| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M J Müller, K J Acheson, A G Burger, E Jequie. Evidence that hyperglycaemia per se does not inhibit hepatic glucose production in man. European journal of applied physiology and occupational physiology. vol 60. issue 4. 1990-08-01. PMID:1972675. |
the effect of hyperglycaemia on hepatic glucose production (ra) was investigated in nine healthy men using sequential clamp protocols during somatostatin infusion and euglycaemia (0-150 min), at plasma glucose levels of 165 mg x dl-1 (9.2 mm, 150-270 min) and during insulin infusion (1.0 mu x kg-1 x min-1, 270-360 min) in study 1 or during hypo-insulinaemia and plasma glucose levels of 220 mg x dl-1 (12.2 mm; 270-390 min) in study 2. |
1990-08-01 |
2023-08-11 |
Not clear |
| M J Müller, K J Acheson, A G Burger, E Jequie. Evidence that hyperglycaemia per se does not inhibit hepatic glucose production in man. European journal of applied physiology and occupational physiology. vol 60. issue 4. 1990-08-01. PMID:1972675. |
however, more pronounced hyperglycaemia increased insulin secretion despite somatostatin resulting in a fall in plasma ffa and lipid oxidation. |
1990-08-01 |
2023-08-11 |
Not clear |
| M Nozawa, I Ots. Experience in rat pancreas transplantation at Meikai University. Microsurgery. vol 11. issue 2. 1990-07-26. PMID:2192226. |
arginine-induced serum insulin, glucagon, and somatostatin responses in the grafted pancreas were similar to those in normal pancreas. |
1990-07-26 |
2023-08-11 |
rat |
| R W Jansen, T L Peeters, H J Van Lier, W H Hoefnagel. The effect of oral glucose, protein, fat and water loading on blood pressure and the gastrointestinal peptides VIP and somatostatin in hypertensive elderly subjects. European journal of clinical investigation. vol 20. issue 2. 1990-07-13. PMID:1972066. |
we studied 10 hypertensive elderly subjects (mean age 74 +/- 3 years) for the effects of oral glucose, fat, protein and water loading on bp in relation to plasma concentrations of vasoactive intestinal polypeptide (vip), somatostatin and insulin. |
1990-07-13 |
2023-08-11 |
human |
| K A Alanen, H Joensuu, P J Klemi, S Marin, M Alavaikko, T J Nevalaine. DNA ploidy in pancreatic neuroendocrine tumors. American journal of clinical pathology. vol 93. issue 6. 1990-07-03. PMID:2346135. |
the tumors were classified by immunostaining with antisera for synaptophysin, insulin, gastrin, glucagon, pancreatic polypeptide, somatostatin, and vasoactive intestinal polypeptide. |
1990-07-03 |
2023-08-11 |
Not clear |
| T Messell, H Harling, G Böttcher, A H Johnsen, J J Hols. Galanin in the porcine pancreas. Regulatory peptides. vol 28. issue 2. 1990-06-25. PMID:1693004. |
the output of insulin, glucagon, somatostatin and pancreatic polypeptide (pp) was measured in the effluent. |
1990-06-25 |
2023-08-11 |
Not clear |
| R M Liehr, G Melnykovych, T E Solomo. Growth effects of regulatory peptides on human pancreatic cancer lines PANC-1 and MIA PaCa-2. Gastroenterology. vol 98. issue 6. 1990-06-18. PMID:2186957. |
the growth of human pancreatic cancer lines panc-1 and mia paca-2 was characterized in vitro, and the effects of cholecystokinin, bombesin, insulin, epidermal growth factor, secretin, vasoactive intestinal peptide, and somatostatin were determined. |
1990-06-18 |
2023-08-11 |
human |
| T Bani-Sacchi, D Bani, F Filipponi, A Michel, D Houssi. Immunocytochemical and ultrastructural changes of islet cells in rats treated long-term with cyclosporine at immunotherapeutic doses. Transplantation. vol 49. issue 5. 1990-06-13. PMID:2186526. |
csa induces hyperglycemia and reduced glucose tolerance, and causes a decrease in immunoreactive insulin and an increase of somatostatin and pancreatic polypeptide (pp) immunoreactivities, leaving glucagon immunoreactivity unaffected. |
1990-06-13 |
2023-08-11 |
rat |
| R Saperstein, E W Chapin, E J Brady, E E Slate. Effects of an alpha 2-adrenoceptor antagonist on glucose tolerance in the genetically obese mouse (C57BL/6J ob/ob). Metabolism: clinical and experimental. vol 39. issue 5. 1990-06-08. PMID:1970847. |
concomitant treatment with a potent somatostatin analog to inhibit insulin release blocked the effects of the alpha 2-adrenoceptor antagonist, compound a. |
1990-06-08 |
2023-08-11 |
mouse |
| S Del Prato, R A DeFronzo, P Castellino, J Wahren, A Alvestran. Regulation of amino acid metabolism by epinephrine. The American journal of physiology. vol 258. issue 5 Pt 1. 1990-06-07. PMID:1970711. |
in study iii five individuals received epinephrine with somatostatin plus basal insulin replacement. |
1990-06-07 |
2023-08-11 |
human |
