| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M Bendayan, I S Par. Presence of extrapancreatic islets of Langerhans in the duodenal wall of the rat. Diabetologia. vol 34. issue 8. 1991-12-10. PMID:1682201. |
the insulin cells formed the core of the islets while the glucagon, the somatostatin and the pancreatic polypeptide cells were located at the periphery. |
1991-12-10 |
2023-08-11 |
rat |
| C Orskov, S S Poulse. Glucagonlike peptide-I-(7-36)-amide receptors only in islets of Langerhans. Autoradiographic survey of extracerebral tissues in rats. Diabetes. vol 40. issue 10. 1991-12-06. PMID:1657666. |
we also found binding of 125i-glp-i to insulin-, glucagon-, and somatostatin-immunoreactive cells by combined autoradiographic and immunohistochemical analysis of pancreatic specimens using antisera against insulin, glucagon, and somatostatin. |
1991-12-06 |
2023-08-11 |
rat |
| M Hayakawa, K Yokono, M Nagata, N Hatamori, W Ogawa, A Miki, H Mizoguti, S Bab. Morphological analysis of selective destruction of pancreatic beta-cells by cytotoxic T lymphocytes in NOD mice. Diabetes. vol 40. issue 9. 1991-12-06. PMID:1682198. |
in addition, the concentration of pancreatic hormones in the culture medium, used as a marker of cytolysis, also demonstrated that insulin was significantly increased after 6 h of culture, whereas glucagon and somatostatin were not. |
1991-12-06 |
2023-08-11 |
mouse |
| G D Divertie, M D Jensen, J M Mile. Stimulation of lipolysis in humans by physiological hypercortisolemia. Diabetes. vol 40. issue 10. 1991-12-06. PMID:1936585. |
on both occasions, a pancreatic clamp (0.12 micrograms.kg-1.min-1 somatostatin, 0.05 mu.kg-1.min-1 insulin, and 3 ng.kg-1.min-1 growth hormone) was used to maintain plasma hormone concentrations at desired levels. |
1991-12-06 |
2023-08-11 |
human |
| H J Zhang, J B Redmon, J M Andresen, R P Robertso. Somatostatin and epinephrine decrease insulin messenger ribonucleic acid in HIT cells through a pertussis toxin-sensitive mechanism. Endocrinology. vol 129. issue 5. 1991-12-02. PMID:1682135. |
somatostatin and epinephrine decrease insulin messenger ribonucleic acid in hit cells through a pertussis toxin-sensitive mechanism. |
1991-12-02 |
2023-08-11 |
Not clear |
| H J Zhang, J B Redmon, J M Andresen, R P Robertso. Somatostatin and epinephrine decrease insulin messenger ribonucleic acid in HIT cells through a pertussis toxin-sensitive mechanism. Endocrinology. vol 129. issue 5. 1991-12-02. PMID:1682135. |
the sites of action for somatostatin and epinephrine to inhibit insulin secretion have been reported to be exclusively in the exocytotic pathway. |
1991-12-02 |
2023-08-11 |
Not clear |
| H J Zhang, J B Redmon, J M Andresen, R P Robertso. Somatostatin and epinephrine decrease insulin messenger ribonucleic acid in HIT cells through a pertussis toxin-sensitive mechanism. Endocrinology. vol 129. issue 5. 1991-12-02. PMID:1682135. |
we observed that both somatostatin and epinephrine not only inhibit insulin secretion (53 +/- 2% and 50 +/- 2% of control, respectively) but also decrease insulin mrna levels (54 +/- 5% and 66 +/- 5% of control, respectively) and insulin content in hit cells (61 +/- 2% and 51 +/- 1% of control, respectively). |
1991-12-02 |
2023-08-11 |
Not clear |
| H J Zhang, J B Redmon, J M Andresen, R P Robertso. Somatostatin and epinephrine decrease insulin messenger ribonucleic acid in HIT cells through a pertussis toxin-sensitive mechanism. Endocrinology. vol 129. issue 5. 1991-12-02. PMID:1682135. |
these new observations suggest that somatostatin and epinephrine negatively modulate insulin availability through a guanine nucleotide binding protein-mediated step in insulin synthesis before the exocytotic pathway. |
1991-12-02 |
2023-08-11 |
Not clear |
| P Gilon, G Bertrand, M M Loubatières-Mariani, C Remacle, J C Henqui. The influence of gamma-aminobutyric acid on hormone release by the mouse and rat endocrine pancreas. Endocrinology. vol 129. issue 5. 1991-12-02. PMID:1682137. |
exogenous gaba, baclofen (agonist of gabab receptors), muscimol (agonist of gabaa receptors), or bicuculline (antagonist of gabaa receptors) did not affect insulin and somatostatin release by isolated mouse or rat islets. |
1991-12-02 |
2023-08-11 |
mouse |
| P Gilon, G Bertrand, M M Loubatières-Mariani, C Remacle, J C Henqui. The influence of gamma-aminobutyric acid on hormone release by the mouse and rat endocrine pancreas. Endocrinology. vol 129. issue 5. 1991-12-02. PMID:1682137. |
in conclusion, gaba does not affect insulin and somatostatin secretion, but inhibits a-cells, probably by acting on gabaa receptors. |
1991-12-02 |
2023-08-11 |
mouse |
| D Grube, A Jörn. The endocrine pancreas of glucagon-and somatostatin-immunized rabbits. I. Light microscopy and immunohistochemistry. Cell and tissue research. vol 265. issue 2. 1991-11-25. PMID:1682051. |
