| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jie Gao, Caihong Pi, Junmei Pan, Wei Zho. Research progress of Hippo pathway effector molecules in rheumatic immune system diseases. Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences. 2024-06-20. PMID:38899353. |
effector molecules,such as yes-associated protein (yap), transcriptional coactivator with pdz-binding motif (taz), transcriptional enhanced associate domain transcriptional factor (tead), monopolar spindle-one binder (mob1), large tumor suppressor (lats), can stimulate fibroblast-like synovial cell migration and invasion in rheumatoid arthritis, regulate osteoarthritis disease progression, promote pathological new bone formation in ankylosing spondylitis, sustain submandibular gland development while delaying sjogren's syndrome progression, mediate alpha-smooth muscle actin in systemic sclerosis, and refine the regulation of target genes associated with pulmonary fibrosis. |
2024-06-20 |
2024-06-22 |
Not clear |
| Jongwan Kim, Haiyan Jin, Jinhyuk Kim, Seon Yeon Cho, Sungho Moon, Jianmin Wang, Jiashun Mao, Kyoung Tai N. Leveraging the Fragment Molecular Orbital and MM-GBSA Methods in Virtual Screening for the Discovery of Novel Non-Covalent Inhibitors Targeting the TEAD Lipid Binding Pocket. International journal of molecular sciences. vol 25. issue 10. 2024-05-25. PMID:38791396. |
the transcriptional enhanced associate domain (tead) family of transcription factors acts as a receptor for downstream effectors, namely yes-associated protein (yap) and transcriptional co-activator with pdz-binding motif (taz), which binds to various transcription factors and is essential for stimulated gene transcription. |
2024-05-25 |
2024-05-27 |
Not clear |
| Susu Guo, Xiaodi Hu, Jennifer L Cotton, Lifang Ma, Qi Li, Jiangtao Cui, Yongjie Wang, Ritesh P Thakare, Zhipeng Tao, Y Tony Ip, Xu Wu, Jiayi Wang, Junhao Ma. VGLL2 and TEAD1 fusion proteins drive YAP/TAZ-independent transcription and tumorigenesis by engaging p300. bioRxiv : the preprint server for biology. 2024-05-15. PMID:38746415. |
studies on hippo pathway regulation of tumorigenesis largely center on yap and taz, the transcriptional co-regulators of tead. |
2024-05-15 |
2024-05-27 |
Not clear |
| Kira R Mills, Jyoti Misra, Hedieh Torabifar. Allosteric Modulation of the YAP/TAZ-TEAD Interaction by Palmitoylation and Small-Molecule Inhibitors. The journal of physical chemistry. B. 2024-04-12. PMID:38606592. |
because yap and taz exert their oncogenic effects by binding with tead, it is critical to understand this key interaction to develop cancer therapeutics. |
2024-04-12 |
2024-04-14 |
Not clear |
| Kira R Mills, Jyoti Misra, Hedieh Torabifar. Allosteric Modulation of the YAP/TAZ-TEAD Interaction by Palmitoylation and Small-Molecule Inhibitors. The journal of physical chemistry. B. 2024-04-12. PMID:38606592. |
utilizing molecular dynamics simulations, our investigation not only provides detailed atomistic insight into the yap/taz-tead dynamics but also unveils that the inhibitor studied influences the binding of yap and taz to tead in distinct manners. |
2024-04-12 |
2024-04-14 |
Not clear |
| Oisun Jung, Min-Jeong Baek, Colin Wooldrik, Keith R Johnson, Kurt W Fisher, Jinchao Lou, Tanei J Ricks, Tianmu Wen, Michael D Best, Vincent L Cryns, Richard A Anderson, Suyong Cho. Nuclear phosphoinositide signaling promotes YAP/TAZ-TEAD transcriptional activity in breast cancer. The EMBO journal. 2024-04-02. PMID:38565949. |
the hippo pathway effectors yes-associated protein 1 (yap) and its homolog taz are transcriptional coactivators that control gene expression by binding to tea domain (tead) family transcription factors. |
2024-04-02 |
2024-04-05 |
Not clear |
