| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A Schmidt, J Hescheler, S Offermanns, K Spicher, K D Hinsch, F J Klinz, J Codina, L Birnbaumer, H Gausepohl, R Fran. Involvement of pertussis toxin-sensitive G-proteins in the hormonal inhibition of dihydropyridine-sensitive Ca2+ currents in an insulin-secreting cell line (RINm5F). The Journal of biological chemistry. vol 266. issue 27. 1991-10-29. PMID:1680855. |
in contrast to adrenaline and somatostatin, galanin, another inhibitor of insulin secretion, reduced ca2+ currents by about 40% in a pertussis toxin-insensitive manner. |
1991-10-29 |
2023-08-11 |
rat |
| G Soldevila, M Buscema, V Marini, R Sutton, R F James, S R Bloom, R P Robertson, R Mirakian, R Pujol-Borrell, G F Bottazz. Transfection with SV40 gene of human pancreatic endocrine cells. Journal of autoimmunity. vol 4. issue 3. 1991-10-25. PMID:1680332. |
the presence of neuron specific enolase, protein gene product 9.5, cytokeratin, microvilli, cytoplasmic electrodense granules and the secretion of insulin, glucagon and somatostatin supports the neuroendocrine origin of this cell line. |
1991-10-25 |
2023-08-11 |
human |
| X J Zhang, K R Kunkel, F Jahoor, R R Wolf. Role of basal insulin in the regulation of protein kinetics and energy metabolism in septic patients. JPEN. Journal of parenteral and enteral nutrition. vol 15. issue 4. 1991-10-23. PMID:1680204. |
we have investigated the role of basal insulin concentration on leucine kinetics (determined by means of 1-[13c]leucine) and energy metabolism (determined by indirect calorimetry) in eight septic patients by reducing insulin (and glucagon) secretion by somatostatin infusion. |
1991-10-23 |
2023-08-11 |
Not clear |
| X J Zhang, K R Kunkel, F Jahoor, R R Wolf. Role of basal insulin in the regulation of protein kinetics and energy metabolism in septic patients. JPEN. Journal of parenteral and enteral nutrition. vol 15. issue 4. 1991-10-23. PMID:1680204. |
somatostatin infusion reduced insulin concentration by 52% and glucagon concentration by 64%. |
1991-10-23 |
2023-08-11 |
Not clear |
| P M Piatti, L D Monti, M Pacchioni, A E Pontiroli, G Pozz. Forearm insulin- and non-insulin-mediated glucose uptake and muscle metabolism in man: role of free fatty acids and blood glucose levels. Metabolism: clinical and experimental. vol 40. issue 9. 1991-10-23. PMID:1895958. |
six healthy volunteers were submitted, in a random order, to a 2-hour euglycemic clamp (ec) followed by a 2-hour hyperglycemic (11 mmol/l) clamp (hc) under five different conditions: (1) somatostatin infusion (srif, 500 micrograms/h); (2) srif infusion preceded by a nicotinic acid analogue (acipimox, 250 mg orally, (3) srif plus insulin infusion; (4) srif plus insulin plus intralipid infusion; and (5) srif plus insulin infusion plus acipimox. |
1991-10-23 |
2023-08-11 |
human |
| Y Takeda, M J Escriban. Effects of insulin and somatostatin on the growth and the colony formation of two human pancreatic cancer cell lines. Journal of cancer research and clinical oncology. vol 117. issue 5. 1991-10-16. PMID:1679759. |
effects of insulin and somatostatin on the growth and the colony formation of two human pancreatic cancer cell lines. |
1991-10-16 |
2023-08-11 |
mouse |
| Y Takeda, M J Escriban. Effects of insulin and somatostatin on the growth and the colony formation of two human pancreatic cancer cell lines. Journal of cancer research and clinical oncology. vol 117. issue 5. 1991-10-16. PMID:1679759. |
the effects of insulin and somatostatin on the growth and the colony formation of two human pancreatic cancer cell lines, bxpc-3 and soj-6, were studied. |
1991-10-16 |
2023-08-11 |
mouse |
| Y Takeda, M J Escriban. Effects of insulin and somatostatin on the growth and the colony formation of two human pancreatic cancer cell lines. Journal of cancer research and clinical oncology. vol 117. issue 5. 1991-10-16. PMID:1679759. |
the in vitro growth of bxpc-3 cells was significantly promoted by insulin, and was slightly inhibited by somatostatin, whereas the growth of soj-6 cells was not influenced by these hormones. |
1991-10-16 |
2023-08-11 |
mouse |
| C J Greenbaum, P J Havel, G J Taborsky, L J Klaf. Intra-islet insulin permits glucose to directly suppress pancreatic A cell function. The Journal of clinical investigation. vol 88. issue 3. 1991-10-04. PMID:1679440. |
inhibition of pancreatic glucagon secretion during hyperglycemia could be mediated by (a) glucose, (b) insulin, (c) somatostatin, or (d) glucose in conjunction with insulin. |
1991-10-04 |
2023-08-11 |
Not clear |
