| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| G I Shulman, P E Williams, J E Liljenquist, W W Lacy, U Keller, A D Cherringto. Effect of hyperglycemia independent of changes in insulin or glucagon on lipolysis in the conscious dog. Metabolism: clinical and experimental. vol 29. issue 4. 1980-07-12. PMID:6103495. |
in the face of fixed basal levels of insulin (9 microunits/ml) and glucagon (63 pg/ml) maintained by the infusion of somatostatin and replacement amounts of the two pancreatic hormones, the mean arterial plasma glucose concentration was elevated from 102 to 217 mg/dl by continuous glucose infusion. |
1980-07-12 |
2023-08-12 |
dog |
| F G Williams, G E Baue. Evidence that somatostatin inhibits proinsulin synthesis and insulin release by isolated pancreatic islets of the rat. Metabolism: clinical and experimental. vol 29. issue 4. 1980-07-12. PMID:6103496. |
evidence that somatostatin inhibits proinsulin synthesis and insulin release by isolated pancreatic islets of the rat. |
1980-07-12 |
2023-08-12 |
rat |
| F G Williams, G E Baue. Evidence that somatostatin inhibits proinsulin synthesis and insulin release by isolated pancreatic islets of the rat. Metabolism: clinical and experimental. vol 29. issue 4. 1980-07-12. PMID:6103496. |
conflicting reports on the direction and magnitude of the effect of somatostatin on (pro)insulin synthesis prompted our investigation. |
1980-07-12 |
2023-08-12 |
rat |
| F G Williams, G E Baue. Evidence that somatostatin inhibits proinsulin synthesis and insulin release by isolated pancreatic islets of the rat. Metabolism: clinical and experimental. vol 29. issue 4. 1980-07-12. PMID:6103496. |
somatostatin at a concentration of 10 micrograms/ml inhibited 300 mg/dl glucose-stimulated proinsulin synthesis by 25% from 448 +/- 25 dpm/microunits insulin to 336 +/- 25 dpm/microunits insulin (disintegrations per minute in the proinsulin peak per microunit extractable insulin) (p less than 0.05). |
1980-07-12 |
2023-08-12 |
rat |
| F G Williams, G E Baue. Evidence that somatostatin inhibits proinsulin synthesis and insulin release by isolated pancreatic islets of the rat. Metabolism: clinical and experimental. vol 29. issue 4. 1980-07-12. PMID:6103496. |
glucagon (10 micrograms/ml) reversed the inhibitory effect of somatostatin on proinsulin synthesis from 336 +/- 25 dpm/microunits insulin to 480 +/- 44 dpm/microunits insulin (p less than 0.02). |
1980-07-12 |
2023-08-12 |
rat |
| F G Williams, G E Baue. Evidence that somatostatin inhibits proinsulin synthesis and insulin release by isolated pancreatic islets of the rat. Metabolism: clinical and experimental. vol 29. issue 4. 1980-07-12. PMID:6103496. |
insulin release in 300 mg/dl glucose was inhibited 38% by 10 micrograms/ml somatostatin from 3.05 +/- 0.40 mu medium/mu tissue to 1.90 +/- 0.10 mu medium/mu tissue (p less than 0.01) over a 45-minute incubation period. |
1980-07-12 |
2023-08-12 |
rat |
| F G Williams, G E Baue. Evidence that somatostatin inhibits proinsulin synthesis and insulin release by isolated pancreatic islets of the rat. Metabolism: clinical and experimental. vol 29. issue 4. 1980-07-12. PMID:6103496. |
these data suggest that somatostatin may act on glucose signal transduction on a level at which both insulin synthesis and secretion are affected. |
1980-07-12 |
2023-08-12 |
rat |
| F A Wilson, D L Antonson, B L Hart, T A Warr, A D Cherrington, J E Liljenquis. The effect of somatostatin on the intestinal transport of glucose in vivo and in vitro in the rat. Endocrinology. vol 106. issue 5. 1980-06-27. PMID:6102512. |
somatostatin infusion in vivo produced a significant fall in plasma glucose concentration (p less than 0.001) and a fall in pooled plasma insulin concentration to 51% of control values. |
1980-06-27 |
2023-08-12 |
rat |
| A B Kurtz, J A Matthews, B E Mustaffa, P R Daggett, J D Nabarr. Decrease of antibodies to insulin, proinsulin and contaminating hormones after changing treatment from conventional beef to purified pork insulin. Diabetologia. vol 18. issue 2. 1980-06-27. PMID:6988274. |
all showed antibody binding of insulin, 29 binding of proinsulin, 29 binding of pancreatic polypeptide, two binding of glucagon but none of the sera bound vasoactive intestinal peptide or somatostatin. |
1980-06-27 |
2023-08-12 |
human |
| G C Weir, S Bonner-Weir, D C Edward. Nerve growth factor and pancreatic APUD cells. Endocrine research communications. vol 7. issue 1. 1980-06-25. PMID:6102510. |