the latter changes differed after either immunization: glucagon immunization resulted in hypertrophy and hyperplasia of glucagon cells and a decrease in their hormonal content; somatostatin immunization led to an increased proportion of somatostatin cells and a lowered hormonal content of insulin cells. |
1991-11-25 |
2023-08-11 |
rabbit |
| b' M Zamaklar, N Ribarac-Stepi\\xc4\\x87, N Lali\\xc4\\x87, M Devecerski, S Damjanovi\\xc4\\x87, P Djordjevi\\xc4\\x8. [The effect of somatostatin on specific binding of insulin to receptors in patients with non-insulin dependent diabetes]. Glas. Srpska akademija nauka i umetnosti. Odeljenje medicinskih nauka. issue 41. 1991-11-20. PMID:1680775.' |
[the effect of somatostatin on specific binding of insulin to receptors in patients with non-insulin dependent diabetes]. |
1991-11-20 |
2023-08-11 |
human |
| H Yamagiwa, T Onishi, M Nishi. [Histological study of heterotopic pancreas tissue of the stomach--histogenesis and immunohistochemical findings]. Rinsho byori. The Japanese journal of clinical pathology. vol 39. issue 8. 1991-11-18. PMID:1920887. |
staining behavior by insulin, gastrin, glucagon, somatostatin and serotonin was similar to that of normal pancreas. |
1991-11-18 |
2023-08-11 |
Not clear |
| M M Salem, R M Rosa, D C Batll. Extrarenal potassium tolerance in chronic renal failure: implications for the treatment of acute hyperkalemia. American journal of kidney diseases : the official journal of the National Kidney Foundation. vol 18. issue 4. 1991-11-13. PMID:1928061. |
the role of basal insulin may be even more important than previously appreciated, since somatostatin infusion causes a much greater increase in the fasting plasma potassium in rats with renal failure than in controls. |
1991-11-13 |
2023-08-11 |
rat |
| T Ishiguro, A Iguchi, Y Kunoh, M Goto, K Uemura, H Miura, K Nonogaki, N Sakamot. Relative contribution of nervous system and hormones to hyperglycemia induced by thyrotropin-releasing hormone in fed rats. Neuroendocrinology. vol 54. issue 1. 1991-11-04. PMID:1681438. |
four groups of animals were evaluated: (1) intact rats; (2) rats receiving an infusion of somatostatin with insulin via the femoral vein to inhibit glucagon secretion and to maintain the basal insulin level; (3) rats bilaterally adrenalectomized (adx) to prevent epinephrine secretion, and (4) adx rats administered an infusion of somatostatin and insulin. |
1991-11-04 |
2023-08-11 |
rat |
| T Ishiguro, A Iguchi, Y Kunoh, M Goto, K Uemura, H Miura, K Nonogaki, N Sakamot. Relative contribution of nervous system and hormones to hyperglycemia induced by thyrotropin-releasing hormone in fed rats. Neuroendocrinology. vol 54. issue 1. 1991-11-04. PMID:1681438. |
evaluation of the areas under the glucose curves for the rats receiving somatostatin with insulin, adx rats, and adx rats receiving somatostatin with insulin showed values 202, 50, and 79% of those observed in intact animals. |
1991-11-04 |
2023-08-11 |
rat |
| b' I Hilgert, P Stolba, H Kristofov\\xc3\\xa1, I Stefanov\\xc3\\xa1, B Bendlov\\xc3\\xa1, M Lebl, V Horejs\\xc3\\xa. A monoclonal antibody applicable for determination of C-peptide of human proinsulin by RIA. Hybridoma. vol 10. issue 3. 1991-10-31. PMID:1916848.' |
one of them, c-pep-01, bound the c-peptide with high affinity (kas = 1.1 x 10(9) l/mol), cross-reacted fully with human proinsulin but not with insulin, glucagon or somatostatin and apparently recognized the regions of c-peptide comprising amino acid residues 8-13 and 25-31. |
1991-10-31 |
2023-08-11 |
mouse |
| E Peiró, P Dégano, P Miralles, R A Silvestre, J Marc. Homologous pancreastatin inhibits insulin secretion without affecting glucagon and somatostatin release in the perfused rat pancreas. Regulatory peptides. vol 34. issue 3. 1991-10-30. PMID:1681569. |
homologous pancreastatin inhibits insulin secretion without affecting glucagon and somatostatin release in the perfused rat pancreas. |
1991-10-30 |
2023-08-11 |
rat |
| E Peiró, P Dégano, P Miralles, R A Silvestre, J Marc. Homologous pancreastatin inhibits insulin secretion without affecting glucagon and somatostatin release in the perfused rat pancreas. Regulatory peptides. vol 34. issue 3. 1991-10-30. PMID:1681569. |
since there is great interspecies variability in the amino acid sequence of pancreastatin, we have investigated the influence of rat pancreastatin on insulin, glucagon and somatostatin secretion in a homologous animal model, namely the perfused rat pancreas. |
1991-10-30 |
2023-08-11 |
rat |
| A Schmidt, J Hescheler, S Offermanns, K Spicher, K D Hinsch, F J Klinz, J Codina, L Birnbaumer, H Gausepohl, R Fran. Involvement of pertussis toxin-sensitive G-proteins in the hormonal inhibition of dihydropyridine-sensitive Ca2+ currents in an insulin-secreting cell line (RINm5F). The Journal of biological chemistry. vol 266. issue 27. 1991-10-29. PMID:1680855. |
somatostatin which also inhibits insulin secretion was less efficient (inhibition by 20%). |
1991-10-29 |
2023-08-11 |
rat |