fatty liver disease. Molecular biology reports. 2022-03-29. PMID:35348964. |
methods and results: in 85 confirmed nafld patients and 30 healthy individuals, triglycerides (tg), total cholesterol (chol), low-density lipoprotein (ldl), high-density lipoprotein (hdl), alanine aminotransferase (alt), and aspartate aminotransferase (ast) activities were measured. |
2022-03-29 |
2023-08-13 |
Not clear |
| Meng-Yao Wang, Gai Gao, Er-Wen Li, Xiao-Wei Zhang, Hui Wang, Jiang-Yan Xu, Zhen-Qiang Zhang, Pan Wang, Zhi-Shen Xi. [Mechanism of Zexie Decoction in improvement of nonalcoholic fatty liver disease based on LKB1/AMPK/PGC-1α pathway]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 47. issue 2. 2022-02-18. PMID:35178989. |
as revealed by the mtt assay, zxd had no effect on hepg2 activity, but dose-dependently down-regulated alanine aminotransferase(alt) and aspartate aminotransferase(ast) in the liver cell medium induced by pa, and decreased the plasma levels of alt and ast, and total cholesterol(tc) and triglyceride(tg) levels in the liver. |
2022-02-18 |
2023-08-13 |
mouse |
| Cindy Guerrero-Toro, Kseniia Koroleva, Elizaveta Ermakova, Oleg Gafurov, Polina Abushik, Pasi Tavi, Guzel Sitdikova, Rashid Giniatulli. Testing the Role of Glutamate NMDA Receptors in Peripheral Trigeminal Nociception Implicated in Migraine Pain. International journal of molecular sciences. vol 23. issue 3. 2022-02-15. PMID:35163452. |
glutamate, aspartate, and, to a lesser extent, nmda under free-magnesium conditions, evoked calcium transients in a fraction of isolated tg neurons, indicating functional expression of nmda receptors. |
2022-02-15 |
2023-08-13 |
rat |