| Hironori Otsuki, Takeshi Uemori, Yohei Inai, Yui Suzuki, Tetsuro Araki, Ken-Ichiro Nan-Ya, Kouichi Yoshinar. Reversible and monitorable nephrotoxicity in rats by the novel potent transcriptional enhanced associate domain (TEAD) inhibitor, K-975. The Journal of toxicological sciences. vol 49. issue 4. 2024-03-31. PMID:38556354. |
transcriptional enhanced associate domain (tead), a transcription activator of the hippo pathway, forms the complex with a transcriptional coactivator yes-associated protein (yap) or a transcriptional coactivator pdz-binding motif (taz). |
2024-03-31 |
2024-04-03 |
mouse |
| Shu Li, Xing Li, Yong-Bin Yang, Su-Fang W. YAP/TAZ-TEAD activity promotes the malignant transformation of cervical intraepithelial neoplasia through enhancing the characteristics and Warburg effect of cancer stem cells. Apoptosis : an international journal on programmed cell death. 2024-03-30. PMID:38553612. |
a number of studies have confirmed that yes-associated protein (yap)/transcriptional co-activator with pdz-binding motif (taz)-transcriptional enhanced associate domain (tead) activity is the driver of cancer development. |
2024-03-30 |
2024-04-01 |
human |
| Shu Li, Xing Li, Yong-Bin Yang, Su-Fang W. YAP/TAZ-TEAD activity promotes the malignant transformation of cervical intraepithelial neoplasia through enhancing the characteristics and Warburg effect of cancer stem cells. Apoptosis : an international journal on programmed cell death. 2024-03-30. PMID:38553612. |
next, the expression levels of yap, taz and tead in cervical tissues and cells were observed by immunohistochemistry, qrt-pcr and western blot. |
2024-03-30 |
2024-04-01 |
human |
| Shu Li, Xing Li, Yong-Bin Yang, Su-Fang W. YAP/TAZ-TEAD activity promotes the malignant transformation of cervical intraepithelial neoplasia through enhancing the characteristics and Warburg effect of cancer stem cells. Apoptosis : an international journal on programmed cell death. 2024-03-30. PMID:38553612. |
subsequently, the stemness characteristics, glycolysis level and malignant transformation of cells in each group were observed by sphere-formation assay, commercial kit, mtt, transwell, scratch experiment, xenotransplantation and western blot.the expression of yap, taz and tead increased significantly in cervical cancer tissue and cell line at the stage of cin2/3 and scc. |
2024-03-30 |
2024-04-01 |
human |
| Shubhashree Parimita, Amitava Das, Sanjoy Samant. VGLL1 stabilization of cytoplasmic TAZ promotes EGFR expression and maintains tumor initiating cells in breast cancer independent of TEAD. Cellular signalling. 2024-02-28. PMID:38417636. |
vgll1 stabilization of cytoplasmic taz promotes egfr expression and maintains tumor initiating cells in breast cancer independent of tead. |
2024-02-28 |
2024-03-02 |
Not clear |
| Abraham Behrmann, Dalian Zhong, Li Li, Shangkui Xie, Megan Mead, Parastoo Sabaeifard, Mohammad Goodarzi, Andrew Lemoff, Julia Kozlitina, Dwight A Towle. Wnt16 Promotes Vascular Smooth Muscle Contractile Phenotype and Function via Taz(Wwtr1) Activation in Male LDLR-/- Mice. Endocrinology. 2023-12-20. PMID:38123514. |
wnt16 stimulated taz binding to acta2 chromatin and h3k4me3 methylation.. tead cognates in the acta2 promoter conveyed transcriptional responses to wnt16 and taz. |
2023-12-20 |
2023-12-23 |
mouse |
| Yang Zhao, Marisela Sheldon, Yutong Sun, Li M. New Insights into YAP/TAZ-TEAD-Mediated Gene Regulation and Biological Processes in Cancer. Cancers. vol 15. issue 23. 2023-12-09. PMID:38067201. |
key mammalian hippo pathway kinases, including mst1/2 and lats1/2, inhibit cellular growth by inactivating the tead coactivators, yap, and taz. |
2023-12-09 |
2023-12-17 |
Not clear |