| G K Hendrick, R T Frizzell, P E Williams, A D Cherringto. Effect of hyperglucagonemia on hepatic glycogenolysis and gluconeogenesis after a prolonged fast. The American journal of physiology. vol 258. issue 5 Pt 1. 1990-06-07. PMID:2185665. |
two protocols were used; in one ("hormone replacement"; n = 4), intraportal basal replacement amounts of insulin and glucagon were given during a somatostatin infusion, whereas, in the other ("glucagon excess"; n = 5) basal insulin was given along with somatostatin and excess glucagon. |
1990-06-07 |
2023-08-11 |
Not clear |
| H Hahn von Dorsche, K Fält, M Titlbach, H Reiher, H J Hahn, S Falkme. Immunohistochemical, morphometric, and ultrastructural investigations of the early development of insulin, somatostatin, glucagon, and PP cells in foetal human pancreas. Diabetes research (Edinburgh, Scotland). vol 12. issue 2. 1990-06-06. PMID:2576774. |
immunohistochemical, morphometric, and ultrastructural investigations of the early development of insulin, somatostatin, glucagon, and pp cells in foetal human pancreas. |
1990-06-06 |
2023-08-11 |
human |
| T Mitsukawa, J Takemura, J Asai, M Nakazato, K Kangawa, H Matsuo, S Matsukur. Islet amyloid polypeptide response to glucose, insulin, and somatostatin analogue administration. Diabetes. vol 39. issue 5. 1990-06-05. PMID:1970540. |
islet amyloid polypeptide response to glucose, insulin, and somatostatin analogue administration. |
1990-06-05 |
2023-08-11 |
human |
| T Mitsukawa, J Takemura, J Asai, M Nakazato, K Kangawa, H Matsuo, S Matsukur. Islet amyloid polypeptide response to glucose, insulin, and somatostatin analogue administration. Diabetes. vol 39. issue 5. 1990-06-05. PMID:1970540. |
these results suggest that iapp is cosecreted with insulin in response to a glucose load and secretion of iapp is inhibited by hypoglycemia and somatostatin. |
1990-06-05 |
2023-08-11 |
human |
| B Fischer, U Rausch, P Wollny, H Westphal, J Seitz, G Aumülle. Immunohistochemical localization of the glucocorticoid receptor in pancreatic beta-cells of the rat. Endocrinology. vol 126. issue 5. 1990-05-25. PMID:1691702. |
monospecific polyclonal antisera against insulin, glucagon, somatostatin, and amylase were applied to serial sections in colocalization studies to identify the respective endocrine and exocrine cells. |
1990-05-25 |
2023-08-11 |
rat |
| R Lamberts, W E Schmidt, W Creutzfeld. Light and electron microscopical immunocytochemical localization of pancreastatin-like immunoreactivity in porcine tissues. Histochemistry. vol 93. issue 4. 1990-05-24. PMID:2182573. |
at the electron microscopical (em) level the immunoreactivity was confined to the electron dense core of the secretory granules in the case of somatostatin and insulin cells or to the less electron dense "halo" of the glucagon granules. |
1990-05-24 |
2023-08-11 |
Not clear |
| Y Yasunami, S Ryu, T Kame. FK506 as the sole immunosuppressive agent for prolongation of islet allograft survival in the rat. Transplantation. vol 49. issue 4. 1990-05-16. PMID:1691535. |
immunohistochemically islet grafts stained weakly for insulin, but to the same extent as the controls for glucagon and somatostatin. |
1990-05-16 |
2023-08-11 |
rat |
| R Carretta, B Fabris, F Fischetti, M Costantini, F De Biasi, S Muiesan, M Bardelli, F Vran, L Campanacc. Reduction of blood pressure in obese hyperinsulinaemic hypertensive patients during somatostatin infusion. Journal of hypertension. Supplement : official journal of the International Society of Hypertension. vol 7. issue 6. 1990-05-11. PMID:2576663. |
the somatostatin infusion reduced plasma insulin and increased plasma glucose similarly in both groups. |
1990-05-11 |
2023-08-11 |
Not clear |
| M Nauck, F Stöckmann, W Creutzfeld. Evaluation of a euglycaemic clamp procedure as a diagnostic test in insulinoma patients. European journal of clinical investigation. vol 20. issue 1. 1990-05-01. PMID:1969348. |
somatostatin infusions inhibited insulin secretion (ir-c-peptide plasma concentrations) by 52-88% in subjects without insulinoma and in those insulinoma patients whose tumour cells ultrastructurally contained plenty of normal secretory granules, and to a lesser degree when only abnormal or virtually no secretory granules were present, i.e. |
1990-05-01 |
2023-08-11 |
human |
| M Nauck, F Stöckmann, W Creutzfeld. Evaluation of a euglycaemic clamp procedure as a diagnostic test in insulinoma patients. European journal of clinical investigation. vol 20. issue 1. 1990-05-01. PMID:1969348. |
the presence of metastases, could not be predicted from whether or not insulin secretion was resistant to the inhibitory action of somatostatin. |
1990-05-01 |
2023-08-11 |
human |