| C J Greenbaum, P J Havel, G J Taborsky, L J Klaf. Intra-islet insulin permits glucose to directly suppress pancreatic A cell function. The Journal of clinical investigation. vol 88. issue 3. 1991-10-04. PMID:1679440. |
ventral lobe insulin, glucagon, and somatostatin outputs were then measured in response to a stepped iv glucose infusion. |
1991-10-04 |
2023-08-11 |
Not clear |
| C J Greenbaum, P J Havel, G J Taborsky, L J Klaf. Intra-islet insulin permits glucose to directly suppress pancreatic A cell function. The Journal of clinical investigation. vol 88. issue 3. 1991-10-04. PMID:1679440. |
we concluded that insulin was required in the mediation of glucagon suppression and somatostatin stimulation. |
1991-10-04 |
2023-08-11 |
Not clear |
| C J Greenbaum, P J Havel, G J Taborsky, L J Klaf. Intra-islet insulin permits glucose to directly suppress pancreatic A cell function. The Journal of clinical investigation. vol 88. issue 3. 1991-10-04. PMID:1679440. |
insulin infusion alone did not cause suppression of glucagon or stimulation of somatostatin; however, insulin repletion during glucose infusions did restore the ability of hyperglycemia to suppress glucagon and stimulate somatostatin. |
1991-10-04 |
2023-08-11 |
Not clear |
| C J Greenbaum, P J Havel, G J Taborsky, L J Klaf. Intra-islet insulin permits glucose to directly suppress pancreatic A cell function. The Journal of clinical investigation. vol 88. issue 3. 1991-10-04. PMID:1679440. |
we conclude that intra-islet insulin permits glucose to suppress glucagon secretion and stimulate somatostatin during hyperglycemia. |
1991-10-04 |
2023-08-11 |
Not clear |
| J J Segura, J M Guerrero, R Goberna, J R Calv. Characterization of functional receptors for vasoactive intestinal peptide (VIP) in rat peritoneal macrophages. Regulatory peptides. vol 33. issue 2. 1991-09-30. PMID:1652777. |
glucagon, insulin, somatostatin, pancreastatin and octapeptide of cholecystokinin (cck 26-33) were ineffective. |
1991-09-30 |
2023-08-11 |
rat |
| D Bani, G Biliotti, T B Sacch. Morphological changes in the human endocrine pancreas induced by chronic excess of endogenous glucagon. Virchows Archiv. B, Cell pathology including molecular pathology. vol 60. issue 3. 1991-09-27. PMID:1679271. |
compared with normal pancreatic islets from control subjects, those of the pancreas from the patient with a glucagonoma showed an almost complete disappearance of a cells, a decrease in immunoreactive insulin in b cells associated with cytological features indicating enhanced synthesis and secretion of this hormone, and an increase in immunoreactive somatostatin and pancreatic polypeptide (pp) accompanied by unusually high numbers of d and pp cells. |
1991-09-27 |
2023-08-11 |
human |
| G Jonderko, K Jonderko, T Goła. Effect of somatostatin-14 on gastric emptying and on gastrin and insulin release after ingestion of a mixed solid-liquid meal in man. Materia medica Polona. Polish journal of medicine and pharmacy. vol 21. issue 3. 1991-09-27. PMID:2577474. |
at the same time suppression of the postprandial insulin release by somatostatin was observed--area under the insulin curve, auc0-90, 1450 +/- 161 mu.l-1 min (placebo) vs 501 +/- 60 mu.l-1 min (somatostatin), p less than 0.002. |
1991-09-27 |
2023-08-11 |
Not clear |
| E Peiró, P Dégano, R A Silvestre, J Marc. Inhibition of insulin release by amylin is not mediated by changes in somatostatin output. Life sciences. vol 49. issue 10. 1991-09-26. PMID:1678849. |
inhibition of insulin release by amylin is not mediated by changes in somatostatin output. |
1991-09-26 |
2023-08-11 |
rat |
| E Peiró, P Dégano, R A Silvestre, J Marc. Inhibition of insulin release by amylin is not mediated by changes in somatostatin output. Life sciences. vol 49. issue 10. 1991-09-26. PMID:1678849. |
we have investigated the effect of a high concentration (750 nm) of synthetic amidated rat amylin on unstimulated somatostatin and insulin secretion as well as on the response of these hormones to arginine. |
1991-09-26 |
2023-08-11 |
rat |
| E Peiró, P Dégano, R A Silvestre, J Marc. Inhibition of insulin release by amylin is not mediated by changes in somatostatin output. Life sciences. vol 49. issue 10. 1991-09-26. PMID:1678849. |
amylin consistently reduced insulin output but it did not significantly modify somatostatin release. |
1991-09-26 |
2023-08-11 |
rat |
| R H Bell, T Brinck-Johnsen, D S Longnecke. Inhibitory effect of streptozotocin on tumor development in transgenic mice bearing an elastase I-SV40 T-antigen fusion gene. Pancreas. vol 6. issue 4. 1991-09-20. PMID:1678889. |
the insulinomas and the delta-cell hyperplasia appeared to be functional, as evidenced by changes in plasma glucose, insulin, and somatostatin. |
1991-09-20 |
2023-08-11 |
mouse |