| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| E Vara, L A Idahl, P Lindström, J Sehlin, J Tamarit-Rodrigue. Insulin, glucagon, somatostatin, and thyrotropin-releasing hormone content and secretion by perifused fetal rat islets during culture. Acta endocrinologica. vol 123. issue 3. 1990-12-04. PMID:1978458. |
insulin, glucagon and somatostatin content increased during one week of culture in the presence of 11.1 mmol/l glucose. |
1990-12-04 |
2023-08-11 |
rat |
| E Vara, L A Idahl, P Lindström, J Sehlin, J Tamarit-Rodrigue. Insulin, glucagon, somatostatin, and thyrotropin-releasing hormone content and secretion by perifused fetal rat islets during culture. Acta endocrinologica. vol 123. issue 3. 1990-12-04. PMID:1978458. |
insulin, glucagon and somatostatin responses to glucose were present after one week of culture. |
1990-12-04 |
2023-08-11 |
rat |
| J E DiGiacomo, W W Ha. Effect of hypoinsulinemia and hyperglycemia on fetal glucose utilization. The American journal of physiology. vol 259. issue 4 Pt 1. 1990-11-21. PMID:1977321. |
in fetal sheep, infusion of somatostatin alone decreased fetal insulin concentration 4 microu/ml (33%) from the basal value without a significant change in fetal glucose concentration, umbilical glucose uptake (ugu), or fetal glucose utilization rate (gur). |
1990-11-21 |
2023-08-11 |
Not clear |
| J E DiGiacomo, W W Ha. Effect of hypoinsulinemia and hyperglycemia on fetal glucose utilization. The American journal of physiology. vol 259. issue 4 Pt 1. 1990-11-21. PMID:1977321. |
glucose plus somatostatin infusion produced a significantly lower insulin concentration (54% lower, p less than 0.005) and gur (22% lower, p less than 0.05) at glucose concentration approximately 40 mg/dl compared with glucose infusion alone. |
1990-11-21 |
2023-08-11 |
Not clear |
| M Caruso, G D Divertie, M D Jensen, J M Mile. Lack of effect of hyperglycemia on lipolysis in humans. The American journal of physiology. vol 259. issue 4 Pt 1. 1990-11-21. PMID:1977322. |
in the present study, six subjects with insulin-dependent diabetes and six nondiabetic volunteers were studied during infusion of somatostatin, growth hormone, and insulin at rates designed to maintain basal rates of lipolysis, which was traced using a constant infusion of [1-14c]palmitate. |
1990-11-21 |
2023-08-11 |
human |
| B A Adkins-Marshall, S R Myers, G K Hendrick, P E Williams, K Triebwasser, B Floyd, A D Cherringto. Interaction between insulin and glucose-delivery route in regulation of net hepatic glucose uptake in conscious dogs. Diabetes. vol 39. issue 1. 1990-11-21. PMID:2210065. |
five conscious dogs fasted 18 h were given somatostatin and replacement insulin (245 +/- 34 microu.kg-1.min-1) and glucagon (0.65 ng.kg-1.min-1) infusions intraportally. |
1990-11-21 |
2023-08-11 |
Not clear |
| N Kaiser, A P Corcos, A Tur-Sinai, Y Ariav, B Glaser, H Landau, E Ceras. Regulation of insulin release in persistent hyperinsulinaemic hypoglycaemia of infancy studied in long-term culture of pancreatic tissue. Diabetologia. vol 33. issue 8. 1990-11-16. PMID:2210121. |
although insulin output was high in the absence of glucose, this was not due to passive leak of hormone, since both removal of calcium and addition of somatostatin and epinephrine inhibited the secretion. |
1990-11-16 |
2023-08-11 |
Not clear |
| b' G M Prelevi\\xc4\\x87, M I Wurzburger, L Balint-Peri\\xc4\\x87, J S Nesi\\xc4\\x8. Inhibitory effect of sandostatin on secretion of luteinising hormone and ovarian steroids in polycystic ovary syndrome. Lancet (London, England). vol 336. issue 8720. 1990-11-13. PMID:1976930.' |
somatostatin inhibits insulin and lh secretion in healthy adults, so the effect of treatment with a long-acting somatostatin analogue ('sandostatin') on gonadotropin and androgen secretion in pcos was investigated. |
1990-11-13 |
2023-08-11 |
Not clear |
| J J Holst, C G Ostenson, H Harling, T Messel. Porcine pancreastatin has no effect on endocrine secretion from the pig pancreas. Diabetologia. vol 33. issue 7. 1990-10-26. PMID:1976102. |
pancreastatin in a concentration of 10(-8) mol/l had no effect on basal secretion of insulin, glucagon and somatostatin at a perfusate glucose concentration of 5 mmol/l (n = 4) and neither at 10(-8) nor 10(-7) mol/l influenced the hormone responses to acute elevations of perfusate glucose concentration from 3.5 to 11 mmol/l (n = 7). |
1990-10-26 |
2023-08-11 |
Not clear |
| S E Kahn, L J Klaff, M W Schwartz, J C Beard, R N Bergman, G J Taborsky, D Port. Treatment with a somatostatin analog decreases pancreatic B-cell and whole body sensitivity to glucose. The Journal of clinical endocrinology and metabolism. vol 71. issue 4. 1990-10-23. PMID:2205630. |
