| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M M Salem, R M Rosa, D C Batll. Extrarenal potassium tolerance in chronic renal failure: implications for the treatment of acute hyperkalemia. American journal of kidney diseases : the official journal of the National Kidney Foundation. vol 18. issue 4. 1991-11-13. PMID:1928061. |
the role of basal insulin may be even more important than previously appreciated, since somatostatin infusion causes a much greater increase in the fasting plasma potassium in rats with renal failure than in controls. |
1991-11-13 |
2023-08-11 |
rat |
| T Ishiguro, A Iguchi, Y Kunoh, M Goto, K Uemura, H Miura, K Nonogaki, N Sakamot. Relative contribution of nervous system and hormones to hyperglycemia induced by thyrotropin-releasing hormone in fed rats. Neuroendocrinology. vol 54. issue 1. 1991-11-04. PMID:1681438. |
four groups of animals were evaluated: (1) intact rats; (2) rats receiving an infusion of somatostatin with insulin via the femoral vein to inhibit glucagon secretion and to maintain the basal insulin level; (3) rats bilaterally adrenalectomized (adx) to prevent epinephrine secretion, and (4) adx rats administered an infusion of somatostatin and insulin. |
1991-11-04 |
2023-08-11 |
rat |
| T Ishiguro, A Iguchi, Y Kunoh, M Goto, K Uemura, H Miura, K Nonogaki, N Sakamot. Relative contribution of nervous system and hormones to hyperglycemia induced by thyrotropin-releasing hormone in fed rats. Neuroendocrinology. vol 54. issue 1. 1991-11-04. PMID:1681438. |
evaluation of the areas under the glucose curves for the rats receiving somatostatin with insulin, adx rats, and adx rats receiving somatostatin with insulin showed values 202, 50, and 79% of those observed in intact animals. |
1991-11-04 |
2023-08-11 |
rat |
| b' I Hilgert, P Stolba, H Kristofov\\xc3\\xa1, I Stefanov\\xc3\\xa1, B Bendlov\\xc3\\xa1, M Lebl, V Horejs\\xc3\\xa. A monoclonal antibody applicable for determination of C-peptide of human proinsulin by RIA. Hybridoma. vol 10. issue 3. 1991-10-31. PMID:1916848.' |
one of them, c-pep-01, bound the c-peptide with high affinity (kas = 1.1 x 10(9) l/mol), cross-reacted fully with human proinsulin but not with insulin, glucagon or somatostatin and apparently recognized the regions of c-peptide comprising amino acid residues 8-13 and 25-31. |
1991-10-31 |
2023-08-11 |
mouse |
| E Peiró, P Dégano, P Miralles, R A Silvestre, J Marc. Homologous pancreastatin inhibits insulin secretion without affecting glucagon and somatostatin release in the perfused rat pancreas. Regulatory peptides. vol 34. issue 3. 1991-10-30. PMID:1681569. |
homologous pancreastatin inhibits insulin secretion without affecting glucagon and somatostatin release in the perfused rat pancreas. |
1991-10-30 |
2023-08-11 |
rat |
| E Peiró, P Dégano, P Miralles, R A Silvestre, J Marc. Homologous pancreastatin inhibits insulin secretion without affecting glucagon and somatostatin release in the perfused rat pancreas. Regulatory peptides. vol 34. issue 3. 1991-10-30. PMID:1681569. |
since there is great interspecies variability in the amino acid sequence of pancreastatin, we have investigated the influence of rat pancreastatin on insulin, glucagon and somatostatin secretion in a homologous animal model, namely the perfused rat pancreas. |
1991-10-30 |
2023-08-11 |
rat |
| A Schmidt, J Hescheler, S Offermanns, K Spicher, K D Hinsch, F J Klinz, J Codina, L Birnbaumer, H Gausepohl, R Fran. Involvement of pertussis toxin-sensitive G-proteins in the hormonal inhibition of dihydropyridine-sensitive Ca2+ currents in an insulin-secreting cell line (RINm5F). The Journal of biological chemistry. vol 266. issue 27. 1991-10-29. PMID:1680855. |
somatostatin which also inhibits insulin secretion was less efficient (inhibition by 20%). |
1991-10-29 |
2023-08-11 |
rat |
| A Schmidt, J Hescheler, S Offermanns, K Spicher, K D Hinsch, F J Klinz, J Codina, L Birnbaumer, H Gausepohl, R Fran. Involvement of pertussis toxin-sensitive G-proteins in the hormonal inhibition of dihydropyridine-sensitive Ca2+ currents in an insulin-secreting cell line (RINm5F). The Journal of biological chemistry. vol 266. issue 27. 1991-10-29. PMID:1680855. |
in contrast to adrenaline and somatostatin, galanin, another inhibitor of insulin secretion, reduced ca2+ currents by about 40% in a pertussis toxin-insensitive manner. |
1991-10-29 |
2023-08-11 |
rat |
| G Soldevila, M Buscema, V Marini, R Sutton, R F James, S R Bloom, R P Robertson, R Mirakian, R Pujol-Borrell, G F Bottazz. Transfection with SV40 gene of human pancreatic endocrine cells. Journal of autoimmunity. vol 4. issue 3. 1991-10-25. PMID:1680332. |
the presence of neuron specific enolase, protein gene product 9.5, cytokeratin, microvilli, cytoplasmic electrodense granules and the secretion of insulin, glucagon and somatostatin supports the neuroendocrine origin of this cell line. |
1991-10-25 |
2023-08-11 |
human |