the pancreatic content of glucagon, insulin, and somatostatin was unaffected, suggesting that pancreatic a,b, and d cells are under different developmental control than are cells of known neural crest origin. |
1980-06-25 |
2023-08-12 |
rat |
| S Fuji. Development of pancreatic endocrine cells in the rat fetus. Archivum histologicum Japonicum = Nihon soshikigaku kiroku. vol 42. issue 4. 1980-06-16. PMID:396908. |
2) insulin and pancreatic polypeptide (pp) immunoreactive cells are first demonstrable in small cell clusters budding from the exocrine tubules on day 14, whereas somatostatin and gastrin reactive cells on day 17 and 18, respectively. |
1980-06-16 |
2023-08-11 |
rat |
| B W Inc. Amino acid stimulation of insulin secretion from the in situ perfused eel pancreas; modification by somatostatin, adrenaline, and theophylline. General and comparative endocrinology. vol 40. issue 3. 1980-06-16. PMID:6102537. |
amino acid stimulation of insulin secretion from the in situ perfused eel pancreas; modification by somatostatin, adrenaline, and theophylline. |
1980-06-16 |
2023-08-12 |
Not clear |
| F Malaisse-Lagae, Y Stefan, J Cox, A Perrelet, L Orc. Identification of a lobe in the adult human pancreas rich in pancreatic polypeptide. Diabetologia. vol 17. issue 6. 1980-05-30. PMID:395002. |
a quantitative study of the immunofluorescent endocrine cell types (insulin, glucagon, somatostatin and pancreatic polypeptide cells) in pp-rich and pp-poor regions of pancreases in 8 subjects with ages ranging from 33 fetal weeks to 80 years, showed that the proportions of the cell types were different in youngs and adults. |
1980-05-30 |
2023-08-11 |
human |
| K Hermansen, H Orskov, S E Christense. Streptozotocin diabetes: a glucoreceptor dysfunction affecting D cells as well as B and A cells. Diabetologia. vol 17. issue 6. 1980-05-30. PMID:395006. |
in the diabetic pancreas addition of insulin to the perfusate (25,000 microu/ml) for periods from 10 to 75 minutes aimed at restoring normal extracellular insulin levels in the islets failed to restore either somatostatin or glucagon secretion to normal. |
1980-05-30 |
2023-08-11 |
dog |
| A L Goldma. Inhibition of hepatic regeneration by somatostatin in adult rats receiving insulin and glucagon replacement. Surgical forum. vol 30. 1980-05-30. PMID:395694. |
inhibition of hepatic regeneration by somatostatin in adult rats receiving insulin and glucagon replacement. |
1980-05-30 |
2023-08-11 |
rat |
| T Chiba, T Taminato, S Kadowaki, H Abe, K Chihara, S Matsukura, Y Goto, Y Seino, T Fujit. Effects of insulin and pancreatic polypeptide on gastric somatostatin release. Diabetes. vol 29. issue 4. 1980-05-30. PMID:6987118. |
effects of insulin and pancreatic polypeptide on gastric somatostatin release. |
1980-05-30 |
2023-08-12 |
rat |
| T Chiba, T Taminato, S Kadowaki, H Abe, K Chihara, S Matsukura, Y Goto, Y Seino, T Fujit. Effects of insulin and pancreatic polypeptide on gastric somatostatin release. Diabetes. vol 29. issue 4. 1980-05-30. PMID:6987118. |
effects of arginine and such pancreatic hormones as insulin and pancreatic polypeptide on gastric somatostatin release from the isolated perfused rat stomach were studied. |
1980-05-30 |
2023-08-12 |
rat |
| T Chiba, T Taminato, S Kadowaki, H Abe, K Chihara, S Matsukura, Y Goto, Y Seino, T Fujit. Effects of insulin and pancreatic polypeptide on gastric somatostatin release. Diabetes. vol 29. issue 4. 1980-05-30. PMID:6987118. |
both insulin and pancreatic polypeptide (10(-10), 10(-9), and 10(-8) m) caused a significant decrease in gastric somatostatin secretion. |
1980-05-30 |
2023-08-12 |
rat |
| T Chiba, T Taminato, S Kadowaki, H Abe, K Chihara, S Matsukura, Y Goto, Y Seino, T Fujit. Effects of insulin and pancreatic polypeptide on gastric somatostatin release. Diabetes. vol 29. issue 4. 1980-05-30. PMID:6987118. |
insulin (10(-10) m), furthermore, inhibited the glucagon (5 x 10(-8) m)-induced somatostatin response. |
1980-05-30 |
2023-08-12 |
rat |
| S Seino, H Sakurai, Y Seino, K Tsuda, K Tanigawa, H Kuzuya, Y Goto, H Imur. Starvation-induced changes of somatostatin, glucagon, and insulin secretion from the isolated perfused rat pancreas. Diabetes. vol 29. issue 4. 1980-05-30. PMID:6987123. |
starvation-induced changes of somatostatin, glucagon, and insulin secretion from the isolated perfused rat pancreas. |
1980-05-30 |
2023-08-12 |
rat |