to determine the specific alteration in b-cell function caused by a somatostatin analog in man and to determine the effect of the induced insulin deficiency on insulin action, we administered octreotide (sms 201-995; 50 micrograms twice daily) to nine healthy male subjects, aged 24-35 yr. b-cell function was assessed by measuring the acute insulin response (air) to glucose (airglucose) at fasting glucose and to arginine (airarg) at glucose concentrations of fasting, approximately 14 and more than 28 mm after 2 (n = 7) and 8 days (n = 9) of octreotide. |
1990-10-23 |
2023-08-11 |
human |
| R H Goodman, R P Rehfuss, M Verhave, R Ventimiglia, M J Lo. Somatostatin gene regulation: an overview. Metabolism: clinical and experimental. vol 39. issue 9 Suppl 2. 1990-10-19. PMID:1976213. |
originally characterized as a hypothalamic regulator of growth hormone secretion, somatostatin also regulates the secretion of several other pituitary, pancreatic, and gastrointestinal (gi) hormones including thyrotropin-stimulating hormone, insulin, glucagon, and gastrin. |
1990-10-19 |
2023-08-11 |
Not clear |
| J E Geric. Role of somatostatin and its analogues in the pathogenesis and treatment of diabetes mellitus. Metabolism: clinical and experimental. vol 39. issue 9 Suppl 2. 1990-10-19. PMID:1976221. |
somatostatin secreted by pancreatic d cells is a potent inhibitor of insulin, glucagon and growth hormone secretion, as well as other cells. |
1990-10-19 |
2023-08-11 |
Not clear |
| E Samols, J I Stagne. Islet somatostatin--microvascular, paracrine, and pulsatile regulation. Metabolism: clinical and experimental. vol 39. issue 9 Suppl 2. 1990-10-19. PMID:1976222. |
we have shown by the anterograde and retrograde infusion of antibody directed against insulin, glucagon, or somatostatin into the isolated rat and dog pancreas that blood flow within the islet is from the b-cell core outward to the mantle. |
1990-10-19 |
2023-08-11 |
rat |
| E Samols, J I Stagne. Islet somatostatin--microvascular, paracrine, and pulsatile regulation. Metabolism: clinical and experimental. vol 39. issue 9 Suppl 2. 1990-10-19. PMID:1976222. |
our results demonstrate that the b to a to d cellular order of perfusion is responsible for the regulation of islet hormone secretion, ie, insulin regulates the secretion of glucagon and glucagon (and probably insulin) regulate the secretion of somatostatin. |
1990-10-19 |
2023-08-11 |
rat |
| E Samols, J I Stagne. Islet somatostatin--microvascular, paracrine, and pulsatile regulation. Metabolism: clinical and experimental. vol 39. issue 9 Suppl 2. 1990-10-19. PMID:1976222. |
although each hormone is secreted as pulses, there does not appear to be a consistent phase relationship between insulin, glucagon, or somatostatin. |
1990-10-19 |
2023-08-11 |
rat |
| V L Hood, U Keller, M W Haymond, D Kür. Systemic pH modifies ketone body production rates and lipolysis in humans. The American journal of physiology. vol 259. issue 3 Pt 1. 1990-10-18. PMID:1975988. |
somatostatin, with insulin, glucagon, and growth hormone replacement, was infused in all studies. |
1990-10-18 |
2023-08-11 |
human |
| G Bertrand, R Gross, G Ribes, M M Loubatières-Marian. P2 purinoceptor agonists stimulate somatostatin secretion from dog pancreas. European journal of pharmacology. vol 182. issue 2. 1990-10-17. PMID:1975783. |
this atp analogue (approximately 15 microm) immediately induced stimulation of both somatostatin and insulin secretion, which was accompanied by a slight reduction of glycemia. |
1990-10-17 |
2023-08-11 |
dog |
| G Bertrand, R Gross, G Ribes, M M Loubatières-Marian. P2 purinoceptor agonists stimulate somatostatin secretion from dog pancreas. European journal of pharmacology. vol 182. issue 2. 1990-10-17. PMID:1975783. |
under these conditions, alpha,beta-methylene adp immediately induced the stimulation of somatostatin secretion without affecting basal insulin and glucagon secretion. |
1990-10-17 |
2023-08-11 |
dog |
| S Ullrich, M Prentki, C B Wollhei. Somatostatin inhibition of Ca2(+)-induced insulin secretion in permeabilized HIT-T15 cells. The Biochemical journal. vol 270. issue 1. 1990-10-11. PMID:1975739. |
somatostatin inhibition of ca2(+)-induced insulin secretion in permeabilized hit-t15 cells. |
1990-10-11 |
2023-08-11 |
Not clear |
| S Ullrich, M Prentki, C B Wollhei. Somatostatin inhibition of Ca2(+)-induced insulin secretion in permeabilized HIT-T15 cells. The Biochemical journal. vol 270. issue 1. 1990-10-11. PMID:1975739. |
somatostatin inhibited ca2(+)-induced insulin secretion in permeabilized hit-t15 cells, albeit with decreased sensitivity relative to intact cells. |
1990-10-11 |
2023-08-11 |
Not clear |