| X J Zhang, K R Kunkel, F Jahoor, R R Wolf. Role of basal insulin in the regulation of protein kinetics and energy metabolism in septic patients. JPEN. Journal of parenteral and enteral nutrition. vol 15. issue 4. 1991-10-23. PMID:1680204. |
we have investigated the role of basal insulin concentration on leucine kinetics (determined by means of 1-[13c]leucine) and energy metabolism (determined by indirect calorimetry) in eight septic patients by reducing insulin (and glucagon) secretion by somatostatin infusion. |
1991-10-23 |
2023-08-11 |
Not clear |
| X J Zhang, K R Kunkel, F Jahoor, R R Wolf. Role of basal insulin in the regulation of protein kinetics and energy metabolism in septic patients. JPEN. Journal of parenteral and enteral nutrition. vol 15. issue 4. 1991-10-23. PMID:1680204. |
somatostatin infusion reduced insulin concentration by 52% and glucagon concentration by 64%. |
1991-10-23 |
2023-08-11 |
Not clear |
| P M Piatti, L D Monti, M Pacchioni, A E Pontiroli, G Pozz. Forearm insulin- and non-insulin-mediated glucose uptake and muscle metabolism in man: role of free fatty acids and blood glucose levels. Metabolism: clinical and experimental. vol 40. issue 9. 1991-10-23. PMID:1895958. |
six healthy volunteers were submitted, in a random order, to a 2-hour euglycemic clamp (ec) followed by a 2-hour hyperglycemic (11 mmol/l) clamp (hc) under five different conditions: (1) somatostatin infusion (srif, 500 micrograms/h); (2) srif infusion preceded by a nicotinic acid analogue (acipimox, 250 mg orally, (3) srif plus insulin infusion; (4) srif plus insulin plus intralipid infusion; and (5) srif plus insulin infusion plus acipimox. |
1991-10-23 |
2023-08-11 |
human |
| Y Takeda, M J Escriban. Effects of insulin and somatostatin on the growth and the colony formation of two human pancreatic cancer cell lines. Journal of cancer research and clinical oncology. vol 117. issue 5. 1991-10-16. PMID:1679759. |
effects of insulin and somatostatin on the growth and the colony formation of two human pancreatic cancer cell lines. |
1991-10-16 |
2023-08-11 |
mouse |
| Y Takeda, M J Escriban. Effects of insulin and somatostatin on the growth and the colony formation of two human pancreatic cancer cell lines. Journal of cancer research and clinical oncology. vol 117. issue 5. 1991-10-16. PMID:1679759. |
the effects of insulin and somatostatin on the growth and the colony formation of two human pancreatic cancer cell lines, bxpc-3 and soj-6, were studied. |
1991-10-16 |
2023-08-11 |
mouse |
| Y Takeda, M J Escriban. Effects of insulin and somatostatin on the growth and the colony formation of two human pancreatic cancer cell lines. Journal of cancer research and clinical oncology. vol 117. issue 5. 1991-10-16. PMID:1679759. |
the in vitro growth of bxpc-3 cells was significantly promoted by insulin, and was slightly inhibited by somatostatin, whereas the growth of soj-6 cells was not influenced by these hormones. |
1991-10-16 |
2023-08-11 |
mouse |
| C J Greenbaum, P J Havel, G J Taborsky, L J Klaf. Intra-islet insulin permits glucose to directly suppress pancreatic A cell function. The Journal of clinical investigation. vol 88. issue 3. 1991-10-04. PMID:1679440. |
inhibition of pancreatic glucagon secretion during hyperglycemia could be mediated by (a) glucose, (b) insulin, (c) somatostatin, or (d) glucose in conjunction with insulin. |
1991-10-04 |
2023-08-11 |
Not clear |
| C J Greenbaum, P J Havel, G J Taborsky, L J Klaf. Intra-islet insulin permits glucose to directly suppress pancreatic A cell function. The Journal of clinical investigation. vol 88. issue 3. 1991-10-04. PMID:1679440. |
ventral lobe insulin, glucagon, and somatostatin outputs were then measured in response to a stepped iv glucose infusion. |
1991-10-04 |
2023-08-11 |
Not clear |
| C J Greenbaum, P J Havel, G J Taborsky, L J Klaf. Intra-islet insulin permits glucose to directly suppress pancreatic A cell function. The Journal of clinical investigation. vol 88. issue 3. 1991-10-04. PMID:1679440. |
we concluded that insulin was required in the mediation of glucagon suppression and somatostatin stimulation. |
1991-10-04 |
2023-08-11 |
Not clear |
| C J Greenbaum, P J Havel, G J Taborsky, L J Klaf. Intra-islet insulin permits glucose to directly suppress pancreatic A cell function. The Journal of clinical investigation. vol 88. issue 3. 1991-10-04. PMID:1679440. |
insulin infusion alone did not cause suppression of glucagon or stimulation of somatostatin; however, insulin repletion during glucose infusions did restore the ability of hyperglycemia to suppress glucagon and stimulate somatostatin. |
1991-10-04 |
2023-08-11 |
Not clear |
| C J Greenbaum, P J Havel, G J Taborsky, L J Klaf. Intra-islet insulin permits glucose to directly suppress pancreatic A cell function. The Journal of clinical investigation. vol 88. issue 3. 1991-10-04. PMID:1679440. |
we conclude that intra-islet insulin permits glucose to suppress glucagon secretion and stimulate somatostatin during hyperglycemia. |
1991-10-04 |
2023-08-11 |
Not clear |