| Tao Liu, Jiaojiao Zhou, Yanmin Chen, Jia Fang, Song Liu, Costa Frangou, Hai Wang, Jianmin Zhan. Genome-Wide Characterization of TAZ Binding Sites in Mammary Epithelial Cells. Cancers. vol 15. issue 19. 2023-10-14. PMID:37835407. |
taz bound to enhancer regions following a switch in potential tead and fosl2 transcription factor motifs. |
2023-10-14 |
2023-10-15 |
Not clear |
| Adelya Gabdulkhakova, Yekaterina Krutsenko, Junjie Zhu, Silvia Liu, Minakshi Poddar, Sucha Singh, Xiaochao Ma, Kari Nejak-Bowen, Satdarshan P S Monga, Laura M Molin. Loss of TAZ after YAP deletion severely impairs foregut development and worsens cholestatic hepatocellular injury. Hepatology communications. vol 7. issue 9. 2023-08-09. PMID:37556373. |
taz, a paralog of yap, was significantly upregulated in yapko hepatocytes and interacted with tea domain family member (tead) transcription factors, suggesting possible compensatory activity. |
2023-08-09 |
2023-08-16 |
Not clear |
| Cornelis J Boogerd, Ilaria Perini, Eirini Kyriakopoulou, Su Ji Han, Phit La, Britt van der Swaan, Jari B Berkhout, Danielle Versteeg, Jantine Monshouwer-Kloots, Eva van Rooi. Cardiomyocyte proliferation is suppressed by ARID1A-mediated YAP inhibition during cardiac maturation. Nature communications. vol 14. issue 1. 2023-08-05. PMID:37543677. |
furthermore, we show that arid1a directly binds and inhibits the proliferation-promoting transcriptional coactivators yap and taz, indicating arid1a sequesters yap/taz from their dna-binding partner tead. |
2023-08-05 |
2023-08-14 |
human |
| Chan-I Chung, Junjiao Yang, Xiaokun Sh. Chemogenetic Minitool for Dissecting the Roles of Protein Phase Separation. ACS central science. vol 9. issue 7. 2023-07-31. PMID:37521779. |
to address this question, we have designed a chemogenetic tool, dubbed spark-on, which manipulates the ps of yap and taz without a biological stimulus, forming condensates that are transcriptionally active, containing the dna-binding partner tead, genomic dna, transcriptional machinery, and nascent rna. |
2023-07-31 |
2023-08-14 |
Not clear |
| Kuang Tan, Qiaolin Yang, Yineng Han, Ziyao Zhuang, Yi Zhao, KunYao Guo, Anqi Tan, Yunfei Zheng, Weiran L. Elastic modulus of hydrogel regulates osteogenic differentiation via liquid-liquid phase separation of YAP. Journal of biomedical materials research. Part A. 2023-07-26. PMID:37494632. |
in contrast, the expression of yap, taz and tead was increased in the hbmscs in the low-elastic-modulus gelma. |
2023-07-26 |
2023-08-14 |
rat |
| Yuki Takakura, Takayuki Suzuki, Naoto Hirai, Takuro Araki, Mai Ohishi, Hiromi Sato, Naoto Yamaguchi, Hiroyuki Takano, Noritaka Yamaguch. VGLL3 confers slow-twitch muscle differentiation via PGC-1α expression in C2C12 myocytes. Biochemical and biophysical research communications. vol 669. 2023-06-01. PMID:37262950. |
we also found that vgll3 proteins are degraded by the proteasome, which causes switching of tead cofactors from vgll3 to yes-associated protein (yap) and transcriptional coactivator with a pdz-binding motif (taz). |
2023-06-01 |
2023-08-14 |
Not clear |
| Boting Ning, Andrew M Tilston-Lunel, Justice Simonetti, Julia Hicks-Berthet, Adeline Matschulat, Roxana Pfefferkorn, Avrum Spira, Matthew Edwards, Sarah Mazzilli, Marc E Lenburg, Jennifer E Beane, Xaralabos Varela. Convergence of YAP/TAZ, TEAD and TP63 activity is associated with bronchial premalignant severity and progression. Journal of experimental & clinical cancer research : CR. vol 42. issue 1. 2023-05-07. PMID:37150829. |
evidence has suggested key roles for the hippo pathway effectors yap and taz and associated tead and tp63 transcription factor families in bronchial basal cell biology and lusc. |
2023-05-07 |
2023-08-14 |
Not clear |